Drusen volume development over time and its relevance to the course of age-related macular degeneration

British Journal of Ophthalmology

Volumn 101, Issue 2, 2017, Pages 198-203

  Schlanitz, Ferdinand G ^a   Baumann, Bernhard ^b   Kundi, Michael ^a   Sacu, Stefan ^a   Baratsits, Magdalena ^a   Scheschy, Ulrike ^a   Shahlaee, Abtin ^a   Mittermüller, Tamara J ^a   Montuoro, Alessio ^a   Roberts, Philipp ^a   Pircher, Michael ^b   Hitzenberger, Christoph K ^b   Schmidt Erfurth, Ursula ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Christian Doppler Laboratory for Innovative Optical Imaging and its Translation to Medicine   (Austria)

Author keywords

Degeneration; Imaging; Retina

Indexed keywords

ADULT; AGE RELATED MACULAR DEGENERATION; AGED; ALGORITHM; ARTICLE; AUSTRIA; AUTOMATION; B SCAN; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE COURSE; DRUSEN; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OPHTHALMOLOGY; OPTICAL COHERENCE TOMOGRAPHY; OPTICAL COHERENCE TOMOGRAPHY DEVICE; POLARISATION SENSITIVE OPTICAL COHERENCE TOMOGRAPHY; PREDICTIVE VALUE; PROGNOSIS; PROSPECTIVE STUDY; REFERENCE VALUE; REMISSION; RISK ASSESSMENT; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; SUBRETINAL NEOVASCULARIZATION; UNIVERSITY HOSPITAL; FLUORESCENCE ANGIOGRAPHY; GEOGRAPHIC ATROPHY; MACULAR DEGENERATION; MIDDLE AGED; PATHOLOGY; PROCEDURES; RETINAL DRUSEN; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALGORITHMS; DISEASE PROGRESSION; FEMALE; FLUORESCEIN ANGIOGRAPHY; GEOGRAPHIC ATROPHY; HUMANS; MACULAR DEGENERATION; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; RETINAL DRUSEN; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84963839138     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjophthalmol-2016-308422     Document Type: Article

References (25)

1. Ferris FL III, Wilkinson CP, Bird A, et al. Clinical classification of age-related macular degeneration. Ophthalmology 2013;120:844-51.
2. Davis MD, Gangnon RE, Lee L-Y, et al. The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17. Arch Ophthalmol 2005;123:1484-98.
3. de Sisternes L, Simon N, Tibshirani R, et al. Quantitative SD-OCT imaging biomarkers as indicators of age-related macular degeneration progression. Invest Ophthalmol Vis Sci 2014;55:7093-103.
4. Yehoshua Z, Wang F, Rosenfeld PJ, et al. Natural history of drusen morphology in age-related macular degeneration using spectral domain optical coherence tomography. Ophthalmology 2011;118:2434-41.
5. Khanifar AA, Koreishi AF, Izatt JA, et al. Drusen ultrastructure imaging with spectral domain optical coherence tomography in age-related macular degeneration. Ophthalmology 2008;115:1883-90.
6. Christenbury JG, Folgar FA, O'Connell RV, et al. Progression of intermediate age-related macular degeneration with proliferation and inner retinal migration of hyperreflective foci. Ophthalmology 2013;120:1038-45.
7. Ambati J, Ambati BK, Yoo SH, et al. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol 2003;48:257-93.
8. Donoso LA, Kim D, Frost A, et al. The role of inflammation in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 2006;51:137-52.
9. Pircher M, Hitzenberger CK, Schmidt-Erfurth U. Polarization sensitive optical coherence tomography in the human eye. Prog Retin Eye Res 2011;30:431-51.
10. Baumann B, Baumann S, Konegger T, et al. Polarization sensitive optical coherence tomography of melanin provides tissue inherent contrast based on depolarization. Biomed Opt Express 2012;3:1670-83.
11. Götzinger E, Pircher M, Geitzenauer W, et al. Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography. Opt Express 2008;16:16410-22.
12. Ahlers C, Göetzinger E, Pircher M, et al. Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization sensitive optical coherence tomography. Invest Ophthalmol Vis Sci 2010;51:2149-57.
13. Schlanitz FG, Sacu S, Baumann B, et al. Identification of Drusen characteristics in age-related macular degeneration by polarization-sensitive optical coherence tomography. Am J Ophthalmol 2015;160:335-44.e1.
14. Age-Related Eye Disease Study Research Group. The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1. Control Clin Trials 1999;20:573-600.
15. Baumann B, Götzinger E, Pircher M, et al. Measurements of depolarization distribution in the healthy human macula by polarization sensitive OCT. J Biophotonics 2009;2:426-34.
16. Baumann B, Götzinger E, Pircher M, et al. Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography. J Biomed Opt 2010;15:061704.
17. Schlanitz FG, Baumann B, Spalek T, et al. Performance of automated drusen detection by polarization-sensitive optical coherence tomography. Invest Ophthalmol Vis Sci 2011;52:4571-9.
18. Garcia Filho CA, Yehoshua Z, Gregori G, et al. Change in drusen volume as a novel clinical trial endpoint for the study of complement inhibition in age-related macular degeneration. Ophthalmic Surg Lasers Imaging Retina 2014;45:18-31.
19. Nathoo NA, Or C, Young M, et al. Optical coherence tomography-based measurement of drusen load predicts development of advanced age-related macular degeneration. Am J Ophthalmol 2014;158:757-61.e1.
20. Wu Z, Ayton LN, Luu CD, et al. Relationship between retinal microstructures on optical coherence tomography and microperimetry in age-related macular degeneration. Ophthalmology 2014;121:1445-52.
21. Wu Z, Luu CD, Ayton LN, et al. Optical coherence tomography-defined changes preceding the development of drusen-Associated atrophy in age-related macular degeneration. Ophthalmology 2014;121:2415-22.
22. Bressler NM, Munoz B, Maguire MG, et al. Five-year incidence and disappearance of drusen and retinal pigment epithelial abnormalities. Waterman study. Arch Ophthalmol 1995;113:301-8.
23. Crabb JW, Miyagi M, Gu X, et al. Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci USA 2002;99:14682-7.
24. Complications of Age-Related Macular Degeneration Prevention Trial Research Group. Laser treatment in patients with bilateral large drusen: the complications of age-related macular degeneration prevention trial. Ophthalmology 2006;113:1974-86.
25. Sallo FB, Rechtman E, Peto T, et al. Functional aspects of drusen regression in age-related macular degeneration. Br J Ophthalmol 2009;93:1345-50.