Prevalence and Severity of Anemia in Children Hospitalized with Acute Heart Failure

Congenital Heart Disease

Volumn 11, Issue 6, 2016, Pages 622-629

  Goldberg, Jason F ^a   Shah, Mona D ^a   Kantor, Paul F ^b   Rossano, Joseph W ^c   Shaddy, Robert E ^c   Chiou, Kevin ^a   Hanna, Jonathan ^d   Hagan, Joseph L ^a   Cabrera, Antonio G ^a   Jeewa, Aamir ^a   Price, Jack F ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d DUKE UNIVERSITY   (United States)

Author keywords

Anemia; Heart Failure; Heart Transplantation; Heart Assist Devices

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; HEMOGLOBIN; BIOLOGICAL MARKER;

ACUTE HEART FAILURE; ADOLESCENT; ADULT; ADVERSE OUTCOME; ANEMIA; ARTICLE; ASSISTED CIRCULATION; CEREBROVASCULAR ACCIDENT; CHILD; CONGENITAL HEART DISEASE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DEATH; DISEASE ASSOCIATION; DISEASE SEVERITY; ESTIMATED GLOMERULAR FILTRATION RATE; EVALUATION STUDY; FEMALE; HEART TRANSPLANTATION; HEMOGLOBIN BLOOD LEVEL; HOSPITAL MORTALITY; HOSPITAL READMISSION; HOSPITALIZED CHILD; HUMAN; INFANT; ISCHEMIC CARDIOMYOPATHY; LEFT VENTRICULAR ASSIST DEVICE; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MEDICAL RECORD REVIEW; OUTCOME ASSESSMENT; PREVALENCE; PRIORITY JOURNAL; RESTRICTIVE CARDIOMYOPATHY; RISK ASSESSMENT; TERTIARY CARE CENTER; ACUTE DISEASE; BLOOD; DISEASE COURSE; HEART ASSIST DEVICE; HEART FAILURE; HOSPITAL; HOSPITALIZATION; MEDICAL RECORD; METABOLISM; MORTALITY; PRESCHOOL CHILD; PROGNOSIS; RETROSPECTIVE STUDY; RISK FACTOR; SEVERITY OF ILLNESS INDEX; TEXAS; TIME FACTOR; YOUNG ADULT;

ACUTE DISEASE; ADOLESCENT; ANEMIA; BIOMARKERS; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; HEART FAILURE; HEART TRANSPLANTATION; HEART-ASSIST DEVICES; HEMOGLOBINS; HOSPITAL MORTALITY; HOSPITALIZATION; HOSPITALS, PEDIATRIC; HUMANS; INFANT; MALE; MEDICAL RECORDS; PREVALENCE; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TERTIARY CARE CENTERS; TEXAS; TIME FACTORS; YOUNG ADULT;

EID: 84963829183     PISSN: 1747079X     EISSN: 17470803     Source Type: Journal    
DOI: 10.1111/chd.12355     Document Type: Article

References (35)

1. Silverberg DS, Wexler D, Blum M, et al. The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations. J Am Coll Cardiol. 2000;35:1737–1744.
2. Ezekowitz JA, McAlister FA, Armstrong PW. Anemia is common in heart failure and is associated with poor outcomes insights from a cohort of 12 065 patients with new-onset heart failure. Circulation. 2003;107:223–225.
3. Al-Ahmad A, Rand WM, Manjunath G, et al. Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J Am Coll Cardiol. 2001;38:955–962.
4. Groenveld HF, Januzzi JL, Damman K, et al. Anemia and mortality in heart failure patients. J Am Coll Cardiol. 2008;52:818–827.
5. Go AS, Yang J, Ackerson LM, et al. Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) Study. Circulation. 2006;113:2713–2723.
6. Felker GM, Gattis WA, Leimberger JD, et al. Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure. J Am Coll Cardiol. 2003;92:625–628.
7. Kosiborod M, Smith GL, Radford MJ, Foody JM, Krumholz HM. The prognostic importance of anemia in patients with heart failure. Am J Med. 2003;114:112–119.
8. Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Borenstein J. Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol. 2002;39:1780–1786.
9. Young JB, Abraham WT, Albert NM, et al. Relation of low hemoglobin and anemia to morbidity and mortality in patients hospitalized with heart failure (insight from the OPTIMIZE-HF registry). J Am Coll Cardiol. 2008;101:223–230.
10. Silverberg DS, Wexler D, Blum M, et al. Erythropoietin in heart failure. Semin Nephrol. 2005;25:397–403.
11. Swedberg K, Young JB, Anand IS, et al. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med. 2013;368:1210–1219.
12. Anker SD, Comin-Colet J, Filippatos G, et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009;361:2436–2448.
13. Kammache I, Parrinello G, Marini D, et al. Anaemia is a predictor of early death or cardiac transplantation in children with idiopathic dilated cardiomyopathy. Cardiol Young. 2011;22:293–300.
14. Mueller GC, Schlueter EL, Arndt F, Dodge-Khatami A, Weil J, Mir TS. Prevalence of anemia in children with congestive heart failure due to dilated cardiomyopathy. Int J Pediatr. 2012; 2012:1–4.
15. Rossano JW, Kim JJ, Decker JA, et al. Prevalence, morbidity, and mortality of heart failure-related hospitalizations in children in the United States: a population-based study. J Card Fail. 2012;18:459–470.
16. Zappitelli M, Zhang X, Foster BJ. Estimating glomerular filtration rate in children at serial follow-up when height is unknown. Clin J Am Soc Nephrol. 2010;5:1763–1769.
17. Brugnara C. Appendix 11: normal hematologic values in children. In: Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux SE, eds. Nathan and Oski's Hematology of Infancy and Childhood, 7th edn. Philadephia, PA: Saunders; 2009:1774.
18. Nanas JN, Matsouka C, Karageorgopoulos D, et al. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol. 2006;48:2485–2489.
19. Klip IT, Comin-Colet J, Voors AA, et al. Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J. 2013;165:575.e3–582.e3.
20. Cohen-Solal A, Damy T, Terbah M, et al. High prevalence of iron deficiency in patients with acute decompensated heart failure. Eur J Heart Fail. 2014;16:984–991.
21. Dillmann E, Johnson DG, Martin J, Mackler B, Finch C. Catecholamine elevation in iron deficiency. Am J Physiol. 1979;237:R297–R300.
22. Rossi MA, Carillo SV. Pathogenesis of cardiac hypertrophy in iron deficiency anaemia: the role of noradrenaline. Br J Exp Pathol. 1982;63:269–277.
23. Toblli JE, Lombraña A, Duarte P, Di Gennaro F. Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. J Am Coll Cardiol. 2007;50:1657–1665.
24. Okonko DO, Grzeslo A, Witkowski T, et al. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial. J Am Coll Cardiol. 2008;51:103–112.
25. Ponikowski P, van Veldhuisen DJ, Comin-Colet J, et al. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J. 2015;36:657–668.
26. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011–1023.
27. Torre-Amione G, Kapadia S, Benedict C, Oral H, Young JB, Mann DL. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol. 1996;27:1201–1206.
28. Deswal A, Petersen NJ, Feldman AM, Young JB, White BG, Mann DL. Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the vesnarinone trial (VEST). Circulation. 2001;103:2055–2059.
29. Gaggin HK, Dec GW. The role of treatment for anemia as a therapeutic target in the management of chronic heart failure: insights after RED-HF. Curr Treat Options Cardiovasc Med. 2014;16:279–295.
30. Androne AS, Katz SD, Lund L, LaManca J. Hemodilution is common in patients with advanced heart failure. Circulation. 2003;107:226–229.
31. Howie SR. Blood sample volumes in child health research: review of safe limits. Bull World Health Org. 2010;89:46–53.
32. Lerner NB. Chapter 444: acquired pure red blood cell anemia. In: Kliegman RM, Stanton B, St Geme J, eds. Nelson Textbook of Pediatrics: Expert Consult, 19 edn. Saint Louis, MO: Saunders; 2011:1652.
33. Orbach H, Katz U, Sherer Y, Shoenfeld Y. Intravenous immunoglobulin. Clin Rev Allergy Immunol. 2005;29:173–184.
34. Anand IS. Anemia and chronic heart failure implications and treatment options. J Am Coll Cardiol. 2008;52:501–511.
35. Garty M, Cohen E, Zuchenko A, et al. Blood transfusion for acute decompensated heart failure—friend or foe? Am Heart J. 2009;158:653–658.