Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans

Journal of Translational Medicine

Volumn 14, Issue 1, 2016, Pages

  Fresnay, Stephanie ^a   McArthur, Monica A ^a   Magder, Laurence ^b   Darton, Thomas C ^c   Jones, Claire ^c   Waddington, Claire S ^c   Blohmke, Christoph J ^c   Angus, Brian ^d   Levine, Myron M ^a   Pollard, Andrew J ^c   Sztein, Marcelo B ^a  

^a University of Maryland School of Medicine Center for Vaccine Development   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

CD8 T cells; Cell mediated immunity; CMI; Cytokines; Cytotoxicity; Multifunctional; Salmonella Typhi; Typhoid fever

Indexed keywords

CD45RA ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; AUTOLOGOUS BLAST CELL LINE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DEGRANULATION; DELAYED TIME TO DISEASE ONSET; DISEASE COURSE; EFFECTOR CELL; EPSTEIN BARR VIRUS TRANSFORMED LYMPHOBLASTOID CELL LINE; FEMALE; FLOW CYTOMETRY; HEMATOLOGY; HLA E RESTRICTED AEH B LCL CELL LINE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOBLASTOID CELL LINE; LYMPHOCYTE HOMING; LYMPHOCYTE MIGRATION; MALE; MEMORY T LYMPHOCYTE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; SALMONELLA ENTERICA SEROVAR TYPHI; T CENTRAL MEMORY CELL; T EFFECTOR MEMORY CELL; T LYMPHOCYTE ACTIVATION; TARGET CELL; TYPHOID FEVER; ADOLESCENT; GASTROINTESTINAL TRACT; IMMUNOLOGY; KINETICS; MICROBIOLOGY; MIDDLE AGED; PATHOLOGY; SPECIES DIFFERENCE; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; GASTROINTESTINAL TRACT; HUMANS; KINETICS; MALE; MIDDLE AGED; SALMONELLA TYPHI; SPECIES SPECIFICITY; TREATMENT OUTCOME; TYPHOID FEVER; YOUNG ADULT;

EID: 84963745724     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-016-0819-7     Document Type: Article

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