Optogenetics for suppression of cardiac electrical activity in human and rat cardiomyocyte cultures

Neurophotonics

Volumn 2, Issue 3, 2015, Pages

  Nussinovitch, Udi ^a,b   Gepstein, Lior ^a,c  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b Department of Internal Medicine A ^*  (Israel)

^c Cardiology Department   (Israel)

Author keywords

Archaerhodopsin; Cardiac suppression; Cardiomyocytes; Molecular ablation; Optogenetics

Indexed keywords

GENE THERAPY; HEART; LIGHT SENSITIVE MATERIALS; PHOTOSENSITIVITY; RATS; STEM CELLS;

ARCHAERHODOPSIN; CARDIAC ELECTRICAL ACTIVITY; CARDIAC SUPPRESSION; CARDIOMYOCYTES; HUMAN EMBRYONIC STEM CELLS; MULTIELECTRODE ARRAYS; NEONATAL RAT CARDIOMYOCYTES; OPTOGENETICS;

CYTOLOGY;

ANIMAL CELL; ARTICLE; CARDIAC MUSCLE CELL; CELL CULTURE; CELL THERAPY; CHRONOTROPISM; CONTROLLED STUDY; ELECTROCARDIOGRAM; EMBRYO; HEART CONDUCTION; HEART MUSCLE EXCITABILITY; HUMAN; HUMAN CELL; HUMAN EMBRYONIC STEM CELL; ILLUMINATION; IMMUNOHISTOCHEMISTRY; NEWBORN; NONHUMAN; OPTOGENETICS; PRIMARY CULTURE; RAT;

EID: 84963709274     PISSN: 2329423X     EISSN: 23294248     Source Type: Journal    
DOI: 10.1117/1.NPh.2.3.031204     Document Type: Article

References (23)

1. H. V. Huikuri, A. Castellanos, and R. J. Myerburg, "Sudden death due to cardiac arrhythmias," N. Engl. J. Med. 345, 1473-1482 (2001).
2. Z. Koyak et al., "Sudden cardiac death in adult congenital heart disease," Circulation 126, 1944-1954 (2012).
3. C. Napolitano et al., "Sudden cardiac death and genetic ion channelopathies: Long QT, Brugada, short QT, catecholaminergic polymorphic ventricular tachycardia, and idiopathic ventricular fibrillation," Circulation 125, 2027-2034 (2012).
4. R. J. Czosek et al., "Impact of cardiac devices on the quality of life in pediatric patients," Circ. Arrhythm. Electrophysiol. 5, 1064-1072 (2012).
5. X. Han and E. S. Boyden, "Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution," PLoS One 2, e299 (2007).
6. A. B. Arrenberg, F. Del Bene, and H. Baier, "Optical control of zebrafish behavior with halorhodopsin," Proc. Natl. Acad. Sci. U. S. A. 106, 17968-17973 (2009).
7. K. Inada et al., "Optical dissection of neural circuits responsible for Drosophila larval locomotion with halorhodopsin," PLoS One 6, e29019 (2011).
8. T. Tsunematsu et al., "Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice," J. Neurosci. 31, 10529- 10539 (2011).
9. B. Y. Chow et al., "High-performance genetically targetable optical neural silencing by light-driven proton pumps," Nature 463, 98-102 (2010).
10. Z. Jia et al., "Stimulating cardiac muscle by light: Cardiac optogenetics by cell delivery," Circ. Arrhythm Electrophysiol. 4, 753-760 (2011).
11. U. Nussinovitch, R. Shinnawi, and L. Gepstein, "Modulation of cardiac tissue electrophysiological properties with light-sensitive proteins," Cardiovasc. Res. 102, 176-187 (2014).
12. A. B. Arrenberg et al., "Optogenetic control of cardiac function," Science 330, 971-974 (2010).
13. O. J. Abilez, "Cardiac optogenetics," Conf. Proc. IEEE Eng. Med. Biol. Soc. 2012, 1386-1389 (2012).
14. T. Bruegmann et al., "Optogenetic control of heart muscle in vitro and in vivo," Nat. Methods 7, 897-900 (2010).
15. L. Yankelson et al., "Cell therapy for modification of the myocardial electrophysiological substrate," Circulation 117, 720-731 (2008).
16. I. Kehat et al., "Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes," J. Clin. Invest. 108, 407-414 (2001).
17. S. Lev, I. Kehat, and L. Gepstein, "Differentiation pathways in human embryonic stem cell-derived cardiomyocytes," Ann. N. Y. Acad. Sci. 1047,50-65 (2005).
18. I. Kehat et al., "High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: A novel in vitro model for the study of conduction," Circ. Res. 91, 659-661 (2002).
19. Y. Feld et al., "Electrophysiological modulation of cardiomyocytic tissue by transfected fibroblasts expressing potassium channels: A novel strategy to manipulate excitability," Circulation 105, 522-529 (2002).
20. P. Santangeli and F. E. Marchlinski, "Pulmonary vein isolation for atrial fibrillation: Forever young," J. Am. Coll. Cardiol. 64, 2468-2470 (2014).
21. A. Hofshi et al., "A combined gene and cell therapy approach for restoration of conduction," Heart Rhythm 8, 121-130 (2011).
22. Y. Kurata et al., "Roles of hyperpolarization-activated current If in sinoatrial node pacemaking: Insights from bifurcation analysis of mathematical models," Am. J. Physiol. Heart Circ. Physiol. 298, H1748-1760 (2010).
23. J. Satin et al., "Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes," J. Physiol. 559(Pt.2), 477-494 (2004).