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Volumn 73, Issue 1, 2016, Pages 69-73

Brief Report: Enhanced Normalization of CD4/CD8 Ratio with Earlier Antiretroviral Therapy at Primary HIV Infection

Author keywords

acute HIV infection; CD4 CD8 ratio; CD4:CD8; early antiretroviral therapy; primary HIV infection; seroconversion

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR;

EID: 84963682415     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000001013     Document Type: Article
Times cited : (40)

References (38)
  • 1
    • 0025069873 scopus 로고
    • The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1
    • Fahey JL, Taylor JMG, Detels R, et al. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med. 1990;322:166-172.
    • (1990) N Engl J Med , vol.322 , pp. 166-172
    • Fahey, J.L.1    Taylor, J.M.G.2    Detels, R.3
  • 2
    • 0024553794 scopus 로고
    • CD4 percentage, CD4 number, and CD4:CD8 ratio in HIV infection: Which to choose and how to use
    • Taylor JM, Fahey JL, Detels R, et al. CD4 percentage, CD4 number, and CD4:CD8 ratio in HIV infection: which to choose and how to use. J Acquir Immune Defic Syndr. 1989;2:114-124.
    • (1989) J Acquir Immune Defic Syndr , vol.2 , pp. 114-124
    • Taylor, J.M.1    Fahey, J.L.2    Detels, R.3
  • 3
    • 84899462431 scopus 로고    scopus 로고
    • Predictors of CD4:CD8 ratio normalization and its effect on Health outcomes in the Era of combination antiretroviral therapy
    • Leung V, Gillis J, Raboud J, et al. Predictors of CD4:CD8 ratio normalization and its effect on Health outcomes in the Era of combination antiretroviral therapy. PLoS One. 2013;8:10.
    • (2013) PLoS One , vol.8 , pp. 10
    • Leung, V.1    Gillis, J.2    Raboud, J.3
  • 4
    • 84862215127 scopus 로고    scopus 로고
    • CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: A longitudinal cohort study from COHERE
    • Young J, Psichogiou M, Meyer L, et al. CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE. PLoS Med. 2012;9:e1001194.
    • (2012) PLoS Med , vol.9 , pp. e1001194
    • Young, J.1    Psichogiou, M.2    Meyer, L.3
  • 5
    • 63849227352 scopus 로고    scopus 로고
    • Should HIV therapy be started at a CD4 cell count above 350 cells/microl in asymptomatic HIV-1-infected patients?
    • Sabin CA, Phillips AN. Should HIV therapy be started at a CD4 cell count above 350 cells/microl in asymptomatic HIV-1-infected patients? Curr Opin Infect Dis. 2009;22:191-197.
    • (2009) Curr Opin Infect Dis , vol.22 , pp. 191-197
    • Sabin, C.A.1    Phillips, A.N.2
  • 6
    • 84871746299 scopus 로고    scopus 로고
    • Life expectancy living with HIV: Recent estimates and future implications
    • Nakagawa F, May M, Phillips A. Life expectancy living with HIV: recent estimates and future implications. Curr Opin Infect Dis. 2013;26:17-25.
    • (2013) Curr Opin Infect Dis , vol.26 , pp. 17-25
    • Nakagawa, F.1    May, M.2    Phillips, A.3
  • 7
    • 42549121220 scopus 로고    scopus 로고
    • Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART study
    • Emery S, Neuhaus JA, Phillips AN, et al. Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART study. J Infect Dis. 2008;197: 1133-1144.
    • (2008) J Infect Dis , vol.197 , pp. 1133-1144
    • Emery, S.1    Neuhaus, J.A.2    Phillips, A.N.3
  • 8
    • 84870754271 scopus 로고    scopus 로고
    • The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression
    • Serrano-Villar S, Gutierrez C, Vallejo A, et al. The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression. J Infect. 2013;66:57-66.
    • (2013) J Infect , vol.66 , pp. 57-66
    • Serrano-Villar, S.1    Gutierrez, C.2    Vallejo, A.3
  • 9
    • 84901244816 scopus 로고    scopus 로고
    • Clinical, immunological and treatment-related factors associated with normalised CD4+/CD8+T-cell ratio: Effect of naive and Memory T-cell subsets
    • Tinago W, Coghlan E, Macken A, et al. Clinical, immunological and treatment-related factors associated with normalised CD4+/CD8+T-cell ratio: effect of naive and Memory T-cell subsets. PLoS One. 2014;9:9.
    • (2014) PLoS One , vol.9 , pp. 9
    • Tinago, W.1    Coghlan, E.2    Macken, A.3
  • 10
    • 0033663861 scopus 로고    scopus 로고
    • Characteristics of HIV-1-infected patients with CD4: CD8 lymphocyte ratio normalization on antiretroviral therapy
    • Zaman MM, Recco RA, Raguthu L, et al. Characteristics of HIV-1-infected patients with CD4: CD8 lymphocyte ratio normalization on antiretroviral therapy. Aids Patient Care STDS. 2000;14:647-649.
    • (2000) AIDS Patient Care STDS , vol.14 , pp. 647-649
    • Zaman, M.M.1    Recco, R.A.2    Raguthu, L.3
  • 12
    • 84925426479 scopus 로고    scopus 로고
    • CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: An observational cohort study
    • Mussini C, Lorenzini P, Cozzi-Lepri A, et al. CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study. Lancet HIV. 2015;2:e98-e106.
    • (2015) Lancet HIV , vol.2 , pp. e98-e106
    • Mussini, C.1    Lorenzini, P.2    Cozzi-Lepri, A.3
  • 13
    • 0029009027 scopus 로고
    • Failure of T-cell homeostasis preceding AIDS in HIV-1 infection
    • The Multicenter AIDS cohort study
    • Margolick JB, Munoz A, Donnenberg AD, et al. Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. The Multicenter AIDS cohort study. Nat Med. 1995;1:674-680.
    • (1995) Nat Med , vol.1 , pp. 674-680
    • Margolick, J.B.1    Munoz, A.2    Donnenberg, A.D.3
  • 14
    • 0022974201 scopus 로고
    • Immunological abnormalities in asymptomatic homosexual men: Correlation with antibody to HTLVIII and sequential changes over two years
    • Frazer IH, Mackay IR, Crapper RM, et al. Immunological abnormalities in asymptomatic homosexual men: correlation with antibody to HTLVIII and sequential changes over two years. Q J Med. 1986;61:921-933.
    • (1986) Q J Med , vol.61 , pp. 921-933
    • Frazer, I.H.1    Mackay, I.R.2    Crapper, R.M.3
  • 15
    • 0036606456 scopus 로고    scopus 로고
    • Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy
    • Chun TW, Justement JS, Pandya P, et al. Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy. J Infect Dis. 2002;185:1672-1676.
    • (2002) J Infect Dis , vol.185 , pp. 1672-1676
    • Chun, T.W.1    Justement, J.S.2    Pandya, P.3
  • 17
    • 84896519361 scopus 로고    scopus 로고
    • Multiparametric bioinformatics distinguish the CD4/CD8 ratio as a Suitable Laboratory predictor of combined T cell pathogenesis in HIV infection
    • Buggert M, Frederiksen J, Noyan K, et al. Multiparametric bioinformatics distinguish the CD4/CD8 ratio as a Suitable Laboratory predictor of combined T cell pathogenesis in HIV infection. J Immunol. 2014;192: 2099-2108.
    • (2014) J Immunol , vol.192 , pp. 2099-2108
    • Buggert, M.1    Frederiksen, J.2    Noyan, K.3
  • 18
    • 84906050022 scopus 로고    scopus 로고
    • CD8 T cell persistence in treated HIV infection
    • Mudd JC, Lederman MM. CD8 T cell persistence in treated HIV infection. Curr Opin HIV AIDS. 2014;9:500-505.
    • (2014) Curr Opin HIV AIDS , vol.9 , pp. 500-505
    • Mudd, J.C.1    Lederman, M.M.2
  • 19
    • 84940530289 scopus 로고    scopus 로고
    • Initiation of antiretroviral therapy in early asymptomatic HIV infection
    • Lundgren JD, Babiker AG, Gordin F, et al. Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med. 2015;373: 795-807.
    • (2015) N Engl J Med , vol.373 , pp. 795-807
    • Lundgren, J.D.1    Babiker, A.G.2    Gordin, F.3
  • 20
    • 84872436943 scopus 로고    scopus 로고
    • Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy
    • Le T, Wright EJ, Smith DM, et al. Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy. N Engl J Med. 2013;368:218-230.
    • (2013) N Engl J Med , vol.368 , pp. 218-230
    • Le, T.1    Wright, E.J.2    Smith, D.M.3
  • 21
    • 84872452352 scopus 로고    scopus 로고
    • Short-course antiretroviral therapy in primary HIV infection
    • Fidler S, Porter K, Ewings F, et al. Short-course antiretroviral therapy in primary HIV infection. N Engl J Med. 2013;368:207-217.
    • (2013) N Engl J Med , vol.368 , pp. 207-217
    • Fidler, S.1    Porter, K.2    Ewings, F.3
  • 22
    • 10244270764 scopus 로고    scopus 로고
    • The UK Register of HIV seroconverters: Methods and analytical issues
    • Uk Register Of Hiv Seroconverters Steering Committee
    • Uk Register Of Hiv Seroconverters Steering Committee. The Uk Register of HIV seroconverters: methods and analytical issues. Epidemiol Infect. 1996;117:305-312.
    • (1996) Epidemiol Infect , vol.117 , pp. 305-312
  • 23
    • 84859924095 scopus 로고    scopus 로고
    • Factors influencing the normalization of CD4+ T-cell count, percentage and CD4+/CD8+ T-cell ratio in HIVinfected patients on long-term suppressive antiretroviral therapy
    • Torti C, Prosperi M, Motta D, et al. Factors influencing the normalization of CD4+ T-cell count, percentage and CD4+/CD8+ T-cell ratio in HIVinfected patients on long-term suppressive antiretroviral therapy. Clin Microbiol Infect. 2012;18:449-458.
    • (2012) Clin Microbiol Infect , vol.18 , pp. 449-458
    • Torti, C.1    Prosperi, M.2    Motta, D.3
  • 24
    • 84901686066 scopus 로고    scopus 로고
    • HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality
    • Serrano-Villar S, Sainz T, Lee SA, et al. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 2014;10:e1004078.
    • (2014) PLoS Pathog , vol.10 , pp. e1004078
    • Serrano-Villar, S.1    Sainz, T.2    Lee, S.A.3
  • 25
    • 84899451428 scopus 로고    scopus 로고
    • Delay in cART initiation results in persistent immune dysregulation and poor recovery of T-cell phenotype despite a decade of Successful HIV suppression
    • Ndumbi P, Falutz J, Pant pai N, et al. Delay in cART initiation results in persistent immune dysregulation and poor recovery of T-cell phenotype despite a decade of Successful HIV suppression. PLoS One. 2014;9:e94018.
    • (2014) PLoS One , vol.9 , pp. e94018
    • Ndumbi, P.1    Falutz, J.2    Pant pai, N.3
  • 26
    • 84890494817 scopus 로고    scopus 로고
    • British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2012 (Updated 2013 All changed text is cast in yellow highlight.)
    • Williams I, Churchill D, Anderson J, et al. British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2012 (Updated 2013. All changed text is cast in yellow highlight.). HIV Med. 2014;15(suppl 1):1-85.
    • (2014) HIV Med , vol.15 , pp. 1-85
    • Williams, I.1    Churchill, D.2    Anderson, J.3
  • 27
    • 84904568743 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection: 2014 recommendations of the international Antiviral Society-USA panel
    • Gunthard HF, Aberg JA, Eron JJ, et al. Antiretroviral treatment of adult HIV infection: 2014 recommendations of the international Antiviral Society-Usa panel. JAMA. 2014;312:410-425.
    • (2014) JAMA , vol.312 , pp. 410-425
    • Gunthard, H.F.1    Aberg, J.A.2    Eron, J.J.3
  • 29
    • 84983220621 scopus 로고    scopus 로고
    • 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention. July 2015. Vancouver, Canada. Presentation SUSA0608. Accessed August
    • Doherty M. New directions in the 2015 WHO Consolidated ARV Guidelines. 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention. July 2015. Vancouver, Canada. Presentation SUSA0608. Available at: http://pag.ias2015.org. Accessed August 2015.
    • (2015) New Directions in the 2015 WHO Consolidated ARV Guidelines
    • Doherty, M.1
  • 31
    • 84880571275 scopus 로고    scopus 로고
    • The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: The Swedish HEXA immune study
    • Strindhall J, Skog M, Ernerudh J, et al. The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study. Age (Dordr). 2013;35:985-991.
    • (2013) Age (Dordr) , vol.35 , pp. 985-991
    • Strindhall, J.1    Skog, M.2    Ernerudh, J.3
  • 32
    • 0025950082 scopus 로고
    • More rapid progression to AIDS in older HIV-infected people: The role of CD4+ T-cell counts
    • Phillips AN, Lee CA, Elford J, et al. More rapid progression to AIDS in older HIV-infected people: the role of CD4+ T-cell counts. J Acquir Immune Defic Syndr. 1991;4:970-975.
    • (1991) J Acquir Immune Defic Syndr , vol.4 , pp. 970-975
    • Phillips, A.N.1    Lee, C.A.2    Elford, J.3
  • 33
    • 43249121119 scopus 로고    scopus 로고
    • Plasma drug concentrations and virologic evaluations after stopping treatment with nonnucleoside reverse-transcriptase inhibitors in HIV type 1-infected children
    • Cressey TR, Green H, Khoo S, et al. Plasma drug concentrations and virologic evaluations after stopping treatment with nonnucleoside reverse-transcriptase inhibitors in HIV type 1-infected children. Clin Infect Dis. 2008;46:1601-1608.
    • (2008) Clin Infect Dis , vol.46 , pp. 1601-1608
    • Cressey, T.R.1    Green, H.2    Khoo, S.3
  • 34
    • 34147106431 scopus 로고    scopus 로고
    • Nevirapine clearance from plasma in African adults stopping therapy: A pharmacokinetic substudy
    • Kikaire B, Khoo S, Walker AS, et al. Nevirapine clearance from plasma in African adults stopping therapy: a pharmacokinetic substudy. AIDS. 2007;21:733-737.
    • (2007) AIDS , vol.21 , pp. 733-737
    • Kikaire, B.1    Khoo, S.2    Walker, A.S.3
  • 35
    • 84886769508 scopus 로고    scopus 로고
    • Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
    • Ho YC, Shan L, Hosmane NN, et al. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell. 2013;155:540-551.
    • (2013) Cell , vol.155 , pp. 540-551
    • Ho, Y.C.1    Shan, L.2    Hosmane, N.N.3
  • 36
    • 84925375640 scopus 로고    scopus 로고
    • HIV-1 DNA predicts disease progression and post-treatment virological control
    • Williams JP, Hurst J, Stohr W, et al. HIV-1 DNA predicts disease progression and post-treatment virological control. ELife. 2014;3: e03821.
    • (2014) ELife , vol.3 , pp. e03821
    • Williams, J.P.1    Hurst, J.2    Stohr, W.3
  • 37
    • 84944258447 scopus 로고    scopus 로고
    • Immunological biomarkers predict HIV-1 viral rebound after treatment interruption
    • Hurst J, Hoffmann M, Pace M, et al. Immunological biomarkers predict HIV-1 viral rebound after treatment interruption. Nat Commun. 2015; 6:8495.
    • (2015) Nat Commun , vol.6 , pp. 8495
    • Hurst, J.1    Hoffmann, M.2    Pace, M.3
  • 38
    • 84885058930 scopus 로고    scopus 로고
    • Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size
    • Jain V, Hartogensis W, Bacchetti P, et al. Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size. J Infect Dis. 2013;208:1202-1211.
    • (2013) J Infect Dis , vol.208 , pp. 1202-1211
    • Jain, V.1    Hartogensis, W.2    Bacchetti, P.3


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