A Phase I study of olaparib and irinotecan in patients with colorectal cancer: Canadian Cancer Trials Group IND 187

Investigational New Drugs

Volumn 34, Issue 4, 2016, Pages 450-457

  Chen, Eric X ^a   Jonker, Derek J ^b   Siu, Lillian L ^a   McKeever, Karyn ^a   Keller, Deborah ^b   Wells, Julie ^b   Hagerman, Linda ^c   Seymour, Lesley ^c  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c Clinical Trials Group   (Canada)

Author keywords

Colorectal cancer; Irinotecan; Olaparib; Phase I

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CREATININE; FIRTECAN; IRINOTECAN; OLAPARIB; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; PHTHALAZINE DERIVATIVE; PIPERAZINE DERIVATIVE;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ADULT; ADVANCED CANCER; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANOREXIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CLINICAL ARTICLE; COLITIS; COLORECTAL CANCER; CONSTIPATION; CONTROLLED STUDY; COUGHING; CREATININE BLOOD LEVEL; DEHYDRATION; DIARRHEA; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG FATALITY; DRUG POTENTIATION; DRUG SAFETY; DRUG TOLERABILITY; DYSPNEA; EPISTAXIS; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; FEVER; HUMAN; HUMAN TISSUE; HYPERKALEMIA; HYPERMAGNESEMIA; HYPOALBUMINEMIA; HYPOKALEMIA; HYPONATREMIA; HYPOTENSION; LYMPHOCYTOPENIA; MALE; MUCOSA INFLAMMATION; NAUSEA; NEUTROPENIA; PHASE 1 CLINICAL TRIAL; PNEUMONIA; PRIORITY JOURNAL; SENSORY NEUROPATHY; SEPSIS; SWEATING; THROMBOCYTOPENIA; TUMOR LOCALIZATION; VOMITING; WEAKNESS; ANALOGS AND DERIVATIVES; CLINICAL TRIAL; COLORECTAL TUMOR; MIDDLE AGED; TREATMENT OUTCOME;

AGED; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAMPTOTHECIN; COLORECTAL NEOPLASMS; FEMALE; HUMANS; MALE; MIDDLE AGED; PHTHALAZINES; PIPERAZINES; TREATMENT OUTCOME;

EID: 84963665161     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-016-0351-x     Document Type: Article

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