Asprosin, a Fasting-Induced Glucogenic Protein Hormone

Cell

Volumn 165, Issue 3, 2016, Pages 566-579

  Romere, Chase ^a   Duerrschmid, Clemens ^a   Bournat, Juan ^a   Constable, Petra ^a   Jain, Mahim ^a   Xia, Fan ^a   Saha, Pradip K ^a   Del Solar, Maria ^c   Zhu, Bokai ^a   York, Brian ^a   Sarkar, Poonam ^a   Rendon, David A ^a   Gaber, M Waleed ^a   LeMaire, Scott A ^a   Coselli, Joseph S ^a   Milewicz, Dianna M ^b   Sutton, V Reid ^a   Butte, Nancy F ^a   Moore, David D ^a   Chopra, Atul R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; AMINE; ASPROSIN; BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FIBRILLIN 1; GLUCAGON; GLUCAGON RECEPTOR; GLUCOCORTICOID; GLUCOSE; GLYCOPROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; MESSENGER RNA; PROFIBRILLIN; PROTEIN; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; ANTIBODY; ASPROSIN PROTEIN, HUMAN; PEPTIDE FRAGMENT; PEPTIDE HORMONE; RECOMBINANT PROTEIN;

3T3 CELL LINE; ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATECHOLAMINE BLOOD LEVEL; CELL LEVEL; CELL SURFACE; CONTROLLED STUDY; CORTICOSTEROID BLOOD LEVEL; DIET INDUCED OBESITY; DISEASE ASSOCIATION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; EXON; FIBROBLAST; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC CODE; GENETIC CONSERVATION; GENETIC DISORDER; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; GLUCAGON BLOOD LEVEL; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTAKE; GLUCOSE TRANSPORT; HALF LIFE TIME; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERINSULINEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN DEFICIENCY; INTRACELLULAR SIGNALING; ISOTOPE LABELING; LIVER CELL; LIVER LEVEL; LOW GLUCOSE INTAKE; MALE; MESENCHYMAL STEM CELL; METABOLIC SYNDROME X; MOLECULAR WEIGHT; MOUSE; NEONATAL PROGEROID SYNDROME; NEWBORN; NONHUMAN; NONSENSE MEDIATED MRNA DECAY; PRIORITY JOURNAL; PROADIPOCYTE; PROTECTION; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN SECRETION; PROTEIN TERTIARY STRUCTURE; RAT; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT; WHITE ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; CIRCADIAN RHYTHM; DIET RESTRICTION; FEMALE; GENETICS; INTRAUTERINE GROWTH RETARDATION; LIVER; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; PROGERIA; SEQUENCE ALIGNMENT;

ADIPOSE TISSUE, WHITE; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CIRCADIAN RHYTHM; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FASTING; FEMALE; FETAL GROWTH RETARDATION; GLUCOSE; HUMANS; INSULIN; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDE HORMONES; PROGERIA; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT;

EID: 84963627618     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.02.063     Document Type: Article

References (19)

1. S.L. Aronoff, K. Berkowitz, and B. Shreiner Glucose metabolism and regulation: beyond insulin and glucagon Diabetes Spectr. 17 2004 183 190
2. O.K. Behrens, and W.W. Bromer Biochemistry of the protein hormones Annu. Rev. Biochem. 27 1958 57 100
3. S. Bindlish, L.S. Presswala, and F. Schwartz Lipodystrophy: syndrome of severe insulin resistance Postgrad. Med. 127 2015 511 516
4. J.E. Campbell, and D.J. Drucker Islet α cells and glucagon - critical regulators of energy homeostasis Nat. Rev. Endocrinol. 11 2015 329 338
5. X. Cui, Y. Wang, Y. Tang, Y. Liu, L. Zhao, J. Deng, G. Xu, X. Peng, S. Ju, G. Liu, and H. Yang Seipin ablation in mice results in severe generalized lipodystrophy Hum. Mol. Genet. 20 2011 3022 3030
6. G. Dumoulin, B. Hory, N.U. Nguyen, M.T. Henriet, C. Bresson, J. Regnard, and Y. Saint-Hillier Acute oral calcium load decreases parathyroid secretion and suppresses tubular phosphate loss in long-term renal transplant recipients Am. J. Nephrol. 15 1995 238 244
7. J. Goldblatt, J. Hyatt, C. Edwards, and I. Walpole Further evidence for a marfanoid syndrome with neonatal progeroid features and severe generalized lipodystrophy due to frameshift mutations near the 3′ end of the FBN1 gene Am. J. Med. Genet. A. 155A 2011 717 720
8. L.M. Graul-Neumann, T. Kienitz, P.N. Robinson, S. Baasanjav, B. Karow, G. Gillessen-Kaesbach, R. Fahsold, H. Schmidt, K. Hoffmann, and E. Passarge Marfan syndrome with neonatal progeroid syndrome-like lipodystrophy associated with a novel frameshift mutation at the 3′ terminus of the FBN1-gene Am. J. Med. Genet. A. 152A 2010 2749 2755
9. D. Horn, and P.N. Robinson Progeroid facial features and lipodystrophy associated with a novel splice site mutation in the final intron of the FBN1 gene Am. J. Med. Genet. A. 155A 2011 721 724
10. A. Jacquinet, A. Verloes, B. Callewaert, C. Coremans, P. Coucke, A. de Paepe, U. Kornak, F. Lebrun, J. Lombet, G.E. Piérard, and et al. Neonatal progeroid variant of Marfan syndrome with congenital lipodystrophy results from mutations at the 3′ end of FBN1 gene Eur. J. Med. Genet. 57 2014 230 234
11. L. Lönnqvist, D. Reinhardt, L. Sakai, and L. Peltonen Evidence for furin-type activity-mediated C-terminal processing of profibrillin-1 and interference in the processing by certain mutations Hum. Mol. Genet. 7 1998 2039 2044
12. I. Magnusson, D.L. Rothman, L.D. Katz, R.G. Shulman, and G.I. Shulman Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study J. Clin. Invest. 90 1992 1323 1327
13. D.M. Milewicz, J. Grossfield, S.N. Cao, C. Kielty, W. Covitz, and T. Jewett A mutation in FBN1 disrupts profibrillin processing and results in isolated skeletal features of the Marfan syndrome J. Clin. Invest. 95 1995 2373 2378
14. W. Nickel The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes Eur. J. Biochem. 270 2003 2109 2119
15. B. O'Neill, V. Simha, V. Kotha, and A. Garg Body fat distribution and metabolic variables in patients with neonatal progeroid syndrome Am. J. Med. Genet. A. 143A 2007 1421 1430
16. L. Pereira, S.Y. Lee, B. Gayraud, K. Andrikopoulos, S.D. Shapiro, T. Bunton, N.J. Biery, H.C. Dietz, L.Y. Sakai, and F. Ramirez Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1 Proc. Natl. Acad. Sci. USA 96 1999 3819 3823
17. P.K. Saha, V.T. Reddy, M. Konopleva, M. Andreeff, and L. Chan The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice J. Biol. Chem. 285 2010 40581 40592
18. T. Takenouchi, M. Hida, Y. Sakamoto, C. Torii, R. Kosaki, T. Takahashi, and K. Kosaki Severe congenital lipodystrophy and a progeroid appearance: Mutation in the penultimate exon of FBN1 causing a recognizable phenotype Am. J. Med. Genet. A. 161A 2013 3057 3062
19. P. Trayhurn, C. Bing, and I.S. Wood Adipose tissue and adipokines - energy regulation from the human perspective J. Nutr. 136 Suppl 7 2006 1935S 1939S