Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

Science

Volumn 352, Issue 6282, 2016, Pages 231-235

  Titov, Denis V ^a,b,c   Cracan, Valentin ^a,b,c   Goodman, Russell P ^a   Peng, Jun ^a   Grabarek, Zenon ^a,c   Mootha, Vamsi K ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; HEXAHISTIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRUVATE DEHYDROGENASE PHOSPHATASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REX PROTEIN; MULTIENZYME COMPLEX; OXIDOREDUCTASE;

BIOMANIPULATION; CELLS AND CELL COMPONENTS; ELECTRON; ENZYME ACTIVITY; GENETIC ANALYSIS; METABOLISM; PATHOLOGY; REDOX CONDITIONS;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL FRACTIONATION; CELL PROLIFERATION; CYTOSOL; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; FEMALE; FLUORESCENCE MICROSCOPY; GLUCONEOGENESIS; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LACTOBACILLUS BREVIS; LIVER CELL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION REDUCTION STATE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; THERMUS AQUATICUS; CATALYSIS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON TRANSPORT; ENZYMOLOGY; GENETIC COMPLEMENTATION; GENETICS; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION;

LACTOBACILLUS BREVIS;

CATALYSIS; CYTOSOL; ELECTRON TRANSPORT; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; GENETIC COMPLEMENTATION TEST; GLUCONEOGENESIS; HELA CELLS; HUMANS; LACTOBACILLUS BREVIS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MULTIENZYME COMPLEXES; NAD; NADH, NADPH OXIDOREDUCTASES; OXIDATION-REDUCTION;

EID: 84963591029     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad4017     Document Type: Article

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