Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy

JAMA Ophthalmology

Volumn 134, Issue 4, 2016, Pages 367-373

  Hwang, Thomas S ^a   Gao, Simon S ^a   Liu, Liang ^a   Lauer, Andreas K ^a   Bailey, Steven T ^a   Flaxel, Christina J ^a   Wilson, David J ^a   Huang, David ^a   Jia, Yali ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUTOMATION; CAPILLARY DENSITY; CAPILLARY NONPERFUSION; CLINICAL ARTICLE; CLINICAL PRACTICE; CONTROLLED STUDY; DIABETIC RETINOPATHY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FALSE POSITIVE RESULT; FEMALE; FLUORESCENCE ANGIOGRAPHY; FOLLOW UP; FOVEAL AVASCULAR ZONE; HUMAN; IMAGE ANALYSIS; IMAGE QUALITY; MACULAR ISCHEMIA; MALE; MEASUREMENT REPEATABILITY; OBSERVATIONAL STUDY; OPTICAL COHERENCE TOMOGRAPHY; OPTICAL COHERENCE TOMOGRAPHY DEVICE; OPTICAL COHERENCETOMOGRAPHIC ANGIOGRAPHY; PARAFOVEAL VESSEL DENSITY; PERIFOVEAL VESSEL DENSITY; PILOT STUDY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETINA DISEASE; SENSITIVITY AND SPECIFICITY; TERTIARY CARE CENTER; TOTAL AVASCULAR AREA; VISION; VISUAL ACUITY; VISUAL SYSTEM PARAMETERS; AGED; ALGORITHM; CASE CONTROL STUDY; DIAGNOSTIC IMAGING; ISCHEMIA; MACULAR DEGENERATION; MIDDLE AGED; PATHOPHYSIOLOGY; PROCEDURES; RADIOGRAPHY; RETINA BLOOD VESSEL; SEVERITY OF ILLNESS INDEX; STATISTICS AND NUMERICAL DATA;

ADULT; AGED; ALGORITHMS; AUTOMATION; CASE-CONTROL STUDIES; DIABETIC RETINOPATHY; FEMALE; FLUORESCEIN ANGIOGRAPHY; HUMANS; ISCHEMIA; MACULAR DEGENERATION; MALE; MIDDLE AGED; PILOT PROJECTS; RADIOGRAPHY; RETINAL VESSELS; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84963507420     PISSN: 21686165     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaophthalmol.2015.5658     Document Type: Article

References (33)

1. Early Treatment Diabetic Retinopathy Study Research Group. Fluorescein angiographic risk factors for progression of diabetic retinopathy: ETDRS report number 13. Ophthalmology. 1991;98 (5)(suppl):834-840.
2. Browning DJ, Glassman AR, Aiello LP, et al; Diabetic Retinopathy Clinical Research Network. Relationship between optical coherence tomography-measured central retinal thickness and visual acuity in diabetic macular edema. Ophthalmology. 2007;114(3):525-536.
3. Sim DA, Keane PA, Fung S, et al. Quantitative analysis of diabetic macular ischemia using optical coherence tomography. Invest Ophthalmol Vis Sci. 2014;55(1):417-423.
4. Sakata K, Funatsu H, Harino S, Noma H, Hori S. Relationship between macular microcirculation and progression of diabetic macular edema. Ophthalmology. 2006;113(8):1385-1391.
5. Sakata K, Funatsu H, Harino S, Noma H, Hori S. Relationship of macular microcirculation and retinal thickness with visual acuity in diabetic macular edema. Ophthalmology. 2007;114(11):2061-2069.
6. Arend O, Wolf S, Jung F, et al. Retinal microcirculation in patients with diabetes mellitus: dynamic and morphological analysis of perifoveal capillary network. Br J Ophthalmol. 1991;75(9): 514-518.
7. Bresnick GH, Condit R, Syrjala S, Palta M, Groo A, Korth K. Abnormalities of the foveal avascular zone in diabetic retinopathy. Arch Ophthalmol. 1984; 102(9):1286-1293.
8. Early Treatment Diabetic Retinopathy Study Research Group. Classification of diabetic retinopathy from fluorescein angiograms: ETDRS report number 11. Ophthalmology. 1991;98(5) (suppl):807-822.
9. Conrath J, Giorgi R, Raccah D, Ridings B. Foveal avascular zone in diabetic retinopathy: quantitative vs qualitative assessment. Eye (Lond). 2005;19(3): 322-326.
10. Ishibazawa A, Nagaoka T, Takahashi A, et al. Optical coherence tomography angiography in diabetic retinopathy: a prospective pilot study. Am J Ophthalmol. 2015;160(1):35-44.e1.
11. Miura M, Hong YJ, Yasuno Y, Muramatsu D, Iwasaki T, Goto H. Three-dimensional vascular imaging of proliferative diabetic retinopathy by Doppler optical coherence tomography. Am J Ophthalmol. 2015;159(3):528-38.e3.
12. Jia Y, Bailey ST, Hwang TS, et al. Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye. Proc Natl Acad Sci USA. 2015;112(18):E2395-E2402.
13. Schwartz DM, Fingler J, Kim DY, et al. Phase-variance optical coherence tomography: a technique for noninvasive angiography. Ophthalmology. 2014;121(1):180-187.
14. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191-2194.
15. Wilkinson CP, Ferris FL III, Klein RE, et al; Global Diabetic Retinopathy Project Group. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110(9):1677-1682.
16. Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt Express. 2012;20(4): 4710-4725.
17. Jia Y, Bailey ST, Wilson DJ, et al. Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration. Ophthalmology. 2014;121(7): 1435-1444.
18. Jia Y, Wei E, Wang X, et al. Optical coherence tomography angiography of optic disc perfusion in glaucoma. Ophthalmology. 2014;121(7):1322-1332.
19. Gao SS, Liu G, Huang D, Jia Y. Optimization of the split-spectrum amplitude-decorrelation angiography algorithm on a spectral optical coherence tomography system. Opt Lett. 2015;40 (10):2305-2308.
20. Kraus MF, Liu JJ, Schottenhamml J, et al. Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization. Biomed Opt Express. 2014;5(8):2591-2613.
21. Huang D, Chopra V, Lu AT, Tan O, Francis B, Varma R; Advanced Imaging for Glaucoma Study-AIGS Group. Does optic nerve head size variation affect circumpapillary retinal nerve fiber layer thickness measurement by optical coherence tomography? Invest Ophthalmol Vis Sci. 2012;53(8): 4990-4997.
22. Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem. 1993;39(4):561-577.
23. Ip MS, Domalpally A, Sun JK, Ehrlich JS. Long-term effects of therapy with ranibizumab on diabetic retinopathy severity and baseline risk factors for worsening retinopathy. Ophthalmology. 2015;122(2):367-374.
24. Johnson RN, Fu AD, McDonald R, et al. Fluorescein angiography: basic principles and interpretation. In: Sadda SR, ed. Retina. Vol 1. New York, NY: Elsevier; 2013:2-50.
25. Arend O, Wolf S, Remky A, et al. Perifoveal microcirculation with non-insulin-dependent diabetes mellitus. Graefes Arch Clin Exp Ophthalmol. 1994;232(4):225-231.
26. Zheng Y, Gandhi JS, Stangos AN, Campa C, Broadbent DM, Harding SP. Automated segmentation of foveal avascular zone in fundus fluorescein angiography. Invest Ophthalmol Vis Sci. 2010;51(7):3653-3659.
27. Mansour AM, Schachat A, Bodiford G, Haymond R. Foveal avascular zone in diabetes mellitus. Retina. 1993;13(2):125-128.
28. Bird AC, Weale RA. On the retinal vasculature of the human fovea. Exp Eye Res. 1974;19(5):409-417.
29. Wang Q, Kocaoglu OP, Cense B, et al. Imaging retinal capillaries using ultrahigh-resolution optical coherence tomography and adaptive optics. Invest Ophthalmol Vis Sci. 2011;52(9):6292-6299.
30. Wolf S, Arend O, Schulte K, Ittel TH, Reim M. Quantification of retinal capillary density and flow velocity in patients with essential hypertension. Hypertension. 1994;23(4):464-467.
31. Yousefi S, Wang RK. Simultaneous estimation of bidirectional particle flow and relative flux using MUSIC-OCT: phantom studies. Phys Med Biol. 2014; 59(22):6693-6708.
32. Kim DY, Fingler J, Zawadzki RJ, et al. Noninvasive imaging of the foveal avascular zone with high-speed, phase-variance optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53(1): 85-92.
33. Sander B, Larsen M, Engler C, Lund-Andersen H. Absence of foveal avascular zone demonstrated by laser scanning fluorescein angiography. Acta Ophthalmol (Copenh). 1994;72(5):550-552.