Caspr2 autoantibodies target multiple epitopes

Neurology: Neuroimmunology and NeuroInflammation

Volumn 2, Issue 4, 2015, Pages

  Olsen, Abby L ^a   Lai, Yongjie ^a   Dalmau, Josep ^b   Scherer, Steven S ^a   Lancaster, Eric ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; COMPLEMENTARY DNA; CONTACTIN ASSOCIATED PROTEIN LIKE 2 ANTIBODY; DISCOIDIN; EPITOPE; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE DELETION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE; IMMUNOGENICITY; IMMUNOREACTIVITY; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN TARGETING; PROTEIN TERTIARY STRUCTURE; T LYMPHOCYTE; WESTERN BLOTTING;

EID: 84962942018     PISSN: None     EISSN: 23327812     Source Type: Journal    
DOI: 10.1212/NXI.0000000000000127     Document Type: Article

References (24)

1. Shillito P, Molenaar PC, Vincent A, et al Acquired neuromyotonia: evidence for autoantibodies directed against K1 channels of peripheral nerves. Ann Neurol 1995; 38: 714-722.
2. Hart IK, Waters C, Vincent A., et al. Autoantibodies detected to expressed K1 channels are implicated in neuromyotonia. Ann Neurol 1997; 41:238-246.
3. Tan KM, Lennon VA, Klein C.J., Boeve BF, Pittock SJ. Clinical spectrum of voltage-gated potassium channel autoimmunity. Neurology 2008; 70:1883-1890.
4. Kleopa KA, Elman LB, Lang B, Vincent A., Scherer SS. Neuromyotonia and limbic encephalitis sera target mature Shaker-type K1 channels: subunit specificity correlates with clinical manifestations. Brain 2006; 129: 1570-1584.
5. Lai M, Huijbers MG, Lancaster E, et al Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol 2010; 9:776-785.
6. Irani SR, Alexander S, Waters P., et al. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain 2010; 133:2734-2748.
7. Lancaster E, Huijbers MG, Bar V, et al Investigations of caspr2, an autoantigen of encephalitis and neuromyotonia. Ann Neurol 2011; 69:303-311.
8. Horresh I, Poliak S, Grant S., Bredt D, Rasband MN, Peles E. Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons. J Neurosci 2008; 28:14213-14222.
9. Traka M, Goutebroze L, Denisenko N., et al. Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J Cell Biol 2003; 162:1161-1172.
10. Gu C, Gu Y. Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons. J Biol Chem 2011; 286:25835-25847.
11. Zhou L, Messing A, Chiu SY Determinants of excitability at transition zones in Kv1.1-deficient myelinated nerves. J Neurosci 1999; 19:5768-5781.
12. Gleichman AJ, Spruce LA, Dalmau J, Seeholzer S.H., Lynch DR. Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain. J Neurosci 2012; 32:11082-11094.
13. Raju R, Foote J, Banga J.P., et al. Analysis of GAD65 autoantibodies in Stiff-Person syndrome patients. J Immunol 2005; 175:7755-7762.
14. Lindstrom J, Luo J, Kuryatov A. Myasthenia gravis and the tops and bottoms of AChRs: antigenic structure of the MIR and specific immunosuppression of EAMG using AChR cytoplasmic domains. Ann N Y Acad Sci 2008; 1132:29-41.
15. Makarova O, Kamberov E, Margolis B. Generation of deletion and point mutations with one primer in a single cloning step. Biotechniques 2000; 29:970-972.
16. Poliak S, Gollan L, Martinez R., et al. Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K1 channels. Neuron 1999; 24:1037-1047.
17. Dalmau J, Gleichman AJ, Hughes E.G., et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008; 7:1091-1098.
18. Hughes EG, Peng X, Gleichman A.J., et al. Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J Neurosci 2010; 30:5866-5875.
19. Lai M, Hughes EG, Peng X, et al AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol 2009; 65:424-434.
20. Chatzopoulou E, Miguez A, Savvaki M., et al. Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve. J Neurosci 2008; 28: 7624-7636.
21. Savvaki M, Theodorakis K, Zoupi L., et al. The expression of TAG-1 in glial cells is sufficient for the formation of the juxtaparanodal complex and the phenotypic rescue of tag-1 homozygous mutants in the CNS. J Neurosci 2010; 30: 13943-13954.
22. Tzimourakas A, Giasemi S, Mouratidou M., Karagogeos D. Structure-function analysis of protein complexes involved in the molecular architecture of juxtaparanodal regions of myelinated fibers. Biotechnol J 2007; 2:577-583.
23. Lindstrom J, Luo J. Myasthenogenicity of the main immunogenic region. Ann N Y Acad Sci 2012; 1274: 9-13.
24. Luo J, Lindstrom J. Antigen-specific immunotherapeutic vaccine for experimental autoimmune myasthenia gravis. J Immunol 2014; 193:5044-5055.