Deconstructing Complex Multimorbidity in the Very Old: Findings from the Newcastle 85+ Study

BioMed Research International

Volumn 2016, Issue , 2016, Pages

  Collerton, Joanna ^a   Jagger, Carol ^a   Yadegarfar, Mohammad E ^a   Davies, Karen ^a   Parker, Stuart G ^a   Robinson, Louise ^a   Kirkwood, Thomas B L ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; ASTHMA; ATRIAL FIBRILLATION; CEREBROVASCULAR DISEASE; CHRONIC DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLUSTER ANALYSIS; COGNITIVE DEFECT; COMORBIDITY; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG USE; FALLING; FEMALE; GENERAL PRACTICE; GENERAL PRACTITIONER; GERIATRIC DISORDER; GERIATRIC PATIENT; HEALTH CARE UTILIZATION; HEALTH SERVICE; HEARING IMPAIRMENT; HEART ATRIUM FLUTTER; HEART FAILURE; HOSPITAL ADMISSION; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; OSTEOARTHRITIS; OSTEOPOROSIS; PERIPHERAL VASCULAR DISEASE; POLYPHARMACY; PREVALENCE; RHEUMATOID ARTHRITIS; THYROID DISEASE; URINE INCONTINENCE; VISUAL IMPAIRMENT; GERIATRIC NURSING; HOSPITALIZATION; MORTALITY; VERY ELDERLY;

AGED, 80 AND OVER; CHRONIC DISEASE; COMORBIDITY; FEMALE; GENERAL PRACTITIONERS; GERIATRIC NURSING; HOSPITALIZATION; HUMANS; MALE;

EID: 84962861283     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2016/8745670     Document Type: Article

References (60)

1. M. van den Akker, F. Buntinx, J. A. Knottnerus, "Comorbidity or multimorbidity: what's in a name? A reviewof literature, " European Journal of General Practice, vol. 2, no. 2, pp. 65-70, 1996.
2. A. R. Feinstein, "The pre-therapeutic classification of co-morbidity in chronic disease, " Journal of Chronic Diseases, vol. 23, no. 7, pp. 455-468, 1970.
3. A. Marengoni, S. Angleman, R. Melis et al., "Aging with multimorbidity: A systematic reviewof the literature, " Ageing Research Reviews, vol. 10, no. 4, pp. 430-439, 2011.
4. C. M. Boyd, C. S. Ritchie, E. F. Tipton, S. A. Studenski, D. Wieland, "From Bedside to Bench: summary from the American Geriatrics Society/National Institute on Aging Research conference on comorbidity, multiple morbidity in older adults, " Aging Clinical, Experimental Research, vol. 20, no. 3, pp. 181-188, 2008.
5. C. Salisbury, "Multimorbidity: redesigning health care for people who use it, " The Lancet, vol. 380, no. 9836, pp. 7-9, 2012.
6. D. Mangin, I. Heath, M. Jamoulle, "Beyond diagnosis: rising to the multimorbidity challenge, " British Medical Journal, vol. 344, Article ID e3526, 2012.
7. American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity, "Patient-centered care for older adults with multiple chronic conditions: A stepwise approach from the American Geriatrics Society, " Journal of the American Geriatrics Society, vol. 60, no. 10, pp. 1957-1968, 2012.
8. M. Roland, C. Paddison, "Better management of patients with multimorbidity, " British Medical Journal, vol. 346, Article ID f2510, 2013.
9. M. Fortin, H. Soubhi, C. Hudon, E. A. Bayliss, M. van den Akker, "Multimorbidity's many challenges, " British Medical Journal, vol. 334, no. 7602, pp. 1016-1017, 2007.
10. C. Vogeli, A. E. Shields, T. A. Lee et al., "Multiple chronic conditions: Prevalence, health consequences, implications for quality, caremanagement, costs, " Journal ofGeneral Internal Medicine, vol. 22, supplement 3, pp. 391-395, 2007.
11. A. L. Huntley, R. Johnson, S. Purdy, J. M. Valderas, C. Salisbury, "Measures of multimorbidity, morbidity burden for use in primary care, community settings: A systematic review, guide, " Annals of Family Medicine, vol. 10, no. 2, pp. 134-141, 2012.
12. A. Marengoni, L. Fratiglioni, "Disease clusters in older adults: rationale, need for investigation, " Journal of the American Geriatrics Society, vol. 59, no. 12, pp. 2395-2396, 2011.
13. United Nations Department of Economic, Social Affairs. Population Division, World Population Ageing: 2009, United Nations, 2009, http: //www. un. org/esa/population/publications/ WPA2009/WPA2009 WorkingPaper. pdf.
14. K. Barnett, S. W. Mercer, M. Norbury, G. Watt, S. Wyke, B. Guthrie, "Epidemiology ofmultimorbidity, implications for health care, research, medical education: A cross-sectional study, " The Lancet, vol. 380, no. 9836, pp. 37-43, 2012.
15. M. E. Salive, "Multimorbidity in older adults, " Epidemiologic Reviews, vol. 35, no. 1, pp. 75-83, 2013.
16. J. Collerton, K. Barrass, J. Bond et al., "TheNewcastle 85+ study: biological, clinical, psychosocial factors associated with healthy ageing: study protocol, " BMC Geriatrics, vol. 7, article 14, 2007.
17. J. Collerton, K. Davies, C. Jagger et al., "Health, disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study, " The British Medical Journal, vol. 339, Article ID b4904, 2009.
18. K. Davies, J. C. Collerton, C. Jagger et al., "Engaging the oldest old in research: lessons from the Newcastle 85+ study, " BMC Geriatrics, vol. 10, article 64, 2010.
19. S. K. Inouye, S. Studenski, M. E. Tinetti, G. A. Kuchel, "Geriatric syndromes: clinical, research, policy implications of a core geriatric concept, " Journal of the American Geriatrics Society, vol. 55, no. 5, pp. 780-791, 2007.
20. L. Min, E. A. Kerr, C. S. Blaum, D. Reuben, C. Cigolle, N. Wenger, "Contrasting effects of geriatric versus generalmedical multimorbidity on quality of ambulatory care, " Journal of the American Geriatrics Society, vol. 62, no. 9, pp. 1714-1721, 2014.
21. R. J. Prineas, R. S. Crow, Z.-M. Zhang, TheMinnesota Code Manual of Electrocardiographic Findings, Springer, London, UK, 2010.
22. A. S. Levey, L. A. Stevens, C. H. Schmid et al., "Anewequation to estimate glomerular filtration rate, " Annals of Internal Medicine, vol. 150, no. 9, pp. 604-612, 2009
23. Erratum in Annals of Internal Medicine, vol. 155, no. 6, p. 408, 2011.
24. E. Crowe, D. Halpin, P. Stevens, "Early identification, management of chronic kidney disease: summary of NICE guidance, " British Medical Journal, vol. 337, Article ID a1530, 2008.
25. C. W. Mcgrother, M. M. K. Donaldson, C. Shaw et al., "Storage symptoms of the bladder: Prevalence, incidence, need for services in the UK, " BJU International, vol. 93, no. 6, pp. 763-769, 2004.
26. D. W. Molloy, T. I. M. Standish, "A guide to the standardized Mini-Mental State Examination, " International Psychogeriatrics, vol. 9, supplement 1, pp. 87-94, 1997.
27. C. Diederichs, K. Berger, D. B. Bartels, "The measurement of multiple chronic diseases-a systematic review on existing multimorbidity indices, " Journals of Gerontology Series A: Biological Sciences, Medical Sciences, vol. 66, no. 3, pp. 301-311, 2011.
28. J. A. Sheikh, J. Yesavage, "Geriatric Depression Scale (GDS): recent findings, development of a shorter version, " in Clinical Gerontology: A Guide to Assessment, Intervention, T. L. Brink, Ed., Haworth Press, New York, NY, USA, 1986.
29. NHS: The Information Centre for Health, Social Care, Quality, Outcomes Framework-Prevalence, Achievements, Exceptions Report, Health, Social Care InformationCentre, London, UK, 2014-15, http: //www. hscic. gov. uk/catalogue/ PUB18887/qof-1415-Report%20v1. 1. pdf.
30. J. H. Ward Jr., "Hierarchical grouping to optimize an objective function, " Journal of theAmericanStatistical Association, vol. 58, no. 301, pp. 236-244, 1963.
31. S. R. Newcomer, J. F. Steiner, E. A. Bayliss, "Identifying subgroups of complex patients with cluster analysis, " The American Journal of Managed Care, vol. 17, no. 8, pp. e324-e332, 2011.
32. C. T. Cigolle, K. M. Langa, M. U. Kabeto, Z. Tian, C. S. Blaum, "Geriatric conditions, disability: the health, retirement study, " Annals of Internal Medicine, vol. 147, no. 3, pp. 156-164, 2007.
33. M. E. Tinetti, S. K. Inouye, T. M. Gill, J. T. Doucette, "Shared risk factors for falls, incontinence, functional dependence: unifying the approach to geriatric syndromes, " The Journal of the AmericanMedical Association, vol. 273, no. 17, pp. 1348-1353, 1995.
34. A. Prados-Torres, A. Calderón-Larrañaga, J. Hancco-Saavedra, B. Poblador-Plou, M. van den Akker, "Multimorbidity patterns: A systematic review, " Journal of Clinical Epidemiology, vol. 67, no. 3, pp. 254-266, 2014.
35. C. Violan, Q. Foguet-Boreu, G. Flores-Mateo et al., "Prevalence, determinants, patterns ofmultimorbidity in primary care: A systematic review of observational studies, " PLoS ONE, vol. 9, no. 7, Article IDe102149, 2014.
36. H. J. Dong, E. Wressle, J. Marcusson, "Multimorbidity patterns of, use of health services by Swedish 85-year-olds: An exploratory study, " BMC Geriatrics, vol. 13, article 120, 2013.
37. A. Marengoni, D. Rizzuto, H.-X. Wang, B. Winblad, L. Fratiglioni, "Patterns of chronic multimorbidity in the elderly population, " Journal of the American Geriatrics Society, vol. 57, no. 2, pp. 225-230, 2009.
38. A. Marengoni, F. Bonometti, A. Nobili et al., "In-hospital death, adverse clinical events in elderly patients according to disease clustering: the REPOSI study, " Rejuvenation Research, vol. 13, no. 4, pp. 469-477, 2010.
39. R. John, D. S. Kerby, C. H. Hennessy, "Patterns, impact of comorbidity, multimorbidity among community-resident American Indian elders, " Gerontologist, vol. 43, no. 5, pp. 649-660, 2003.
40. J. E. Cornell, J. A. Pugh, J. W. Williams et al., "Multimorbidity clusters: clustering binary data from multimorbidity clusters: clustering binary data from a large administrative medical database, " Applied Multivariate Research, vol. 12, no. 3, pp. 163-182, 2007.
41. G. Goldstein, J. E. Luther, A. M. Jacoby, G. L. Haas, A. J. Gordon, "A taxonomy ofmedical comorbidity for veterans who are homeless, " Journal of Health Care for the Poor, Underserved, vol. 19, no. 3, pp. 991-1005, 2008.
42. F. Formiga, A. Ferrer, H. Sanz, A. Marengoni, J. Alburquerque, R. Pujol, "Octabaix studymembers. Patterns of comorbidity, multimorbidity in the oldest old: the Octabaix study, " European Journal of Internal Medicine, vol. 24, pp. 40-44, 2013.
43. C. F. Simpson, C. M. Boyd, M. C. Carlson, M. E. Griswold, J. M. Guralnik, L. P. Fried, "Agreement between self-report of disease diagnoses, medical record validation in disabled older women: factors that modify agreement, " Journal of the American Geriatrics Society, vol. 52, no. 1, pp. 123-127, 2004.
44. D. M. W. Kriegsman, B. W. J. H. Penninx, J. T. M. van Eijk, A. J. P. Boeke, D. J. H. Deeg, "Self-reports, general practitioner information on the presence of chronic diseases in community dwelling elderly. A study on the accuracy of patients' selfreports, on determinants of inaccuracy, " Journal of Clinical Epidemiology, vol. 49, no. 12, pp. 1407-1417, 1996.
45. The Italian Longitudinal Study on Aging Working Group, "Prevalence of chronic diseases in older Italians: comparing self-reported, clinical diagnoses, " International Journal of Epidemiology, vol. 26, no. 5, pp. 995-1002, 1997.
46. M. E. Tinetti, T. Fried, "The end of the disease era, "American Journal of Medicine, vol. 116, no. 3, pp. 179-185, 2004.
47. J. Collerton, Health, Disease in the Very Old: Findings from the Newcastle 85+ Study Newcastle upon Tyne, Newcastle University, 2012.
48. C. M. Boyd, J. Darer, C. Boult, L. P. Fried, L. Boult, A. W. Wu, "Clinical practice guidelines, quality of care for older patients with multiple comorbid diseases: implications for pay for performance, "The Journal of theAmericanMedical Association, vol. 294, no. 6, pp. 716-724, 2005.
49. L. D. Hughes, M. E. T. McMurdo, B. Guthrie, "Guidelines for people not for diseases: the challenges of applying UK clinical guidelines to people with multimorbidity, " Age, Ageing, vol. 42, no. 1, Article ID afs100, pp. 62-69, 2013.
50. S. M. Smith, H. Soubhi, M. Fortin, C. Hudon, T. O'Dowd, "Managing patients with multimorbidity: systematic review of interventions in primary care, community settings, " British Medical Journal, vol. 345, no. 7874, Article IDe5205, 2012.
51. H. G. C. Van Spall, A. Toren, A. Kiss, R. A. Fowler, "Eligibility criteria of randomized controlled trials published in high-impact general medical journals: A systematic sampling review, " The Journal of the American Medical Association, vol. 297, no. 11, pp. 1233-1240, 2007.
52. D. M. Zulman, J. B. Sussman, X. Chen, C. T. Cigolle, C. S. Blaum, R. A. Hayward, "Examining the evidence: A systematic review of the inclusion, analysis of older adults in randomized controlled trials, " Journal of General InternalMedicine, vol. 26, no. 7, pp. 783-790, 2011.
53. M. E. Tinetti, S. T. Bogardus Jr., J. V. Agostini, "Potential pitfalls of disease-specific guidelines for patients with multiple conditions, "The New England Journal of Medicine, vol. 351, no. 27, pp. 2786-2874, 2004.
54. L. Cox, M. Kloseck, R. Crilly, C. McWilliam, L. Diachun, "Underrepresentation of individuals 80 years of age, older in chronic disease clinical practice guidelines, " Canadian Family Physician, vol. 57, no. 7, pp. e263-e269, 2011.
55. J. L. Haggerty, "Ordering the chaos for patients with multimorbidity, " British Medical Journal, vol. 345, no. 7876, Article ID e5915, 2012.
56. U. Kadam, "Redesigning the general practice consultation to improve care for patients with multimorbidity, " British Medical Journal, vol. 345, Article IDe6202, 2012.
57. B. Guthrie, K. Payne, P. Alderson, M. E. T. McMurdo, S. W. Mercer, "Adapting clinical guidelines to take account of multimorbidity, " BritishMedical Journal, vol. 345, no. 7878, Article ID e6341, 2012.
58. C. Muth, M. van den Akker, J. W. Blom et al., "The Ariadne principles: how to handle multimorbidity in primary care consultations, " BMC Medicine, vol. 12, article 223, 2014.
59. A. Vilà, E. Villegas, J. Cruanyes et al., "Cost-effectiveness of a Barcelona home care program for individuals with multimorbidity, " Journal of the American Geriatrics Society, vol. 63, no. 5, pp. 1017-1024, 2015.
60. NHS England, NHS Five Year Forward View, 2014, http: // www. england. nhs. uk/wp-content/uploads/2014/10/5yfv-web. pdf.