Phase separation of signaling molecules promotes T cell receptor signal transduction

Science

Volumn 352, Issue 6285, 2016, Pages 595-599

  Su, Xiaolei ^a   Ditlev, Jonathon A ^a,b   Hui, Enfu ^a   Xing, Wenmin ^a,b   Banjade, Sudeep ^a,b   Okrut, Julia ^a   King, David S ^c   Taunton, Jack ^a   Rosen, Michael K ^a,b   Vale, Ronald D ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CD45 ANTIGEN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; LAT PROTEIN; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN SH3; PROTEIN TYROSINE PHOSPHATASE 1B; SOS PROTEIN; T LYMPHOCYTE RECEPTOR; LAT PROTEIN, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; GENE EXPRESSION; MEMBRANE; NUMERICAL MODEL; PROTEIN;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ARTICLE; ARTIFICIAL MEMBRANE; CONTROLLED STUDY; DEPOLYMERIZATION; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HUMAN; HUMAN CELL; JURKAT CELL LINE; LIPID BILAYER; LIPID COMPOSITION; MEMBRANE RECONSTITUTION; PHASE SEPARATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEPHOSPHORYLATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; AGONISTS; METABOLISM; PHOSPHORYLATION; POLYMERIZATION; T LYMPHOCYTE;

ACTINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HUMANS; JURKAT CELLS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; POLYMERIZATION; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84962798412     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad9964     Document Type: Article

References (43)

1. A. P. Vorster, J. Born, Neurosci. Biobehav. Rev. 50, 103-119 (2015).
2. R. Allada, J. M. Siegel, Curr. Biol. 18, R670-R679 (2008).
3. R. V. Rial et al., Neurosci. Biobehav. Rev. 34, 1144-1160 (2010).
4. C. Smith, Neurosci. Biobehav. Rev. 9, 157-168 (1985).
5. J. E. Zimmerman, N. Naidoo, D. M. Raizen, A. I. Pack, Trends Neurosci. 31, 371-376 (2008).
6. D. Bushey, G. Tononi, C. Cirelli, Science 332, 1576-1581 (2011).
7. P. S. Low, S. S. Shank, T. J. Sejnowski, D. Margoliash, Proc. Natl. Acad. Sci. U.S.A. 105, 9081-9086 (2008).
8. R. J. Greenspan, G. Tononi, C. Cirelli, P. J. Shaw, Trends Neurosci. 24, 142-145 (2001).
9. A. L. Loomis, E. N. Harvey, G. A. Hobart III, J. Exp. Psychol. 21, 127-144 (1937).
10. E. Aserinsky, N. Kleitman, Science 118, 273-274 (1953).
11. M. Jouvet, Prog. Brain Res. 18, 20-62 (1965).
12. R. E. Brown, R. Basheer, J. T. McKenna, R. E. Strecker, R. W. McCarley, Physiol. Rev. 92, 1087-1187 (2012).
13. M. Monnier, Experientia 36, 16-19 (1980).
14. N. C. Rattenborg, Brain Res. Bull. 69, 20-29 (2006).
15. N. C. Rattenborg, D. Martinez-Gonzalez, J. A. Lesku, Neurosci. Biobehav. Rev. 33, 253-270 (2009).
16. J. M. Siegel, Trends Neurosci. 31, 208-213 (2008).
17. R. V. Rial et al., Brain Res. Bull. 72, 183-186 (2007).
18. P. A. Libourel, A. Herrel, Biol. Rev. Camb. Philos. Soc. (2015).
19. J. A. Hobson, Nature 437, 1254-1256 (2005).
20. W. F. Flanigan Jr., Brain Behav. Evol. 8, 401-416 (1973).
21. K. Hartse, in Principles and Practice of Sleep Medicine, M.H. Kryger, T. Roth, D.W. Dement, Eds. (Elsevier Saunders, ed. 2, 1994), pp. 95-104.
22. F. Ayala-Guerrero, G. Mexicano, Comp. Biochem. Physiol. A 151, 305-312 (2008).
23. G. F. Striedter, J. Comp. Neurol. 524, 496-517 (2016).
24. J. Voigts, J. H. Siegle, D. L. Pritchett, C. I. Moore, Front. Syst. Neurosci. 7, 8 (2013).
25. A. G. Siapas, M. A. Wilson, Neuron 21, 1123-1128 (1998).
26. J. OKeefe, Exp. Neurol. 51, 78-109 (1976).
27. G. Buzsáki, Z. Horváth, R. Urioste, J. Hetke, K. Wise, Science 256, 1025-1027 (1992).
28. G. Buzsáki, Hippocampus 25, 1073-1188 (2015).
29. A. Draguhn, R. D. Traub, D. Schmitz, J. G. Jefferys, Nature 394, 189-192 (1998).
30. J. M. Siegel, in Principles and Practice of Sleep Medicine, M. H. Kryger, T. Roth, W. C. Dement, Eds. (Elsevier Saunders, ed. 4, 2005), pp. 120-135.
31. D. J. Foster, M. A. Wilson, Nature 440, 680-683 (2006).
32. M. A. Wilson, B. L. McNaughton, Science 265, 676-679 (1994).
33. J. Lu, D. Sherman, M. Devor, C. B. Saper, Nature 441, 589-594 (2006).
34. F. Weber et al., Nature 526, 435-438 (2015).
35. J. A. Hobson, R. W. McCarley, P. W. Wyzinski, Science 189, 55-58 (1975).
36. Y. Hayashi et al., Science 350, 957-961 (2015).
37. C. B. Saper, T. C. Chou, T. E. Scammell, Trends Neurosci. 24, 726-731 (2001).
38. C. B. Saper, T. E. Scammell, J. Lu, Nature 437, 1257-1263 (2005).
39. R. G. Northcutt, Annu. Rev. Neurosci. 4, 301-350 (1981).
40. F. Grenier, I. Timofeev, M. Steriade, J. Neurophysiol. 86, 1884-1898 (2001).
41. D. Paré, D. R. Collins, J. G. Pelletier, Trends Cogn. Sci. 6, 306-314 (2002).
42. A. Sirota, J. Csicsvari, D. Buhl, G. Buzsáki, Proc. Natl. Acad. Sci. U.S.A. 100, 2065-2069 (2003).
43. H. J. Karten, Brain Behav. Evol. 38, 264-272 (1991).