Control of REM sleep by ventral medulla GABAergic neurons

Nature

Volumn 526, Issue 7573, 2015, Pages 435-438

  Weber, Franz ^a   Chung, Shinjae ^a   Beier, Kevin T ^b   Xu, Min ^a   Luo, Liqun ^b   Dan, Yang ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; CHANNELRHODOPSIN 2; RHODOPSIN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID;

BEHAVIORAL RESPONSE; BRAIN; EYE; GENE EXPRESSION; GROOMING; MUSCLE; NEUROLOGY; SKELETON; SLEEP;

4 AMINOBUTYRIC ACID RELEASE; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL POPULATION; CONTROLLED STUDY; DREAMING; EATING; ELECTRODE; FEMALE; GABAERGIC SYSTEM; GROOMING; MALE; MEDULLA OBLONGATA; MESENCEPHALON; MOUSE; NERVE CELL; NERVE CELL NETWORK; NERVE PROJECTION; NONHUMAN; OPTOGENETICS; PERIAQUEDUCTAL GRAY MATTER; PHYSICAL ACTIVITY; PONS; PRIORITY JOURNAL; REM SLEEP; SPINAL CORD; VENTRAL MEDULLA; WAKEFULNESS; ANIMAL; CYTOLOGY; METABOLISM; NERVE TRACT; PHYSIOLOGY; SECRETION (PROCESS); TIME FACTOR;

MUS;

ANIMALS; EATING; FEMALE; GABAERGIC NEURONS; GAMMA-AMINOBUTYRIC ACID; GROOMING; MALE; MEDULLA OBLONGATA; MICE; NEURAL PATHWAYS; OPTOGENETICS; PERIAQUEDUCTAL GRAY; PONS; SLEEP, REM; SPINAL CORD; TIME FACTORS; WAKEFULNESS;

EID: 84944351071     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14979     Document Type: Article

References (34)

1. Aserinsky, E. & Kleitman, N. Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. Science 118, 273-274 (1953).
2. Jouvet, M. Recherches sur les structures nerveuses et les mécanismes responsables des différentes phases du sommeil physiologique. Arch. Ital. Biol. 100, 125-206 (1962).
3. Dement, W. The occurrence of low voltage, fast, electroencephalogram patterns during behavioral sleep in the cat. Electroencephalogr. Clin. Neurophysiol. 10, 291-296 (1958).
4. Hobson, J. A., McCarley, R. W. & Wyzinski, P. W. Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups. Science 189, 55-58 (1975).
5. Boissard, R., Fort, P., Gervasoni, D., Barbagli, B. & Luppi, P. H. Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset. Eur. J. Neurosci. 18, 1627-1639 (2003).
6. Clément, O., Sapin, E., Bérod, A., Fort, P. & Luppi, P. H. Evidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergic. Sleep 34, 419-423 (2011).
7. Lu, J., Sherman, D., Devor,M. & Saper, C. B. A putative flip-flop switch for control of REM sleep. Nature 441, 589-594 (2006).
8. VanDort, C. J. et al. Optogenetic activation of cholinergic neurons in the PPT orLDT induces REM sleep. Proc. Natl Acad. Sci. USA 112, 584-589 (2015).
9. Siegel, J. M.,Wheeler, R. L.& McGinty,D. J. Activity ofmedullary reticular formation neurons in the unrestrained cat during waking and sleep. Brain Res. 179, 49-60 (1979).
10. Sakai, K., Kanamori, N. & Jouvet, M. Activités unitaires spécifiques du sommeil paradoxal dans la formation réticulée bulbaire chez le chat non-restreint. C.R. Seances Acad. Sci. D 289, 557-561 (1979).
11. Maloney, K. J., Mainville, L. & Jones, B. E. c-Fos expression in GABAergic, serotonergic, and other neurons of the pontomedullary reticular formation and raphe after paradoxical sleep deprivation and recovery. J. Neurosci. 20, 4669-4679 (2000).
12. Sapin, E. et al. Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep. PLoS One 4, e4272 (2009).
13. Sirieix, C., Gervasoni, D., Luppi, P. H. & Léger, L. Role of the lateral paragigantocellular nucleus in the network of paradoxical (REM) sleep: an electrophysiological and anatomical study in the rat. PLoS One 7, e28724 (2012).
14. Jego, S. et al.Optogenetic identification of a rapid eyemovement sleepmodulatory circuit in the hypothalamus. Nature Neurosci. 16, 1637-1643 (2013).
15. Armbruster,B.N., Li, X., Pausch, M. H.,Herlitze, S.&Roth,B. L.Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc. Natl Acad. Sci. USA 104, 5163-5168 (2007).
16. Kovács, K. J. c-Fos as a transcription factor: a stressful (re)view from a functional map. Neurochem. Int. 33, 287-297 (1998).
17. Holmes, C. J. & Jones, B. E. Importance of cholinergic, GABAergic, serotonergic and other neurons in the medial medullary reticular formation for sleep-wake states studied by cytotoxic lesions in the cat. Neuroscience 62, 1179-1200 (1994).
18. Aston-Jones, G., Ennis, M., Pieribone, V. A., Nickell, W. T. & Shipley, M. T. The brain nucleus locus coeruleus: restricted afferent control of a broad efferent network. Science 234, 734-737 (1986).
19. Aston-Jones, G. & Bloom, F. E. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J. Neurosci. 1, 876-886 (1981).
20. Loewy, A. D., Wallach, J. H. & McKellar, S. Efferent connections of the ventral medulla oblongata in the rat. Brain Res. Rev. 3, 63-80 (1981).
21. Magoun, H. W. & Rhines, R. An inhibitory mechanism in the bulbar reticular formation. J. Neurophysiol. 9, 165-171 (1946).
22. Schenkel, E. & Siegel, J. M. REM sleep without atonia after lesions of the medial medulla. Neurosci. Lett. 98, 159-165 (1989).
23. Vanni-Mercier, G., Sakai, K., Lin, J. S. & Jouvet, M. Carbachol microinjections in the mediodorsal pontine tegmentum are unable to induce paradoxical sleep after caudal pontine and prebulbar transections in the cat. Neurosci. Lett. 130, 41-45 (1991).
24. Webster, H. H., Friedman, L. & Jones, B. E. Modification of paradoxical sleep following transections of the reticular formation at the pontomedullary junction. Sleep 9, 1-23 (1986).
25. Kohyama, J., Lai, Y. Y. & Siegel, J. M. Inactivation of the pons blocks medullaryinduced muscle tone suppression in the decerebrate cat. Sleep 21, 695-699 (1998).
26. Siegel, J. M., Nienhuis, R. & Tomaszewski, K. S. Rostral brainstem contributes to medullary inhibition of muscle tone. Brain Res. 268, 344-348 (1983).
27. Carter, M. E. et al. Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nature Neurosci. 13, 1526-1533 (2010).
28. White, S. R., Fung, S. J. & Barnes, C. D. Norepinephrine effects on spinal motoneurons. Prog. Brain Res. 88, 343-350 (1991).
29. Kaur, S., Saxena, R. N.& Mallick, B.N. GABAergic neurons in prepositus hypoglossi regulate REM sleep by its action on locus coeruleus in freely moving rats. Synapse 42, 141-150 (2001).
30. Taheri, S., Zeitzer, J. M. & Mignot, E. The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu. Rev. Neurosci. 25, 283-313 (2002).
31. Franklin, K.B.J.&Paxinos, G. The Mouse Brain in Stereotaxic Coordinates 3rd edn, 88 (Academic Press, 2007).
32. Miyamichi, K. et al. Dissecting local circuits: parvalbumin interneurons underlie broad feedback control of olfactory bulb output. Neuron 80, 1232-1245 (2013).
33. Anikeeva, P. et al. Optetrode: a multichannel readout for optogenetic control in freely moving mice. Nature Neurosci. 15, 163-170 (2012).
34. Schmitzer-Torbert, N., Jackson, J., Henze, D., Harris, K. & Redish, A. D. Quantitative measures of cluster quality for use in extracellular recordings. Neuroscience 131, 1-11 (2005).