FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study

Psychoneuroendocrinology

Volumn 69, Issue , 2016, Pages 98-105

  Watkins, Laura E ^a,b   Han, Shizhong ^c   Harpaz Rotem, Ilan ^a,b   Mota, Natalie P ^d   Southwick, Steven M ^a,b   Krystal, John H ^a,b   Gelernter, Joel ^a,b   Pietrzak, Robert H ^a,b  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Childhood abuse; FKBP5; Gene environment interaction; HPA axis; Posttraumatic stress disorder

Indexed keywords

ADULT; ALLELE; AROUSAL; ARTICLE; AVOIDANCE BEHAVIOR; CHILD ABUSE; COGNITION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; EUROPEAN AMERICAN; FEMALE; FKBP5 GENE; GENE; GENE IDENTIFICATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MOOD; OUTCOME ASSESSMENT; PHYSICAL ABUSE; POSTTRAUMATIC STRESS DISORDER; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SCORING SYSTEM; SEXUAL ABUSE; SINGLE NUCLEOTIDE POLYMORPHISM; SYMPTOM; VETERAN; CHILD; DRUG DEPENDENCE; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; PSYCHOLOGY;

FK 506 BINDING PROTEIN; TACROLIMUS BINDING PROTEIN 5;

ADULT; ALLELES; CHILD; CHILD ABUSE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LINKAGE DISEQUILIBRIUM; MALE; PITUITARY-ADRENAL SYSTEM; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; STRESS DISORDERS, POST-TRAUMATIC; SUBSTANCE-RELATED DISORDERS; TACROLIMUS BINDING PROTEINS; VETERANS;

EID: 84962677589     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2016.04.001     Document Type: Article

References (27)

1. Armour C., Tsai J., Durham T.A., Charak R., Biehn T.L., Elhai J.D., Pietrzak R.H. Dimensional structure of DSM-5 posttraumatic stress symptoms: support for a hypbrid Anhednoia and Externalizing Behaviors model. J. Psychaitr. Res. 2015, 61:106-113.
2. Binder E.B., Bradley R.G., Liu W., Epstein M.P., Deveau T.C., Mercer K.B., et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 2008, 299:1291-1305.
3. Binder E.B. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 2009, 34:S186-S195.
4. Carlson E.B., Smith S.R., Palmieri P.A., Dalenberg C., Ruzek J.I., Kimerling R., et al. Development and validation of a brief self-report measure of trauma exposure: the trauma history screen. Psychol. Assess. 2011, 23:463-477.
5. Carpenter L.L., Carvalho J.P., Tyrka A.R., Wier L.M., Mello A.F., Mello M.F., et al. Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment. Biol. Psychiatry 2007, 62:1080-1087.
6. Cheung J., Bryant R.A. FKBP5 risk alleles and the development of intrusive memories. Neurobiol. Learn. Mem. 2015, 125:258-264.
7. Cuthbert B.N. The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry 2014, 13:28-35.
8. Delaneau O., Marchini J., Zagury J.F. A linear complexity phasing method for thousands of genomes. Nat. Methods 2012, 9:179-181.
9. Fani N., Gutman D., Tone E.B., Almli L., Mercer K.B., Davis J., et al. FKBP5 and attention bias for threat: associations with hippocampal function and shape. JAMA Psychiatry 2013, 70:392-400.
10. Hall B.J., Elhai J.D., Grubaugh A., Tuerk P., Magruder K. Examining the factor structure of PTSD between male and female veterans in primary care. J. Anxiety Disord. 2012, 26:409-415.
11. Hoge C.W., Riviere L.A., Wilk J.E., Herrell R.K., Weathers F.W. The prevalence of post-traumatic stress disorder (PTSD) in US combat soldiers: a head-to-head comparison of DSM-5 versus DSM-iV-TR symptom criteria with the PTSD checklist. Lancet Psychiatry 2014, 1:269-277.
12. Howie B.N., Donnelly P., Marchini J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies PLoS Genet. 5, e1000529. PLoS Genet. 2009, 5:e1000529.
13. King D.W., Leskin G.A., King L.A., Weathers F.W. Confirmatory factor analysis of the Clinician-administered PTSD Scale: evidence of the dimensionality of posttraumatic stress disorder. Psychol. Assess. 1998, 10:90-96.
14. Koenen K.C., Saxe G., Purcell S., Smoller J.W., Bartholomew D., Miller A., et al. Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children. Mol. Psychiatry 2005, 10:1058-1059.
15. McGloin J.M., Widom C.S. Resilience among abused and neglected children grown up. Dev. Psychopathol. 2001, 13:1021-1038.
16. Mehta D., Binder E.B. Gene x environment vulnerability factors for PTSD: the HPA-axis. Neuropharmacology 2012, 62:654-662.
17. Pietrzak R.H., Rosenheck R.A., Cramer J.A., Vessichio J.C., Tsai J., Southwick S.M., et al. Elucidating the transdiagnostic dimensional structure of trauma-related psychopathology: findings from VA cooperative study 504-risperidone treatment for military service related chronic posttraumatic stress disorder. J. Affect. Disord. 2014, 172:331-336.
18. Price A.L., Patterson N.J., Plenge R.M., Weinblatt M.E., Shadick N.A., Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 2006, 38:904-909.
19. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 2007, 8:559-575.
20. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavas J., Weiller E., et al. The Mini-international Neuropsychiatric Interview (M.I.N.I): the development and validation of a structured diagnostic psychiatric interview for DSM-iV and ICD-10. J. Clin. Psychiatry 1998, 59:22-33.
21. Velders F.P., Kunigas M., Kumari M., Dekker M.J., Uitterlinden A.G., Kirschbaum C. Genetics of cortisol secretion and depressive symptoms: a candidate gene and genome wide association approach. Psychoneuroendocrinology 2011, 36:1053-1061.
22. Weathers F.W., Litz B.T., Herman D.S., Huska J.A., Keane T.M. The PTSD checklist (PCL): reliability, validity, and diagnostic utility. Paper Presented at the Annual Meeting of the International Society of Traumatic Stress Studies 1993, (Oct).
23. White M.G., Bogdan R., Fisher P.M., Munoz K.E., Williamson D.E., Hariri A.R. FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity. Genes. Brain Behav. 2012, 11:869-878.
24. Wisco B.E., Marx B.P., Wolf E.J., Miller M.W., Southwick S.M., Pietrzak R.H. Posttraumatic stress disorder in the US veteran population: results from the National Health and Resilience in Veterans Study. J. Clin. Psychiatry 2014, 75:1338-1346.
25. Xie P., Kranzler H.R., Poling J., Stein M.B., Anton R.F., Farrer L.A., Gelernter J. Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder. Neuropsychopharmacology 2010, 335:1684-1692.
26. Zannas A.S., Wiechmann T., Gassen N.C., Binder E.B. Gene-stress-epigenetic regulation of FKBP5: clinical and translational implications. Neuropsychopharmacology 2016, 41:261-274.
27. de Kloet C.S., Vermetten E., Geuze E., Kavelaars A., Heijnen C.J., Westenberg H.G.M. Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. J. Psychiatr. Res. 2006, 40:550-567.