The role of lutein and zeaxanthin in protection against age-related macular degeneration

Acta Horticulturae

Volumn 1106, Issue , 2015, Pages 153-159

  Bernstein, P S ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Areds2; Blindness; Carotenoid; Macula; Nutrition; Retina; Xanthophyll

Indexed keywords

EID: 84962561534     PISSN: 05677572     EISSN: None     Source Type: Book Series    
DOI: 10.17660/ActaHortic.2015.1106.24     Document Type: Article

References (27)

1. Age-Related Eye Disease Study 2 Research Group. (2013). Lutein + zeaxanthin and omega-3 fatty acids for agerelated macular degeneration: The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA 309, 2005-2015 http://dx.doi.org/10.1001/jama.2013.4997. PubMed.
2. Age-Related Eye Disease Study Research Group. (2001). A randomized, placebo-controlled, clinical trial of highdose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch. Ophthalmol. 119, 1417-1436 http://dx.doi.org/10.1001/archopht.119.10.1417. PubMed.
3. Age-Related Eye Disease Study Research Group, SanGiovanni, J.P., Chew, E.Y., Clemons, T.E., Ferris, F.L. 3rd, Gensler, G., Lindblad, A.S., Milton, R.C., Seddon, J.M., and Sperduto, R.D.. (2007). The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch. Ophthalmol. 125, 1225-1232 http://dx.doi.org/10.1001/archopht.125.9.1225. PubMed.
4. Barker, F.M. 2nd, Snodderly, D.M., Johnson, E.J., Schalch, W., Koepcke, W., Gerss, J., and Neuringer, M. (2011). Nutritional manipulation of primate retinas, V: Effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage. Invest. Ophthalmol. Vis. Sci. 52, 3934-3942 http://dx.doi.org/10.1167/iovs.10-5898. PubMed.
5. Beatty, S., Koh, H., Phil, M., Henson, D., and Boulton, M. (2000). The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv. Ophthalmol. 45, 115-134 http://dx.doi.org/10.1016/S0039-6257(00)00140-5. PubMed.
6. Bernstein, P.S., Khachik, F., Carvalho, L.S., Muir, G.J., Zhao, D.Y., and Katz, N.B. (2001). Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye. Exp. Eye Res. 72, 215-223 http://dx.doi.org/10.1006/exer.2000.0954. PubMed.
7. Bernstein, P.S., Delori, F.C., Richer, S., van Kuijk, F.J., and Wenzel, A.J. (2010). The value of measurement of macular carotenoid pigment optical densities and distributions in age-related macular degeneration and other retinal disorders. Vision Res. 50, 716-728 http://dx.doi.org/10.1016/j.visres.2009.10.014. PubMed.
8. Bhosale, P., Larson, A.J., Frederick, J.M., Southwick, K., Thulin, C.D., and Bernstein, P.S. (2004). Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye. J. Biol. Chem. 279, 49447-49454 http://dx.doi.org/10.1074/jbc.M405334200. PubMed.
9. Bian, Q., Gao, S., Zhou, J., Qin, J., Taylor, A., Johnson, E.J., Tang, G., Sparrow, J.R., Gierhart, D., and Shang, F. (2012). Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells. Free Radic. Biol. Med. 53, 1298-1307 http://dx.doi.org/10.1016/j.freeradbiomed.2012.06.024. PubMed.
10. Borel, P., Drai, J., Faure, H., Fayol, V., Galabert, C., Laromiguière, M., and Le Moël, G. (2005). [Recent knowledge about intestinal absorption and cleavage of carotenoids]. Ann. Biol. Clin. (Paris) 63, 165-177. PubMed.
11. Chew, E.Y., Clemons, T., SanGiovanni, J.P., Danis, R., Domalpally, A., McBee, W., Sperduto, R., and Ferris, F.L.; AREDS2 Research Group. (2012). The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). Ophthalmology 119, 2282-2289 http://dx.doi.org/10.1016/j.ophtha.2012.05.027. PubMed.
12. Chew, E.Y., Clemons, T.E., Sangiovanni, J.P., Danis, R.P., Ferris, F.L. 3rd, Elman, M.J., Antoszyk, A.N., Ruby, A.J., Orth, D., Bressler, S.B. et al; Age-Related Eye Disease Study 2 (AREDS2) Research Group. (2014). Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3. JAMA Ophthalmol 132, 142-149 http://dx.doi.org/10.1001/jamaophthalmol.2013.7376. PubMed.
13. During, A., Doraiswamy, S., and Harrison, E.H. (2008). Xanthophylls are preferentially taken up compared with beta-carotene by retinal cells via a SRBI-dependent mechanism. J. Lipid Res. 49, 1715-1724 http://dx.doi.org/10.1194/jlr.M700580-JLR200. PubMed.
14. Friedman, D.S., O'Colmain, B.J., Muñoz, B., Tomany, S.C., McCarty, C., de Jong, P.T., Nemesure, B., Mitchell, P., and Kempen, J.; Eye Diseases Prevalence Research Group. (2004). Prevalence of age-related macular degeneration in the United States. Arch. Ophthalmol. 122, 564-572 http://dx.doi.org/10.1001/archopht.122.4.564. PubMed.
15. Landrum, J.T., and Bone, R.A. (2001). Lutein, zeaxanthin, and the macular pigment. Arch. Biochem. Biophys. 385, 28-40 http://dx.doi.org/10.1006/abbi.2000.2171. PubMed.
16. Li, B., Vachali, P., Frederick, J.M., and Bernstein, P.S. (2011). Identification of StARD3 as a lutein-binding protein in the macula of the primate retina. Biochemistry 50, 2541-2549 http://dx.doi.org/10.1021/bi101906y. PubMed.
17. Li, B., Vachali, P.P., Gorusupudi, A., Shen, Z., Sharifzadeh, H., Besch, B.M., Nelson, K., Horvath, M.M., Frederick, J.M., Baehr, W., and Bernstein, P.S. (2014). Inactivity of human β, β-carotene-9', 10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment. Proc. Natl. Acad. Sci. U.S.A. 111, 10173-10178 http://dx.doi.org/10.1073/pnas.1402526111. PubMed.
18. Loughman, J., Nolan, J.M., Howard, A.N., Connolly, E., Meagher, K., and Beatty, S. (2012). The impact of macular pigment augmentation on visual performance using different carotenoid formulations. Invest. Ophthalmol. Vis. Sci. 53, 7871-7880 http://dx.doi.org/10.1167/iovs.12-10690. PubMed.
19. Nolan, J.M., Akkali, M.C., Loughman, J., Howard, A.N., and Beatty, S. (2012). Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment. Exp. Eye Res. 101, 9-15 http://dx.doi.org/10.1016/j.exer.2012.05.006. PubMed.
20. Nolan, J.M., Meagher, K., Kashani, S., and Beatty, S. (2013). What is meso-zeaxanthin, and where does it come from? Eye (Lond) 27, 899-905 http://dx.doi.org/10.1038/eye.2013.98. PubMed.
21. Rosenthal, J.M., Kim, J., de Monasterio, F., Thompson, D.J., Bone, R.A., Landrum, J.T., de Moura, F.F., Khachik, F., Chen, H., Schleicher, R.L., et al. (2006). Dose-ranging study of lutein supplementation in persons aged 60 years or older. Invest. Ophthalmol. Vis. Sci. 47, 5227-5233 http://dx.doi.org/10.1167/iovs.05-1513. PubMed.
22. Seddon, J.M. (2013). Genetic and environmental underpinnings to age-related ocular diseases. Invest. Ophthalmol. Vis. Sci. 54, ORSF28-30 http://dx.doi.org/10.1167/iovs.13-13234. PubMed.
23. Seddon, J.M., Ajani, U.A., Sperduto, R.D., Hiller, R., Blair, N., Burton, T.C., Farber, M.D., Gragoudas, E.S., Haller, J., Miller, D.T., et al; Eye Disease Case-Control Study Group. (1994). Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA 272, 1413-1420 http://dx.doi.org/10.1001/jama.1994.03520180037032. PubMed.
24. Stringham, J.M., and Hammond, B.R. (2008). Macular pigment and visual performance under glare conditions. Optom Vis Sci 85, 82-88 http://dx.doi.org/10.1097/OPX.0b013e318162266e. PubMed.
25. Sui, G.Y., Liu, G.C., Liu, G.Y., Gao, Y.Y., Deng, Y., Wang, W.Y., Tong, S.H., and Wang, L. (2013). Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysis. Br J Ophthalmol 97, 389-394 http://dx.doi.org/10.1136/bjophthalmol-2012-302281. PubMed.
26. Vachali, P.P., Besch, B.M., Gonzalez-Fernandez, F., and Bernstein, P.S. (2013). Carotenoids as possible interphotoreceptor retinoid-binding protein (IRBP) ligands: A surface plasmon resonance (SPR) based study. Arch. Biochem. Biophys. 539, 181-186 http://dx.doi.org/10.1016/j.abb.2013.07.008. PubMed.
27. Woodell, A., and Rohrer, B. (2014). A mechanistic review of cigarette smoke and age-related macular degeneration. Adv. Exp. Med. Biol. 801, 301-307 http://dx.doi.org/10.1007/978-1-4614-3209-8-38. PubMed.