Inactivity of human β,β-carotene-9′, 10-′dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 28, 2014, Pages 10173-10178

  Li, Binxing ^a   Vachali, Preejith P ^a   Gorusupudi, Aruna ^a   Shen, Zhengqing ^a   Sharifzadeh, Hassan ^a   Besch, Brian M ^a   Nelson, Kelly ^a   Horvath, Madeleine M ^a   Frederick, Jeanne M ^a   Baehr, Wolfgang ^a,b   Bernstein, Paul S ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA, BETA CAROTENE 9' ,10' DIOXYGENASE; CAROTENOID; ENZYME; MESSENGER RNA; UNCLASSIFIED DRUG; VISUAL PIGMENT; XANTHOPHYLL; ZEAXANTHIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN; IMMUNOHISTOCHEMISTRY; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RETINA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SURFACE PLASMON RESONANCE; WESTERN BLOTTING;

ANIMALS; DIOXYGENASES; EYE PROTEINS; GLUTATHIONE S-TRANSFERASE PI; HUMANS; LUTEIN; MICE; MICE, KNOCKOUT; RETINA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECIES SPECIFICITY; XANTHOPHYLLS;

EID: 84904317478     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402526111     Document Type: Article

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