Patterns of neuropsychiatric symptoms in mild cognitive impairment and risk of dementia

American Journal of Geriatric Psychiatry

Volumn 24, Issue 2, 2016, Pages 117-125

  Forrester, Sarah N ^a,b   Gallo, Joseph J ^b   Smith, Gwenn S ^a   Leoutsakos, Jeannie Marie S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

dementia; MCI; neuropsychiatric symptoms

Indexed keywords

AGED; AGGRESSION; AGITATION; ALZHEIMER DISEASE; ANXIETY; APATHY; ARTICLE; COHORT ANALYSIS; DELUSION; DEMENTIA; DEPRESSION; DISEASE COURSE; DYSPHORIA; EMOTIONAL DISORDER; EUPHORIA; FEMALE; FOLLOW UP; HALLUCINATION; HUMAN; INHIBITION (PSYCHOLOGY); IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; MOTOR DYSFUNCTION; MULTIINFARCT DEMENTIA; NEUROLOGIC DISEASE; RISK; SLEEP DISORDER; VERY ELDERLY; COGNITIVE DYSFUNCTION; KAPLAN MEIER METHOD; MARYLAND; NEUROPSYCHOLOGICAL TEST; PROPORTIONAL HAZARDS MODEL; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; RESTLESSNESS; RISK ASSESSMENT;

AGED; AGED, 80 AND OVER; ANXIETY; APATHY; COGNITIVE DYSFUNCTION; DEMENTIA; DEPRESSION; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; IRRITABLE MOOD; KAPLAN-MEIER ESTIMATE; MALE; MARYLAND; NEUROPSYCHOLOGICAL TESTS; PROPORTIONAL HAZARDS MODELS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMOTOR AGITATION; RISK ASSESSMENT;

EID: 84962555606     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1016/j.jagp.2015.05.007     Document Type: Article

References (36)

1. J.J. Manly, M.X. Tang, N. Schupf, and et al. Frequency and course of mild cognitive impairment in a multiethnic community Ann Neurol 63 2008 494 506
2. R.C. Petersen, R. Doody, A. Kurz, and et al. Current concepts in mild cognitive impairment Arch Neurol 58 2001 1985 1992
3. M.E. Peters, P.B. Rosenberg, M. Steinberg, and et al. Prevalence of neuropsychiatric symptoms in CIND and its subtypes: the Cache County Study Am J Geriatr Psychiatry 20 2012 416 424
4. F. Di Iulio, K. Palmer, C. Blundo, and et al. Occurrence of neuropsychiatric symptoms and psychiatric disorders in mild Alzheimer's disease and mild cognitive impairment subtypes Int Psychogeriatr 22 2010 629 640
5. C.G. Lyketsos, J.M. Sheppard, M. Steinberg, and et al. Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County study Int J Geriatr Psychiatry 16 2001 1043 1053
6. M. Steinberg, H. Shao, P. Zandi, and et al. Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study Int J Geriatr Psychiatry 23 2008 170 177
7. P.V. Rabins, S. Schwartz, B.S. Black, and et al. Predictors of progression to severe Alzheimer's disease in an incidence sample Alzheim Dement 9 2013 204 207
8. L.G. Apostolova, and J.L. Cummings Neuropsychiatric manifestations in mild cognitive impairment: a systematic review of the literature Dement Geriatr Cogn Disord 25 2008 115 126
9. K. Palmer, F. Di Iulio, A.E. Varsi, and et al. Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: the role of depression and apathy J Alzheimers Dis 20 2010 175 183
10. P.B. Rosenberg, M.M. Mielke, B. Appleby, and et al. Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction Int J Geriatr Psychiatry 26 2011 364 372
11. H. Brodaty, M.H. Connors, J. Xu, and et al. Predictors of institutionalization in dementia: a three year longitudinal study J Alzheimers Dis 40 2014 221 226
12. M. Ganguli, H.H. Dodge, C. Shen, and et al. Alzheimer disease and mortality: a 15-year epidemiological study Arch Neurol 62 2005 779 784
13. M.P. Copeland, E. Daly, V. Hines, and et al. Psychiatric symptomatology and prodromal Alzheimer's disease Alzheimer Dis Assoc Disord 17 2003 1 8
14. F.E. Taragano, R.F. Allegri, H. Krupitzki, and et al. Mild behavioral impairment and risk of dementia: a prospective cohort study of 358 patients J Clin Psychiatry 70 2009 584 592
15. A. Mowla, M. Mosavinasab, and A. Pani Does fluoxetine have any effect on the cognition of patients with mild cognitive impairment? A double-blind, placebo-controlled, clinical trial J Clin Psychopharmacol 27 2007 67 70
16. R.K. Bhalla, M.A. Butters, B.H. Mulsant, and et al. Persistence of neuropsychologic deficits in the remitted state of late-life depression Am J Geriatr Psychiatry 14 2006 419 427
17. M. Moran, C. Walsh, A. Lynch, and et al. Syndromes of behavioural and psychological symptoms in mild Alzheimer's disease Int J Geriatr Psychiatry 19 2004 359 364
18. D.L. Beekly, E.M. Ramos, W.W. Lee, and et al. The National Alzheimer's Coordinating Center (NACC) database: the Uniform Data Set Alzheimer Dis Assoc Disord 21 2007 249 258
19. S. Weintraub, D. Salmon, N. Mercaldo, and et al. The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery Alzheimer Dis Assoc Disord 23 2009 91 101
20. J.L. Cummings, M. Mega, K. Gray, and et al. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia Neurology 44 1994 2308 2314
21. M.F. Folstein, S.E. Folstein, and P.R. McHugh "Mini-Mental State." A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 1975 189 198
22. J.Y. Sheikh, and J.A. Yesavage, Geriatric Depression Scale (GDS): recent evidence and development of a shorter version T.L. Brink, Clinical Gerontology: A Guide to Assessment and Intervention 1986 The Haworth Press New York 165 173
23. R.C. Petersen Mild cognitive impairment as a diagnostic entity J Intern Med 256 2004 183 194
24. G. McKhann, D. Drachman, M. Folstein, and et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease Neurology 34 1984 939 944
25. G.C. Roman, T.K. Tatemichi, T. Erkinjuntti, and et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop Neurology 43 1993 250 260
26. D. Neary, J.S. Snowden, L. Gustafson, and et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria Neurology 51 1998 1546 1554
27. J.A. Hagenaars, and A.L. McCutcheon, Applied Latent Class Analysis 2002 Cambridge University Press Cambridge, UK
28. J. Vermunt Latent class modeling with covariates: two improved three-step approaches Polit Anal 18 2010 450 469
29. T.M. Asparouhov, and B.O. Muthén, Auxiliary Variables in Mixture Modeling: 3-Step Approaches Using Mplus 2013 Retrieved from www.Statmodel.com
30. StataCorp Stata Statistical Software: Release 13 2013 StataCorp LP College Station, TX
31. Muthén LM, Muthén, BO: Mplus User's Guide. 7th ed. Los Angeles, CA, Múthen & Múthen, 1998-2012.
32. K. Nylund, A. Bellmore, A. Nishina, and et al. Subtypes, severity, and structural stability of peer victimization: what does latent class analysis say? Child Dev 78 2007 1706 1722
33. P.M.T. Grambsch, and T.M. Therneau Proportional hazards tests and diagnostics based on weighted residuals Biometrika 81 1994 515 526
34. C.G. Lyketsos Neuropsychiatric symptoms (behavioral and psychological symptoms of dementia) and the development of dementia treatments Int Psychogeriatr 19 2007 409 420
35. J.J. Hanfelt, J. Wuu, A.B. Sollinger, and et al. An exploration of subgroups of mild cognitive impairment based on cognitive, neuropsychiatric and functional features: analysis of data from the National Alzheimer's Coordinating Center Am J Geriatr Psychiatry 19 2011 940 950
36. K. Hirao, G. Pontone, and G. Smith Molecular imaging of neuropsychiatric symptoms in Alzheimer's and Parkinson's disease Neurosci Biobehav Rev 49C 2014 157 170