The combined-disk boronic acid test as an accurate strategy for the detection of KPC carbapenemase in Central America

Journal of Infection in Developing Countries

Volumn 10, Issue 3, 2016, Pages 298-303

  Zúñiga, Julio ^a   Cruz, Gerardo ^b   Pérez, Carlos ^b   Tarajia, Musharaf ^c  

^a GORGAS MEMORIAL INSTITUTE FOR HEALTH STUDIES   (Panama)

^b HMDrAAM CSS)   (Panama)

^c INSTITUTO DE INVESTIGACIONES CIENTÍFICAS Y SERVICIOS DE ALTA TECNOLOGÍA   (Panama)

Author keywords

Carbapenemase; Disease outbreaks; Drug resistance; Polymerase chain reaction; Public health

Indexed keywords

IMIPENEM; MEROPENEM; BACTERIAL PROTEIN; BETA LACTAMASE; BORONIC ACID DERIVATIVE; CARBAPENEMASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM DETECTION; BACTERIUM IDENTIFICATION; BLOOD SAMPLING; CARBAPENEMASE PRODUCING ENTEROBACTERIACEAE; CENTRAL AMERICA; CLINICAL ARTICLE; COMBINED DISK BORONIC ACID TEST; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; FEMALE; HUMAN; INTENSIVE CARE UNIT; KLEBSIELLA PNEUMONIAE INFECTION; MALE; MINIMUM INHIBITORY CONCENTRATION; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; TERTIARY CARE CENTER; URINALYSIS; DISK DIFFUSION; ENZYMOLOGY; EVALUATION STUDY; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTION; KLEBSIELLA PNEUMONIAE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PANAMA; PROCEDURES;

BACTERIAL PROTEINS; BETA-LACTAMASES; BORONIC ACIDS; DISK DIFFUSION ANTIMICROBIAL TESTS; FEMALE; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MIDDLE AGED; PANAMA; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY;

EID: 84962473595     PISSN: 20366590     EISSN: 19722680     Source Type: Journal    
DOI: 10.3855/jidc.7213     Document Type: Article

References (26)

1. World Health Organization (2014) Antimicrobial resistance: global report on surveillance 2014. Available: http://www.who.int/drugresistance/documents/surveillancereport/en/. Accessed May 6, 2015.
2. Tängdén T, Giske CG (2014) Global dissemination of extensively drug-resistant carbapenemase-producing Enterobacteriaceae: clinical perspectives on detection, treatment and infection control. J Intern Med 277: 501-512.
3. Harris PNA, Tambyah PA, Paterson DL (2015) β-lactam and β-lactamase inhibitor combinations in the treatment of extended-spectrum β-lactamase producing Enterobacteriaceae: time for a reappraisal in the era of few antibiotic options? Lancet Infect Dis 15: 475-485.
4. Nordmann P (2014) Carbapenemase-producing Enterobacteriaceae: overview of a major public health challenge. Med Mal Infect 44: 51-56.
5. Nordmann P, Naas T, Poirel L (2011) Global spread of Carbapenemase-producing Enterobacteriaceae. Emerging Infect Dis 17: 1791-1798.
6. Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M, Cornaglia G, Garau J, Gniadkowski M, Hayden MK, Kumarasamy K, Livermore DM, Maya JJ, Nordmann P, Patel JB, Paterson DL, Pitout J, Villegas MV, Wang H, Woodford N, Quinn JP (2013) Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis 13: 785-796.
7. Lopez JA, Correa A, Navon-Venezia S, Correa AL, Torres JA, Briceño DF, Montealegre MC, Quinn JP, Carmeli Y, Villegasz MV (2011) Intercontinental spread from Israel to Colombia of a KPC-3-producing Klebsiella pneumoniae strain. Clin Microbiol Infect 17: 52-56.
8. Tzouvelekis LS, Markogiannakis A, Psichogiou M, Tassios PT, Daikos GL (2012) Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin Microbiol Rev 25: 682-707.
9. Nordmann P, Gniadkowski M, Giske CG, Poirel L, Woodford N, Miriagou V (2012) Identification and screening of carbapenemase-producing Enterobacteriaceae. Clin Microbiol Infect 18: 432-438.
10. Nordmann P, Cuzon G, Naas T (2009) The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 9: 228-236.
11. Doern CD, Dunne WM, Burnham AD (2011) Detection of Klebsiella pneumoniae carbapenemase (KPC) production in non-Klebsiella pneumoniae Enterobacteriaceae isolates by use of the Phoenix, Vitek 2, and disk diffusion methods. J Clin Microbiol 49: 1143-1147.
12. Hirsch EB, Tam VH (2010) Detection and treatment options for Klebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug-resistant infection. J Antimicrob Chemother 65: 1119-1125.
13. Krishna NK, Cunnion KM (2012) Role of molecular diagnostics in the management of infectious disease emergencies. Med Clin North Am 96: 1067-1078.
14. Pasteran F, Mendez T, Guerriero L, Rapoport M, Corso A (2009) Sensitive screening tests for suspected class A carbapenemase production in species of Enterobacteriaceae. J Clin Microbiol 47: 1631-1639.
15. Landman D, Salvani JK, Bratu S, Quale J (2005) Evaluation of techniques for detection of carbapenem-resistant Klebsiella pneumoniae in stool surveillance cultures. J Clin Microbiol 43: 5639-5641.
16. Pasteran F, Lucero C, Soloaga R, Rapoport M, Corso A (2011) Can we use imipenem and meropenem Vitek 2 MICs for detection of suspected KPC and other-carbapenemase producers among species of Enterobacteriaceae? J Clin Microbiol 49: 697-701.
17. Center for Disease Control and Prevention (2012) Guidance for Control of Carbapenem-Resistent Enterobacteriaceae, 2012 CRE Toolkit. Available: http://www.cdc.gov/hai/pdfs/cre/CRE-guidance-508.pdf. Accessed May 8, 2015.
18. Clinical and Laboratory Standard Institute (2012) Performance Standard for Antimicrobial Susceptibility testing: twenty second informational supplement. Available: http://clsi.org/standards/micro/. Accessed May 15, 2015.
19. Tsakris A, Kristo I, Poulou A, Markou F, Ikonomidis A, Pournaras S (2008) First occurrence of KPC-2-possessing Klebsiella pneumoniae in a Greek hospital and recommendation for detection with boronic acid disc tests. J Antimicrob Chemother 62: 1257-1260.
20. Bebell LM, Muiru AN (2014) Antibiotic use and emerging resistance: how can resource-limited countries turn the tide? Glob Heart 9: 347-358.
21. Tsakris A, Kristo I, Poulou A, Themeli-Digalaki K, Ikonomidis A, Petropoulou D, Pournaras S, Sofianou D (2009) Evaluation of boronic acid disk tests for differentiating KPC-possessing Klebsiella pneumoniae isolates in the clinical laboratory. J Clin Microbiol 47: 362-367.
22. Tsakris A, Themeli-Digalaki K, Poulou A, Vrioni G, Voulgari E, Koumaki V, Agodi A, Pournaras S, Sofianou D (2011) Comparative evaluation of combined-disk tests using different boronic acid compounds for detection of Klebsiella pneumoniae carbapenemase-producing enterobacteriaceae clinical isolates. J Clin Microbiol 49: 2804-2809.
23. Pournaras S, Poulou A, Tsakris A (2010) Inhibitor-based methods for the detection of KPC carbapenemase-producing Enterobacteriaceae in clinical practice by using boronic acid compounds. J Antimicrob Chemother 65: 1319-1321.
24. Ministry of Health of Panama (2011). Carbapenemase producing Enterobacteriaceas controls measures. Available: http://190.34.154.88/Observatorio/KPC/A.%20DOCUMENTO%20-MEDIDAS%20DE%20CONTROL%20PARA%20BROTE%20KPC%20DEF.pdf. Accessed May 11, 2015.
25. Giani T, Tascini C, Arena F, Ciullo I, Conte V, Leonildi A, Menichetti F, Rossolini GM (2012) Rapid detection of intestinal carriage of Klebsiella pneumoniae producing KPC carbapenemase during an outbreak. J Hosp Infect 81: 119-122.
26. Pournaras S, Zarkotou O, Poulou A, Kristo I, Vrioni G, Themeli-Digalaki K, Tsakris A (2013) A combined disk test for direct differentiation of carbapenemase-producing enterobacteriaceae in surveillance rectal swabs. J Clin Microbiol 51: 2986-2990.