Specific gene expression patterns of 108 schizophrenia-associated loci in cortex

Schizophrenia Research

Volumn 174, Issue 1-3, 2016, Pages 35-38

  Ohi, Kazutaka ^a   Shimada, Takamitsu ^a   Nitta, Yusuke ^a   Kihara, Hiroaki ^a   Okubo, Hiroaki ^a   Uehara, Takashi ^a   Kawasaki, Yasuhiro ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

GRIN2A; KCNB1; MEF2C; SATB2; Schizophrenia; Temporal spatial expression

Indexed keywords

AMYGDALA; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN REGION; BRAIN TISSUE; CEREBELLUM CORTEX; CORPUS STRIATUM; DEVELOPMENTAL STAGE; EGR1 GENE; FRONTAL CORTEX; GENE; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE OVEREXPRESSION; GRIN2A GENE; HIPPOCAMPUS; HUMAN; HUMAN CELL; KCNB1 GENE; KCNV1 GENE; MEF2C GENE; NEOCORTEX; NRGN GENE; OSBPL3 GENE; PRIORITY JOURNAL; RGS6 GENE; SATB2 GENE; SCHIZOPHRENIA; THALAMUS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROARRAY ANALYSIS;

KCNB1 PROTEIN, HUMAN; MATRIX ATTACHMENT REGION BINDING PROTEIN; MEF2C PROTEIN, HUMAN; MYOCYTE ENHANCER FACTOR 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N-METHYL D-ASPARTATE RECEPTOR SUBTYPE 2A; SATB2 PROTEIN, HUMAN; SHAB POTASSIUM CHANNEL; TRANSCRIPTION FACTOR;

CEREBRAL CORTEX; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC LOCI; HUMANS; MATRIX ATTACHMENT REGION BINDING PROTEINS; MEF2 TRANSCRIPTION FACTORS; MICROARRAY ANALYSIS; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA; SHAB POTASSIUM CHANNELS; TRANSCRIPTION FACTORS;

EID: 84962436609     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2016.03.032     Document Type: Article

References (16)

1. Adriano F., Caltagirone C., Spalletta G. Hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis. Neuroscientist 2012, 18:180-200.
2. Benes F.M. Amygdalocortical circuitry in schizophrenia: from circuits to molecules. Neuropsychopharmacology 2010, 35:239-257.
3. Benita Y., Cao Z., Giallourakis C., Li C., Gardet A., Xavier R.J. Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor. Blood 2010, 115:5376-5384.
4. Birnbaum R., Jaffe A.E., Hyde T.M., Kleinman J.E., Weinberger D.R. Prenatal expression patterns of genes associated with neuropsychiatric disorders. Am. J. Psychiatry 2014, 171:758-767.
5. Birnbaum R., Jaffe A.E., Chen Q., Hyde T.M., Kleinman J.E., Weinberger D.R. Investigation of the prenatal expression patterns of 108 schizophrenia-associated genetic loci. Biol. Psychiatry 2015, 77:e43-e51.
6. Dougherty J.D., Schmidt E.F., Nakajima M., Heintz N. Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells. Nucleic Acids Res. 2010, 38:4218-4230.
7. Endele S., Rosenberger G., Geider K., Popp B., Tamer C., Stefanova I., Milh M., Kortum F., Fritsch A., Pientka F.K., Hellenbroich Y., Kalscheuer V.M., Kohlhase J., Moog U., Rappold G., Rauch A., Ropers H.H., von Spiczak S., Tonnies H., Villeneuve N., Villard L., Zabel B., Zenker M., Laube B., Reis A., Wieczorek D., Van Maldergem L., Kutsche K. Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes. Nat. Genet. 2010, 42:1021-1026.
8. Jaffe A.E., Shin J., Collado-Torres L., Leek J.T., Tao R., Li C., Gao Y., Jia Y., Maher B.J., Hyde T.M., Kleinman J.E., Weinberger D.R. Developmental regulation of human cortex transcription and its clinical relevance at single base resolution. Nat. Neurosci. 2015, 18:154-161.
9. Kang H.J., Kawasawa Y.I., Cheng F., Zhu Y., Xu X., Li M., Sousa A.M., Pletikos M., Meyer K.A., Sedmak G., Guennel T., Shin Y., Johnson M.B., Krsnik Z., Mayer S., Fertuzinhos S., Umlauf S., Lisgo S.N., Vortmeyer A., Weinberger D.R., Mane S., Hyde T.M., Huttner A., Reimers M., Kleinman J.E., Sestan N. Spatio-temporal transcriptome of the human brain. Nature 2011, 478:483-489.
10. Lonsdale J., Thomas J., Salvatore M., Phillips R., Lo E., Shad S., Hasz R., Walters G. The Genotype-Tissue Expression (GTEx) project. Nat. Genet. 2014, 45:580-585.
11. Nowakowska B.A., Obersztyn E., Szymanska K., Bekiesinska-Figatowska M., Xia Z., Ricks C.B., Bocian E., Stockton D.W., Szczaluba K., Nawara M., Patel A., Scott D.A., Cheung S.W., Bohan T.P., Stankiewicz P. Severe mental retardation, seizures, and hypotonia due to deletions of MEF2C. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010, 153B:1042-1051.
12. Rakic P. Evolution of the neocortex: a perspective from developmental biology. Nat. Rev. Neurosci. 2009, 10:724-735.
13. Ripke S., Neale B.M., Corvin A., Walters J.T., Farh K.H., Holmans P.A., Lee P., Bulik-Sullivan B., Collier D.A., Huang H., Pers T.H., Agartz I., Agerbo E., Albus M., Alexander M., Amin F., Bacanu S.A., Begemann M., Belliveau R.A., Bene J., Bergen S.E., Bevilacqua E., Bigdeli T.B., Black D.W., Bruggeman R., Buccola N.G., Buckner R.L., Byerley W., Cahn W., Cai G., Campion D., Cantor R.M., Carr V.J., Carrera N., Catts S.V., Chambert K.D., Chan R.C., Chen R.Y., Chen E.Y., Cheng W., Cheung E.F., Chong S.A., Cloninger C.R., Cohen D., Cohen N., Cormican P., Craddock N., Crowley J.J., Curtis D., Davidson M., Davis K.L., Degenhardt F., Del Favero J., Demontis D., Dikeos D., Dinan T., Djurovic S., Donohoe G., Drapeau E., Duan J., Dudbridge F., Durmishi N., Eichhammer P., Eriksson J., Escott-Price V., Essioux L., Fanous A.H., Farrell M.S., Frank J., Franke L., Freedman R., Freimer N.B., Friedl M., Friedman J.I., Fromer M., Genovese G., Georgieva L., Giegling I., Giusti-Rodríguez P., Godard S., Goldstein J.I., Golimbet V., Gopal S., Gratten J., de Haan L., Hammer C., Hamshere M.L., Hansen M., Hansen T., Haroutunian V., Hartmann A.M., Henskens F.A., Herms S., Hirschhorn J.N., Hoffmann P., Hofman A., Hollegaard M.V., Hougaard D.M., Ikeda M., Joa I., Julià A., Kahn R.S., Kalaydjieva L., Karachanak-Yankova S., Karjalainen J., Kavanagh D., Keller M.C., Kennedy J.L., Khrunin A., Kim Y., Klovins J., Knowles J.A., Konte B., Kucinskas V., Ausrele Kucinskiene Z., Kuzelova-Ptackova H., Kähler A.K., Laurent C., Keong J.L., Lee S.H., Legge S.E., Lerer B., Li M., Li T., Liang K.Y., Lieberman J., Limborska S., Loughland C.M., Lubinski J., Lönnqvist J., Macek M., Magnusson P.K., Maher B.S., Maier W., Mallet J., Marsal S., Mattheisen M., Mattingsdal M., McCarley R.W., McDonald C., McIntosh A.M., Meier S., Meijer C.J., Melegh B., Melle I., Mesholam-Gately R.I., Metspalu A., Michie P.T., Milani L., Milanova V., Mokrab Y., Morris D.W., Mors O., Murphy K.C., Murray R.M., Myin-Germeys I., Müller-Myhsok B., Nelis M., Nenadic I., Nertney D.A., Nestadt G., Nicodemus K.K., Nikitina-Zake L., Nisenbaum L., Nordin A., O'Callaghan E., O'Dushlaine C., O'Neill F.A., Oh S.Y., Olincy A., Olsen L., Van Os J., Pantelis C., Papadimitriou G.N., Papiol S., Parkhomenko E., Pato M.T., Paunio T., Pejovic-Milovancevic M., Perkins D.O., Pietiläinen O., Pimm J., Pocklington A.J., Powell J., Price A., Pulver A.E., Purcell S.M., Quested D., Rasmussen H.B., Reichenberg A., Reimers M.A., Richards A.L., Roffman J.L., Roussos P., Ruderfer D.M., Salomaa V., Sanders A.R., Schall U., Schubert C.R., Schulze T.G., Schwab S.G., Scolnick E.M., Scott R.J., Seidman L.J., Shi J., Sigurdsson E., Silagadze T., Silverman J.M., Sim K., Slominsky P., Smoller J.W., So H.C., Spencer C.A., Stahl E.A., Stefansson H., Steinberg S., Stogmann E., Straub R.E., Strengman E., Strohmaier J., Stroup T.S., Subramaniam M., Suvisaari J., Svrakic D.M., Szatkiewicz J.P., Söderman E., Thirumalai S., Toncheva D., Tosato S., Veijola J., Waddington J., Walsh D., Wang D., Wang Q., Webb B.T., Weiser M., Wildenauer D.B., Williams N.M., Williams S., Witt S.H., Wolen A.R., Wong E.H., Wormley B.K., Xi H.S., Zai C.C., Zheng X., Zimprich F., Wray N.R., Stefansson K., Visscher P.M., Adolfsson R., Andreassen O.A., Blackwood D.H., Bramon E., Buxbaum J.D., Børglum A.D., Cichon S., Darvasi A., Domenici E., Ehrenreich H., Esko T., Gejman P.V., Gill M., Gurling H., Hultman C.M., Iwata N., Jablensky A.V., Jönsson E.G., Kendler K.S., Kirov G., Knight J., Lencz T., Levinson D.F., Li Q.S., Liu J., Malhotra A.K., McCarroll S.A., McQuillin A., Moran J.L., Mortensen P.B., Mowry B.J., Nöthen M.M., Ophoff R.A., Owen M.J., Palotie A., Pato C.N., Petryshen T.L., Posthuma D., Rietschel M., Riley B.P., Rujescu D., Sham P.C., Sklar P., St Clair D., Weinberger D.R., Wendland J.R., Werge T., Daly M.J., Sullivan P.F., O'Donovan M.C. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014, 511:421-427.
14. Rosenfeld J.A., Ballif B.C., Lucas A., Spence E.J., Powell C., Aylsworth A.S., Torchia B.A., Shaffer L.G. Small deletions of SATB2 cause some of the clinical features of the 2q33.1 microdeletion syndrome. PLoS One 2009, 4.
15. Xu X., Wells A.B., O'Brien D.R., Nehorai A., Dougherty J.D. Cell type-specific expression analysis to identify putative cellular mechanisms for neurogenetic disorders. J. Neurosci. 2014, 34:1420-1431.
16. Yao H., Zhou K., Yan D., Li M., Wang Y. The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity. J. Neurochem. 2009, 108:909-919.