Role of activin A in the pathogenesis of endothelial cell dysfunction in preeclampsia

Pregnancy Hypertension

Volumn 6, Issue 2, 2016, Pages 130-133

  Hobson, Sebastian R ^a,b   Acharya, Rutu ^a   Lim, Rebecca ^a   Chan, Siow Teng ^a   Mockler, Joanne ^a,b   Wallace, Euan M ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b SOUTHERN HEALTH   (Australia)

Author keywords

Activin; Endothelin; Follistatin; ICAM; Preeclampsia; VCAM

Indexed keywords

ACTIVIN A; ENDOTHELIN 1; FOLLISTATIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; VASCULAR CELL ADHESION MOLECULE 1; ACTIVIN; BIOLOGICAL MARKER;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; PATHOGENESIS; PATHOPHYSIOLOGY; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERUM; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; ANTAGONISTS AND INHIBITORS; BLOOD; CASE CONTROL STUDY; METABOLISM; PHYSIOLOGY; PRE-ECLAMPSIA; PREGNANCY;

ACTIVINS; ADULT; BIOMARKERS; CASE-CONTROL STUDIES; ENDOTHELIN-1; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; PRE-ECLAMPSIA; PREGNANCY; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84962376231     PISSN: 22107789     EISSN: 22107797     Source Type: Journal    
DOI: 10.1016/j.preghy.2016.03.001     Document Type: Article

References (25)

1. F. Lyall, and I.A. Greer Pre-eclampsia: a multifaceted vascular disorder of pregnancy J. Hypertens. 12 12 1994 1339 1345
2. S.E. Maynard, J.Y. Min, J. Merchan, K.H. Lim, J. Li, S. Mondal, and et al. Excess placental soluble fms-like tyrosine kinase 1 (sflt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia J. Clin. Invest. 111 5 2003 649 658
3. R.J. Levine, S.E. Maynard, C. Qian, K.H. Lim, L.J. England, K.F. Yu, and et al. Circulating angiogenic factors and the risk of preeclampsia N. Engl. J. Med. 350 7 2004 672 683
4. R.J. Levine, C. Lam, C. Qian, K.F. Yu, S.E. Maynard, B.P. Sachs, and et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia N. Engl. J. Med. 355 10 2006 992 1005
5. C. Fenton, S.R. Hobson, E.M. Wallace, and R. Lim Future therapies for pre-eclampsia: beyond treading water Aust. N. Z. J. Obstet. Gynaecol. 2013
6. F. Petraglia Inhibin, activin and follistatin in the human placenta - a new family of regulatory proteins Placenta 18 1 1997 3 8
7. P.A. Fowler, L.W. Evans, N.P. Groome, A. Templeton, and P.G. Knight A longitudinal study of maternal serum inhibin-a, inhibin-b, activin-a, activin-ab, pro-alphac and follistatin during pregnancy Hum. Reprod. 13 12 1998 3530 3536
8. M. Schneider-Kolsky, D. D'Antona, L.W. Evans, N. Taylor, A. O'Connor, N.P. Groome, and et al. Maternal serum total activin a and follistatin in pregnancy and parturition BJOG 107 8 2000 995 1000
9. S. Muttukrishna, P.G. Knight, N.P. Groome, C.W. Redman, and W.L. Ledger Activin a and inhibin a as possible endocrine markers for pre-eclampsia Lancet 349 9061 1997 1285 1288
10. M. Schneider-Kolsky, U. Manuelpillai, C. Gargett, and E.M. Wallace Activin betaa-subunit and activin receptors in human myometrium at term and during labour BJOG 108 8 2001 869 874
11. U. Manuelpillai, M. Schneider-Kolsky, A. Dole, and E.M. Wallace Activin a and activin receptors in gestational tissue from preeclamptic pregnancies J. Endocrinol. 171 1 2001 57 64
12. S. Muttukrishna, R.A. North, J. Morris, J.C. Schellenberg, R.S. Taylor, J. Asselin, and et al. Serum inhibin a and activin a are elevated prior to the onset of pre-eclampsia Hum. Reprod. 15 7 2000 1640 1645
13. M.E. Schneider-Kolsky, U. Manuelpillai, K. Waldron, A. Dole, and E.M. Wallace The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour Placenta 23 4 2002 294 302
14. R. Lim, R. Acharya, P. Delpachitra, S. Hobson, C.G. Sobey, G.R. Drummond, and et al. Activin and nadph-oxidase in preeclampsia: Insights from in vitro and murine studies Am. J. Obstet. Gynecol. 2014
15. S. Gurusinghe, E.M. Wallace, and R. Lim The relationship between activin a and anti-angiogenic factors in the development of pre-eclampsia Pregnancy Hypertens. 4 1 2014 3 6
16. S.A. Lowe, L. Bower, K. Lust, L.P. McMahon, M.R. Morton, R.A. North, and et al. Guidelines for the management of hypertensive disorders of pregnancy 2014 Aust. N. Z. J. Obstet. Gynaecol. 49 3 2014 242 246
17. E.A. Jaffe, R.L. Nachman, C.G. Becker, and C.R. Minick Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria J. Clin. Invest. 52 11 1973 2745 2756
18. R. Lim, R. Acharya, P. Delpachitra, S. Hobson, C.G. Sobey, G.R. Drummond, and et al. Activin and nadph-oxidase in preeclampsia: Insights from in vitro and murine studies Am. J. Obstet. Gynecol. 212 1 2015 86 (e1-12)
19. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method Methods 25 4 2001 402 408
20. D. D'Antona, F.M. Reis, C. Benedetto, L.W. Evans, N.P. Groome, D.M. de Kretser, and et al. Increased maternal serum activin a but not follistatin levels in pregnant women with hypertensive disorders J. Endocrinol. 165 1 2000 157 162
21. F. Scalera, D. Schlembach, and E. Beinder Production of vasoactive substances by human umbilical vein endothelial cells after incubation with serum from preeclamptic patients Eur. J. Obstet. Gynecol. Reprod. Biol. 99 2 2001 172 178
22. E.D. Gallery, J. Rowe, S. Campbell, and T. Hawkins Effect of serum on secretion of prostacyclin and endothelin-1 by decidual endothelial cells from normal and preeclamptic pregnancies Am. J. Obstet. Gynecol. 173 3 Pt 1 1995 918 923
23. W. Heyl, S. Handt, F. Reister, J. Gehlen, C. Mittermayer, and W. Rath The role of soluble adhesion molecules in evaluating endothelial cell activation in preeclampsia Am. J. Obstet. Gynecol. 180 1 Pt 1 1999 68 72
24. J. Kahler, S. Mendel, J. Weckmuller, H.D. Orzechowski, C. Mittmann, R. Koster, and et al. Oxidative stress increases synthesis of big endothelin-1 by activation of the endothelin-1 promoter J. Mol. Cell. Cardiol. 32 8 2000 1429 1437
25. R. Lim, S. Adhikari, S. Gurusinghe, B. Leaw, R. Acharya, R. Rahman, and et al. Inhibition of activin a signalling in a mouse model of pre-eclampsia Placenta 36 8 2015 926 931