Mitochondrial defects associated with β-alanine toxicity: relevance to hyper-beta-alaninemia

Molecular and Cellular Biochemistry

Volumn 416, Issue 1-2, 2016, Pages 11-22

  Shetewy, Aza ^a   Shimada Takaura, Kayoko ^a   Warner, Danielle ^a   Jong, Chian Ju ^a   Mehdi, Abu Bakr Al ^a   Alexeyev, Mikhail ^a   Takahashi, Kyoko ^b   Schaffer, Stephen W ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Electron transport chain; Mitochondrial fragmentation; Oxidative stress; Respiration; Taurine

Indexed keywords

BETA ALANINE; CASPASE 3; CASPASE 9; GLUTAMIC ACID; MALIC ACID; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; TAURINE;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; AMINOACIDEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; CARDIAC MUSCLE CELL; CELL LEVEL; CELL STRUCTURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; HYPERBETAALANINEMIA; MITOCHONDRIAL FRAGMENTATION; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; MOLECULAR PATHOLOGY; MOUSE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; RAT; ANIMAL; BIOSYNTHESIS; GENETICS; HEART MITOCHONDRION; MAMMALIAN EMBRYO; METABOLISM; PATHOLOGY; SEIZURE; SOMNOLENCE;

ANIMALS; BETA-ALANINE; DISORDERS OF EXCESSIVE SOMNOLENCE; ELECTRON TRANSPORT COMPLEX I; EMBRYO, MAMMALIAN; FIBROBLASTS; MICE; MITOCHONDRIA, HEART; MITOCHONDRIAL DISEASES; MYOCYTES, CARDIAC; OXYGEN CONSUMPTION; RATS; SEIZURES; TAURINE;

EID: 84962237703     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-016-2688-z     Document Type: Article

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