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Volumn 36, Issue , 2016, Pages 95-99

The FcγR/IgG Interaction as Target for the Treatment of Autoimmune Diseases

Author keywords

Fc gamma receptor; Fc R; Fc RIIB; IgG; SM101; SM201; soluble Fc R

Indexed keywords

FC RECEPTOR; FC RECEPTOR IIB; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; SM 201; UNCLASSIFIED DRUG; PROTEIN BINDING;

EID: 84962177996     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-016-0272-7     Document Type: Article
Times cited : (16)

References (38)
  • 1
    • 37549036732 scopus 로고    scopus 로고
    • Fcγ receptors as regulators of immune responses
    • COI: 1:CAS:528:DC%2BD2sXhsVKrsLnK, PID: 18064051
    • Nimmerjahn F, Ravetch JV. Fcγ receptors as regulators of immune responses. Nat Rev Immunol. 2008;8:34–47.
    • (2008) Nat Rev Immunol , vol.8 , pp. 34-47
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 2
    • 84918825382 scopus 로고    scopus 로고
    • IgG subclasses and allotypes: from structure to effector functions
    • PID: 25368619
    • Vidarsson G, Dekkers G, Rispens T. IgG subclasses and allotypes: from structure to effector functions. Front Immunol. 2014. doi:10.3389/fimmu.2014.00520.
    • (2014) Front Immunol
    • Vidarsson, G.1    Dekkers, G.2    Rispens, T.3
  • 3
    • 61649087668 scopus 로고    scopus 로고
    • Glycosylation as a strategy to improve antibody-based therapeutics
    • COI: 1:CAS:528:DC%2BD1MXisVShtb0%3D, PID: 19247305
    • Jefferis R. Glycosylation as a strategy to improve antibody-based therapeutics. Nat Rev Drug Discov. 2009;8:226–34.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 226-234
    • Jefferis, R.1
  • 4
    • 24344435166 scopus 로고    scopus 로고
    • Fc receptors and their interaction with complement in autoimmunity
    • COI: 1:CAS:528:DC%2BD2MXpvFaktL8%3D, PID: 16125792
    • Schmidt RE, Gessner JE. Fc receptors and their interaction with complement in autoimmunity. Immunol Lett. 2005;100:56–67.
    • (2005) Immunol Lett , vol.100 , pp. 56-67
    • Schmidt, R.E.1    Gessner, J.E.2
  • 5
    • 0035168783 scopus 로고    scopus 로고
    • Differential modulation of stimulatory and inhibitory Fc receptors on human monocytes by Th1 and Th2 cytokines
    • COI: 1:CAS:528:DC%2BD3MXis1ensA%3D%3D, PID: 11123333
    • Pricop L, Redecha P, Teillaud J-L, Frey J, Fridman WH, Sautes-Fridman C, et al. Differential modulation of stimulatory and inhibitory Fc receptors on human monocytes by Th1 and Th2 cytokines. J Immunol. 2001;166:531–7.
    • (2001) J Immunol , vol.166 , pp. 531-537
    • Pricop, L.1    Redecha, P.2    Teillaud, J.-L.3    Frey, J.4    Fridman, W.H.5    Sautes-Fridman, C.6
  • 6
    • 0036676975 scopus 로고    scopus 로고
    • Roles of Fc receptors in autoimmunity
    • COI: 1:CAS:528:DC%2BD38XlslGru7Y%3D, PID: 12154377
    • Takai T. Roles of Fc receptors in autoimmunity. Nat Rev Immunol. 2002;2:580–92.
    • (2002) Nat Rev Immunol , vol.2 , pp. 580-592
    • Takai, T.1
  • 7
    • 0027204803 scopus 로고
    • Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications
    • PID: 8517920
    • van de Winkel JG, Capel PJ. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol Today. 1993;14:215–21.
    • (1993) Immunol Today , vol.14 , pp. 215-221
    • van de Winkel, J.G.1    Capel, P.J.2
  • 8
    • 44049110041 scopus 로고
    • Release of soluble FcgammaRII/CD32 molecules by human Langerhans cells: a subtle balance between shedding and secretion?
    • PID: 1431201
    • de la Salle C, Esposito-Farese M-E, Bieber T, Moncuit J, Morales M, Wollenberg A, et al. Release of soluble FcgammaRII/CD32 molecules by human Langerhans cells: a subtle balance between shedding and secretion? J Investig Dermatol. 1992;99:15S–7S.
    • (1992) J Investig Dermatol , vol.99 , pp. 15S-17S
    • de la Salle, C.1    Esposito-Farese, M.-E.2    Bieber, T.3    Moncuit, J.4    Morales, M.5    Wollenberg, A.6
  • 9
    • 0027844985 scopus 로고
    • A soluble form of the human Fc receptor Fc gamma RIIA: cloning, transcript analysis and detection
    • COI: 1:CAS:528:DyaK2cXhvV2hsL0%3D, PID: 8513871
    • Rappaport EF, Cassel DL, Walterhouse DO, McKenzie SE, Surrey S, Keller MA, et al. A soluble form of the human Fc receptor Fc gamma RIIA: cloning, transcript analysis and detection. Exp Hematol. 1993;21:689–96.
    • (1993) Exp Hematol , vol.21 , pp. 689-696
    • Rappaport, E.F.1    Cassel, D.L.2    Walterhouse, D.O.3    McKenzie, S.E.4    Surrey, S.5    Keller, M.A.6
  • 10
    • 0022643411 scopus 로고
    • Human monocyte cell line (U937) releases suppressive IgG-binding factor(s)
    • COI: 1:CAS:528:DyaL28Xht1Oqtbs%3D, PID: 2936610
    • Calvo CF, Watanabe S, Mètivier D, Senik A. Human monocyte cell line (U937) releases suppressive IgG-binding factor(s). Eur J Immunol. 1986;16:25–30.
    • (1986) Eur J Immunol , vol.16 , pp. 25-30
    • Calvo, C.F.1    Watanabe, S.2    Mètivier, D.3    Senik, A.4
  • 11
    • 0028265826 scopus 로고
    • Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated human granulocytes. Induction of cleavage of L-selectin via CD16
    • COI: 1:CAS:528:DyaK2cXhvV2it7s%3D, PID: 7507963
    • Bazil V, Strominger JL. Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated human granulocytes. Induction of cleavage of L-selectin via CD16. J Immunol. 1994;152:1314–22.
    • (1994) J Immunol , vol.152 , pp. 1314-1322
    • Bazil, V.1    Strominger, J.L.2
  • 12
    • 0015993418 scopus 로고
    • Immunoglobulin-binding factor present on and produced by thymus-processed lymphocytes (T cells)
    • COI: 1:CAS:528:DyaE2cXhtlWmtLY%3D, PID: 4549031
    • Fridman WH, Golstein P. Immunoglobulin-binding factor present on and produced by thymus-processed lymphocytes (T cells). Cell Immunol. 1974;11:442–55.
    • (1974) Cell Immunol , vol.11 , pp. 442-455
    • Fridman, W.H.1    Golstein, P.2
  • 13
    • 0027368961 scopus 로고
    • Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction
    • COI: 1:CAS:528:DyaK3sXmtVWnt7Y%3D, PID: 8228810
    • Ierino FL, Powell MS, McKenzie IF, Hogarth PM. Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction. J Exp Med. 1993;178:1617–28.
    • (1993) J Exp Med , vol.178 , pp. 1617-1628
    • Ierino, F.L.1    Powell, M.S.2    McKenzie, I.F.3    Hogarth, P.M.4
  • 14
    • 0024796884 scopus 로고
    • Recombinant soluble receptors for the Fcγ portion inhibit antibody productionin vitro
    • COI: 1:CAS:528:DyaK3cXps1KhsQ%3D%3D, PID: 2532600
    • Varin N, Sautès C, Galinha A, Even J, Hogarth PM, Fridman WH. Recombinant soluble receptors for the Fcγ portion inhibit antibody productionin vitro. Eur J Immunol. 1989;19:2263–8.
    • (1989) Eur J Immunol , vol.19 , pp. 2263-2268
    • Varin, N.1    Sautès, C.2    Galinha, A.3    Even, J.4    Hogarth, P.M.5    Fridman, W.H.6
  • 16
    • 0031877112 scopus 로고    scopus 로고
    • Soluble CD16 in the treatment of murine lupus nephritis
    • COI: 1:CAS:528:DyaK1cXlsVGlsb4%3D, PID: 9683555
    • Watanabe H, Sherris D, Gilkeson GS. Soluble CD16 in the treatment of murine lupus nephritis. Clin Immunol Immunopathol. 1998;88:91–5.
    • (1998) Clin Immunol Immunopathol , vol.88 , pp. 91-95
    • Watanabe, H.1    Sherris, D.2    Gilkeson, G.S.3
  • 17
    • 0028968718 scopus 로고
    • Ligands and biological activities of soluble Fcγ receptors
    • COI: 1:CAS:528:DyaK2MXkvFGqur8%3D, PID: 7797248
    • Galon J, Bouchard C, Fridman WH, Sautès C. Ligands and biological activities of soluble Fcγ receptors. Immunol Lett. 1995;44:175–81.
    • (1995) Immunol Lett , vol.44 , pp. 175-181
    • Galon, J.1    Bouchard, C.2    Fridman, W.H.3    Sautès, C.4
  • 18
    • 0032586977 scopus 로고    scopus 로고
    • Human Fc gamma receptor IIb expressed in Escherichia coli reveals IgG binding capability
    • COI: 1:CAS:528:DyaK1MXksVWgu78%3D, PID: 10430038
    • Sondermann P, Jacob U. Human Fc gamma receptor IIb expressed in Escherichia coli reveals IgG binding capability. Biol Chem. 1999;380:717–21.
    • (1999) Biol Chem , vol.380 , pp. 717-721
    • Sondermann, P.1    Jacob, U.2
  • 19
    • 0033614846 scopus 로고    scopus 로고
    • Characterization and crystallization of soluble human Fcγ receptor II (CD32) isoforms produced in insect cells
    • COI: 1:CAS:528:DyaK1MXjs1Wisb4%3D, PID: 10387093
    • Sondermann P, Jacob U, Kutscher C, Frey J. Characterization and crystallization of soluble human Fcγ receptor II (CD32) isoforms produced in insect cells. Biochemistry. 1999;38:8469–77.
    • (1999) Biochemistry , vol.38 , pp. 8469-8477
    • Sondermann, P.1    Jacob, U.2    Kutscher, C.3    Frey, J.4
  • 20
    • 0035977068 scopus 로고    scopus 로고
    • The human low affinity Fcgamma receptors IIa, IIb, and III bind IgG with fast kinetics and distinct thermodynamic properties
    • COI: 1:CAS:528:DC%2BD3MXovFegurc%3D
    • Maenaka K, van der Merwe PA, Stuart DI, Jones EY, Sondermann P. The human low affinity Fcgamma receptors IIa, IIb, and III bind IgG with fast kinetics and distinct thermodynamic properties. J Biol Chem. 2001;276:44,898–904.
    • (2001) J Biol Chem , vol.276 , pp. 44,898-44,904
    • Maenaka, K.1    van der Merwe, P.A.2    Stuart, D.I.3    Jones, E.Y.4    Sondermann, P.5
  • 21
    • 0033106166 scopus 로고    scopus 로고
    • Crystal structure of the soluble form of the human Fcgamma -receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution
    • COI: 1:CAS:528:DyaK1MXhvFOltLc%3D, PID: 10064577
    • Sondermann P, Huber R, Jacob U. Crystal structure of the soluble form of the human Fcgamma -receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution. EMBO J. 1999;18:1095–103.
    • (1999) EMBO J , vol.18 , pp. 1095-1103
    • Sondermann, P.1    Huber, R.2    Jacob, U.3
  • 22
    • 0034691322 scopus 로고    scopus 로고
    • The 3.2-Å crystal structure of the human IgG1 Fc ragment–FcγRIII complex
    • Sondermann P, Huber R, Oosthuizen V, Jacob U. The 3.2-Å crystal structure of the human IgG1 Fc ragment–FcγRIII complex. Nature. 2000;406:267–73.
    • (2000) Nature , vol.406 , pp. 267-273
    • Sondermann, P.1    Huber, R.2    Oosthuizen, V.3    Jacob, U.4
  • 23
    • 38749091375 scopus 로고    scopus 로고
    • Treatment of lupus-prone NZB/NZW F1 mice with recombinant soluble Fc receptor II (CD32)
    • COI: 1:STN:280:DC%2BD1c%2FisVyruw%3D%3D, PID: 17557887
    • Werwitzke S, Trick D, Sondermann P, Kamino K, Schlegelberger B, Kniesch K, et al. Treatment of lupus-prone NZB/NZW F1 mice with recombinant soluble Fc receptor II (CD32). Ann Rheum Dis. 2008;67:154–61.
    • (2008) Ann Rheum Dis , vol.67 , pp. 154-161
    • Werwitzke, S.1    Trick, D.2    Sondermann, P.3    Kamino, K.4    Schlegelberger, B.5    Kniesch, K.6
  • 24
    • 41549089104 scopus 로고    scopus 로고
    • Amelioration of collagen-induced arthritis by human recombinant soluble FcγRIIb
    • COI: 1:CAS:528:DC%2BD1cXks1aksrY%3D, PID: 18346938
    • Magnusson SE, Andrén M, Nilsson KE, Sondermann P, Jacob U, Kleinau S. Amelioration of collagen-induced arthritis by human recombinant soluble FcγRIIb. Clin Immunol. 2008;127:225–33.
    • (2008) Clin Immunol , vol.127 , pp. 225-233
    • Magnusson, S.E.1    Andrén, M.2    Nilsson, K.E.3    Sondermann, P.4    Jacob, U.5    Kleinau, S.6
  • 25
    • 84922621645 scopus 로고    scopus 로고
    • Recombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisita
    • COI: 1:CAS:528:DC%2BC2MXitlOqsb0%3D, PID: 25330298
    • Iwata H, Pipi E, Möckel N, Sondermann P, Vorobyev A, Beek NV, et al. Recombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisita. J Investig Dermatol. 2015;135:916–9.
    • (2015) J Investig Dermatol , vol.135 , pp. 916-919
    • Iwata, H.1    Pipi, E.2    Möckel, N.3    Sondermann, P.4    Vorobyev, A.5    Beek, N.V.6
  • 26
    • 77951610700 scopus 로고    scopus 로고
    • FcγRIIB in autoimmunity and infection: evolutionary and therapeutic implications
    • COI: 1:CAS:528:DC%2BC3cXltV2ktb8%3D, PID: 20414206
    • Smith KGC, Clatworthy MR. FcγRIIB in autoimmunity and infection: evolutionary and therapeutic implications. Nat Rev Immunol. 2010;10:328–43.
    • (2010) Nat Rev Immunol , vol.10 , pp. 328-343
    • Smith, K.G.C.1    Clatworthy, M.R.2
  • 27
    • 84962238032 scopus 로고    scopus 로고
    • Soluble Fc-gamma IIb receptor SM101 as potential therapy in autoimmune diseases – results from a Phase 0/Ia clinical trial in healthy volunteers
    • Tillmanns S, Sondermann P, Schrödter A, Schubert C, Nilius S, Buckel P. Soluble Fc-gamma IIb receptor SM101 as potential therapy in autoimmune diseases – results from a Phase 0/Ia clinical trial in healthy volunteers. Ann Rheum Dis. 2011;70:618.
    • (2011) Ann Rheum Dis , vol.70 , pp. 618
    • Tillmanns, S.1    Sondermann, P.2    Schrödter, A.3    Schubert, C.4    Nilius, S.5    Buckel, P.6
  • 28
    • 84962314272 scopus 로고    scopus 로고
    • Interim results from a phase Ib/IIa clinical trial with the soluble Fc-gamma IIb receptor SM101 for the treatment of primary immune thrombocytopenia
    • Konstaninova TS, Leonidovna IV, Hellmann A, Kyrcz-Krzemien S, Tillmanns S, Sondermann P, et al. Interim results from a phase Ib/IIa clinical trial with the soluble Fc-gamma IIb receptor SM101 for the treatment of primary immune thrombocytopenia. Blood. 2012;120:3388.
    • (2012) Blood , vol.120 , pp. 3388
    • Konstaninova, T.S.1    Leonidovna, I.V.2    Hellmann, A.3    Kyrcz-Krzemien, S.4    Tillmanns, S.5    Sondermann, P.6
  • 29
    • 84929618948 scopus 로고    scopus 로고
    • SM101, a novel recombinant, soluble, human Fc gamma IIb receptor, in the treatment of systemic lupus erythematosus: results of a double-blind, placebo-controlled multicenter study
    • Tillmanns S, Kolligs C, DP D’C, Doria A, Hachulla E, Voll RE, et al. SM101, a novel recombinant, soluble, human Fc gamma IIb receptor, in the treatment of systemic lupus erythematosus: results of a double-blind, placebo-controlled multicenter study. Arthritis Rheum. 2014;66:S1238.
    • (2014) Arthritis Rheum , vol.66 , pp. S1238
    • Tillmanns, S.1    Kolligs, C.2    DP, D.C.3    Doria, A.4    Hachulla, E.5    Voll, R.E.6
  • 30
    • 0034655265 scopus 로고    scopus 로고
    • Mapping of the C1q binding site on Rituxan, a chimeric antibody with a human IgG1 Fc
    • COI: 1:CAS:528:DC%2BD3cXis1WksrY%3D, PID: 10754313
    • Idusogie EE, Presta LG, Gazzano-Santoro H, Totpal K, Wong PY, Ultsch M, et al. Mapping of the C1q binding site on Rituxan, a chimeric antibody with a human IgG1 Fc. J Immunol. 2000;164:4178–84.
    • (2000) J Immunol , vol.164 , pp. 4178-4184
    • Idusogie, E.E.1    Presta, L.G.2    Gazzano-Santoro, H.3    Totpal, K.4    Wong, P.Y.5    Ultsch, M.6
  • 31
    • 34548229364 scopus 로고    scopus 로고
    • FcRn: the neonatal Fc receptor comes of age
    • COI: 1:CAS:528:DC%2BD2sXpsV2qtbw%3D, PID: 17703228
    • Roopenian DC, Akilesh S. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol. 2007;7:715–25.
    • (2007) Nat Rev Immunol , vol.7 , pp. 715-725
    • Roopenian, D.C.1    Akilesh, S.2
  • 32
    • 84881058016 scopus 로고    scopus 로고
    • Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules
    • Weflen AW, Baier N, Tang Q-J, Van den Hof M, Blumberg RS, Lencer WI, et al. Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules. Mol Biol Cell. 2013;24:2398–405.
    • (2013) Mol Biol Cell , vol.24 , pp. 2398-2405
    • Weflen, A.W.1    Baier, N.2    Tang, Q.-J.3    Van den Hof, M.4    Blumberg, R.S.5    Lencer, W.I.6
  • 33
    • 0036672044 scopus 로고    scopus 로고
    • X-ray crystallographic studies of IgG-FcγR interactions
    • COI: 1:CAS:528:DC%2BD38XntVensb0%3D, PID: 12196119
    • Sondermann P, Oosthuizen V. X-ray crystallographic studies of IgG-FcγR interactions. Biochem Soc Trans. 2002;30:481–6.
    • (2002) Biochem Soc Trans , vol.30 , pp. 481-486
    • Sondermann, P.1    Oosthuizen, V.2
  • 34
    • 84962317823 scopus 로고    scopus 로고
    • Development of human B-lymphocyte targeted bi-specific DART® molecules for the treatment of autoimmune disorders (THER5P. 830)
    • Chen W, Nordstrom J, Burke S, Shah K, Ciccarone V, Li H, et al. Development of human B-lymphocyte targeted bi-specific DART® molecules for the treatment of autoimmune disorders (THER5P. 830). J Immunol. 2014;192(1 Supplement):200–9.
    • (2014) J Immunol , vol.192 , pp. 200-209
    • Chen, W.1    Nordstrom, J.2    Burke, S.3    Shah, K.4    Ciccarone, V.5    Li, H.6
  • 35
    • 84899761799 scopus 로고    scopus 로고
    • Suppression of rheumatoid arthritis B cells by XmAb5871, an anti-CD19 antibody that coengages B cell antigen receptor complex and Fcγ receptor IIb inhibitory receptor
    • COI: 1:CAS:528:DC%2BC2cXhtlyktLbF
    • Chu SY, Yeter K, Kotha R, Pong E, Miranda Y, Phung S, et al. Suppression of rheumatoid arthritis B cells by XmAb5871, an anti-CD19 antibody that coengages B cell antigen receptor complex and Fcγ receptor IIb inhibitory receptor. Arthritis Rheum. 2014;66:1153–64.
    • (2014) Arthritis Rheum , vol.66 , pp. 1153-1164
    • Chu, S.Y.1    Yeter, K.2    Kotha, R.3    Pong, E.4    Miranda, Y.5    Phung, S.6
  • 36
    • 84902381561 scopus 로고    scopus 로고
    • Characterization of SM201, an anti-hFcγRIIB antibody not interfering with ligand binding that mediates immune complex dependent inhibition of B cells
    • COI: 1:CAS:528:DC%2BC2cXitlertrc%3D, PID: 24472604
    • Rieth N, Carle A, Müller M, Meer DT, Direnberger C, Pohl T, et al. Characterization of SM201, an anti-hFcγRIIB antibody not interfering with ligand binding that mediates immune complex dependent inhibition of B cells. Immunol Lett. 2014;160:145–50.
    • (2014) Immunol Lett , vol.160 , pp. 145-150
    • Rieth, N.1    Carle, A.2    Müller, M.3    Meer, D.T.4    Direnberger, C.5    Pohl, T.6
  • 37
    • 0033151596 scopus 로고    scopus 로고
    • SHIP recruitment attenuates FcγRIIB-induced B cell apoptosis
    • COI: 1:CAS:528:DyaK1MXksVSmsbg%3D, PID: 10403650
    • Pearse RN, Kawabe T, Bolland S, Guinamard R, Kurosaki T, Ravetch JV. SHIP recruitment attenuates FcγRIIB-induced B cell apoptosis. Immunity. 1999;10:753–60.
    • (1999) Immunity , vol.10 , pp. 753-760
    • Pearse, R.N.1    Kawabe, T.2    Bolland, S.3    Guinamard, R.4    Kurosaki, T.5    Ravetch, J.V.6
  • 38
    • 33947575824 scopus 로고    scopus 로고
    • FcγRIIb controls bone marrow plasma cell persistence and apoptosis
    • COI: 1:CAS:528:DC%2BD2sXjt1SqsL8%3D, PID: 17322888
    • Xiang Z, Cutler AJ, Brownlie RJ, Fairfax K, Lawlor KE, Severinson E, et al. FcγRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immunol. 2007;8:419–29.
    • (2007) Nat Immunol , vol.8 , pp. 419-429
    • Xiang, Z.1    Cutler, A.J.2    Brownlie, R.J.3    Fairfax, K.4    Lawlor, K.E.5    Severinson, E.6


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