Characterization of SM201, an anti-hFcγRIIB antibody not interfering with ligand binding that mediates immune complex dependent inhibition of B cells

Immunology Letters

Volumn 160, Issue 2, 2014, Pages 145-150

  Rieth, N ^a   Carle, A ^a   Muller M A ^a   ter Meer, D ^a   Direnberger, C ^a   Pohl, T ^a   Sondermann, P ^a  

^a SuppreMol GmbH   (Germany)

Author keywords

Autoimmune disease; B cell signaling; Fc RIIB; Immune complex

Indexed keywords

B LYMPHOCYTE RECEPTOR; EPITOPE; FC RECEPTOR IIA; FC RECEPTOR IIB; FC RECEPTOR IIB ANTIBODY; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; RECEPTOR ANTIBODY; RITUXIMAB; SM 201; UNCLASSIFIED DRUG; ANTIGEN ANTIBODY COMPLEX; FC RECEPTOR; HYBRID PROTEIN; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN BINDING;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGEN RECOGNITION; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BINDING SITE; CONTROLLED STUDY; CROSS REACTION; HUMAN; HUMAN CELL; LIGAND BINDING; LYMPHOCYTE ACTIVATION; LYMPHOID CELL LINE; NATURAL KILLER CELL; PHOSPHORYLATION; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; CHEMISTRY; CHO CELL LINE; CRICETULUS; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HYBRIDOMA; IMMUNOLOGY; PHARMACOLOGY; PRIMARY CELL CULTURE; RAT; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY COMPLEX; B-LYMPHOCYTES; CELL LINE, TUMOR; CHO CELLS; CRICETULUS; GENE EXPRESSION REGULATION; HUMANS; HYBRIDOMAS; IMMUNOGLOBULIN G; LIGANDS; PRIMARY CELL CULTURE; PROTEIN BINDING; RATS; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, IGG; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 84902381561     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2014.01.012     Document Type: Article

References (26)

1. Cassel D.L., Keller M.A., Surrey S., Schwartz E., Schreiber A.D., Rappaport E.F., et al. Differential expression of Fc gamma RIIA, Fc gamma RIIB and Fc gamma RIIC in hematopoietic cells: analysis of transcripts. Mol Immunol 1993, 30:451-460.
2. Dhodapkar K.M., Kaufman J.L., Ehlers M., Banerjee D.K., Bonvini E., Koenig S., et al. Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells. PNAS 2005, 102:2910-2915.
3. Smith K.G., Clatworthy M.R. FcγRIIB in autoimmunity and infection: evolutionary and therapeutic implications. Nat Rev Immunol 2010, 10:328-343.
4. Horton H.M., Chu S.Y., Ortiz E.C., Pong E., Cemerski S., Leung I.W., et al. Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus. J Immunol 2011, 186(7):4223-4233.
5. Nimmerjahn F., Ravetch J.V. Fcγ receptors as regulators of immune responses. Nat Rev Immunol 2008, 8:34-47.
6. Takai T. Roles of Fc receptors in autoimmunity. Nat Rev Immunol 2002, 2:580-592.
7. Pearse R.N., Kawabe T., Bolland S., Guinamard R., Kurosaki T., Ravetch J.V. SHIP recruitment attenuates FcγRIIB-induced B cell apoptosis. Immunity 1999, 10:753-760.
8. Brooks D.G., Qiu W.Q., Luster A.D., Ravetch J.V. Structure and expression of human IgG FcRII (CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J Exp Med 1989, 170:1369-1385.
9. Veri M.C., Gorlatov S., Li H., Burke S., Johnson S., Stavenhagen J., et al. Monoclonal antibodies capable of discriminating the human inhibitory Fcγ-receptor IIB (CD32B) from the activating Fcγ-receptor IIA (CD32A): biochemical, biological and functional characterization. Immunology 2007, 121:392-404.
10. Lund J., Takahashi N., Nakagawa H., Goodall M., Bentley T., Hindley S.A., et al. Control of IgG/Fc glycosylation: a comparison of oligosaccharides from chimeric human/mouse and mouse subclass immunoglobulin Gs. Mol Immunol 1993, 30:741-748.
11. Billadeau D.D., Leibson P.J. ITAMs versus ITIMs: striking a balance during cell regulation. J Clin Invest 2002, 109:161-168.
12. Fournier E.M., Sibéril S., Costes A., Varin A., Fridman W.H., Teillaud J.L., et al. Activation of human peripheral IgM+ B cells is transiently inhibited by BCR-independent aggregation of FcγRIIB. J Immunol 2008, 181:5350-5359.
13. Maloney D.G., Smith B., Rose A. Rituximab: mechanism of action and resistance. Semin Oncol 2002, 29:2-9.
14. Ashman R.F., Peckham D., Stunz L.L. Fc receptor off-signal in the B cell involves apoptosis. J Immunol 1996, 157:5-11.
15. Coggeshall K.M. Inhibitory signaling by B cell FcγRIIb. Curr Opin Immunol 1998, 10:306-312.
16. Veri M.C., Burke S., Huang L., Li H., Gorlatov S., Tuaillon N., et al. Therapeutic control of B cell activation via recruitment of Fcγreceptor IIb (CD32b) inhibitory function with a novel bispecific antibody scaffold. Arthritis Rheum 2010, 62:1933-1943.
17. Mackay M., Stanevsky A., Wang T., Aranow C., Li M., Koenig S., et al. Selective dysregulation of the FcγIIB receptor on memory B cells in SLE. J Exp Med 2006, 203:2157-2164.
18. Bolland S., Ravetch J.V. Spontaneous autoimmune disease in FcγRIIB-deficient mice results from strain-specific epistasis. Immunity 2000, 13:277-285.
19. Liu X.G., Ma S.H., Sun J.Z., Ren J., Shi Y., Sun L., et al. High-dose dexamethasone shifts the balance of stimulatory and inhibitory Fcγ receptors on monocytes in patients with primary immune thrombocytopenia. Blood 2011, 117:2061-2069.
20. Wijngaarden S., van de Winkel J.G., Jacobs K.M., Bijlsma J.W., Lafeber F.P., van Roon J.A. A shift in the balance of inhibitory and activating Fcγ receptors on monocytes toward the inhibitory Fcγ receptor IIb is associated with prevention of monocyte activation in rheumatoid arthritis. Arthritis Rheum 2004, 50:3878-3887.
21. Chan A.C., Carter P.J. Therapeutic antibodies for autoimmunity and inflammation. Nat Rev Immunol 2009, 10:301-316.
22. Magnusson S., Engström M., Jacob U., Ulfgren A.K., Kleinau S. High synovial expression of the inhibitory FcγRIIb in rheumatoid arthritis. Arthritis Res Ther 2007, 9:R51.
23. Ono M., Bolland S., Tempst P., Ravetch J.V. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB. Nature 1996, 383:263-266.
24. Tzeng S.J., Bolland S., Inabe K., Kurosaki T., Pierce S.K. The B cell inhibitory Fc receptor triggers apoptosis by a novel c-Abl family kinase-dependent pathway. J Biol Chem 2005, 280:35247-35254.
25. Xiang Z., Cutler A.J., Brownlie R.J., Fairfax K., Lawlor K.E., Severinson E., et al. FcγRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immunol 2007, 8:419-429.
26. Borrego F., Robertson M.J., Ritz J., Peña J., Solana R. CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor. Immunology 1999, 97:159-165.