Genetic variation in SLC17A7 promoter associated with response to sport-related concussions

Brain Injury

Volumn 30, Issue 7, 2016, Pages 908-913

  Madura, Stephanie A ^a   McDevitt, Jane K ^a   Tierney, Ryan T ^a   Mansell, Jamie L ^a   Hayes, David J ^a   Gaughan, John P ^b   Krynetskiy, Evgeny ^c  

^a TEMPLE UNIVERSITY   (United States)

^b Biostatistics Consulting Center   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF PHARMACY   (United States)

Author keywords

athletes; head impact; mild traumatic brain injury; Polymorphism; prolonged recovery; rs74174284; vesicular transporters; VGLUT1

Indexed keywords

GENOMIC DNA; VESICULAR GLUTAMATE TRANSPORTER 1; SLC17A7 PROTEIN, HUMAN;

ADOLESCENT; ARTICLE; BRAIN CONCUSSION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DNA EXTRACTION; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC VARIATION; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MALE; PHYSICIAN; PROMOTER REGION; SALIVA ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SLC17A7 GENE; SPORT INJURY; ADULT; ALLELE; ATHLETE; CONVALESCENCE; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; INJURY SCALE; NEUROPSYCHOLOGICAL TEST; TIME FACTOR; YOUNG ADULT;

ADOLESCENT; ADULT; ALLELES; ATHLETES; ATHLETIC INJURIES; BRAIN CONCUSSION; FEMALE; GENE-ENVIRONMENT INTERACTION; GENOTYPE; HUMANS; INJURY SEVERITY SCORE; MALE; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RECOVERY OF FUNCTION; TIME FACTORS; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1; YOUNG ADULT;

EID: 84962110262     PISSN: 02699052     EISSN: 1362301X     Source Type: Journal    
DOI: 10.3109/02699052.2016.1146958     Document Type: Article

References (32)

1. C.Giza, D.Hovda The neurometabolic cascade of concussion. Journal of Athletic Training 2001;36:228–235.
2. J.Upshaw, J.Gosserand, N.Williams, J.Edwards Sports-related concussions. Pediatric Emergency Care 2012;28:926–932.
3. th International Conference on Concussion in Sport held in Zurich, November 2012. British Journal of Sports Medicine 2013;47:250–258.
4. W.Meehan, d’Hemecourt P, Comstock R. High school concussions in the 2008-2009 academic year: mechanisms, symptoms, and management. American Journal of Sports Medicine 2010; 38:2405–2409.
5. M.Makdissi, D.Darby, P.Maruff Natural history of concussion in sports: markers of severity and implications for management. American Journal of Sports Medicine 2010;28:464–471.
6. J.Finnoff, E.Jelsing, S.J.BiomarkersSmith J., genetics, and risk factors for concussions. Physical Medicine & Rehabilitation 2011;3:S452–S459.
7. S.Slobounov, E.Slobounov, W.Sebastianelli, C.Cao, K.Newell Differential rate of recovery in athletes after first and second concussion episodes. Neurosurgery 2007;61:338–344.
8. K.Schaal, M.Tafflet, H.Nassif, V.Thibault, C.Pichard, M.Alcotte, T.Guillet, N.El Helou, G.Berhelot, S.Simon, et al. Psychological balance in high level athletes: gender-based differences and sport-specific patterns. Plos One 2011;6:1–9.
9. T.Terrell, R.Bostick, R.Abramson, D.Xie, W.Barfield, R.Cantu, M.Stanek, E.T.APOEEwing T., APOE promoter, and tau genotypes and risk for concussion in college athletes. Clinical Journal of Sports Medicine 2008;18:10–17.
10. R.Tierney, J.Mansell, M.Higgins, J.McDevitt, N.Toone, J.Gaughan, A.Mishra, E.Krynestskiy Apolipoprotein E genotype and concussion in college athletes. Clinical Journal of Sports Medicine 2010;20:464–468.
11. K.G.Harmon, J.A.Drezner, M.Gammons, K.M.Guskiewicz, M.Halstead, S.A.Herring, J.S.Kutcher, A.Pana, M.Putukian, W.O.Roberts American Medical Society for Sports Medicine position statement: concussion in sports. British Journal of Sports Medicine 2013;47:15–26.
12. S.Broglio, S.Macciocchi, M.Ferrara Sensitivity of the concussion assessment battery. Neurosurgery 2007;60:1050–1058.
13. M.Marar, N.M.Mcllvain, S.K.Fields, R.D.Comstock Epidemiology of concussions among United States high school athletes in 20 sports. American Journal of Sports Medicine 2012;40:747–755.
14. M.McCrea, W.B.Barr, K.Guskiewicz, C.Randolph, S.W.Marshall, R.Cantu, J.A.Onate, J.P.Kelly Standard regression-based methods for measuring recovery after sports-related concussion. Journal of the International Neuropsychological Society 2005;11:58–69.
15. B.C.Lau, A.P.Kontos, M.W.Collins, A.Mucha, M.R.Lovell Which on-field signs/symptoms predict protracted recovery from sport related concussion among high school football players. American Journal of Sports Medicine 2011;39:2311–2318.
16. M.Makdissi, R.Cantu, K.Johnston, P.McCrory, W.Meeuwisse The difficult concussion patient: what is the best approach to investigation and management of persistent (> 10 days) postconcussive symptoms. British Journal of Sports Medicine 2013;47:308–313.
17. J.McDevitt, R.T.Tierney, J.Mansell, N.Toone, M.Higgins, A.Mishra, E.Krynetskiy Neuronal structure polymorphisms and concussion in collegiate athletes. Brain Injury 2011;25:1108–1113.
18. th ed. San Francisco (CA): Pearson Education Inc; 2007. p A34–A38.
19. G.Barkhoudarian, D.A.Hovda, C.C.Giza The molecular pathophysiology of concussive brain injury. Clinical Sports Medicine 2011;30:33–48.
20. M.Beneyto, L.Kristiansen, R.McCullumsmith, J.Meador-Woodruff Glutamatergic mechanisms in Schizophrenia: current concepts. Current Psychosis & Therapeutics Reports 2006;4:27–33.
21. M.Liguz-Lecznar, J.Skangiel-Kramska Vesicular glutamate transporters VGLUT1 and VGLUT2 in the developing mouse barrel cortex. International Journal of Developmental Neuroscience 2007;25:107–114.
22. S.Wojcik, J.Rhee, E.Herzog, A.Sigler, R.Jahn, S.Takamori, N.Brose, C.Rosenmund An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size. Proceedings of the National Academy of Science USA 2004;101:7158–7163.
23. R.Fremeau, K.Kam, T.Qureshi, J.Johnson, D.R.Copenhagen, J.Storm-Mathisen, F.A.Chaudhry, R.A.Nicoll, R.H.Ewards Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science 2004;304:1815–1819.
24. R.Fremeau, M.Troyer, I.Pahner, G.Nygaard, C.Tran, R.Reimer, R.H.Edwards The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron 2001;31:247–260.
25. P.Schatz, J.Pardini, M.Lovell, M.Collins, K.Podell Sensitivity and specificity of the ImPACT test battery for concussions in athletes. Archives of Clinical Neuropsychology 2006;21:91–99.
26. H.McCrea, K.Perrine, S.Noigi, R.Härtl Concussion in sports. Sports Health 2013;5:160–164.
27. S.MRSchulz, M.SWMarshall, M.FOMueller, J.Yang, W.NLWeaver, K.WDKalsbeek, B.JMBowling. Incidence and risk factors for concussion in high school athletes, North Carolina, 1996-1999. American Journal of Epidemiology 2004;160:937–944.
28. P.Schatz, R.Moser, T.Covassin, R.Karpf Early indicators of enduring symptoms in high school athletes with multiple previous concussions. Neurosurgery 2011;68:1562–1567.
29. S.Signoretti, G.Lazzarino, B.Tavazzi, R.Vagnozzi The pathophysiology of concussion. PM R 2011;3(10 Suppl 2):s359–s368.
30. L.Gessel, S.Fields, C.Collins, R.Dicks, R.Comstock Concussions among United States high school and collegiate athletes. Journal of Athletic Training 2007;42:495–503.
31. K.Guskiewicz, N.Weaver, D.Padua, W.Garrett Epidemiology of concussion in collegiate and high school football players. America Journal of Sports Medicine 2000;28:643–650.
32. S.Broglio, B.Schnebel, J.Sosnoff, S.Shin, X.Feng, X.He, J.Zimmerman The biomechanical properties of concussions in high school football. Medicine & Science in Sports & Exercise 2010;42:2064–2071.