WomenWith Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inf lammation, Glucose, and Free Fatty Acids: A Pilot Study

Diabetes Care

Volumn 39, Issue 1, 2016, Pages 39-42

  Hernandez, Teri L ^a,b   Pelt, Rachael Van E ^a   Anderson, Molly A ^a   Reece, Melanie S ^a   Reynolds, Regina M ^c   De La Houssaye, Becky A ^c   Heerwagen, Margaret ^c   Donahoo, William T ^a,d   Daniels, Linda J ^d   Chartier Logan, Catherine ^a   Janssen, Rachel C ^c   Friedman, Jacob E ^c   Barbour, Linda A ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c University of Colorado Denver and Children s Hospital Colorado   (United States)

^d KAISER PERMANENTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; FATTY ACID; GLUCOSE; GLYCOPROTEIN RECEPTOR 43; INSULIN; INTERLEUKIN 1BETA; RECEPTOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL;

ADULT; ARTICLE; CARBOHYDRATE DIET; CHILDHOOD OBESITY; CLINICAL ARTICLE; CONTROLLED STUDY; DIET THERAPY; DISEASE ASSOCIATION; FATTY ACID BLOOD LEVEL; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; INFANT; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPOLYSIS; LOW FAT DIET; MALE; PILOT STUDY; PREGNANCY DIABETES MELLITUS; ADIPOSE TISSUE; BLOOD; DIABETIC DIET; DIET RESTRICTION; GLYCEMIC INDEX; INFLAMMATION; METABOLISM; OBESITY; PREGNANCY; RANDOMIZED CONTROLLED TRIAL; YOUNG ADULT;

ADIPOSE TISSUE; ADULT; BLOOD GLUCOSE; DIABETES, GESTATIONAL; DIET, DIABETIC; DIET, FAT-RESTRICTED; FASTING; FATTY ACIDS, NONESTERIFIED; FEMALE; GLYCEMIC INDEX; HUMANS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; OBESITY; OVERWEIGHT; PILOT PROJECTS; PREGNANCY; YOUNG ADULT;

EID: 84962109158     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc15-0515     Document Type: Article

References (15)

1. American College of Obstetricians and Gynecologists. Gestational Diabetes Mellitus.Washington, DC, American College of Obstetricians and Gynecologists, 2013 (ACOG practice bulletin no. 137)
2. Blumer I, Hadar E, Hadden DR, et al. Diabetes and pregnancy: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2013;98:4227-4249
3. Hernandez TL, Anderson MA, Chartier-Logan C, Friedman JE, Barbour LA. Strategies in the nutritional management of gestational diabetes. Clin Obstet Gynecol 2013;56:803-815
4. McCurdy CE, Bishop JM, Williams SM, et al. Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest 2009;119:323-335
5. Harmon KA, Gerard L, Jensen DR, et al. Continuous glucose profiles in obese and normalweight pregnant women on a controlled diet: Metabolic determinants of fetal growth. Diabetes Care 2011;34:2198-2204
6. Schaefer-Graf UM, Graf K, Kulbacka I, et al. Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus. Diabetes Care 2008;31:1858-1863
7. Hernandez TL, Van Pelt RE, AndersonMA, et al. A higher-complex carbohydrate diet in gestational diabetes mellitus achieves glucose targets and lowers postprandial lipids: A randomized crossover study. Diabetes Care 2014;37:1254-1262
8. Hernandez TL, Kittelson JM, Law CK, et al. Fat redistribution following suction lipectomy: Defense of body fat and patterns of restoration. Obesity (Silver Spring) 2011;19:1388-1395
9. Coleman WP 3rd, Katz B, Bruck M, et al. The efficacy of powered liposuction. Dermatol Surg 2001;27:735-738
10. Engfeldt P, Hellmér J, Wahrenberg H, Arner P. Effects of insulin on adrenoceptor binding and the rate of catecholamine-induced lipolysis in isolated human fat cells. J Biol Chem 1988;263: 15553-15560
11. McCurdy CE, Schenk S, Holliday MJ, et al. Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice. Diabetes 2012;61:2495-2505
12. Metzger BE, Lowe LP, Dyer AR, et al.; HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008;358:1991-2002
13. Catalano PM, Huston L, Amini SB, Kalhan SC. Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational diabetes mellitus. Am J Obstet Gynecol 1999;180:903-916
14. Barbour LA, McCurdy CE, Hernandez TL, Friedman JE. Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDMwomen with impaired glucose tolerance postpartum. J Clin EndocrinolMetab 2011;96:1431-1441
15. Kimura I, Inoue D, Hirano K, Tsujimoto G. The SCFA receptor GPR43 and energy metabolism. Front Endocrinol (Lausanne) 2014;5:85