메뉴 건너뛰기




Volumn 114, Issue , 2016, Pages 68-77

Moderate alcohol consumption in chronic form enhances the synthesis of cholesterol and C-21 steroid hormones, while treatment with Tinospora cordifolia modulate these events in men

Author keywords

Alcoholism; Androstenedione; Biosteroids; Metabolomics; Testosterone; Tinospora cordifolia

Indexed keywords

ALCOHOL; ANDROSTENEDIONE; CHOLESTEROL; CORTICOSTERONE; ESTRADIOL; GAMMA GLUTAMYLTRANSFERASE; GLUCURONIDE; HYDROCORTISONE; LOW DENSITY LIPOPROTEIN; STEROID; TESTOSTERONE; TINOSPORA CORDIFOLIA EXTRACT; TRIACYLGLYCEROL; PLANT EXTRACT;

EID: 84962077733     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2016.03.016     Document Type: Article
Times cited : (27)

References (47)
  • 1
    • 0036743044 scopus 로고    scopus 로고
    • Cardioprotective effects of light–moderate consumption of alcohol: a review of putative mechanisms
    • [1] Agarwal, D.P., Cardioprotective effects of light–moderate consumption of alcohol: a review of putative mechanisms. Alcohol Alcohol. 37 (2002), 409–415.
    • (2002) Alcohol Alcohol. , vol.37 , pp. 409-415
    • Agarwal, D.P.1
  • 2
    • 80051923956 scopus 로고    scopus 로고
    • 11β-Hydroxylation of cortexolone (Reichstein's compound S) to hydrocortisone using immobilized Cunninghamella elegans spores
    • [2] Allam, R.F., Shafei, M.S., Refai, A.E., Ali, M.I., Mohamed, S.S., 11β-Hydroxylation of cortexolone (Reichstein's compound S) to hydrocortisone using immobilized Cunninghamella elegans spores. Malays. J. Microbiol. 7:1 (2011), 7–13.
    • (2011) Malays. J. Microbiol. , vol.7 , Issue.1 , pp. 7-13
    • Allam, R.F.1    Shafei, M.S.2    Refai, A.E.3    Ali, M.I.4    Mohamed, S.S.5
  • 3
    • 0030912640 scopus 로고    scopus 로고
    • Alcohol increases plasma levels of cholesterol diet-induced atherogenic lipoproteins and aortic atherosclerosis in rabbits
    • [3] Aviv, S., Pape, M., Rea, T., Rai, A., Srivastava, K., Latour, Mickey A., Hopkins, D., Schonfeld, G., Alcohol increases plasma levels of cholesterol diet-induced atherogenic lipoproteins and aortic atherosclerosis in rabbits. Arterioscler. Thromb. Vasc. Biol. 17 (1997), 1091–1097.
    • (1997) Arterioscler. Thromb. Vasc. Biol. , vol.17 , pp. 1091-1097
    • Aviv, S.1    Pape, M.2    Rea, T.3    Rai, A.4    Srivastava, K.5    Latour, M.A.6    Hopkins, D.7    Schonfeld, G.8
  • 5
    • 0036693231 scopus 로고    scopus 로고
    • Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats
    • [5] Bishayi, B., Roychowdhury, S., Ghosh, S., Sengupta, M., Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats. J. Toxicol. Sci. 27 (2002), 139–146.
    • (2002) J. Toxicol. Sci. , vol.27 , pp. 139-146
    • Bishayi, B.1    Roychowdhury, S.2    Ghosh, S.3    Sengupta, M.4
  • 6
    • 0021215560 scopus 로고
    • Effects of alcohol on plasma lipoproteins and cholesterol and triglyceride metabolism in man
    • [6] Crouse, John R., Grundy, S.M., Effects of alcohol on plasma lipoproteins and cholesterol and triglyceride metabolism in man. J. Lipid Res. 25 (1984), 486–496.
    • (1984) J. Lipid Res. , vol.25 , pp. 486-496
    • Crouse, J.R.1    Grundy, S.M.2
  • 7
    • 80054896281 scopus 로고    scopus 로고
    • Acute stress differentially affects aromatase activity in specific brain nuclei of adult male and female quail
    • [7] Dickens, M.J., Cornil, C.A., Balthazart, J., Acute stress differentially affects aromatase activity in specific brain nuclei of adult male and female quail. Endocrinol. 152 (2011), 4242–4251.
    • (2011) Endocrinol. , vol.152 , pp. 4242-4251
    • Dickens, M.J.1    Cornil, C.A.2    Balthazart, J.3
  • 9
    • 80955177064 scopus 로고    scopus 로고
    • Associations of corticosterone and testosterone with alcohol drinking in F2 populations derived from AA and ANA rat lines
    • [9] Etelalahti, Tiina J., Saarikoski, Sirkku T., Eriksson, C.J., Associations of corticosterone and testosterone with alcohol drinking in F2 populations derived from AA and ANA rat lines. Alcohol 45 (2011), 421–426.
    • (2011) Alcohol , vol.45 , pp. 421-426
    • Etelalahti, T.J.1    Saarikoski, S.T.2    Eriksson, C.J.3
  • 10
    • 0028873659 scopus 로고
    • Consequence of long-term exposure to corticosterone or dexamethasone on ethanol consumption in the adrenalectomized rat, and the effect of type I and type II corticosteroid receptor antagonists
    • [10] Fahlke, C., Hård, E., Hansen, S., Eriksson, C.J.P., Engel, J.A., Consequence of long-term exposure to corticosterone or dexamethasone on ethanol consumption in the adrenalectomized rat, and the effect of type I and type II corticosteroid receptor antagonists. Psychopharmacology 117 (1995), 216–224.
    • (1995) Psychopharmacology , vol.117 , pp. 216-224
    • Fahlke, C.1    Hård, E.2    Hansen, S.3    Eriksson, C.J.P.4    Engel, J.A.5
  • 11
    • 85045545180 scopus 로고    scopus 로고
    • Alcohol dependence and sexual dysfunction: a clinical review
    • [11] Fernandes, A., De Sousa, A., Alcohol dependence and sexual dysfunction: a clinical review. Med. Sci., 2014, 3.
    • (2014) Med. Sci. , pp. 3
    • Fernandes, A.1    De Sousa, A.2
  • 12
    • 0037326906 scopus 로고    scopus 로고
    • Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemia
    • [12] Frances, D., Bulpitt, Christopher J., Agarwal, S., Donaldson, M., Rajkumar, C., Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemia. Clin. Sci., 104(2), 2003, 195.
    • (2003) Clin. Sci. , vol.104 , Issue.2 , pp. 195
    • Frances, D.1    Bulpitt, C.J.2    Agarwal, S.3    Donaldson, M.4    Rajkumar, C.5
  • 13
    • 0036131166 scopus 로고    scopus 로고
    • Effects of acute alcohol intoxication on pituitary–gonadal axis hormones, pituitary–adrenal axis hormones, β-endorphin and prolactin in human adults of both sexes
    • [13] Frias, J., Torres, J.M., Miranda, M.T., Ruiz, E., Ortega, E., Effects of acute alcohol intoxication on pituitary–gonadal axis hormones, pituitary–adrenal axis hormones, β-endorphin and prolactin in human adults of both sexes. Alcohol Alcohol. 37 (2002), 169–173.
    • (2002) Alcohol Alcohol. , vol.37 , pp. 169-173
    • Frias, J.1    Torres, J.M.2    Miranda, M.T.3    Ruiz, E.4    Ortega, E.5
  • 14
    • 84864192409 scopus 로고    scopus 로고
    • TLC based analysis of allelopathic effects on tinosporoside contents in Tinospora cordifolia
    • [14] Gahlaut, A., Gothwal, A., Dabur, R., TLC based analysis of allelopathic effects on tinosporoside contents in Tinospora cordifolia. J. Chem. Pharm. Res., 2012, 4.
    • (2012) J. Chem. Pharm. Res. , pp. 4
    • Gahlaut, A.1    Gothwal, A.2    Dabur, R.3
  • 15
    • 0018169134 scopus 로고
    • The effects of alcoholic liver disease and alcohol ingestion on sex hormone levels
    • [15] Gordon, Gary G., Louis Southren, A., Charles, S. Lieber, The effects of alcoholic liver disease and alcohol ingestion on sex hormone levels. Alcohol. Clin. Exp. Res. 2 (1978), 259–263.
    • (1978) Alcohol. Clin. Exp. Res. , vol.2 , pp. 259-263
    • Gordon, G.G.1    Louis Southren, A.2    Charles, S.L.3
  • 17
    • 74049139484 scopus 로고    scopus 로고
    • Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression
    • [17] Hao, Z., Wei, J., Xue, R., Wu, J.D., Zhao, W., Wang, Z.Z., Wang, S.K., et al. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism 59 (2010), 285–292.
    • (2010) Metabolism , vol.59 , pp. 285-292
    • Hao, Z.1    Wei, J.2    Xue, R.3    Wu, J.D.4    Zhao, W.5    Wang, Z.Z.6    Wang, S.K.7
  • 18
    • 0028926108 scopus 로고
    • Hypothalamic-pituitary-gonadal axis, prolactin, and cortisol in alcoholics during withdrawal and after three weeks of abstinence: comparison with healthy control subjects
    • [18] Heinz, A., Rommelspacher, H., Graf, Klaus-Jurgen, Kürten, I., Otto, M., Baumgartner, A., Hypothalamic-pituitary-gonadal axis, prolactin, and cortisol in alcoholics during withdrawal and after three weeks of abstinence: comparison with healthy control subjects. Psychiatry Res. 56 (1995), 81–95.
    • (1995) Psychiatry Res. , vol.56 , pp. 81-95
    • Heinz, A.1    Rommelspacher, H.2    Graf, K.-J.3    Kürten, I.4    Otto, M.5    Baumgartner, A.6
  • 19
    • 0035836027 scopus 로고    scopus 로고
    • Effect of alcohol consumption on systemic markers of inflammation
    • [19] Imhof, A., Froehlich, M., Brenner, H., Boeing, H., Pepys, Mark B., Koenig, W., Effect of alcohol consumption on systemic markers of inflammation. The Lancet 357 (2001), 763–767.
    • (2001) The Lancet , vol.357 , pp. 763-767
    • Imhof, A.1    Froehlich, M.2    Brenner, H.3    Boeing, H.4    Pepys, M.B.5    Koenig, W.6
  • 20
    • 84928952863 scopus 로고    scopus 로고
    • Antioxidant activity of ethanolic extract of Tinospora cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male Wister albino rats
    • [20] Jayaprakash, R., Ramesh, V., Sridhar, M.P., Sasikala, C., Antioxidant activity of ethanolic extract of Tinospora cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male Wister albino rats. J. Pharm. Bioallied Sci. 7:Suppl. 1 (2015), S40–S45, 10.4103/0975-7406.155791.
    • (2015) J. Pharm. Bioallied Sci. , vol.7 , pp. S40-S45
    • Jayaprakash, R.1    Ramesh, V.2    Sridhar, M.P.3    Sasikala, C.4
  • 21
    • 84866942909 scopus 로고    scopus 로고
    • The relationship of appetitive, reproductive and posterior pituitary hormones to alcoholism and craving in humans
    • [21] Kenna, G.A., Swift, R.M., Hillemacher, T., Leggio, L., The relationship of appetitive, reproductive and posterior pituitary hormones to alcoholism and craving in humans. Neuropsychol. Rev. 22 (2012), 211–228.
    • (2012) Neuropsychol. Rev. , vol.22 , pp. 211-228
    • Kenna, G.A.1    Swift, R.M.2    Hillemacher, T.3    Leggio, L.4
  • 23
    • 33747138329 scopus 로고    scopus 로고
    • Alcohol abuse-duration dependent decrease in plasma testosterone and antioxidants in males
    • [23] Maneesh, M., Dutta, S., Chakrabarti, A., Vasudevan, D.M., Alcohol abuse-duration dependent decrease in plasma testosterone and antioxidants in males. Indian J. Physiol. Pharmacol. 50 (2006), 291–295.
    • (2006) Indian J. Physiol. Pharmacol. , vol.50 , pp. 291-295
    • Maneesh, M.1    Dutta, S.2    Chakrabarti, A.3    Vasudevan, D.M.4
  • 24
    • 33846091628 scopus 로고    scopus 로고
    • Controlled study on the combined effect of alcohol and tobacco smoking on testosterone in alcohol-dependent men
    • [24] Marc, W., Gerhard, U., Gerlach, M., Weijers, Heinz-Gerd, Boening, J., Wiesbeck, Gerhard A., Controlled study on the combined effect of alcohol and tobacco smoking on testosterone in alcohol-dependent men. Alcohol Alcohol. 42 (2007), 19–23.
    • (2007) Alcohol Alcohol. , vol.42 , pp. 19-23
    • Marc, W.1    Gerhard, U.2    Gerlach, M.3    Weijers, H.-G.4    Boening, J.5    Wiesbeck, G.A.6
  • 25
    • 84929154529 scopus 로고    scopus 로고
    • Detection of new human metabolic urinary markers in chronic alcoholism and their reversal by aqueous extract of Tinospora cordifolia stem
    • [25] Mittal, A., Dabur, R., Detection of new human metabolic urinary markers in chronic alcoholism and their reversal by aqueous extract of Tinospora cordifolia stem. Alcohol Alcohol. 50 (2015), 271–281.
    • (2015) Alcohol Alcohol. , vol.50 , pp. 271-281
    • Mittal, A.1    Dabur, R.2
  • 26
    • 0021181906 scopus 로고
    • Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood
    • [26] Orentreich, N., Brind, J.L., Rizer, R.L., Vogelman, J.H., Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J. Clin. Endocrino. Metabolism. 59 (1984), 551–555.
    • (1984) J. Clin. Endocrino. Metabolism. , vol.59 , pp. 551-555
    • Orentreich, N.1    Brind, J.L.2    Rizer, R.L.3    Vogelman, J.H.4
  • 27
    • 0028947766 scopus 로고
    • Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men
    • [27] Perry, I.J., Wannamethee, S.G., Walker, M.K., Thomson, A.G., Whincup, P.H., Shaper, A.G., Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men. BMJ 310 (1995), 560–564.
    • (1995) BMJ , vol.310 , pp. 560-564
    • Perry, I.J.1    Wannamethee, S.G.2    Walker, M.K.3    Thomson, A.G.4    Whincup, P.H.5    Shaper, A.G.6
  • 28
    • 0027136186 scopus 로고
    • Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors
    • [28] Piazza, P.V., Deroche, V., Deminière, J.M., Maccari, S., Le Moal, M., Simon, H., Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors. Proc. Natl. Acad. Sci. U.S.A. 90 (1993), 11738–11742.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 11738-11742
    • Piazza, P.V.1    Deroche, V.2    Deminière, J.M.3    Maccari, S.4    Le Moal, M.5    Simon, H.6
  • 30
    • 49849105117 scopus 로고    scopus 로고
    • Cardioprotective effect of ‘Marutham’ a polyherbal formulation on isoproterenol induced myocardial infarction in Wistar rats
    • [30] Prince, P.S., Suman, S., Devika, P.T., Vaithianathan, M., Cardioprotective effect of ‘Marutham’ a polyherbal formulation on isoproterenol induced myocardial infarction in Wistar rats. Fitoterapia. 79 (2008), 433–438.
    • (2008) Fitoterapia. , vol.79 , pp. 433-438
    • Prince, P.S.1    Suman, S.2    Devika, P.T.3    Vaithianathan, M.4
  • 31
    • 84873702172 scopus 로고    scopus 로고
    • Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes
    • [31] Sangeetha, M.K., Priya, C.D., Vasanthi, Hannah R., Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes. Phytomedicine 20 (2013), 246–248.
    • (2013) Phytomedicine , vol.20 , pp. 246-248
    • Sangeetha, M.K.1    Priya, C.D.2    Vasanthi, H.R.3
  • 32
    • 0037392018 scopus 로고    scopus 로고
    • Testosterone increases in men after a low dose of alcohol
    • [32] Sarkola, T., Eriksson, C.J., Testosterone increases in men after a low dose of alcohol. Alcohol. Clin. Exp. Res. 27 (2003), 682–685.
    • (2003) Alcohol. Clin. Exp. Res. , vol.27 , pp. 682-685
    • Sarkola, T.1    Eriksson, C.J.2
  • 33
    • 84960087758 scopus 로고    scopus 로고
    • Protective effects of Tinospora cordifolia on hepatic and gastrointestinal toxicity induced by chronic and moderate alcoholism
    • [33] Sharma, B., Dabur, R., Protective effects of Tinospora cordifolia on hepatic and gastrointestinal toxicity induced by chronic and moderate alcoholism. Alcohol Alcohol. 51 (2016), 1–10, 10.1093/alcalc/agv130.
    • (2016) Alcohol Alcohol. , vol.51 , pp. 1-10
    • Sharma, B.1    Dabur, R.2
  • 34
    • 85040379626 scopus 로고    scopus 로고
    • Phytochemical composition changes in untreated stem juice of Tinospora cordifolia (W) Mier during refrigerated storage
    • [34] Shirolkar, A., Gahlaut, A., Hooda, V., Dabur, R., Phytochemical composition changes in untreated stem juice of Tinospora cordifolia (W) Mier during refrigerated storage. J. Pharm. Res. 7 (2013), 1–6.
    • (2013) J. Pharm. Res. , vol.7 , pp. 1-6
    • Shirolkar, A.1    Gahlaut, A.2    Hooda, V.3    Dabur, R.4
  • 35
    • 2442661716 scopus 로고    scopus 로고
    • Effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate, testosterone, and estradiol levels in middle-aged men and postmenopausal women: a diet-controlled intervention study
    • [35] Sierksma, A., Sarkola, T., Eriksson, C.J., Martijn, S. Gaag, Diederick, E. Grobbee, Hendriks, Henk F.J., Effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate, testosterone, and estradiol levels in middle-aged men and postmenopausal women: a diet-controlled intervention study. Alcohol. Clin. Exp. Res. 28 (2004), 780–785.
    • (2004) Alcohol. Clin. Exp. Res. , vol.28 , pp. 780-785
    • Sierksma, A.1    Sarkola, T.2    Eriksson, C.J.3    Martijn, S.G.4    Diederick, E.G.5    Hendriks, H.F.J.6
  • 36
    • 2442645641 scopus 로고    scopus 로고
    • Characterizing the ontogeny of ethanol-associated increases in corticosterone
    • [36] Silveri, Marisa M., Spear, P.L., Characterizing the ontogeny of ethanol-associated increases in corticosterone. Alcohol 32 (2004), 145–155.
    • (2004) Alcohol , vol.32 , pp. 145-155
    • Silveri, M.M.1    Spear, P.L.2
  • 38
    • 0026730840 scopus 로고
    • The incidence of ethanol-induced hypoglycemia
    • Sep
    • [38] Sporer, K.A., Ernst, A.A., Conte, R., Nick, T.G., The incidence of ethanol-induced hypoglycemia. Am. J. Emerg. Med. 10:5 (1992 Sep), 403–405.
    • (1992) Am. J. Emerg. Med. , vol.10 , Issue.5 , pp. 403-405
    • Sporer, K.A.1    Ernst, A.A.2    Conte, R.3    Nick, T.G.4
  • 39
    • 84883873703 scopus 로고    scopus 로고
    • Tinospora cordifolia (Amrita)-A miracle herb and lifeline to many diseases
    • [39] Srivastava, P., Tinospora cordifolia (Amrita)-A miracle herb and lifeline to many diseases. Int. J. Med. Aromat. Plants 1 (2011), 57–61.
    • (2011) Int. J. Med. Aromat. Plants , vol.1 , pp. 57-61
    • Srivastava, P.1
  • 40
    • 0022857282 scopus 로고
    • Redox effects of ethanol on steroid metabolism
    • [40] Stig, A., Cronholm, T., Sjovall, J., Redox effects of ethanol on steroid metabolism. Alcohol. Clin. Exp. Res. 10 (1986), 55S–63S.
    • (1986) Alcohol. Clin. Exp. Res. , vol.10 , pp. 55S-63S
    • Stig, A.1    Cronholm, T.2    Sjovall, J.3
  • 41
    • 0025639217 scopus 로고
    • The pulsatile secretion of gonadotropins and growth hormone, and the biological activity of luteinizing hormone in men acutely intoxicated with ethanol
    • [41] Valimaki, M., Tuominen, J.A., Huhtaniemi, I., Ylikahri, R., The pulsatile secretion of gonadotropins and growth hormone, and the biological activity of luteinizing hormone in men acutely intoxicated with ethanol. Alcohol Clin. Exp. Res. 14 (1990), 928–931.
    • (1990) Alcohol Clin. Exp. Res. , vol.14 , pp. 928-931
    • Valimaki, M.1    Tuominen, J.A.2    Huhtaniemi, I.3    Ylikahri, R.4
  • 42
    • 0018599046 scopus 로고
    • The effect of chronic alcohol abuse on sexual function
    • [42] Thiel, Van., David, H., Lester, R., The effect of chronic alcohol abuse on sexual function. Clin. Endocrinol. Metab. 8 (1979), 499–510.
    • (1979) Clin. Endocrinol. Metab. , vol.8 , pp. 499-510
    • Thiel, V.1    David, H.2    Lester, R.3
  • 43
    • 0018746231 scopus 로고
    • Evidence for an adrenal origin of plasma estrogens in alcoholic men
    • [43] Thiel, Van, David, H., Loriaux, D.L., Evidence for an adrenal origin of plasma estrogens in alcoholic men. Metabolism 28:5 (1979), 536–541.
    • (1979) Metabolism , vol.28 , Issue.5 , pp. 536-541
    • Thiel, V.1    David, H.2    Loriaux, D.L.3
  • 44
    • 84988927705 scopus 로고    scopus 로고
    • Antihyperlipidemic effect of Tinospora cordifolia extract in streptozotocin induced diabetic rats
    • [44] Vetrivadivelan, K., Venkateswaran, K.V., Selvasubramanian, S., Sesh, P.S.L., Antihyperlipidemic effect of Tinospora cordifolia extract in streptozotocin induced diabetic rats. Int. J. Pharm. Sci. Res. 3:5 (2012), 1423–1429.
    • (2012) Int. J. Pharm. Sci. Res. , vol.3 , Issue.5 , pp. 1423-1429
    • Vetrivadivelan, K.1    Venkateswaran, K.V.2    Selvasubramanian, S.3    Sesh, P.S.L.4
  • 45
    • 84896544682 scopus 로고    scopus 로고
    • Involvement of CRH and hCG in the induction of aromatase by cortisol in human placental syncytiotrophoblasts
    • [45] Wang, W.S., Liu, C., Li, W.J., Zhu, P., Li, J.N., Sun, K., Involvement of CRH and hCG in the induction of aromatase by cortisol in human placental syncytiotrophoblasts. Placenta 35:1 (2014), 30–36, 10.1016/j.placenta.2013.10.018.
    • (2014) Placenta , vol.35 , Issue.1 , pp. 30-36
    • Wang, W.S.1    Liu, C.2    Li, W.J.3    Zhu, P.4    Li, J.N.5    Sun, K.6
  • 46
    • 19944374769 scopus 로고    scopus 로고
    • Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
    • [46] Weijia, K., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat. Med. 10 (2004), 1344–1351.
    • (2004) Nat. Med. , vol.10 , pp. 1344-1351
    • Weijia, K.1    Wei, J.2    Abidi, P.3    Lin, M.4    Inaba, S.5    Li, C.6    Wang, Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.