Overexpression of Dyrk1A, a down syndrome candidate, decreases excitability and impairs gamma oscillations in the prefrontal cortex

Journal of Neuroscience

Volumn 36, Issue 13, 2016, Pages 3648-3659

  Ruiz Mejias, Marcel ^a   de Lagran, Maria Martinez ^b,c,d   Mattia, Maurizio ^e   Castano Prat, Patricia ^a   Perez Mendez, Lorena ^a   Ciria Suarez, Laura ^a   Gener, Thomas ^b,c,d   Sancristobal, Belen ^b,c,d   García Ojalvo, Jordi ^c   Gruart, Agnès ^f   Delgado García, José M ^f   Sanchez Vives, Maria V ^a,g   Dierssen, Mara ^b,c,d  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b BARCELONA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Spain)

^c UNIVERSITAT POMPEU FABRA   (Spain)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^e ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^f UNIVERSIDAD PABLO DE OLAVIDE   (Spain)

^g INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Down syndrome; DYRK1A; Gamma oscillations; Prefrontal cortex; Transgenic mouse model

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; COGNITIVE DEFECT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN SYNDROME; DYRK1A GENE; EXCITABILITY; FEMALE; FIRING RATE; GENE; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NONHUMAN; PHOSPHORYLATION; PREFRONTAL CORTEX; PRIORITY JOURNAL; ACTION POTENTIAL; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; COMPUTER SIMULATION; CYTOLOGY; GAMMA RHYTHM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY; SPECTROSCOPY; TRANSGENIC MOUSE; WAKEFULNESS;

4 AMINOBUTYRIC ACID CARRIER; DYRK KINASE; PARVALBUMIN; PHOTOPROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SLC17A7 PROTEIN, MOUSE; SOMATOSTATIN; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR INHIBITORY AMINO ACID TRANSPORTER; VIAAT PROTEIN, MOUSE;

ACTION POTENTIALS; ANIMALS; COMPUTER SIMULATION; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA RHYTHM; GENE EXPRESSION REGULATION; LUMINESCENT PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, NEUROLOGICAL; NEURONS; PARVALBUMINS; PREFRONTAL CORTEX; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SOMATOSTATIN; SPECTRUM ANALYSIS; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1; VESICULAR INHIBITORY AMINO ACID TRANSPORT PROTEINS; WAKEFULNESS;

EID: 84962025392     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2517-15.2016     Document Type: Article

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