Possible pitfalls in the diagnostic of progressive multifocal leukoencephalopathy

Clinical Neuropathology

Volumn 35, Issue 2, 2016, Pages 66-71

  Živanović, Milanka ^a   Savšek, Lina ^b   Poljak, Mario ^a   Popović, Mara ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b General Hospital Celje   (Slovenia)

Author keywords

Immunohistochemistry (IHC); In; JC virus (JCV); Progressive multifocal leukoencephalopathy (PML); Real; Situ hybridization (ISH); Time PCR

Indexed keywords

BRAIN PROTEIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUDARABINE; GADOLINIUM; GLUCOSE; METHYLPREDNISOLONE; MITOXANTRONE; PREDNISOLONE; RITUXIMAB; VINCRISTINE; VIRUS DNA;

ADULT; ARM WEAKNESS; ARTICLE; ASTROCYTE; AUTOPSY; BRAIN ATROPHY; BRAIN BIOPSY; CANCER COMBINATION CHEMOTHERAPY; CANCER REGRESSION; CAPSULA INTERNA; CASE REPORT; CEREBRAL PEDUNCLE; CEREBROSPINAL FLUID ANALYSIS; CONTRAST ENHANCEMENT; DEATH; DETERIORATION; DRUG MEGADOSE; DYSARTHRIA; DYSPHASIA; FEMALE; FOLLOW UP; GLUCOSE BRAIN LEVEL; HUMAN; HUMAN TISSUE; HYPERESTHESIA; IMMUNOHISTOCHEMISTRY; JC VIRUS; LARGE CELL LYMPHOMA; LEG SWELLING; MAINTENANCE THERAPY; MULTIPLE CYCLE TREATMENT; MYELOFIBROSIS; NEUROIMAGING; NEUROLOGIC EXAMINATION; NONHODGKIN LYMPHOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOGENESIS AND MALIGNANT TRANSFORMATION; PNEUMONIA; POLYCYTHEMIA VERA; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; PUTAMEN; REAL TIME POLYMERASE CHAIN REACTION; RECURRENT INFECTION; SPEECH DISORDER; STEROID THERAPY; SUPERIOR FRONTAL GYRUS; VIRUS DETECTION; WHITE MATTER LESION; BIOPSY; IN SITU HYBRIDIZATION; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; MIDDLE AGED; NEURONAVIGATION;

BIOPSY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; JC VIRUS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; MIDDLE AGED; NEURONAVIGATION; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84962018431     PISSN: 07225091     EISSN: None     Source Type: Journal    
DOI: 10.5414/NP300911     Document Type: Article

References (20)

1. Weissert R. Progressive multifocal leukoencephalopathy. J Neuroimmunol. 2011; 231: 73-77. CrossRef PubMed
2. Lima MA. Progressive multifocal leukoencephalopathy:new concepts. Arq Neuropsiquiatr. 2013; 71 (9B): 699-702. CrossRef PubMed
3. Pinto M, Dobson S. BK and JC virus: a review. J Infect. 2014; 68 (Suppl 1): S2-S8. CrossRef PubMed
4. Bellizzi A, Anzivino E, Rodio DM, Palamara AT, Nencioni L, Pietropaolo V. New insights on human polyomavirus jc and pathogenesis of progressive multifocal leukoencephalopathy. Clin Dev Immunol. 2013; 2013: 839719. PubMed
5. Radhakrishnan S, Otte J, Enam S, Del Valle L, Khalili K, Gordon J. JC virus-induced changes in cellular gene expression in primary human astrocytes. J Virol. 2003; 77: 10638-10644. CrossRef PubMed
6. White MK, Khalili K. Pathogenesis of progressive multifocal leukoencephalopathy - revisited. J Infect Dis. 2011; 203: 578-586. CrossRef PubMed
7. Adiele RC, Adiele CA. Progressive multifocal leukoencephalopathy. J Mult Scler. 2014; 1: 2. CrossRef
8. Dang L, Dang X, Koralnik IJ, Todd PK, Todd KP. JC polyomavirus granule cell neuronopathy in a patient treated with rituximab. JAMA Neurol. 2014; 71: 487-489. CrossRef PubMed
9. Tan CS, Koralnik IJ. Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol. 2010; 9: 425-437. CrossRef PubMed
10. Berger JR. The clinical features of PML. Cleve Clin J Med. 2011; 78 (Suppl 2): S8-S12. CrossRef PubMed
11. Bogdanovic G, Priftakis P, Hammarin AL, Söderström M, Samuelson A, Lewensohn-Fuchs I, Dalianis T. Detection of JC virus in cerebrospinal fluid (CSF) samples from patients with progressive multifocal leukoencephalopathy but not in CSF samples from patients with herpes simplex encephalitis, enteroviral meningitis, or multiple sclerosis. J Clin Microbiol. 1998; 36: 1137-1138. PubMed
12. Amaker BH, Chandler FW Jr, Huey LO, Colwell RM. Molecular detection of JC virus in embalmed, formalin-fixed, paraffin-embedded brain tissue. J Forensic Sci. 1997; 42: 1157-1159. CrossRef PubMed
13. Samorei IW, Schmid M, Pawlita M, Vinters HV, Diebold K, Mundt C, von Einsiedel RW. High sensitivity detection of JC-virus DNA in postmortem brain tissue by in situ PCR. J Neurovirol. 2000; 6:61-74. CrossRef PubMed
14. Mori M, Kurata H, Tajima M, Shimada H. JC virus detection by in situ hybridization in brain tissue from elderly patients. Ann Neurol. 1991; 29:428-432. CrossRef PubMed
15. Schmidbauer M, Budka H, Shah KV. Progressive multifocal leukoencephalopathy (PML) in AIDS and in the pre-AIDS era. A neuropathological comparison using immunocytochemistry and in situ DNA hybridization for virus detection. Acta Neuropathol. 1990; 80: 375-380. CrossRef PubMed
16. Muñoz-Mármol AM, Mola G, Fernández-Vasalo A, Vela E, Mate JL, Ariza A. JC virus early protein detection by immunohistochemistry in progressive multifocal leukoencephalopathy: a comparative study with in situ hybridization and polymerase chain reaction. J Neuropathol Exp Neurol. 2004; 63: 1124-1130. PubMed
17. Tan CS, Ellis LC, Wüthrich C, Ngo L, Broge TA Jr, Saint-Aubyn J, Miller JS, Koralnik IJ. JC virus latency in the brain and extraneural organs of patients with and without progressive multifocal leukoencephalopathy. J Virol. 2010; 84: 9200-9209. CrossRef PubMed
18. Perez-Liz G, Del Valle L, Gentilella A, Croul S, Khalili K. Detection of JC virus DNA fragments but not proteins in normal brain tissue. Ann Neurol. 2008; 64: 379-387. CrossRef PubMed
19. Ferrante P, Caldarelli-Stefano R, Omodeo-Zorini E, Vago L, Boldorini R, Costanzi G. PCR detection of JC virus DNA in brain tissue from patients with and without progressive multifocal leukoencephalopathy. J Med Virol. 1995; 47: 219-225. CrossRef PubMed
20. Elsner C, Dörries K. Evidence of human polyomavirus BK and JC infection in normal brain tissue. Virology. 1992; 191: 72-80. CrossRef PubMed