Interleukin-12 inhibits the hepatocellular carcinoma growth by inducing macrophage polarization to the M1-like phenotype through downregulation of Stat-3

Molecular and Cellular Biochemistry

Volumn 415, Issue 1-2, 2016, Pages 157-168

  Wang, Qin ^a   Cheng, Feng ^a   Ma, Ting ting ^a   Xiong, Hai Yu ^a   Li, Zi Wei ^a   Xie, Chang Li ^a   Liu, Cui Ying ^a   Tu, Zhi Guang ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

CD197; CD206; Hepatocellular carcinoma; IL 12; M1 macrophages

Indexed keywords

ADENOVIRUS VECTOR; CD14 ANTIGEN; CD206 ANTIGEN; CHEMOKINE RECEPTOR CCR7; GELATINASE B; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; MANNOSE RECEPTOR; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN A; STAT3 PROTEIN, HUMAN;

ADENOVIRIDAE; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL DIFFERENTIATION; CELL INVASION ASSAY; CELL VIABILITY ASSAY; COCULTURE; COLONY FORMATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MACROPHAGE; MACROPHAGE ACTIVATION; MOLECULAR BIOLOGY; MONOCYTE; MOUSE; NONHUMAN; ONCOGENE C MYC; POLARIZATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; CELL POLARITY; CELL PROLIFERATION; DOWN REGULATION; LIVER TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; TUMOR INVASION;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL POLARITY; CELL PROLIFERATION; COCULTURE TECHNIQUES; DOWN-REGULATION; HUMANS; INTERLEUKIN-12; LIVER NEOPLASMS; MACROPHAGES; NEOPLASM INVASIVENESS; STAT3 TRANSCRIPTION FACTOR;

EID: 84961828545     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-016-2687-0     Document Type: Article

References (42)

1. Llovet JM, Burroughs A, Bruix J (2003) Hepatocellular carcinoma. Lancet 362:1907–1917
2. Parkin DM, Bray F, Ferlay J et al (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108
3. Shirabe K, Kanematsu T, Matsumata T et al (1991) Factors linked to early recurrence of small hepatocellular carcinoma after hepatectomy: univariate and multivariate analyses. Hepatology 14:802–805
4. Yamashita Y, Morita K, Iguchi T et al (2011) Surgical impacts of an en bloc resection of the diaphragm for hepatocellular carcinoma with gross diaphragmatic involvement. Surg Today 41:101–106
5. Sakaguchi T, Suzuki S, Morita Y et al (2010) Impact of the preoperative des-gamma-carboxy prothrombin level on prognosis after hepatectomy for hepatocellular carcinoma meeting the Milan criteria. Surg Today 40:638–645
6. Taketomi A, Fukuhara T, Morita K et al (2010) Improved results of a surgical resection for the recurrence of hepatocellular carcinoma after living donor liver transplantation. Ann Surg Oncol 17:2283–2289
7. de Visser KE, Eichten A, Coussens LM (2006) Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6:24–37
8. Lewis CE, Pollard JW (2006) Distinct role of macrophages in different tumor microenvironments. Cancer Res 66:605–612
9. Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122:787–795
10. Porta C, Riboldi E, Totaro MG et al (2011) Macrophages in cancer and infectious diseases: the ‘good’ and the ‘bad’. Immunotherapy 3:1185–1202
11. Baay M, Brouwer A, Pauwels P et al (2011) Tumor cells and tumor-associated macrophages: secreted proteins as potential targets for therapy. Clin Dev Immunol 2011:565187
12. Coffelt SB, Hughes R, Lewis CE (2009) Tumor-associated macrophages: effectors of angiogenesis and tumor progression. Biochim Biophys Acta 1796:11–18
13. Satoh T, Saika T, Ebara S et al (2003) Macrophages transduced with an adenoviral vector expressing interleukin 12 suppress tumor growth and metastasis in a preclinical metastatic prostate cancer model. Cancer Res 63:7853–7860
14. Chehimi J, Trinchieri G (1994) Interleukin-12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency. J Clin Immunol 14:149–161
15. Beadling C, Slifka MK (2006) Regulation of innate and adaptive immune responses by the related cytokines IL-12, IL-23, and IL-27. Arch Immunol Ther Exp 54:15–24
16. Del Vecchio M, Bajetta E, Canova S et al (2007) Interleukin-12: biological properties and clinical application. Clin Cancer Res 13:4677–4685
17. Hamza T, Barnett JB, Li B (2010) Interleukin 12 a key immunoregulatory cytokine in infection applications. Int J Mol Sci 11:789–806
18. Tatsumi T, Huang J, Gooding WE et al (2003) Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity. Cancer Res 63:6378–6386
19. Watkins SK, Egilmez NK, Suttles J et al (2007) IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo. J Immunol 178:1357–1362
20. Ma TT, Wu BT, Lin Y et al (2015) IL-12 could induce monocytic tumor cells directional differentiation. Mol Cell Biochem 402:157–169
21. Cheng F, Kuang WB, Wang Q et al (2012) construction of adenovirus vector containning hIL-12 gene and its effects on the proliferation and TGF- expression of Hep3B cells. Chin J Immunol 28:402–406
22. Davies JQ, Gordon S (2005) Isolation and culture of human macrophages. Methods Mol Biol 290:105–116
23. Wermuth PJ, Del Galdo F, Jiménez SA (2009) Induction of the expression of profibrotic cytokines and growth factors in normal human peripheral blood monocytes by gadolinium contrast agents. Arthritis Rheum 60:1508–1518
24. Zhou JR, Yu L, Mai Z et al (2004) Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice. Int J Cancer 108:8–14
25. Zhou JR, Mukherjee P, Gugger ET et al (1998) Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis. Cancer Res 58:5231–5238
26. Kuwai T, Kitadai Y, Tanaka S et al (2003) Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. Int J Cancer 105:176–181
27. Mantovani A, Biswas SK, Galdiero MR et al (2013) Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol 229:176–185
28. Allavena P, Sica A, Solinas G et al (2008) The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit Rev Oncol Hematol 66:1–9
29. Gordon S, Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5:953–964
30. Martinez FO, Helming L, Gordon S (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 27:451–483
31. Vicari AP, Chiodoni C, Vaure C et al (2002) Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin10 receptor antibody. J Exp Med 196:541–549
32. Barrios B, Baez NS, Reynolds D et al (2014) Abrogation of TNFα production during cancer immunotherapy is crucial for suppressing side effects due to the systemic expression of IL-12. PLoS One 9:e90116
33. Bai J, Adriani G, Dang TM et al (2015) Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions. Oncotarget 6:25295–25307
34. Genin M, Clement F, Fattaccioli A et al (2015) M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide. BMC Cancer 15:577
35. Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122:787–795
36. Solinas G, Germano G, Mantovani A et al (2009) Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 86:1065–1073
37. Ugel S, Delpozzo F, Desantis G et al (2009) Therapeutic targeting of myeloid-derived suppressor cells. Curr Opin Pharmacol 9:470–841
38. Sica A, Bronte V (2007) Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest 117:1155–1166
39. Wan S, Zhao E, Kryczek I et al (2014) Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology 147:1393–1404
40. Mano Y, Aishima S, Fujita N et al (2013) Tumor-associated macrophage promotes tumor progression via STAT3 signaling in hepatocellular carcinoma. Pathobiology 80:146–154
41. Zhou N, Zhang Y, Zhang X et al (2015) Exposure of tumor-associated macrophages to apoptotic MCF-7 cells promotes breast cancer growth and metastasis. Int J Mol Sci 16:11966–11982
42. Pello OM, De Pizzol M, Mirolo M et al (2012) Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology. Blood 119:411–421