Posterior accumulation of tau and concordant hypometabolism in an early-onset Alzheimer's disease patient with presenilin-1 mutation

Journal of Alzheimer's Disease

Volumn 51, Issue 2, 2016, Pages 339-343

  Smith, Ruben ^a   Wibom, Moa ^b   Olsson, Tomas ^a   Hägerström, Douglas ^a   Jögi, Jonas ^a   Rabinovici, Gil D ^c   Hansson, Oskar ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b Angelholm Hospital   (Sweden)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; positron emission tomography; presenilins; tau proteins

Indexed keywords

AMYLOID BETA PROTEIN; ASPARAGINE; FLORTAUCIPIR F 18; FLUORODEOXYGLUCOSE F 18; FLUTEMETAMOL F 18; PRESENILIN 1; TAU PROTEIN; THREONINE; ANILINE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; FLUTEMETAMOL; MAPT PROTEIN, HUMAN; PSEN1 PROTEIN, HUMAN; RADIOPHARMACEUTICAL AGENT;

ADULT; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ANTEROGRADE AMNESIA; ARTICLE; BRAIN METABOLISM; CASE REPORT; CONTROLLED STUDY; DRUG METABOLISM; DRUG UPTAKE; EPISODIC MEMORY; GENE MUTATION; HUMAN; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NEUROIMAGING; NEUROPATHOLOGY; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OCCIPITAL CORTEX; PARIETAL CORTEX; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; POSTERIOR CINGULATE; PRECUNEUS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TAUOPATHY; BRAIN; BRAIN MAPPING; DIAGNOSTIC IMAGING; GENETICS; METABOLISM; ONSET AGE;

ADULT; AGE OF ONSET; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANILINE COMPOUNDS; BENZOTHIAZOLES; BRAIN; BRAIN MAPPING; FLUORODEOXYGLUCOSE F18; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; POSITRON-EMISSION TOMOGRAPHY; PRESENILIN-1; RADIOPHARMACEUTICALS; TAU PROTEINS;

EID: 84961782665     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-151004     Document Type: Article

References (10)

1. Hutton M, Hardy J. (1997). The presenilins and Alzheimer's disease. Hum Mol Genet 6, 1639-1646.
2. Lehmann M, Ghosh PM, Madison C, Laforce R Jr, Corbetta-Rastelli C, Weiner MW, Greicius MD, Seeley WW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD. (2013). Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease. Brain 136, 844-858.
3. Ossenkoppele R, Zwan MD, Tolboom N, Van Assema DM, Adriaanse SF, Kloet RW, Boellaard R, Windhorst AD, Barkhof F, Lammertsma AA, Scheltens P, Van Der Flier WM, van BerckelBN(2012). Amyloid burden and metabolic function in early-onset Alzheimer's disease: Parietal lobe involvement. Brain 135, 2115-2125.
4. Chien DT, Bahri S, Szardenings AK, Walsh JC, Mu F, Su MY, Shankle WR, Elizarov A, Kolb HC. (2013). Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807. J Alzheimers Dis 34, 457-468.
5. American Psychiatric Association. Work Group to Revise DSM-III. (1987). Diagnostic and statistical manual of mental disorders: DSM-III-R, American Psychiatric Association, Washington, DC.
6. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
7. Nelissen N, Van Laere K, Thurfjell L, Owenius R, VandenbulckeM, Koole M, Bormans G, Brooks DJ, Vandenberghe R. (2009). Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease. J Nucl Med 50, 1251-1259.
8. Romero I, Jorgensen P, Bolwig G, Fraser PE, Rogaeva E, Mann D, Havsager AM, Jorgensen AL. (1999). A presenilin-1 Thr116Asn substitution in a family with early-onset Alzheimer's disease. Neuroreport 10, 2255-2260.
9. Ossenkoppele R, Schonhaut DR, Baker SL, O'Neil JP, Janabi M, Ghosh PM, Santos M, Miller ZA, Bettcher BM, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD. (2015). Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy. Ann Neurol 77, 338-342.
10. Marquie M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, Frosch MP, Hyman BT, Gomez-Isla T. (2015). Validating novel tau positron emission tomography tracer [F-18]-AV-1451. (T807). on postmortem brain tissue. Ann Neurol 78, 787-800.