Tranexamic acid compared with placebo for reducing total blood loss in hip replacement surgery: A randomized clinical trial

Anesthesia and Analgesia

Volumn 122, Issue 4, 2016, Pages 986-995

  Barrachina, Borja ^a   Lopez Picado, Amanda ^a   Remon, Maria ^b   Fondarella, Ana ^a   Iriarte, Ibai ^a   Bastida, Rebeca ^a   Rodríguez Gascón, Alicia ^c   Achaerandio, Maria Aranzazu ^a   Iturricastillo, Maria Carmen ^a   Aizpuru, Felipe ^a   Valero, Cesar Augusto ^a   Tobalina, Ricardo ^a   Hernanz, Roberto ^a  

^a HOSPITAL TXAGORRITXU   (Spain)

^b HOSPITAL GARCÍA ORCOYEN   (Spain)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; SODIUM CHLORIDE; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ACUTE GASTROENTERITIS; AGED; ARTICLE; BLEEDING; BLOOD TRANSFUSION; CHOLECYSTITIS; CLINICAL ARTICLE; CONTROL GROUP; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG INFUSION; FEMALE; HEMATOCRIT; HIP ARTHROPLASTY; HUMAN; INFECTIOUS COMPLICATION; LEG EDEMA; LEG PAIN; LUNG EDEMA; LUNG EMBOLISM; MALE; MULTICENTER STUDY; PATIENT CODING; PATIENT SAFETY; POSTOPERATIVE HEMORRHAGE; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; SWELLING; THROMBOSIS; TOTAL HIP PROSTHESIS; VIRUS INFECTION; ADVERSE EFFECTS; BLOOD LOSS, SURGICAL; CLINICAL TRIAL; COMPARATIVE STUDY; HIP REPLACEMENT; MIDDLE AGED; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; BLOOD LOSS, SURGICAL; FEMALE; HUMANS; MALE; MIDDLE AGED; TRANEXAMIC ACID;

EID: 84961782296     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0000000000001159     Document Type: Article

References (43)

1. Muñoz Gómez M, Páramo Fernández JA, [Intravenous administration of tranexamic acid to decrease bleeding and transfusion in knee and hip prosthetic surgery: is it safe and cost-Effective?]. Med Clin (Barc) 2013 141 207 9
2. Agency for Healthcare Research and Quality. HCUPnet National and regional estimates on hospital use for all patients from the HCUP Nationwide Inpatient sample (NIS). 2010 national statistics-principal procedure only-Total and partial hip replacement and knee arthroplasty 2013. Available at: http://hcupnet.ahrq.gov/HCUPnet.jsp. Accessed April 1, 2015
3. Foss NB, Kehlet H, Hidden blood loss after surgery for hip fracture. J Bone Joint Surg Br 2006 88 1053 9
4. Lemay E, Guay J, Côté C, Roy A, Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement. Can J Anaesth 2004 51 31 7
5. Bierbaum BE, Callaghan JJ, Galante JO, Rubash HE, Tooms RE, Welch RB, An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg Am 1999 81 2 10
6. Klein HG, Spahn DR, Carson JL, Red blood cell transfusion in clinical practice. Lancet 2007 370 415 26
7. Pedersen AB, Mehnert F, Overgaard S, Johnsen SP, Allogeneic blood transfusion and prognosis following total hip replacement: a population-based follow up study. BMC Musculoskelet Disord 2009 10 167
8. Bosch J, Muñoz MJ, Martínez M, de la Torre A, Estrada-Peña A, Vector-borne pathogen spread through ticks on migratory birds: a probabilistic spatial risk model for South-Western europe. Transbound Emerg Dis 2013 60 403 15
9. Segal JB, Blasco-Colmenares E, Norris EJ, Guallar E, Preoperative acute normovolemic hemodilution: a meta-Analysis. Transfusion 2004 44 632 44
10. Carless P, Moxey A, O'Connell D, Henry D, Autologous transfusion techniques: a systematic review of their efficacy. Transfus Med 2004 14 123 44
11. Cardone D, Klein AA, Perioperative blood conservation. Eur J Anaesthesiol 2009 26 722 9
12. Laupacis A, Fergusson D, Erythropoietin to minimize perioperative blood transfusion: a systematic review of randomized trials. The International Study of Peri-operative Transfusion (ISPOT) Investigators. Transfus Med 1998 8 309 17
13. Cuenca J, García-Erce JA, Martínez F, Cardona R, Pérez-Serrano L, Muñoz M, Preoperative haematinics and transfusion protocol reduce the need for transfusion after total knee replacement. Int J Surg 2007 5 89 94
14. Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB, Leppaniemi A, Parr M, Vincent JL, Tortella BJ, Dimsits J, Bouillon B, CONTROL Study Group Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma 2010 69 489 500
15. Kozek-Langenecker SA, Afshari A, Albaladejo P, Santullano CA, De Robertis E, Filipescu DC, Fries D, Görlinger K, Haas T, Imberger G, Jacob M, Lancé M, Llau J, Mallett S, Meier J, Rahe-Meyer N, Samama CM, Smith A, Solomon C, Van der Linden P, Wikkelsø AJ, Wouters P, Wyffels P, Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol 2013 30 270 382
16. Kotzé A, Carter LA, Scally AJ, Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality improvement cycle. Br J Anaesth 2012 108 943 52
17. Mannucci PM, Levi M, Prevention and treatment of major blood loss. N Engl J Med 2007 356 2301 11
18. Zufferey P, Merquiol F, Laporte S, Decousus H, Mismetti P, Auboyer C, Samama CM, Molliex S, Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery? Anesthesiology 2006 105 1034 46
19. Henry D, Carless P, Fergusson D, Laupacis A, The safety of aprotinin and lysine-Derived antifibrinolytic drugs in cardiac surgery: a meta-Analysis. CMAJ 2009 180 183 93
20. CRASH-2 trial collaborators Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S, CRASH-2 trial collaborators Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010 376 23 32
21. Poeran J, Rasul R, Suzuki S, Danninger T, Mazumdar M, Opperer M, Boettner F, Memtsoudis SG, Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety. BMJ 2014 349 g4829
22. Sukeik M, Alshryda S, Haddad FS, Mason JM, Systematic review and meta-Analysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg Br 2011 93 39 46
23. Gandhi R, Evans HM, Mahomed SR, Mahomed NN, Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-Analysis. BMC Res Notes 2013 6 184
24. Zhou XD, Tao LJ, Li J, Wu LD, Do we really need tranexamic acid in total hip arthroplasty? A meta-Analysis of nineteen randomized controlled trials. Arch Orthop Trauma Surg 2013 133 1017 27
25. Pinzón-Florez CE, Vélez Cañas KM, Díaz Quijano DM, Efficiency of tranexamic acid in perioperative blood loss in hip arthroplasty: a systematic literature review and meta-Analysis. Rev Esp Anestesiol Reanim 2015 62 253 64
26. Camarasa MA, Ollé G, Serra-Prat M, Martín A, Sánchez M, Ricós P, Pérez A, Opisso L, Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth 2006 96 576 82
27. Sehat KR, Evans RL, Newman JH, Hidden blood loss following hip and knee arthroplasty. Correct management of blood loss should take hidden loss into account. J Bone Joint Surg Br 2004 86 561 5
28. Clavé A, Fazilleau F, Dumser D, Lacroix J, Efficacy of tranexamic acid on blood loss after primary cementless total hip replacement with rivaroxaban thromboprophylaxis: a case-control study in 70 patients. Orthop Traumatol Surg Res 2012 98 484 90
29. Imai N, Dohmae Y, Suda K, Miyasaka D, Ito T, Endo N, Tranexamic acid for reduction of blood loss during total hip arthroplasty. J Arthroplasty 2012 27 1838 43
30. Nadler SB, Hidalgo JH, Bloch T, Prediction of blood volume in normal human adults. Surgery 1962 51 224 32
31. Gross JB, Estimating allowable blood loss: corrected for dilution. Anesthesiology 1983 58 277 80
32. Alshryda S, Sarda P, Sukeik M, Nargol A, Blenkinsopp J, Mason JM, Tranexamic acid in total knee replacement: a systematic review and meta-Analysis. J Bone Joint Surg Br 2011 93 1577 85
33. Blanié A, Bellamy L, Rhayem Y, Flaujac C, Samama CM, Fontenay M, Rosencher N, Duration of postoperative fibrinolysis after total hip or knee replacement: a laboratory follow-up study. Thromb Res 2013 131 e6 11
34. Hai FZZJY, Effect of tranexamic acid on the hidden blood loss after total hip arthroplasty. J Chongqing Med Univ 2012 37 359
35. Malhotra R, Grover V, Kapoor A, Kapur R, Alkaline phosphatase as a periodontal disease marker. Indian J Dent Res 2010 21 531 6
36. Yamasaki S, Masuhara K, Fuji T, Tranexamic acid reduces blood loss after cementless total hip arthroplasty-prospective randomized study in 40 cases. Int Orthop 2004 28 69 73
37. Claeys MA, Vermeersch N, Haentjens P, Reduction of blood loss with tranexamic acid in primary total hip replacement surgery. Acta Chir Belg 2007 107 397 401
38. Gungorduk K, Yildirim G, Asicioʇlu O, Gungorduk OC, Sudolmus S, Ark C, Efficacy of intravenous tranexamic acid in reducing blood loss after elective cesarean section: a prospective, randomized, double-blind, placebo-controlled study. Am J Perinatol 2011 28 233 40
39. Ortmann E, Besser MW, Klein AA, Antifibrinolytic agents in current anaesthetic practice. Br J Anaesth 2013 111 549 63
40. Horrow JC, Van Riper DF, Strong MD, Grunewald KE, Parmet JL, The dose-response relationship of tranexamic acid. Anesthesiology 1995 82 383 92
41. Breuer T, Martin K, Wilhelm M, Wiesner G, Schreiber C, Hess J, Lange R, Tassani P, The blood sparing effect and the safety of aprotinin compared to tranexamic acid in paediatric cardiac surgery. Eur J Cardiothorac Surg 2009 35 167 71
42. Elwatidy S, Jamjoom Z, Elgamal E, Zakaria A, Turkistani A, El-Dawlatly A, Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: a prospective, randomized, double-blind, placebo-controlled study. Spine (Phila Pa 1976) 2008 33 2577 80
43. Goobie SM, Meier PM, Pereira LM, McGowan FX, Prescilla RP, Scharp LA, Rogers GF, Proctor MR, Meara JG, Soriano SG, Zurakowski D, Sethna NF, Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology 2011 114 862 71