Individualized Household Allergen Intervention Lowers Allergen Level But Not Asthma Medication Use: A Randomized Controlled Trial

Journal of Allergy and Clinical Immunology: In Practice

Volumn 4, Issue 4, 2016, Pages 671-679.e4

  DiMango, Emily ^a   Serebrisky, Denise ^b   Narula, Surinder ^a   Shim, Chang ^b   Keating, Claire ^a   Sheares, Beverly ^a   Perzanowski, Matthew ^c   Miller, Rachel ^a   DiMango, Angela ^a   Andrews, Howard ^c   Merle, David ^c   Liu, Xinhua ^c   Calatroni, Agustin ^d   Kattan, Meyer ^a  

^a Department of Medicine   (United States)

^b JACOBI MEDICAL CENTER   (United States)

^c Department of Medicine   (United States)

^d Rho Federal Systems Division Inc   (United States)

Author keywords

Allergens; Asthma; Asthma controller; Cockroach; Mouse

Indexed keywords

ALLERGEN; FLUTICASONE PROPIONATE; FLUTICASONE PROPIONATE PLUS SALMETEROL; HOUSE DUST ALLERGEN; MONTELUKAST; SALBUTAMOL; ANTIASTHMATIC AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; ASTHMA; AVOIDANCE BEHAVIOR; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; ENVIRONMENTAL EXPOSURE; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HEALTH PROGRAM; HUMAN; MAJOR CLINICAL STUDY; MALE; NEW YORK; PERSONALIZED MEDICINE; RANDOMIZED CONTROLLED TRIAL; SENSITIZATION; TREATMENT OUTCOME; TREATMENT RESPONSE; ANIMAL; CAT; COCKROACH; DOG; HOUSING; IMMUNOLOGY; MIDDLE AGED; MOUSE; PATHOPHYSIOLOGY; PREVENTION AND CONTROL; PYROGLYPHIDAE; URBAN POPULATION; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ALLERGENS; ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; CATS; CHILD; COCKROACHES; DOGS; ENVIRONMENTAL EXPOSURE; FEMALE; FORCED EXPIRATORY VOLUME; HOUSING; HUMANS; MALE; MICE; MIDDLE AGED; NEW YORK CITY; PYROGLYPHIDAE; URBAN POPULATION; YOUNG ADULT;

EID: 84961780771     PISSN: 22132198     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaip.2016.01.016     Document Type: Article

References (48)

1. Chew, G.L., Perzanowski, M.S., Canfield, S.M., Goldstein, I.F., Mellins, R.B., Hoepner, L.A., et al. Cockroach allergen levels and associations with cockroach-specific IgE. J Allergy Clin Immunol 121 (2008), 240–245.
2. Rosenstreich, D.L., Eggleston, P., Kattan, M., Baker, D., Slavin, R.G., Gergen, P., et al. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med 336 (1997), 1356–1363.
3. Ahluwalia, S.K., Peng, R.D., Breysse, P.N., Diette, G.B., Curtin-Brosnan, J., Aloe, C., et al. Mouse allergen is the major allergen of public health relevance in Baltimore City. J Allergy Clin Immunol 132 (2013), 830–835.e1-2.
4. Gruchalla, R.S., Pongracic, J., Plaut, M., Evans, R. III, Visness, C.M., Walter, M., et al. Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. J Allergy Clin Immunol 115 (2005), 478–485.
5. Morgan, W.J., Crain, E.F., Gruchalla, R.S., O'Connor, G.T., Kattan, M., Evans, R. III, et al. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med 351 (2004), 1068–1080.
6. Arbes, S.J. Jr., Gergen, P.J., Vaughn, B., Zeldin, D.C., Asthma cases attributable to atopy: results from the Third National Health and Nutrition Examination Survey. J Allergy Clin Immunol 120 (2007), 1139–1145.
7. Perzanowski, M.S., Sporik, R., Squillace, S.P., Gelber, L.E., Call, R., Carter, M., et al. Association of sensitization to Alternaria allergens with asthma among school-age children. J Allergy Clin Immunol 101 (1998), 626–632.
8. Perzanowski, M.S., Ronmark, E., Platts-Mills, T.A., Lundback, B., Effect of cat and dog ownership on sensitization and development of asthma among preteenage children. Am J Respir Crit Care Med 166 (2002), 696–702.
9. Nelson, H.S., Weiss, S.T., Bleecker, E.R., Yancey, S.W., Dorinsky, P.M., Group, S.S., The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 129 (2006), 15–26.
10. Wechsler, M.E., Lehman, E., Lazarus, S.C., Lemanske, R.F. Jr., Boushey, H.A., Deykin, A., et al. Beta-adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med 173 (2006), 519–526.
11. Wu, A.C., Butler, M.G., Li, L., Fung, V., Kharbanda, E.O., Larkin, E.K., et al. Primary adherence to controller medications for asthma is poor. Ann Am Thorac Soc 12 (2015), 161–166.
12. Engelkes, M., Janssens, H.M., de Jongste, J.C., Sturkenboom, M.C., Verhamme, K.M., Medication adherence and the risk of severe asthma exacerbations: a systematic review. Eur Respir J 45 (2015), 396–407.
13. McNally, K.A., Rohan, J., Schluchter, M., Riekert, K.A., Vavrek, P., Schmidt, A., et al. Adherence to combined montelukast and fluticasone treatment in economically disadvantaged African American youth with asthma. J Asthma 46 (2009), 921–927.
14. Carlton, B.G., Lucas, D.O., Ellis, E.F., Conboy-Ellis, K., Shoheiber, O., Stempel, D.A., The status of asthma control and asthma prescribing practices in the United States: results of a large prospective asthma control survey of primary care practices. J Asthma 42 (2005), 529–535.
15. Finkelstein, J.A., Lozano, P., Shulruff, R., Inui, T.S., Soumerai, S.B., Ng, M., et al. Self-reported physician practices for children with asthma: are national guidelines followed?. Pediatrics 106:Suppl (2000), 886–896.
16. Gotzsche, P.C., Johansen, H.K., House dust mite control measures for asthma: systematic review. Allergy 63 (2008), 646–659.
17. Woodcock, A., Forster, L., Matthews, E., Martin, J., Letley, L., Vickers, M., et al. Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma. N Engl J Med 349 (2003), 225–236.
18. Platts-Mills, T.A., Tovey, E.R., Mitchell, E.B., Mozarro, H., Long-term effects of living in a dust-free room on patients with allergic asthma—reversal of bronchial hyper-reactivity. Monogr Allergy 18 (1983), 153–155.
19. Crain, E.F., Walter, M., O'Connor, G.T., Mitchell, H., Gruchalla, R.S., Kattan, M., et al. Home and allergic characteristics of children with asthma in seven U.S. urban communities and design of an environmental intervention: the Inner-City Asthma Study. Env Health Perspect 110 (2002), 939–945.
20. Carter, M.C., Perzanowski, M.S., Raymond, A., Platts-Mills, T.A., Home intervention in the treatment of asthma among inner-city children. J Allergy Clin Immunol 108 (2001), 732–737.
21. Torjusen, E.N., Diette, G.B., Breysse, P.N., Curtin-Brosnan, J., Aloe, C., Matsui, E.C., Dose-response relationships between mouse allergen exposure and asthma morbidity among urban children and adolescents. Indoor Air 23 (2013), 268–274.
22. Phipatanakul, W., Eggleston, P.A., Wright, E.C., Wood, R.A., Mouse allergen, I: the prevalence of mouse allergen in inner-city homes. The National Cooperative Inner-City Asthma Study. J Allergy Clin Immunol 106 (2000), 1070–1074.
23. Phipatanakul, W., Eggleston, P.A., Wright, E.C., Wood, R.A., National Coooperative Inner-City Asthma Study. Mouse allergen, II: the relationship of mouse allergen exposure to mouse sensitization and asthma morbidity in inner-city children with asthma. J Allergy Clin Immunol 106 (2000), 1075–1080.
24. Chew, G.L., Perzanowski, M.S., Miller, R.L., Correa, J.C., Hoepner, L.A., Jusino, C.M., et al. Distribution and determinants of mouse allergen exposure in low-income New York City apartments. Env Health Perspect 111 (2003), 1348–1351.
25. Halken, S., Host, A., Niklassen, U., Hansen, L.G., Nielsen, F., Pedersen, S., et al. Effect of mattress and pillow encasings on children with asthma and house dust mite allergy. J Allergy Clin Immunol 111 (2003), 169–176.
26. NAEaP Program, Expert Panel Report 3, Guidelines for the diagnosis and management of asthma. 2007, Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD.
27. Donohue, K.M., Al-alem, U., Perzanowski, M.S., Chew, G.L., Johnson, A., Divjan, A., et al. Anti-cockroach and anti-mouse IgE are associated with early wheeze and atopy in an inner-city birth cohort. J Allergy Clin Immunol 122 (2008), 914–920.
28. Busse, W.W., Morgan, W.J., Gergen, P.J., Mitchell, H.E., Gern, J.E., Liu, A.H., et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N Engl J Med 364 (2011), 1005–1015.
29. Szefler, S.J., Mitchell, H., Sorkness, C.A., Gergen, P.J., O'Connor, G.T., Morgan, W.J., et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet 372 (2008), 1065–1072.
30. Filep, S., Tsay, A., Vailes, L., Gadermaier, G., Ferreira, F., Matsui, E., et al. A multi-allergen standard for the calibration of immunoassays: CREATE principles applied to eight purified allergens. Allergy 67 (2012), 235–241.
31. Olmedo, O., Goldstein, I.F., Acosta, L., Divjan, A., Rundle, A.G., Chew, G.L., et al. Neighborhood differences in exposure and sensitization to cockroach, mouse, dust mite, cat, and dog allergens in New York City. J Allergy Clin Immunol 128 (2011), 284–292.e7.
32. American Thoracic Society, European Respiratory Society, ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 171 (2005), 912–930.
33. Nathan, R.A., Sorkness, C.A., Kosinski, M., Schatz, M., Li, J.T., Marcus, P., et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 113 (2004), 59–65.
34. Liu, A.H., Zeiger, R.S., Sorkness, C.A., Ostrom, N.K., Chipps, B.E., Rosa, K., et al. The Childhood Asthma Control Test: retrospective determination and clinical validation of a cut point to identify children with very poorly controlled asthma. J Allergy Clin Immunol 126 (2010), 267–273 273.e1.
35. Juniper, E.F., Guyatt, G.H., Cox, F.M., Ferrie, P.J., King, D.R., Development and validation of the Mini Asthma Quality of Life Questionnaire. Eur Respir J 14 (1999), 32–38.
36. Wildfire, J.J., Gergen, P.J., Sorkness, C.A., Mitchell, H.E., Calatroni, A., Kattan, M., et al. Development and validation of the Composite Asthma Severity Index–an outcome measure for use in children and adolescents. J Allergy Clin Immunol 129 (2012), 694–701.
37. Wang, R., Lagakos, S.W., Ware, J.H., Hunter, D.J., Drazen, J.M., Statistics in medicine–reporting of subgroup analyses in clinical trials. N Engl J Med 357 (2007), 2189–2194.
38. Wood, S.N., Stable and efficient multiple smoothing parameter estimation for generalized additive models. J Am Stat Assoc 99 (2004), 673–686.
39. Team RDC, R: a language and environment for statistical computing. 2009, R Foundation for Statistical Computing, Vienna, Austria.
40. Little, R.J., Rubin, D.B., Causal effects in clinical and epidemiological studies via potential outcomes: concepts and analytical approaches. Ann Rev Public Health 21 (2000), 121–145.
41. Kivity, S., Solomon, A., Soferman, R., Schwarz, Y., Mumcuoglu, K.Y., Topilsky, M., Mite asthma in childhood: a study of the relationship between exposure to house dust mites and disease activity. J Allergy Clin Immunol 91 (1993), 844–849.
42. van der Heide, S., de Monchy, J.G., de Vries, K., Bruggink, T.M., Kauffman, H.F., Seasonal variation in airway hyperresponsiveness and natural exposure to house dust mite allergens in patients with asthma. J Allergy Clin Immunol 93 (1994), 470–475.
43. van Strien, R.T., Verhoeff, A.P., van Wijnen, J.H., Doekes, G., de Meer, G., Brunekreef, B., Infant respiratory symptoms in relation to mite allergen exposure. Eur Respir J 9 (1996), 926–931.
44. Huss, K., Adkinson, N.F. Jr., Eggleston, P.A., Dawson, C., Van Natta, M.L., Hamilton, R.G., House dust mite and cockroach exposure are strong risk factors for positive allergy skin test responses in the Childhood Asthma Management Program. J Allergy Clin Immunol 107 (2001), 48–54.
45. Gergen, P.J., Togias, A., Inner city asthma. Immunol Allergy Clin North Am 35 (2015), 101–114.
46. Liu, A.H., Zeiger, R.S., Sorkness, C.A., Ostrom, N.K., Chipps, B.E., Rosa, K., et al. The Childhood Asthma Control Test: retrospective determination and clinical validation of a cut point to identify children with very poorly controlled asthma. J Allergy Clin Immunol 126 (2010), 267–273 273.e1.
47. Juniper, E.F., Guyatt, G.H., Cox, F.M., Ferrie, P.J., King, D.R., Development and validation of the Mini Asthma Quality of Life Questionnaire. Eur Respir J 14 (1999), 32–38.
48. Nathan, R.A., Sorkness, C.A., Kosinski, M., Schatz, M., Li, J.T., Marcus, P., et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 113 (2004), 59–65.