Inner City Asthma

Immunology and Allergy Clinics of North America

Volumn 35, Issue 1, 2015, Pages 101-114

  Gergen, Peter J ^a   Togias, Alkis ^a  

^a Center for Asthma Research Division of Pulmonary Allergy and Critical Care Medicine Department of Medicine   (United States)

Author keywords

Asthma; Disparities; Inner city; Intervention; Poverty; Severity

Indexed keywords

ALLERGEN; CARBON MONOXIDE; CORTICOSTEROID; NITROGEN DIOXIDE; OMALIZUMAB; OZONE; POLYCYCLIC AROMATIC HYDROCARBON; SULFUR DIOXIDE; TOBACCO SMOKE; SMOKE;

AIR POLLUTION; ASTHMA; DISEASE ASSOCIATION; DISEASE CONTROL; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; ENVIRONMENTAL EXPOSURE; ETHNIC DIFFERENCE; GENOTYPE ENVIRONMENT INTERACTION; HEALTH CARE ACCESS; HEALTH CARE QUALITY; HEALTH DISPARITY; HIGH RISK POPULATION; HOSPITALIZATION; HOUSING; HUMAN; LOWEST INCOME GROUP; MEDICATION COMPLIANCE; MORBIDITY; MORTALITY; OBESITY; OUTCOME ASSESSMENT; PARTICULATE MATTER; PATIENT COMPLIANCE; PEAK EXPIRATORY FLOW; POVERTY; PREMATURITY; PREVALENCE; PRIORITY JOURNAL; RACE DIFFERENCE; REVIEW; SENSITIZATION; SOCIAL PSYCHOLOGY; SOCIAL STATUS; URBAN POPULATION; ADVERSE EFFECTS; HEALTH CARE DISPARITY; IMMUNOLOGY; RISK FACTOR; SMOKE; SOCIAL CLASS;

ASTHMA; ENVIRONMENTAL EXPOSURE; HEALTHCARE DISPARITIES; HUMANS; NITROGEN DIOXIDE; OBESITY; POVERTY AREAS; QUALITY OF HEALTH CARE; RISK FACTORS; SMOKE; SOCIAL CLASS;

EID: 84927695002     PISSN: 08898561     EISSN: 15578607     Source Type: Journal    
DOI: 10.1016/j.iac.2014.09.006     Document Type: Review

References (95)

1. Moorman J.E., Akinbami L.J., Bailey C.M., et al. National surveillance of asthma: United States, 2001-2010. Vital Health Stat 3 2012, 1-67.
2. Akinbami L.J., Moorman J.E., Garbe P.L., et al. Status of childhood asthma in the United States, 1980-2007. Pediatrics 2009, 123(Suppl 3):S131-S145.
3. Carter-Pokras O.D., Gergen P.J. Reported asthma among Puerto Rican, Mexican-American, and Cuban children, 1982 through 1984. Am J Public Health 1993, 83:580-582.
4. Akinbami L.J., Rhodes J.C., Lara M. Racial and ethnic differences in asthma diagnosis among children who wheeze. Pediatrics 2005, 115:1254-1260.
5. Gupta R.S., Zhang X., Sharp L.K., et al. Geographic variability in childhood asthma prevalence in Chicago. JAllergy Clin Immunol 2008, 121:639-645.e1.
6. Ledogar R.J., Penchaszadeh A., Garden C.C., et al. Asthma and Latino cultures: different prevalence reported among groups sharing the same environment. Am J Public Health 2000, 90:929-935.
7. Cohen R.T., Canino G.J., Bird H.R., et al. Area of residence, birthplace, and asthma in Puerto Rican children. Chest 2007, 131:1331-1338.
8. Esteban C.A., Klein R.B., McQuaid E.L., et al. Conundrums in childhood asthma severity, control, and health care use: Puerto Rico versus Rhode Island. JAllergy Clin Immunol 2009, 124:238-244. 244.e1-5.
9. Fritz G.K., McQuaid E.L., Kopel S.J., et al. Ethnic differences in perception of lung function: a factor in pediatric asthma disparities?. Am J Respir Crit Care Med 2010, 182:12-18.
10. Akinbami L.J., Moorman J.E., Simon A.E., et al. Trends in racial disparities for asthma outcomes among children 0 to 17 years, 2001-201. J Allergy Clin Immunol 2014, 134:547-553.
11. Szefler S.J., Mitchell H., Sorkness C.A., et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet 2008, 372:1065-1072.
12. Kwong K.Y., Morphew T., Scott L., et al. Asthma control and future asthma-related morbidity in inner-city asthmatic children. Ann Allergy Asthma Immunol 2008, 101:144-152.
13. Boudreaux E.D., Emond S.D., Clark S., et al. Race/ethnicity and asthma among children presenting to the emergency department: differences in disease severity and management. Pediatrics 2003, 111:e615-e621.
14. Okelo S.O., Wu A.W., Merriman B., et al. Are physician estimates of asthma severity less accurate in black than in white patients?. JGen Intern Med 2007, 22:976-981.
15. Information on poverty and income statistics: a summary of 2013 current population survey data 2013, ASPE Issue Brief: Department of Health and Human Services, Office of the Assistant Secretary for Planning and Evaluation, Available at:, Accessed January 29, 2014. http://aspe.hhs.gov/hsp/13/PovertyandIncomeEst/ib_poverty2013.pdf.
16. Smith L.A., Hatcher-Ross J.L., Wertheimer R., et al. Rethinking race/ethnicity, income, and childhood asthma: racial/ethnic disparities concentrated among the very poor. Public Health Rep 2005, 120:109-116.
17. Thakur N., Oh S.S., Nguyen E.A., et al. Socioeconomic status and childhood asthma in urban minority youths. The GALA II and SAGE II studies. Am J Respir Crit Care Med 2013, 188:1202-1209.
18. Williams D.R., Sternthal M., Wright R.J. Social determinants: taking the social context of asthma seriously. Pediatrics 2009, 123(Suppl 3):S174-S184.
19. Williams D.R., Collins C. Racial residential segregation: a fundamental cause of racial disparities in health. Public Health Rep 2001, 116(5):404-416.
20. Sternthal M.J., Jun H.J., Earls F., et al. Community violence and urban childhood asthma: a multilevel analysis. Eur Respir J 2010, 36(6):1400-1409.
21. Williams L.K., Joseph C.L., Peterson E.L., et al. Race-ethnicity, crime, and other factors associated with adherence to inhaled corticosteroids. JAllergy Clin Immunol 2007, 119:168-175.
22. Wright R.J., Mitchell H., Visness C.M., et al. Community violence and asthma morbidity: the Inner-City Asthma Study. Am J Public Health 2004, 94:625-632.
23. Beck A.F., Huang B., Simmons J.M., et al. Role of financial and social hardships in asthma racial disparities. Pediatrics 2014, 133:1-9.
24. Beck A.F., Moncrief T., Huang B., et al. Inequalities in neighborhood child asthma admission rates and underlying community characteristics in one US county. JPediatr 2013, 163:574-580.
25. Guilbert T.W., Garris C., Jhingran P., et al. Asthma that is not well-controlled is associated with increased healthcare utilization and decreased quality of life. JAsthma 2011, 48:126-132.
26. Auger K.A., Kahn R.S., Davis M.M., et al. Medical home quality and readmission risk for children hospitalized with asthma exacerbations. Pediatrics 2013, 131:64-70.
27. Crocker D., Brown C., Moolenaar R., et al. Racial and ethnic disparities in asthma medication usage and health-care utilization: data from the National Asthma Survey. Chest 2009, 136:1063-1071.
28. Finkelstein J.A., Brown R.W., Schneider L.C., et al. Quality of care for preschool children with asthma: the role of social factors and practice setting. Pediatrics 1995, 95:389-394.
29. Ortega A.N., Gergen P.J., Paltiel A.D., et al. Impact of site of care, race, and Hispanic ethnicity on medication use for childhood asthma. Pediatrics 2002, 109:E1.
30. Stewart K.A., Higgins P.C., McLaughlin C.G., et al. Differences in prevalence, treatment, and outcomes of asthma among a diverse population of children with equal access to care: findings from a study in the military health system. Arch Pediatr Adolesc Med 2010, 164:720-726.
31. Williams L.K., Peterson E.L., Wells K., et al. Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence. JAllergy Clin Immunol 2011, 128:1185-1191.
32. McQuaid E.L., Everhart R.S., Seifer R., et al. Medication adherence among Latino and non-Latino white children with asthma. Pediatrics 2012, 129:e1404-e1410.
33. Smith L.A., Bokhour B., Hohman K.H., et al. Modifiable risk factors for suboptimal control and controller medication underuse among children with asthma. Pediatrics 2008, 122:760-769.
34. Bloomberg G.R., Banister C., Sterkel R., et al. Socioeconomic, family, and pediatric practice factors that affect level of asthma control. Pediatrics 2009, 123:829-835.
35. Sunshine J., Song L., Krieger J. Written action plan use in inner-city children: is it independently associated with improved asthma outcomes?. Ann Allergy Asthma Immunol 2011, 107:207-213.
36. Yin H.S., Gupta R.S., Tomopoulos S., et al. Readability, suitability, and characteristics of asthma action plans: examination of factors that may impair understanding. Pediatrics 2013, 131:e116-e126.
37. Gruchalla R.S., Pongracic J., Plaut M., et al. Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. JAllergy Clin Immunol 2005, 115:478-485.
38. Eggleston P.A., Rosenstreich D., Lynn H., et al. Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma. JAllergy Clin Immunol 1998, 102:563-570.
39. Rosenstreich D.L., Eggleston P., Kattan M., et al. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. NEngl J Med 1997, 336:1356-1363.
40. Phipatanakul W., Eggleston P.A., Wright E.C., et al. Mouse allergen. II. The relationship of mouse allergen exposure to mouse sensitization and asthma morbidity in inner-city children with asthma. JAllergy Clin Immunol 2000, 106:1075-1080.
41. Perry T., Matsui E., Merriman B., et al. The prevalence of rat allergen in inner-city homes and its relationship to sensitization and asthma morbidity. JAllergy Clin Immunol 2003, 112:346-352.
42. Arbes S.J., Cohn R.D., Yin M., et al. House dust mite allergen in US beds: results from the First National Survey of Lead and Allergens in Housing. JAllergy Clin Immunol 2003, 111:408-414.
43. Cohn R.D., Arbes S.J., Jaramillo R., et al. National prevalence and exposure risk for cockroach allergen in US households. Environ Health Perspect 2006, 114:522-526.
44. Wilson J., Dixon S.L., Breysse P., et al. Housing and allergens: a pooled analysis of nine US studies. Environ Res 2010, 110:189-198.
45. Arbes S.J., Cohn R.D., Yin M., et al. Dog allergen (Can f 1) and cat allergen (Fel d 1) in US homes: results from the National Survey of Lead and Allergens in Housing. JAllergy Clin Immunol 2004, 114:111-117.
46. Baxi S.N., Muilenberg M.L., Rogers C.A., et al. Exposures to molds in school classrooms of children with asthma. Pediatr Allergy Immunol 2013, 24:697-703.
47. Salo P.M., Sever M.L., Zeldin D.C. Indoor allergens in school and day care environments. JAllergy Clin Immunol 2009, 124:185-192.
48. Arbes S.J., Gergen P.J., Elliott L., et al. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. JAllergy Clin Immunol 2005, 116:377-383.
49. Stevenson L.A., Gergen P.J., Hoover D.R., et al. Sociodemographic correlates of indoor allergen sensitivity among United States children. JAllergy Clin Immunol 2001, 108:747-752.
50. Northridge J., Ramirez O.F., Stingone J.A., et al. The role of housing type and housing quality in urban children with asthma. JUrban Health 2010, 87:211-224.
51. Rosenfeld L., Rudd R., Chew G.L., et al. Are neighborhood-level characteristics associated with indoor allergens in the household?. JAsthma 2010, 47:66-75.
52. Olmedo O., Goldstein I.F., Acosta L., et al. Neighborhood differences in exposure and sensitization to cockroach, mouse, dust mite, cat, and dog allergens in New York City. JAllergy Clin Immunol 2011, 128:284-292.
53. Diette G.B., Hansel N.N., Buckley T.J., et al. Home indoor pollutant exposures among inner-city children with and without asthma. Environ Health Perspect 2007, 115:1665-1669.
54. Vesper S., Barnes C., Ciaccio C.E., et al. Higher environmental relative moldiness index (ERMI) values measured in homes of asthmatic children in Boston, Kansas City, and San Diego. JAsthma 2013, 50:155-161.
55. Akinbami L.J., Kit B.K., Simon A.E. Impact of environmental tobacco smoke on children with asthma, United States, 2003-2010. Acad Pediatr 2013, 13:508-516.
56. Chilmonczyk B.A., Salmun L.M., Megathlin K.N., et al. Association between exposure to environmental tobacco smoke and exacerbations of asthma in children. NEngl J Med 1993, 328:1665-1669.
57. National Center for Health Statistics. Health, United States, 2012: with special feature on emergency care. Hyattsville (MD): 2013.
58. Kit B.K., Simon A.E., Brody D.J., et al. US prevalence and trends in tobacco smoke exposure among children and adolescents with asthma. Pediatrics 2013, 131:407-414.
59. Butz A.M., Halterman J.S., Bellin M., et al. Factors associated with second-hand smoke exposure in young inner-city children with asthma. JAsthma 2011, 48:449-457.
60. Belanger K., Gent J.F., Triche E.W., et al. Association of indoor nitrogen dioxide exposure with respiratory symptoms in children with asthma. Am J Respir Crit Care Med 2006, 173:297-303.
61. Kattan M., Gergen P.J., Eggleston P., et al. Health effects of indoor nitrogen dioxide and passive smoking on urban asthmatic children. JAllergy Clin Immunol 2007, 120:618-624.
62. Akinbami L.J., Lynch C.D., Parker J.D., et al. The association between childhood asthma prevalence and monitored air pollutants in metropolitan areas, United States, 2001-2004. Environ Res 2010, 110:294-301.
63. Gasana J., Dillikar D., Mendy A., et al. Motor vehicle air pollution and asthma in children: a meta-analysis. Environ Res 2012, 117:36-45.
64. Nishimura K.K., Galanter J.M., Roth L.A., et al. Early-life air pollution and asthma risk in minority children. The GALA II and SAGE II studies. Am J Respir Crit Care Med 2013, 188:309-318.
65. Li S., Batterman S., Wasilevich E., et al. Asthma exacerbation and proximity of residence to major roads: a population-based matched case-control study among the pediatric Medicaid population in Detroit, Michigan. Environ Health 2011, 10:34.
66. Patel M.M., Quinn J.W., Jung K.H., et al. Traffic density and stationary sources of air pollution associated with wheeze, asthma, and immunoglobulin E from birth to age 5 years among New York City children. Environ Res 2011, 111:1222-1229.
67. Juhn Y.J., Qin R., Urm S., et al. The influence of neighborhood environment on the incidence of childhood asthma: a propensity score approach. JAllergy Clin Immunol 2010, 125:838-843.
68. Perzanowski M.S., Chew G.L., Divjan A., et al. Early-life cockroach allergen and polycyclic aromatic hydrocarbon exposures predict cockroach sensitization among inner-city children. JAllergy Clin Immunol 2013, 131:886-893.
69. Ruffin J. Arenewed commitment to environmental justice in health disparities research. Am J Public Health 2011, 101(Suppl 1):S12-S14.
70. Cureton S. Environmental victims: environmental injustice issues that threaten the health of children living in poverty. Rev Environ Health 2011, 26:141-147.
71. Boehmer T.K., Foster S.L., Henry J.R., et al. Residential proximity to major highways-United States, 2010. MMWR Surveill Summ 2013, 62(Suppl 3):46-50.
72. Iqbal S., Oraka E., Chew G.L., et al. Association between birthplace and current asthma: the role of environment and acculturation. Am J Public Health 2014, 104(Suppl 1):S175-S182.
73. Belamarich P.F., Luder E., Kattan M., et al. Do obese inner-city children with asthma have more symptoms than nonobese children with asthma?. Pediatrics 2000, 106:1436-1441.
74. Kattan M., Kumar R., Bloomberg G.R., et al. Asthma control, adiposity, and adipokines among inner-city adolescents. JAllergy Clin Immunol 2010, 125:584-592.
75. Jensen M.E., Gibson P.G., Collins C.E., et al. Diet-induced weight loss in obese children with asthma: a randomized controlled trial. Clin Exp Allergy 2013, 43:775-784.
76. Gessner B.D., Chimonas M.A. Asthma is associated with preterm birth but not with small for gestational age status among a population-based cohort of Medicaid-enrolled children <10 years of age. Thorax 2007, 62:231-236.
77. Svanes C., Omenaas E., Heuch J.M., et al. Birth characteristics and asthma symptoms in young adults: results from a population-based cohort study in Norway. Eur Respir J 1998, 12:1366-1370.
78. Joseph C.L., Ownby D.R., Peterson E.L., et al. Does low birth weight help to explain the increased prevalence of asthma among African-Americans?. Ann Allergy Asthma Immunol 2002, 88:507-512.
79. Crump C., Winkleby M.A., Sundquist J., et al. Risk of asthma in young adults who were born preterm: a Swedish National Cohort Study. Pediatrics 2011, 127:e913-e920.
80. Martin J.A., Hamilton B.E., Osterman M.J., et al. Births: final data for 2012. Natl Vital Stat Rep 2013, 62(9):1-87.
81. Weil C.M., Wade S.L., Bauman L.J., et al. The relationship between psychosocial factors and asthma morbidity in inner-city children with asthma. Pediatrics 1999, 104:1274-1280.
82. Bartlett S.J., Kolodner K., Butz A.M., et al. Maternal depressive symptoms and emergency department use among inner-city children with asthma. Arch Pediatr Adolesc Med 2001, 155:347-353.
83. Wood R.A., Bloomberg G.R., Kattan M., et al. Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban Environment and Childhood Asthma study). JAllergy Clin Immunol 2011, 127:913-919.
84. Evans R., Gergen P.J., Mitchell H., et al. Arandomized clinical trial to reduce asthma morbidity among inner-city children: results of the National Cooperative Inner-City Asthma Study. JPediatr 1999, 135:332-338.
85. Bruzzese J.M., Sheares B.J., Vincent E.J., et al. Effects of a school-based intervention for urban adolescents with asthma. A controlled trial. Am J Respir Crit Care Med 2011, 183:998-1006.
86. Halterman J.S., Szilagyi P.G., Fisher S.G., et al. Randomized controlled trial to improve care for urban children with asthma: results of the School-Based Asthma Therapy trial. Arch Pediatr Adolesc Med 2011, 165:262-268.
87. Flores G., Bridon C., Torres S., et al. Improving asthma outcomes in minority children: a randomized, controlled trial of parent mentors. Pediatrics 2009, 124:1522-1532.
88. Gergen P.J., Mortimer K.M., Eggleston P.A., et al. Results of the National Cooperative Inner-City Asthma Study (NCICAS) environmental intervention to reduce cockroach allergen exposure in inner-city homes. JAllergy Clin Immunol 1999, 103:501-506.
89. Morgan W.J., Crain E.F., Gruchalla R.S., et al. Results of a home-based environmental intervention among urban children with asthma. NEngl J Med 2004, 351:1068-1080.
90. Breysse J., Dixon S., Gregory J., et al. Effect of weatherization combined with community health worker in-home education on asthma control. Am J Public Health 2014, 104:e57-e64.
91. Takaro T.K., Krieger J., Song L., et al. The breathe-easy home: the impact of asthma-friendly home construction on clinical outcomes and trigger exposure. Am J Public Health 2011, 101:55-62.
92. Butz A.M., Tsoukleris M.G., Donithan M., et al. Effectiveness of nebulizer use-targeted asthma education on underserved children with asthma. Arch Pediatr Adolesc Med 2006, 160:622-628.
93. Lanphear B.P., Hornung R.W., Khoury J., et al. Effects of HEPA air cleaners on unscheduled asthma visits and asthma symptoms for children exposed to secondhand tobacco smoke. Pediatrics 2011, 127:93-101.
94. Joseph C.L., Havstad S.L., Johnson D., et al. Factors associated with nonresponse to a computer-tailored asthma management program for urban adolescents with asthma. JAsthma 2010, 47:667-673.
95. Busse W.W., Morgan W.J., Gergen P.J., et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. NEngl J Med 2011, 364:1005-1015.