Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury

Experimental and Therapeutic Medicine

Volumn 11, Issue 5, 2016, Pages 1955-1960

  Deng, Wen Sheng ^a   Xu, Qing ^a   Liu, Ye ^a   Jiang, Chun Hui ^a   Zhou, Hong ^a   Gu, Lei ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Lipid peroxidation; Liver function; Liver ischemia reperfusion injury; Melatonin

Indexed keywords

GLUTATHIONE; MALONALDEHYDE; MELATONIN; SUPEROXIDE DISMUTASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; COLORIMETRY; CONTROLLED STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION ASSAY; LIVER FUNCTION; LIVER ISCHEMIA; MALE; NONHUMAN; PROTEIN CONTENT; RAT; REPERFUSION INJURY; ULTRAVIOLET SPECTROPHOTOMETRY; VASCULAR CLAMP;

EID: 84961775842     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2016.3160     Document Type: Article

References (34)

1. Ebrahimkhani MR, Daneshmand A, Mazumder A, Allocca M, Calvo JA, Abolhassani N, Jhun I, Muthupalani S, Ayata C and Samson LD: Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney. Proc Natl Acad Sci USA 111: E4878-E4886, 2014.
2. Rao J, Qin J, Qian X, Lu L, Wang P, Wu Z, Zhai Y, Zhang F, Li G and Wang X: Lipopolysaccharide preconditioning protects hepatocytes from ischemia/reperfusion injury (IRI) through inhibiting ATF4-CHOP pathway in mice. PLoS One 8: e65568, 2013.
3. García JJ, López-Pingarrón L, Almeida-Souza P, Tres A, Escudero P, García-Gil FA, Tan DX, Reiter RJ, Ramírez JM and Bernal-Pérez M: Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: A review. J Pineal Res 56: 225-237, 2014.
4. Acuña-Castroviejo D, Escames G, Venegas C, Díaz-Casado ME, Lima-Cabello E, López LC, Rosales-Corral S, Tan DX and Reiter RJ: Extrapineal melatonin: Sources, regulation, and potential functions. Cell Mol Life Sci 71: 2997-3025, 2014.
5. Martins PN and Markmann JF: Age-related differences in hepatic ischemia/reperfusion: Gene activation, liver injury, and protective effect of melatonin. J Surg Res 85: e19-e21, 2013.
6. Frich L, Mala T and Gladhaug IP: Hepatic radiofrequency ablation using perfusion electrodes in a pig model: Effect of the Pringle manoeuvre. Eur J Surg Oncol 32: 527-532, 2006.
7. Koh PO: Melatonin prevents hepatic injury-induced decrease in Akt downstream targets phosphorylations. J Pineal Res 51: 214-219, 2011.
8. Aydogan MS, Erdogan MA, Polat A, Yücel A, Ozgül U, Parlakpinar H, Duran ZR, Yildiz A and Durmus M: Protective effects of melatonin and β-d-glucan against liver injury in rats - a comparative study. Adv Clin Exp Med 22: 621-627, 2012.
9. Kireev R, Bitoun S, Cuesta S, Tejerina A, Ibarrola C, Moreno E, Vara E and Tresguerres JA: Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis. Eur J Pharmacol 701: 185-193, 2013.
10. Kireev RA, Cuesta S, Ibarrola C, Bela T, Gonzalez EM, Vara E and Tresguerres JA: Age-related differences in hepatic ischemia/reperfusion: Gene activation, liver injury, and protective effect of melatonin. J Surg Res 178: 922-934, 2012.
11. Kang JW and Lee SM: Melatonin inhibits type 1 interferon signaling of toll-like receptor 4 via heme oxygenase-1 induction in hepatic ischemia/reperfusion. J Pineal Res 53: 67-76, 2012.
12. Kang JW, Koh EJ and Lee SM: Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway. J Pineal Res 50: 403-411, 2011.
13. Selvam NT, Venkatakrishnan V, Dhamodharan R, Murugesan S and Kumar SD: Hepatoprotective activity of methanolic extract of Syzygium jambos (Linn.) leaf against paracetamol intoxicated Wistar albino rats. Ayu 34: 305-308, 2013.
14. Jin LM, Jin SF, Liu YX, Zhou L, Xie HY, Yan S, Xu X and Zheng SS: Ischemic preconditioning enhances hepatocyte proliferation in the early phase after ischemia under hemi-hepatectomy in rats. Hepatobiliary Pancreat Dis Int 11: 521-526, 2012.
15. Pires KM, Lanzetti M, Rueff-Barroso CR, Castro P, Abrahão A, Koatz VL, Valença SS and Porto LC: Oxidative damage in alveolar macrophages exposed to cigarette smoke extract and participation of nitric oxide in redox balance. Toxicol In Vitro 26: 791-798, 2012.
16. Papadopoulos D, Siempis T, Theodorakou E and Tsoulfas G: Hepatic ischemia and reperfusion injury and trauma: Current concepts. Arch Trauma Res 2: 63-70, 2013.
17. Peralta C, Jiménez-Castro MB and Gracia-Sancho J: Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu. J Hepatol 59: 1094-1106, 2013
18. Jaeschke H and Woolbright BL: Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species. Transplant Rev (Orlando) 26: 103-114, 2012.
19. Jaeschke H: Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol 284: G15-G26, 2003.
20. Mendes-Braz M, Elias-Miró M, Jiménez-Castro MB, Casillas-Ramírez A, Ramalho FS and Peralta C: The current state of knowledge of hepatic ischemia-reperfusion injury based on its study in experimental models. J Biomed Biotechnol 2012: 298657, 2012.
21. Bai J, Dong L, Song Z, Ge H, Cai X, Wang G and Liu P: The role of melatonin as an antioxidant in human lens epithelial cells. Free Radic Res 47: 635-642, 2013.
22. Vishwas DK, Mukherjee A, Haldar C, Dash D and Nayak MK: Improvement of oxidative stress and immunity by melatonin: An age dependent study in golden hamster. Exp Gerontol 48: 168-182, 2013.
23. Bandyopadhyay D, Biswas K, Bandyopadhyay U, Reiter RJ and Banerjee RK: Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical. J Pineal Res 29: 143-151, 2000.
24. Dominguez-Rodriguez A and Abreu-Gonzalez P: Myocardial ischemia-reperfusion injury: Possible role of melatonin. World J Cardiol 2: 233-236, 2010.
25. Elias-Miró M, Jiménez-Castro MB, Rodés J and Peralta C: Current knowledge on oxidative stress in hepatic ischemia/reperfusion. Free Radic Res 47: 555-568, 2013.
26. van Golen RF, van Gulik TM and Heger M. Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia/reperfusion injury. Free Radic Biol Med 52: 1382-1402, 2012.
27. Palladini G, Ferrigno A, Rizzo V, Tarantola E, Bertone V, Freitas I, Perlini S, Richelmi P and Vairetti M: Lung matrix metalloproteinase activation following partial hepatic ischemia/reperfusion injury in rats. ScientificWorldJournal 2014: 867548, 2014.
28. Parlaktas BS, Atilgan D, Ozyurt H, Gencten Y, Akbas A, Erdemir F and Uluocak N: The biochemical effects of ischemia-reperfusion injury in the ipsilateral and contralateral testes of rats and the protective role of melatonin. Asian J Androl 16: 314-318, 2014.
29. Kerem H, Akdemir O, Ates U, Uyanıkgıl Y, Demırel Sezer E, Bılkay U, Turgut M, Sozmen E and Songur E: The effect of melatonin on a dorsal skin flap model. J Invest Surg 27: 57-64 2014.
30. Ortiz F, García J A, Acuña-Castroviejo D, Doerrier C, López A, Venegas C, Volt H, Luna-Sánchez M, López LC and Escames G: The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: Inhibition of iNOS and preservation of nNOS. J Pineal Res 56: 71-81, 2014.
31. Hernández-Esquivel L, Pavón N, Buelna-Chontal M, González-Pacheco H, Belmont J and Chávez E: Citicoline (CDP-choline) protects myocardium from ischemia/reperfusion injury via inhibiting mitochondrial permeability transition. Life Sci 96: 53-58, 2014.
32. Wang P, Yin L, Liang D, Li C, Ma F and Yue Z: Delayed senescence of apple leaves by exogenous melatonin treatment: Toward regulating the ascorbate-glutathione cycle. J Pineal Res 53: 11-20, 2012.
33. Reiter RJ, Tan DX, Manchester LC, and El-Sawi MR: Melatonin reduces oxidant damage and promotes mitochondrial respiration: Implications for aging. Ann NY Acad Sci 959: 238-250, 2002.
34. Lhuillier F, Parmantier P, Goudable J, Crova P, Delafosse B, Annat G, Cespuglio R and Viale JP: Hepatic ischemia is associated with an increase in liver parenchyma nitric oxide that is in part enzyme-independent. Anesthesiology 98: 373-378, 2003.