New Dendrimer-Based Nanoparticles Enhance Curcumin Solubility

Planta Medica

Volumn 83, Issue 5, 2017, Pages 420-425

  Falconieri, Maria Cristina ^a   Adamo, Mauro ^b   Monasterolo, Claudio ^b   Bergonzi, Maria Camilla ^a   Coronnello, Marcella ^a   Bilia, Anna Rita ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

Curcuma longa; curcumin; new polyamidoamine dendrimer based spherical nanoparticles; solubility; Zingiberaceae

Indexed keywords

CURCUMIN; DENDRIMER; NANOCARRIER; POLYAMIDOAMINE; DELAYED RELEASE FORMULATION; NANOPARTICLE; PLANT EXTRACT; TURMERIC EXTRACT;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CURCUMA LONGA; DISPERSITY; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; FEMALE; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; MCF-7 CELL LINE; MICHAEL ADDITION; NANOENCAPSULATION; NANOPHARMACEUTICS; PARTICLE SIZE; POLYMERIZATION; CHEMISTRY; CHEMOPROPHYLAXIS; CURCUMA; DELAYED RELEASE FORMULATION; SOLUBILITY; TOXICITY; TUMOR CELL LINE;

CELL LINE, TUMOR; CHEMOPREVENTION; CURCUMA; DELAYED-ACTION PREPARATIONS; DENDRIMERS; HUMANS; NANOPARTICLES; PLANT EXTRACTS; SOLUBILITY;

EID: 84961625696     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0042-103161     Document Type: Article

References (20)

1. Ammon H P Wahl M A Pharmacology of Curcuma longa Planta Med 1991 57 1 7
2. Pescosolido N Giannotti R Plateroti A M Pascarella A Nebbioso M Curcumin: therapeutical potential in ophthalmology Planta Med 2014 80 249 254
3. Kim M H Kim S H Yang W M Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimerʼs disease Planta Med 2014 80 1249 1258
4. Sandur S K Pandey M K Sung B Ahn K S Murakami A Sethi G Limtrakul P Badmaev V Aggarwal B B Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and tumerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-indipendent mechanism Carcinogenesis 2007 28 1765 1773
5. Sharma R A Steward W P Gescher A J Pharmacokinetics and pharmacodynamics of curcumin Adv Exp Med Biol 2007 595 453 470
6. Isacchi B Bergonzi M C Grazioso M Righeschi C Pietretti A Severini C Bilia A R Artemisinin and artemisinin plus curcumin liposomal formulations: enhanced antimalarial efficacy against Plasmodium berghei-infected mice Eur J Pharm Biopharm 2012 80 528 534
7. Lapenna S Bilia A R Morris G A Nilsson M Novel artemisinin and curcumin micellar formulations: drug solubility studies by NMR spectroscopy J Pharm Sci 2009 98 3666 3675
8. Tahmasebi Mirgani M Isacchi B Sadeghizadeh M Marra F Bilia A R Mowla S J Najafi F Babaei E Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells Int J Nanomedicine 2014 9 403 417
9. Bergonzi M C Hamdouch R Mazzacuva F Isacchi B Bilia A R Optimization, characterization and in vitro evaluation of curcumin microemulsions LWT-Food Sci Technol 2014 59 148 155
10. Righeschi C Bergonzi M C Isacchi B Bilia A R Solid lipid nanoparticles for oral delivery of curcumin Planta Med 2013 79 PN14
11. Bergonzi M C Righeschi C Guccione C Bilia A R Lipid nanovectors for oral delivery of curcumin and evaluation of their performance through PAMPA systems Planta Med 2014 80 P2N4
12. Mazzacuva F Guidelli G Bergonzi M C Bilia A R Enhanced water solubility and stability of curcumin by microinclusion in natural and semi-synthetic cyclodextrins Planta Med 2011 77 PK9
13. Kolhe P Khandare J Pillai O Kannan S Lieh-Lai M Kannan R M Preparation, cellular transport and activity of polyamidoamine-based dendritic nanodevices with a high drug payload Biomaterials 2006 27 660 669
14. Mollazade M Nejati-Koshki K Akbarzadeh A Zarghami N Nasiri M Jahanban-Esfahlan R Alibakhshi A PAMAM dendrimers augment inhibitory effects of curcumin on cancer cell proliferation: possible inhibition of telomerase Asian Pac J Cancer Prev 2013 14 6925 6928
15. Cao J Zhang H Wang Y Yang J Jiang F Investigation on the interaction behavior between curcumin and PAMAM dendrimer by spectral and docking studies Spectrochim Acta A Mol Biomol Spectrosc 2013 108 251 255
16. Abderrezak A Bourassa P Mandeville J S Sedaghat-Herati R Tajmir-Riahi H A Dendrimers bind antioxidant polyphenols and cisplatin drug PLoS One 2012 7 e33102
17. Shi W Dolai S Rizk S Hussain A Tariq H Averick S LʼAmoreaux W El Idrissi A Banerjee P Raja K Synthesis of monofunctional curcumin derivatives, clicked curcumin dimer, and a PAMAM dendrimer curcumin conjugate for therapeutic applications Org Lett 2007 9 5461 5464
18. Fant K Esbjörner E K Jenkins A Grossel M C Lincoln P Nordén B Effects of PEGylation and acetylation of PAMAM dendrimers on DNA binding, cytotoxicity and in vitro transfection efficiency Mol Pharm 2010 7 1734 1746
19. Tianzhu Y Liu X Bolcato-Bellemin A Wang Y Liu C Erbacher P Qu F Rocchi P Behr J Peng L An amphiphilic dendrimer for effective delivery of small interfering RNA and gene silencing in vitro and in vivo Angew Chem Int Ed Engl 2012 5 8478 8484
20. Skehan P Storeng R Scudiero D Monks A McMahon J Vistica D Warren J T Bokesch H Kenney S Boyd M R New colorimetric cytotoxicity assay for anticancer-drug screening J Natl Cancer Inst 1990 82 1107 1112