Artemisinin and artemisinin plus curcumin liposomal formulations: Enhanced antimalarial efficacy against Plasmodium berghei-infected mice

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 80, Issue 3, 2012, Pages 528-534

  Isacchi, Benedetta ^a   Bergonzi, Maria Camilla ^a   Grazioso, Margherita ^a   Righeschi, Chiara ^a   Pietretti, Alessia ^b   Severini, Carlo ^b   Bilia, Anna Rita ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Antimalarial efficacy; Artemisinin; Conventional and PEGylated liposomes; Curcumin; Plasmodium berghei; Stability

Indexed keywords

ARTEMISININ; CURCUMIN; DRUG CARRIER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG FORMULATION; DRUG STABILITY; ENCAPSULATION; FEMALE; LIFE CYCLE; LIPOSOMAL DELIVERY; MONOTHERAPY; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PLASMODIUM BERGHEI INFECTION;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CHEMISTRY, PHARMACEUTICAL; CURCUMIN; DRUG CARRIERS; DRUG STABILITY; DRUG THERAPY, COMBINATION; FEMALE; LIPOSOMES; MALARIA; MICE; MICE, INBRED BALB C; NANOPARTICLES; PARTICLE SIZE; PLASMODIUM BERGHEI; POLYETHYLENE GLYCOLS;

EID: 84858155431     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.11.015     Document Type: Article

References (28)

1. World Health Organization, 2008. World Malaria Report WHO/HTM/GMP/2008.1. WHO, Geneva.
2. World Health Organization, 2006. Guidelines for the Treatment of Malaria (1st ed.). World Malaria Report WHO/HTM/MAL/2006.1108. WHO, Geneva.
3. F. Nosten, and N.J. White Artemisinin-based combination treatment of falciparum malaria Am. J. Trop. Med. Hyg. 77 6 2007 181 192
4. A. Ogbonna, and C. Uneke Artemisinin-based combination therapy for uncomplicated malaria in sub-Saharan Africa: the efficacy, safety, resistance and policy implementation since Abuja 2000 Trans. Roy. Soc. Trop. Med. Hyg. 102 7 2008 621 627
5. P.B. Bloland A contrarian view of malaria therapy policy in Africa Am. J. Trop. Med. Hyg. 68 2 2003 125 126 (Pubitemid 38240532)
6. Y. Chen, L. Xianfu, P. Hyunjin, and R. Greever Study of artemisinin nanocapsules as anticancer drug delivery systems Nanomedicine 5 2009 316 322
7. D.L. Klaiman Quinghaosu (artemisinin): an antimalarial drug from China Science 228 1985 1049 1055
8. B. Isacchi, S. Arrigucci, G. la Marca, M.C. Bergonzi, M.G. Vannucchi, A. Novelli, and A.R. Bilia Conventional and long-circulating liposomes of artemisinin: preparation, characterization, and pharmacokinetic profile in mice J. Lipos. Res. 2011 1 8
9. R.C. Reddy, P.G. Vatsala, V.G. Keshamouni, G. Padmanaban, and P.N. Rangarajan Curcumin for malaria therapy Biochem. Biophys. Res. Commun. 326 2005 472 474 (Pubitemid 39593570)
10. D.N. Nandakumar, V.A. Nagaraj, P.G. Vathsala, P. Rangarajan, and G. Padmanaban Curcumin-artemisinin combination therapy for malaria Antimicrob. Agents Chemot. 50 2006 1859 1860
11. G. Shoba, D. Joy, T. Joseph, M. Majeed, R. Rajendran, and P.S. Srinivas Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers Planta Med. 64 1998 353 356 (Pubitemid 28234275)
12. P. Anand, A.B. Kunnumakkara, R.A. Newman, and B.B. Aggarwal Bioavailability of curcumin: problems and promises Mol. Pharmacol. 4 2007 807 818
13. H. Pinto-Alphandary, A. Andremont, and P. Couvreur Targeted delivery of antibiotics using liposomes and nanoparticles: research and applications Int. J. Antimicrob. Agents 13 2000 155 168
14. E. Cauchetier, M. Paul, D. Rivollet, H. Fessi, A. Astier, and M. Deniaiu Therapeutic evaluation of free and nanocapsule-encapsulated atovaquone in the treatment of murine visceral leishmaniasis Ann. Trop. Med. Parasitol. 97 2003 259 268 (Pubitemid 36606358)
15. V.C. Mosqueira, P.M. Loiseau, C. Bories, P. Legrand, J.P. Devissaguet, and G. Barrat Efficacy and pharmacokinetics of intravenous nanocapsule formulations of halofantrine in Plasmodium berghei-infected mice Antimicrob. Agents Chemother. 48 2004 1222 1228 (Pubitemid 38405476)
16. M. Gabriels, and J. Plaizier-Vercammen Physical and chemical evaluation of liposomes, containing artesunate J. Pharm. Biomed. Anal. 31 4 2003 655 667 (Pubitemid 36315707)
17. B. Chimanuka, M. Gabriëls, M.R. Detaevernier, and J.A. Plaizier-Vercammen Preparation of beta-artemether liposomes, their HPLC-UV evaluation and relevance for clearing recrudescent parasitaemia in Plasmodium chabaudi malaria infected mice J. Pharm. Biomed. Anal. 28 1 2002 13 22 (Pubitemid 34171642)
18. R. Carter, and C.L. Diggs Plasmodium of rodents J.P. Kreier, Parasitic Protozoa vol. 3 1977 Academic Press New York, NY 359 465
19. A.D. Bangham, M.M. Standish, and J.C. Watkins Diffusion of univalent ions across the lamellae of swollen phospholipids J. Mol. Biol. 13 1965 238 252
20. B. Gumbede, P. Folb, and B. Ryffel Oral artesunate prevents Plasmodium berghei Anka infection in mice Parasitol. Int. 52 2003 53 59 (Pubitemid 36110521)
21. D.J. Knight, and W. Peters The antimalarial action of N-benzyloxy dihydrotriazines. The action of cycolguanil (BRL50216) against rodent malaria and studies on its mode of action Ann. Trop. Med. Parasitol. 74 1980 393 404 (Pubitemid 11224160)
22. L. Tona, K. Mesia, N.P. Ngimbi, B. Chrimwami, Okond'ahoka, K. Cimanga, T. De Bruyne, S. Apers, N. Hermans, J. Totte, L. Peters, and A.J. Vlietinck In vivo antimalarial activity of Cassia occindentalis, Morinda morindoides and Phyllanthus niruri Ann. Trop. Med. Parasitol. 95 2001 47 57 (Pubitemid 32178732)
23. L.H. Carvalho, M.G.L. Brandão, D. Santos-Filho, J.L.C. Lopes, and A.U. Krettli Antimalarial activity of crude extracts from Brazilian plants studied in vivo in Plasmodium berghei-infected mice and in vitro against Plasmodium falciparum in culture Braz. J. Med. Biol. Res. 24 1991 1113 1123
24. C. Sinico, C. Caddeo, D. Valenti, A.M. Fadda, A.R. Bilia, and F.F. Vincieri Liposomes as carriers for verbascoside: stability and skin permeation studies J. Lipos. Res. 18 2008 83 90 (Pubitemid 351414948)
25. A. Martinelli, L.A. Rodrigues, and P. Cravo Plasmodium chabaudi: efficacy of artemisinin + curcumin combination treatment on a clone selected for artemisinin resistance in mice Exp. Parasitol. 199 2008 304 307
26. J.W. Wong, K.H. Yuen, S. Nagappan, W.S. Shahul, S.S. David Ho, E.K. Gan, and W.T. Toh Therapeutic equivalence of a low dose artemisinin formulation in falciparum malaria patients J. Pharm. Pharmacol. 55 2003 193 198 (Pubitemid 36277756)
27. Qinghaosu Antimalaria Coordinating Research Group, Antimalarial studies on qinghaosu. Chinese Medical Journal, 92 (1979) 811-816.
28. S.R. Meshnick Artemisinin antimalarials mechanism of action and resistance Med. Trop. 58 1998 13 17 (Pubitemid 128707811)