Oral oxycodone for pain after caesarean section: A randomized comparison with nurse-administered IV morphine in a pragmatic study

Scandinavian Journal of Pain

Volumn 7, Issue , 2015, Pages 17-24

  Niklasson, Boel ^a,b   Arnelo, Catarina ^a   Georgsson Öhman, Susanne ^b,c   Segerdahl, Märta ^c   Blanck, Agneta ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SOPHIAHEMMET UNIVERSITY COLLEGE   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Caesarean section; Codeine; Multimodal treatment; Newborn; Oxycodone; Postoperative pain

Indexed keywords

CODEINE; HEXOBARBITAL; IBUPROFEN; MORPHINE; OXYCODONE; PARACETAMOL; NARCOTIC ANALGESIC AGENT;

ACIDOSIS; ADAPTATION SYNDROME; ADULT; APGAR SCORE; ARTICLE; CESAREAN SECTION; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DIZZINESS; DRUG BIOAVAILABILITY; DRUG SAFETY; DRUG USE; FATIGUE; FEMALE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; NAUSEA; NEUROLOGIC EXAMINATION; NEUROLOGICAL ADAPTIVE CAPACITY SCORE; OPEN STUDY; PAIN ASSESSMENT; PAIN INTENSITY; PALPATION; PARALLEL DESIGN; PATIENT SAFETY; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PRURITUS; PULMONARY ADAPTATION SYNDROME; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; REST; SPINAL ANESTHESIA; TREATMENT DURATION; WEIGHT REDUCTION; COMPARATIVE STUDY; ELECTIVE SURGERY; FOLLOW UP; INTRAVENOUS DRUG ADMINISTRATION; NEWBORN; NURSE; ORAL DRUG ADMINISTRATION; PAIN MEASUREMENT; TREATMENT OUTCOME; YOUNG ADULT;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ADULT; ANALGESICS, OPIOID; CESAREAN SECTION; ELECTIVE SURGICAL PROCEDURES; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT, NEWBORN; MORPHINE; NURSES; OXYCODONE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84961344227     PISSN: 18778860     EISSN: 18778879     Source Type: Journal    
DOI: 10.1016/j.sjpain.2015.01.003     Document Type: Article

References (30)

1. Karlstrom A., Engstrom-Olofsson R., Norbergh K.G., Sjoling M., Hildingsson I. Postoperative pain after cesarean birth affects breastfeeding and infant care. J Obstet Gynecol Neonatal Nurs 2007, 36:430-440.
2. Apfelbaum J.L., Chen C., Mehta S.S., Gan T.J. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg 2003, 97:534-540. [table of contents].
3. Kuczkowski K.M. Postoperative pain control in the parturient: new challenges in the new millennium. J Matern Fetal Neonatal Med 2011, 24:301-304.
4. Aiono-Le Tagaloa L., Butwick A.J., Carvalho B. A survey of perioperative and postoperative anesthetic practices for cesarean delivery. Anesthesiol Res Pract 2009, 2009:510642.
5. Lavoie A., Toledo P. Multimodal postcesarean delivery analgesia. Clin Perinatol 2013, 40:443-455.
6. Toms L., Derry S., Moore R.A., McQuay H.J. Single dose oral paracetamol (acetaminophen) with codeine for postoperative pain in adults. Cochrane Database Syst Rev 2009, CD001547.
7. Kehlet H., Wilmore D.W. Multimodal strategies to improve surgical outcome. Am J Surg 2002, 183:630-641.
8. Buvanendran A., Kroin J.S. Multimodal analgesia for controlling acute postoperative pain. Curr Opin Anaesthesiol 2009, 22:588-593.
9. Snell P., Hicks C. An exploratory study in the UK of the effectiveness of three different pain management regimens for post-caesarean section women. Midwifery 2006, 22:249-261.
10. Kirchheiner J., Schmidt H., Tzvetkov M., Keulen J.T., Lotsch J., Roots I., Brockmoller J. Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. Pharmacogenomics J 2007, 7:257-265.
11. Ingelman-Sundberg M. Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J 2005, 5:6-13.
12. Madadi P.R.C., Hayden M.R., Carleton B.C., Gaedigk A., Leeder J.S., Koren G. Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin Pharmacol Ther 2009, 85:31-35.
13. Koren G., Cairns J., Chitayat D., Gaedigk A., Leeder S.J. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet 2006, 368:704.
14. Kalso E., Vainio A. Morphine and oxycodone hydrochloride in the management of cancer pain. Clin Pharmacol Ther 1990, 47:639-646.
15. Lauretti G.R., Oliveira G.M., Pereira N.L. Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients. Br J Cancer 2003, 89:2027-2030.
16. Kalso E.V.A. Morphine and oxycodone hydrochloride in the management of cancer pain. Clin Pharmacol Ther 1990, 47:639-646.
17. Seaton S., Reeves M., McLean S. Oxycodone as a component of multimodal analgesia for lactating mothers after caesarean section: relationships between maternal plasma, breast milk and neonatal plasma levels. Aust N Z J Obstet Gynaecol 2007, 47:181-185.
18. McPherson M. Demystifying opoid conversion calculations: a guide for effective dosing 2009, American Society of Health-System Pharmacists, USA.
19. Amiel-Tison C., Barrier G., Shnider S.M., Levinson G., Hughes S.C., Stefani S.J. A new neurologic and adaptive capacity scoring system for evaluating obstetric medications in full-term newborns. Anesthesiology 1982, 56:340-350.
20. Lenz H., Sandvik L., Qvigstad E., Bjerkelund C.E., Raeder J. A comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy. Anesth Analg 2009, 109:1279-1283.
21. Gaskell H., Derry S., Moore R.A., McQuay H.J. Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults. Cochrane Database Syst Rev 2009, CD002763.
22. Heiskanen T., Kalso E. Controlled-release oxycodone and morphine in cancer related pain. Pain 1997, 73:37-45.
23. Kantor T.G., Hopper M., Laska E. Adverse effects of commonly ordered oral narcotics. J Clin Pharmacol 1981, 21:1-8.
24. Davis K.M., Esposito M.A., Meyer B.A. Oral analgesia compared with intravenous patient-controlled analgesia for pain after cesarean delivery: a randomized controlled trial. Am J Obstet Gynecol 2006, 194:967-971.
25. Halpern S.H., Littleford J.A., Brockhurst N.J., Youngs P.J., Malik N., Owen H.C. The neurologic and adaptive capacity score is not a reliable method of newborn evaluation. Anesthesiology 2001, 94:958-962.
26. Lam J., Kelly L., Ciszkowski C., Landsmeer M.L., Nauta M., Carleton B.C., Hayden M.R., Madadi P., Koren G. Central nervous system depression of neonates breastfed by mothers receiving oxycodone for postpartum analgesia. J Pediatr 2012, 160. 33-7.e2.
27. Rivers C.M., Olsen D., Nelson L.S. Breastfeeding and oxycodone. J Pediatr 2012, 161:174. [author reply 174].
28. van den Anker J.N. Is it safe to use opioids for obstetric pain while breastfeeding?. J Pediatr 2012, 160:4-5.
29. Ito S. Drug therapy for breast-feeding women. N Engl J Med 2000, 343:118-126.
30. Evans K.C., Evans R.G., Royal R., Esterman A.J., James S.L. Effect of caesarean section on breast milk transfer to the normal term newborn over the first week of life. Arch Dis Child Fetal Neonatal Ed 2003, 88:F380-F382.