Oxycodone as a component of multimodal analgesia for lactating mothers after Caesarean section: Relationships between maternal plasma, breast milk and neonatal plasma levels

Australian and New Zealand Journal of Obstetrics and Gynaecology

Volumn 47, Issue 3, 2007, Pages 181-185

  Seaton, Suzette ^a   Reeves, Mark ^a   Mclean, Stuart ^b  

^a North West Regional Hospital   (Australia)

^b UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Breast milk; Caesarean section; Neonate; Oral analgesia; Oxycodone

Indexed keywords

DICLOFENAC; OXYCODONE; PARACETAMOL;

ADULT; ARTICLE; BREAST FEEDING; BREAST MILK; CESAREAN SECTION; DRUG BLOOD LEVEL; DRUG MILK LEVEL; DRUG SAFETY; FEMALE; HUMAN; INFANT; LACTATION; MALE; MATERNAL PLASMA; NEWBORN; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PRIORITY JOURNAL;

ADULT; ANALGESICS, OPIOID; CESAREAN SECTION; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INFANT, NEWBORN; MALE; MILK, HUMAN; OXYCODONE; PAIN; PREGNANCY;

EID: 34250309642     PISSN: 00048666     EISSN: 1479828X     Source Type: Journal    
DOI: 10.1111/j.1479-828X.2007.00715.x     Document Type: Article

References (21)

1. Nyman U, Hall O. Some varieties of Papaver somniferum L. with changed morphine alkaloid content. Hereditas 1976; 84: 69-76.
2. Mundipharma. Product information approved by the Therapeutic Goods Administration: Oxynorm. Australia, 17/4/2002.
3. Mundipharma. Product information approved by the Therapeutic Goods Administration: Oxycontin. Australia, 1/4/2005.
4. Sigma. Product information approved by the Therapeutic Goods Administration: Endone. Australia, 1/11/1996.
5. Davis KM, Esposito MA, Meyer BA. Oral analgesia compared with intravenous patient-controlled analgesia for pain after Cesarean delivery: A randomized controlled trial. Am J Obstet Gynecol 2006; 194: 967-971.
6. Spigset O, Hagg S. Analgesics and breast-feeding: Safety considerations. Paediatr Drugs 2000; 2: 223-238.
7. Ito S. Drug therapy for breast-feeding women. N Engl J Med 2000; 343: 118-126.
8. Micromedex. Drugdex Drug Evaluation -Oxycodone. Health Communication Network, 2006. [Accessed 10 October 2006.] Available from http://micromedex.hcn.net.au.
9. Ravin DS. Narcotic analgesics and breastfeeding. J Hum Lact 1995; 11: 47-50.
10. Pokela ML, Anttila E, Seppala T, Olkkola KT. Marked variation in oxycodone pharmacokinetics in infants. Paediatr Anaesth 2005; 15: 560-565.
11. Mundipharma. Product information approved by the Therapeutic Goods Administration: Oxynorm. Australia, 09/05/2005.
12. Marx CM, Pucino F, Carlson JD, Driscoll JW, Ruddock V. Oxycodone excretion in human milk in the puerperium [Abstract]. Drug Intell Clin Pharm 1986; 20: 474.
13. Poyhia R, Seppala T. Liposolubility and protein binding of oxycodone in vitro. Pharmacol Toxicol 1994; 74: 23-27.
14. Atkinson HC, Begg EJ, Darlow BA. Drugs in human milk: Clinical pharmacokinetic considerations. Clin Pharmacokinet 1998; 14: 217-240.
15. Olkkola KT, Hamunen K, Maunuksela E. Clinical pharmacokinetics and pharmacodynamics of opioid analgesics in infants and children. Clin Pharmacokinet 1995; 28: 385-404.
16. Edwards SR, Smith MT. Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2005; 814: 241-249.
17. Spencer JP, Gonzalez LS, Barnhart DJ. Medications in the breast-feeding mother. Am Fam Physician 2001; 64: 119-126.
18. Marks JM, Spatz DL. Medications and lactation: What PNPs need to know. J Pediatr Health Care 2003; 17: 311-317.
19. Hanley JA, Lippman-Hand A. If nothing goes wrong, is everything all right? Interpreting zero numerators. JAMA 1983; 249: 1743-1745.
20. Evans KC, Evans RG, Royal R, Esterman AJ, James SL. Effect of caesarean section on breast milk transfer to the normal term newborn over the first week of life. Arch Dis Child Fetal Neonatal Ed 2003; 88: 380.
21. Kemp CA, McDowell JM (eds). Paediatric Pharmacopoeia Royal Children's Hospital, 13th edn. Melbourne: Pharmacy Department, Royal Children's Hospital, 2002.