[89Zr]Oxinate4 for long-term in vivo cell tracking by positron emission tomography

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 42, Issue 2, 2015, Pages 278-287

  Charoenphun, Putthiporn ^a   Meszaros, Levente K ^a   Chuamsaamarkkee, Krisanat ^a   Sharif Paghaleh, Ehsan ^a   Ballinger, James R ^a   Ferris, Trevor J ^b   Went, Michael J ^b   Mullen, Gregory E D ^a   Blower, Philip J ^a,c  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

89Zr; Cell labelling; Cell tracking; Leukocyte labelling; PET

Indexed keywords

OXINATE 4 INDIUM 111; OXINATE 4 ZIRCONIUM 89; RADIOISOTOPE; UNCLASSIFIED DRUG; (89ZR)OXINATE(4); 8 QUINOLINOL; INDIUM OXINE; ORGANOMETALLIC COMPOUND; RADIOPHARMACEUTICAL AGENT; ZIRCONIUM;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL TRACKING; CELL VIABILITY; IN VIVO STUDY; ISOTOPE LABELING; LIVER CELL; MOUSE; NONHUMAN; PET-CT SCANNER; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; SPLEEN CELL; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; HUMAN; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; HUMANS; MICE; MICE, INBRED C57BL; ORGANOMETALLIC COMPOUNDS; OXYQUINOLINE; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; ZIRCONIUM;

EID: 84961291463     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-014-2945-x     Document Type: Article

References (43)

1. Segal AW, Arnot RN, Thakur ML, Lavender JP. Indium-111-labelled leucocytes for localisation of abscesses. Lancet 1976;2:1056–8.
2. Peters AM. A brief history of cell labelling. Q J Nucl Med Mol Imaging 2005;49:304–7.
3. Basu S, Zhuang HM, Torigian DA, Rosenbaum J, Chen WG, Alavi A. Functional imaging of inflammatory diseases using nuclear medicine techniques. Semin Nucl Med 2009;39:124–45.
4. Intenzo CM, Desai AG, Thakur ML, Park CH. Comparison of leukocytes labeled with indium-111-2-mercaptopyridine-N-oxide and indium-111 oxine for abscess detection. J Nucl Med 1987;28:438–41.
5. Kotzé HF, Heyns AD, Lötter MG, Pieters H, Roodt JP, Sweetlove MA, et al. Comparison of oxine and tropolone methods for labeling human platelets with indium-111. J Nucl Med 1991;32:62–6.
6. Ellis BL, Sampson CB, Abeysinghe RD, Porter JB, Hider RC. 6-Alkoxymethyl-3-hydroxy-4H-pyranones: potential ligands for cell-labelling with indium. Eur J Nucl Med 1999;26:1400–6.
7. 99mTc]HMPAO-leukocytes for imaging infection. Semin Nucl Med 1994;24:110–27.
8. Puncher MRB, Blower PJ. Autoradiography and density gradient separation of technetium-99m-exametazime (HMPAO) labelled leucocytes reveals selectivity for eosinophils. Eur J Nucl Med 1994;21:1175–82.
9. Lukawska JJ, Livieratos L, Sawyer BM, Lee T, O’Doherty M, Blower PJ, et al. Real-time differential tracking of human neutrophil and eosinophil migration in vivo. J Allergy Clin Immunol 2014;133:233–9.
10. Sharif-Paghaleh E, Sunassee K, Tavaré R, Ratnasothy K, Koers A, Ali N, et al. In vivo SPECT reporter gene imaging of regulatory T cells. PLoS One 2011;6:e25857. doi:10.1371/journal.pone.0025857.
11. Griessinger CM, Kehlbach R, Bukala D, Wiehr S, Bantleon R, Cay F, et al. In vivo tracking of Th1 cells by PET reveals quantitative and temporal distribution and specific homing in lymphatic tissue. J Nucl Med 2014;55:301–7.
12. Ruparelia P, Szczepura KR, Summers C, Solanki CK, Balan K, Newbold P, et al. Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease. Eur J Nucl Med Mol Imaging 2011;38:911–9.
13. Tavaré R, Sagoo P, Varama G, Tanriver Y, Warely A, Diebold SS, et al. Monitoring of in vivo function of superparamagnetic iron oxide labelled murine dendritic cells during anti-tumour vaccination. PLoS One 2011;6:e19662. doi:10.1371/journal.pone.0019662.
14. Leech JM, Sharif-Paghaleh E, Maher J, Livieratos L, Lechler RI, Mullen GE, et al. Whole-body imaging of adoptively transferred T cells using magnetic resonance imaging, single photon emission computed tomography and positron emission tomography techniques, with a focus on regulatory T cells. Clin Exp Immunol 2013;172:169–77.
15. 131I]FIAU labeling of genetically transduced, tumor-reactive lymphocytes: cell-level dosimetry and dose-dependent toxicity. Eur J Nucl Med Mol Imaging 2006;33:988–97.
16. Elhami E, Goertzen AL, Xiang B, Deng JX, Stillwell C, Mzengeza S, et al. Viability and proliferation potential of adipose-derived stem cells following labeling with a positron-emitting radiotracer. Eur J Nucl Med Mol Imaging 2011;38:1323–34.
17. 18F-FDG labelling of human leukocytes. Nucl Med Commun 2000;21:691–4.
18. 18F]FDG labeling of neural stem cells for in vivo cell tracking with positron emission tomography: inhibition of tracer release by phloretin. Mol Imaging 2012;11:1–12.
19. Welch MJ, Thakur ML, Coleman RE, Patel M, Siegel BA, Terpogossian MM. Gallium-68 labeled red cells and platelets: new agents for positron tomography. J Nucl Med 1977;18:558–62.
20. 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for microPET imaging. Mol Imaging 2008;7:1–11.
21. 64Cu-PTSM for cell tracking using chronic myelogenous leukemia cells expressing HSV1-tk and firefly luciferase. Cancer Biother Radiopharm 2012;27:719–28.
22. 64Cu-pyruvaldehyde-bis(N-4-methylthiosemicarbazone) for imaging cell trafficking in mice with positron-emission tomography. Proc Natl Acad Sci U S A 2002;99:3030–5.
23. Charoenphun P, Paul R, Weeks A, Berry D, Shaw K, Mullen G, et al. PET tracers for cell labelling with the complexes of copper 64 with lipophilic ligands. Eur J Nucl Med Mol Imaging 2011;38:S294.
24. 64Cu-labeled PEGylated polyethylenimine for cell trafficking and tumor imaging. Mol Imaging Biol 2009;11:415–23.
25. 18F-FDG. Nucl Med Biol 2009;36:545–9.
26. 89Zr-Oxine complex: a long-lived radiolabel for cell tracking using PET. 2013 World Molecular Imaging Congress. http://www.wmis.org/abstracts/2013/data/index.htm. Accessed 15 June 2014.
27. Ferris T, Charoenphun P, Went M, Blower P. Medical imaging utilising zirconium complexes (abstract). Nucl Med Commun 2013;34:362–411.
28. Kathirgamanathan P, Surendrakumar S, Antipan-Lara J, Ravichandran S, Reddy VR, Ganeshamurugan S, et al. Discovery of two new phases of zirconium tetrakis(8-hydroxyquinolinolate): synthesis, crystal structure and their electron transporting characteristics in organic light emitting diodes (OLEDs). J Mater Chem 2011;21:1762–71.
29. Muetterties EL, Algeranti CW. Chelate chemistry. VI. Solution behavior of tropolonates. J Am Chem Soc 1969;91:4420–5.
30. Guérard F, Lee YS, Tripier R, Szajek LP, Deschamps JR, Brechbiel MW. Investigation of Zr(IV) and 89Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging. Chem Commun 2013;49:1002–4.
31. Nepveu F, Jasanada F, Walz L. Structural characterization of two lipophilic tris(tropolonato) gallium(III) and indium(III) complexes of radiopharmaceutical interest. Inorg Chim Acta 1993;211:141–7.
32. Abrahams I, Choi N, Henrick K, Joyce H, Matthews RW, McPartlin M, et al. The crystal and molecular-structures of the blood-cell labeling agents tris(2-hydroxy-2,4,6-cycloheptatrien-1-onato-O,O′)indium(III) and trans-(tris(4-iso-propyl-2-hydroxy-2,4,6-cycloheptatrien-1-onato-O,O′) indium(III)). Polyhedron 1994;13:513–6.
33. Radl J, Croese JW, Zurcher C, Van den Enden-Vieveen MHM, de Leeuw AM. Animal model of human disease. Multiple myeloma. Am J Pathol 1988;132:593–7.
34. Vanderkerken K, Asosingh K, Croucher P, Van Camp B. Multiple myeloma biology: lessons from the 5TMM models. Immunol Rev 2003;194:196–206.
35. Vanderkerken K, De Greef C, Asosingh K, Arteta B, De Veerman M, Vande Broek I, et al. Selective initial in vivo homing pattern of 5T2 multiple myeloma cells in the C57BL/KalwRij mouse. Br J Cancer 2000;82:953–9.
36. Vanderkerken K, De Raeve H, Goes E, Van Meirvenne S, Radl J, Van Riet I, et al. Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRij mouse. Br J Cancer 1997;76:451–60.
37. Garrett IR, Dallas S, Radl J, Mundy GR. A murine model of human myeloma bone disease. Bone 1997;20:515–20.
38. Snyderman R, Pike MC, Fischer DG, Koren HS. Biologic and biochemical activities of continuous macrophage cell lines P388D1 and J774.1. J Immunol 1977;119:2060–6.
39. Cailleau R, Olivé M, Cruciger QV. Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization. In Vitro 1978;14:911–5.
40. Alici E, Konstantinidis KV, Aints A, Dilber MS, Abedi-Valugerdi M. Visualization of 5T33 myeloma cells in the C57BL/KaLwRij mouse: establishment of a new syngeneic murine model of multiple myeloma. Exp Hematol 2004;32:1064–72.
41. 89Zr-nanocolloidal albumin for sentinel node identification in oral cancer patients. J Nucl Med 2013;54:585–9.
42. 89Zr in mice. Nucl Med Biol 2011;38:675–81.
43. Ma MT, Meszaros L, Berry DJ, Cooper M, Clark SJ, Ballinger JR, et al. A tripodal tris(hydroxypyridinone) ligand for immunoconjugate PET imaging with zirconium-89. J Biol Inorg Chem 2014;19:S649.