Exercise ventilatory inefficiency in mild to end-stage COPD

European Respiratory Journal

Volumn 45, Issue 2, 2015, Pages 377-387

  Neder, J Alberto ^a,b   Arbex, Flavio F ^b   Alencar, Maria Clara N ^b   O'donnell, Conor D J ^a   Cory, Julia ^a   Webb, Kathy A ^a   O'Donnell, Denis E ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE;

AGED; AIRWAY OBSTRUCTION; AIRWAY RESISTANCE; ARTERIAL OXYGEN SATURATION; ARTICLE; BREATHING RATE; CARDIOPULMONARY EXERCISE TEST; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE MARKER; DISEASE SEVERITY; DYSPNEA; END STAGE CHRONIC OBSTRUCTIVE LUNG DISEASE; END TIDAL CARBON DIOXIDE TENSION; EXERCISE; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; INSPIRATORY CAPACITY; LUNG DIFFUSION CAPACITY; LUNG DISEASE; LUNG MINUTE VOLUME; LUNG VENTILATION; MAJOR CLINICAL STUDY; MALE; MILD CHRONIC OBSTRUCTIVE LUNG DISEASE; RESIDUAL VOLUME; RETROSPECTIVE STUDY; TIDAL VOLUME; TOTAL LUNG CAPACITY; VENTILATORY INEFFICIENCY; BREATHING; CASE CONTROL STUDY; DISEASE COURSE; LUNG FUNCTION TEST; LUNG GAS EXCHANGE; MIDDLE AGED; PATHOPHYSIOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REST; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

AGED; CARBON DIOXIDE; CASE-CONTROL STUDIES; DISEASE PROGRESSION; DYSPNEA; EXERCISE; EXERCISE TEST; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY GAS EXCHANGE; RESPIRATION; RESPIRATORY FUNCTION TESTS; REST; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84961290736     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00135514     Document Type: Article

References (39)

1. Whipp BJ, Ward SA. Cardiopulmonary coupling during exercise. J Exp Biol 1982;100:175-193.
2. Whipp BJ, Ward SA. The coupling of ventilation to pulmonary gas exchange during exercise. In: Whipp BJ, Wasserman K., eds. Pulmonary Physiology and Pathophysiology of Exercise. New York, Dekker, 1991: pp. 271-307.
3. Wasserman K, Casaburi R. Acid-base regulation during exercise in humans. In: Whipp B. J. Wasserman K, eds. Pulmonary Physiology and Pathophysiology of Exercise. New York, Dekker, 1991; pp. 405-448.
4. Whipp BJ. The control of exercise hyperpnea. In: Hornbein T, ed. The Regulation of Breathing. Dekker, New York, 1981; pp. 1069-1139.
5. Whipp BJ. Control of the exercise hyperpnea: the unanswered question. Adv Exp Med Biol 2008;605:16-21.
6. Whipp BJ, Ward SA, Wasserman K. Ventilatory responses to exercise and their control in man. Am Rev Respir Dis 1984;129:S17-S20.210.
7. Sue DY. Excess ventilation during exercise and prognosis in chronic heart failure. Am J Respir Crit Care Med 2011;183:1302-1310.
8. Ferreira EV, Ota-Arakaki JS, Ramos RP, et al. Optimizing the evaluation of excess exercise ventilation for prognosis assessment in pulmonary arterial hypertension. Eur J Prev Cardiol 2014;21:1409-1419.
9. Paoletti P, De Filippis F, et al. Cardiopulmonary exercise testing (CPET) in pulmonary emphysema. Respir Physiol Neurobiol 2011;179:167-173.
10. Thirapatarapong W, Armstrong HF, Thomashow BM, et al. Differences in gas exchange between severities of chronic obstructive pulmonary disease. Respir Physiol Neurobiol 2013;186:81-86.
11. Chin RC, Guenette JA, Cheng S, et al. Does the respiratory system limit exercise in mild chronic obstructive pulmonary disease? Am J Respir Crit Care Med 2013;187:1315-1323.
12. Thirapatarapong W, Armstrong HF, Bartels MN. Comparison of cardiopulmonary exercise testing variables in COPD patients with and without coronary artery disease. Heart Lung 2014;43:146-151.
13. Guazzi M, Myers J, Vicenzi M, et al. Cardiopulmonary exercise testing characteristics in heart failure patients with and without concomitant chronic obstructive pulmonary disease. Am Heart J 2010;160:900-905.
14. Holverda S, Bogaard HJ, Groepenhoff H, et al. Cardiopulmonary exercise test characteristics in patients with chronic obstructive pulmonary disease and associated pulmonary hypertension. Respiration 2008;76:160-167.
15. Vonbank K, Funk GC, Marzluf B, et al. Abnormal pulmonary arterial pressure limits exercise capacity in patients with COPD. Wien Klin Wochenschr 2008;120:749-755.
16. Peters MM, Webb KA, O'Donnell DE. Combined physiological effects of bronchodilators and hyperoxia on exertional dyspnoea in normoxic COPD. Thorax 2006;61:559-567.
17. Torchio R, Guglielmo M, Giardino R, et al. Exercise ventilatory inefficiency and mortality in patients with chronic obstructive pulmonary disease undergoing surgery for non-small cell lung cancer. Eur J Cardiothorac Surg 2010;38:14919.
18. Habedank D, Ewert R, Hummel M, et al. The effects of bilateral lung transplantation on ventilatory efficiency, oxygen uptake and the right heart: a two-yr follow-up. Clin Transplant 11;25:E38-E45.
19. Kim V, Kretschman DM, Sternberg AL, et al. Weight gain after lung reduction surgery is related to improved lung function and ventilatory efficiency. Am J Respir Crit Care Med 2012;186:1109-1116.
20. O'Donnell DE, Laveneziana P, Webb K, et al. Chronic obstructive pulmonary disease: clinical integrative physiology. Clin Chest Med 2014;35:51-69.
21. Sun XG, Hansen JE, Garatachea N, et al. Ventilatory efficiency during exercise in healthy subjects. Am J Respir Crit Care Med 2002;166:1443-1448.
22. Caviedes IR, Delgado I, Soto R. Ventilatory inefficiency as a limiting factor for exercise in patients with COPD. Respir Care 2012;57:583-589.
23. Teopompi E, Tzani P, Aiello M, et al. Excess ventilation and ventilatory constraints during exercise in patients with chronic obstructive pulmonary disease. Respir Physiol Neurobiol 2014;197:9-14.
24. Teopompi E, Tzani P, Aiello M, et al. Ventilatory response to carbon dioxide output in subjects with congestive heart failure and in patients with COPD with comparable exercise capacity. Respir Care 2014;59:1034-1041.
25. Gargiulo P, Apostolo A, Perrone-Filardi P, et al. A non invasive estimate of dead space ventilation from exercise measurements. PLoS One 2014;9:e87395.
26. Neder JA, Nery LE, Peres C, et al. Reference values for dynamic responses to incremental cycle ergometry in males and females aged 20 to 80. Am J Respir Crit Care Med 2001;164:1481-1486.
27. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease Updated 2014. www.goldcopd.org/guidelines-globalstrategy-for-diagnosis-management.html Date last accessed: July 23, 2014. Date last updated: January 2014.
28. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982;14:377-381.
29. Oren A, Wasserman K, Davis JA, et al. Effect of CO2 set point on ventilatory response to exercise. J Appl Physiol Respir Environ Exerc Physiol 1981;51:185-189.
30. Jensen D, O'Donnell DE, Li R, et al. Effects of dead space loading on neuro-muscular and neuro-ventilatory coupling of the respiratory system during exercise in healthy adults: implications for dyspnea and exercise tolerance. Respir Physiol Neurobiol 2011;179:219-226.
31. Ward SA, Whipp BJ. Ventilatory control during exercise with increased external dead space. J Appl Physiol Respir Environ Exerc Physiol 1980;48:225-231.
32. Poon CS. Potentiation of exercise ventilatory response by airway CO2 and dead space loading. J Appl Physiol 1992;73:591-595.
33. Gagnon P, Bussières JS, Ribeiro F, et al. Influences of spinal anesthesia on exercise tolerance in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012;186:606-615.
34. Poon CS, Tin C. Mechanism of augmented exercise hyperpnea in chronic heart failure and dead space loading. Respir Physiol Neurobiol 2013;186:114-130.
35. Ward SA. Commentary on "Mechanism of augmented exercise hyperpnea in chronic heart failure and dead space loading" by Poon and Tin. Respir Physiol Neurobiol 2013;189:203-210.
36. Lewis DA, Sietsema KE, Casaburi R, et al. Inaccuracy of noninvasive estimates of VD/VT in clinical exercise testing. Chest 1994;106:1476-1480.
37. Yamanaka MK, Sue DY. Comparison of arterial-end-tidal PCO2 difference and dead space/tidal volume ratio in respiratory failure. Chest 1987;92:832-835.
38. Steinacker JM, Dehnert C, Whipp BJ. Effect of exercise intensity on the changes in alveolar slopes of carbon dioxide and oxygen expiratory profiles in humans. Eur J Appl Physiol 2001;85:56-61.
39. Palange P, Forte S, Onorati P, et al. Ventilatory and metabolic adaptations to walking and cycling in patients with COPD. J Appl Physiol 2000;88:1715-1720.