Tumor budding correlates with occult cervical lymph node metastasis and poor prognosis in clinical early-stage tongue squamous cell carcinoma

Journal of Oral Pathology and Medicine

Volumn 44, Issue 4, 2015, Pages 266-272

  Xie, Nan ^a   Wang, Cheng ^a   Liu, Xiqiang ^a   Li, Ruyao ^a   Hou, Jinsong ^a   Chen, Xiaohua ^a   Huang, Hongzhang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Occult lymph node metastasis; Prognostic factor; Tongue squamous cell carcinoma; Tumor budding

Indexed keywords

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CELL BUDDING; CERVICAL LYMPH NODE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TONGUE CARCINOMA; TUMOR BUDDING; TUMOR INVASION; CANCER STAGING; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; FOLLOW UP; HEAD AND NECK NEOPLASMS; IMMUNOHISTOCHEMISTRY; LYMPH NODE; LYMPH NODE DISSECTION; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; TONGUE NEOPLASMS; TUMOR RECURRENCE; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; FEMALE; FOLLOW-UP STUDIES; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; RETROSPECTIVE STUDIES; TONGUE NEOPLASMS; YOUNG ADULT;

EID: 84961290056     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/jop.12242     Document Type: Article

References (28)

1. Lydiatt DD, Robbins KT, Byers RM, et al. Treatment of stage I and II oral tongue cancer. Head Neck 1993; 15: 308-12.
2. Yuen AP, Lam KY, Chan AC, et al. Clinicopathological analysis of elective neck dissection for N0 neck of early oral tongue carcinoma. Am J Surg 1999; 177: 90-2.
3. Ganly I, Patel S, Shah J. Early stage squamous cell cancer of the oral tongue-clinicopathologic features affecting outcome. Cancer 2012; 118: 101-11.
4. Kurokawa H, Yamashita Y, Takeda S, et al. Risk factors for late cervical lymph node metastases in patients with stage I or II carcinoma of the tongue. Head Neck 2002; 24: 731-6.
5. Brandwein-Gensler M, Teixeira MS, Lewis CM, et al. Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol 2005; 29: 167-78.
6. Ueno H, Murphy J, Jass JR, et al. Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology 2002; 40: 127-32.
7. Dawson H, Koelzer VH, Karamitopoulou E, et al. The apoptotic and proliferation rate of tumour budding cells in colorectal cancer outlines a heterogeneous population of cells with various impacts on clinical outcome. Histopathology 2014; 64: 577-84.
8. Lugli A, Karamitopoulou E, Zlobec I. Tumour budding: a promising parameter in colorectal cancer. Br J Cancer 2012; 106: 1713-7.
9. Luo WR, Gao F, Li SY, et al. Tumour budding and the expression of cancer stem cell marker aldehyde dehydrogenase 1 in nasopharyngeal carcinoma. Histopathology 2012; 61: 1072-81.
10. Nakagawa Y, Ohira M, Kubo N, et al. Tumor budding and E-cadherin expression are useful predictors of nodal involvement in T1 esophageal squamous cell carcinoma. Anticancer Res 2013; 33: 5023-9.
11. Han G, Lim D, Leitao MM Jr, et al. Histological features associated with occult lymph node metastasis in FIGO clinical stage I, grade I endometrioid carcinoma. Histopathology 2014; 64: 389-98.
12. Almangush A, Bello IO, Keski-Santti H, et al. Depth of invasion, tumor budding, and worst pattern of invasion: prognostic indicators in early-stage oral tongue cancer. Head Neck 2014; 36: 811-8.
13. Huang SH, Hwang D, Lockwood G, et al. Predictive value of tumor thickness for cervical lymph-node involvement in squamous cell carcinoma of the oral cavity: a meta-analysis of reported studies. Cancer 2009; 115: 1489-97.
14. Wang C, Huang H, Huang Z, et al. Tumor budding correlates with poor prognosis and epithelial-mesenchymal transition in tongue squamous cell carcinoma. J Oral Pathol Med 2011; 40: 545-51.
15. Liu LK, Jiang XY, Zhou XX, et al. Upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome. Mod Pathol 2010; 23: 213-24.
16. Landis JR, Koch GG. An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers. Biometrics 1977; 33: 363-74.
17. Kantola S, Parikka M, Jokinen K, et al. Prognostic factors in tongue cancer - relative importance of demographic, clinical and histopathological factors. Br J Cancer 2000; 83: 614-9.
18. Tan WJ, Chia CS, Tan HK, et al. Prognostic significance of invasion depth in oral tongue squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec 2012; 74: 264-70.
19. Fukano H, Matsuura H, Hasegawa Y, et al. Depth of invasion as a predictive factor for cervical lymph node metastasis in tongue carcinoma. Head Neck 1997; 19: 205-10.
20. Li QL, Chen FJ, Zeng ZY, et al. [Clinical and pathological related factors of occult cervical lymph node metastasis in squamous cell carcinoma of tongue]. Ai zheng = Aizheng = Chin J Cancer 2003; 22: 66-70.
21. Ling W, Mijiti A, Moming A. Survival pattern and prognostic factors of patients with squamous cell carcinoma of the tongue: a retrospective analysis of 210 cases. J Oral Maxillofac Surg 2013; 71: 775-85.
22. Hase K, Shatney C, Johnson D, et al. Prognostic value of tumor "budding" in patients with colorectal cancer. Dis Colon Rectum 1993; 36: 627-35.
23. Teramoto H, Koike M, Tanaka C, et al. Tumor budding as a useful prognostic marker in T1-stage squamous cell carcinoma of the esophagus. J Surg Oncol 2013; 108: 42-6.
24. Masuda R, Kijima H, Imamura N, et al. Tumor budding is a significant indicator of a poor prognosis in lung squam-ous cell carcinoma patients. Mol Med Rep 2012; 6: 937-43.
25. Karamitopoulou E, Zlobec I, Born D, et al. Tumour budding is a strong and independent prognostic factor in pancreatic cancer. Eur J Cancer 2013; 49: 1032-9.
26. Liang F, Cao W, Wang Y, et al. The prognostic value of tumor budding in invasive breast cancer. Pathol Res Pract 2013; 209: 269-75.
27. Zlobec I, Molinari F, Martin V, et al. Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients. World J Gastroenterol 2010; 16: 4823-31.
28. Marangon Junior H, Rocha VN, Leite CF, et al. Laminin-5 gamma 2 chain expression is associated with intensity of tumor budding and density of stromal myofibroblasts in oral squamous cell carcinoma. J Oral Pathol Med 2014; 43: 199-204.