Improved oral absorption of doxorubicin by amphiphilic copolymer of lysine-linked ditocopherol polyethylene glycol 2000 succinate: In vitro characterization and in vivo evaluation

Molecular Pharmaceutics

Volumn 12, Issue 2, 2015, Pages 463-473

  Wang, Jinling ^a,c   Li, Lin ^a   Du, Yuqian ^a   Sun, Jin ^b   Han, Xiaopeng ^a   Luo, Cong ^a   Ai, Xiaoyu ^a   Zhang, Qi ^a   Wang, Yongjun ^a   Fu, Qiang ^a   Yang, Zhifu ^d   He, Zhonggui ^a  

^a School of Pharmacy   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

amphiphilic copolymer; doxorubicin; micelles; oral absorption; P glycoprotein; vitamin E succinate

Indexed keywords

AMPHOPHILE; CAVEOLIN; CLATHRIN; COPOLYMER; DOXORUBICIN; GLIMEPIRIDE; LYSINE LINKED DITOCOPHEROL POLYETHYLENE GLYCOL 2000 SUCCINATE; MACROGOL 2000; MULTIDRUG RESISTANCE PROTEIN; NANOCARRIER; PHENOLSULFONPHTHALEIN; SUCCINIC ACID DERIVATIVE; UNCLASSIFIED DRUG; LYSINE; MACROGOL DERIVATIVE; MICELLE; POLYMER; TOCOPHEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CACO 2 CELL LINE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG PENETRATION; DRUG UPTAKE; DUODENUM; ELECTROSPRAY MASS SPECTROMETRY; ENDOCYTOSIS; ILEUM; IN VITRO STUDY; IN VIVO STUDY; INTESTINE PERFUSION; LIQUID LIQUID EXTRACTION; MAXIMUM PLASMA CONCENTRATION; MICELLE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; RAT; SMALL INTESTINE ABSORPTION; SYSTEMIC CIRCULATION; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSCYTOSIS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ZETA POTENTIAL; CHEMICAL PHENOMENA; CHEMISTRY; HUMAN; METABOLISM;

CACO-2 CELLS; DOXORUBICIN; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LYSINE; MICELLES; POLYETHYLENE GLYCOLS; POLYMERS; TOCOPHEROLS;

EID: 84961289932     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500833m     Document Type: Article

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