Hepatoprotective constituents of Firmiana simplex stem bark against ethanol insult to primary rat hepatocytes

Pharmacognosy Magazine

Volumn 11, Issue 41, 2015, Pages 55-60

  Kim, Jung Wha ^a   Yang, Heejung ^b   Cho, Namki ^a   Kim, Bitnarae ^a   Kim, Young Choong ^a   Sung, Sang Hyun ^a  

^a Seoul National University   (South Korea)

^b Kangwon National University   (South Korea)

Author keywords

Ethanol; Firmiana simplex; hepatoprotective; primary rat hepatocytes; quercitrin

Indexed keywords

ACETIC ACID ETHYL ESTER; ALCOHOL; ANTIOXIDANT; BUTANOL; CHLOROFORM; FLAVONOID GLYCOSIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HEXANE; LIVER PROTECTIVE AGENT; METHANOL; QUERCITRIN; REACTIVE OXYGEN METABOLITE; SEPHADEX; SILICA GEL; TAMARIXETIN 3 O RHAMNOPYRANOSIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BARK; CELL VIABILITY; COLUMN CHROMATOGRAPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; FIRMIANA SIMPLEX; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MALE; MALVACEAE; METHYLATION; NONHUMAN; OXIDATIVE STRESS; PLANT STEM; PRIMARY CELL; PROTEIN DEPLETION; RAT; STRUCTURE ACTIVITY RELATION;

EID: 84961289785     PISSN: 09731296     EISSN: 09764062     Source Type: Journal    
DOI: 10.4103/0973-1296.149704     Document Type: Article

References (25)

1. Stewart S, Jones D, Day CP. Alcoholic liver disease: New insights into mechanisms and preventative strategies. Trends Mol Med 2001;7:408-13.
2. Tilg H, Day CP. Management strategies in alcoholic liver disease. Nat Clin Pract Gastroenterol Hepatol 2007;4:24-34.
3. Zakhari S. Overview: How is alcohol metabolized by the body?. Alcohol Res Health 2006;29:245-54.
4. Park JH, Kim Y, Kim SH. Green tea extract (Camellia sinensis) fermented by Lactobacillus fermentum attenuates alcohol-induced liver damage. Biosci Biotechnol Biochem 2012;76:2294-300.
5. Jones CA, Moore BP, Cohen GM, Fry JR, Bridges JW. Studies on the metabolism and excretion of benzo (a) pyrene in isolated adult rat hepatocytes. Biochem Pharmacol 1978;27:693-702.
6. Kondeva-Burdina M, Zheleva-Dimitrova D, Nedialkov P, Girreser U, Mitcheva M. Cytoprotective and antioxidant effects of phenolic compounds from Haberlea rhodopensis friv. (Gesneriaceae). Pharmacogn Mag 2013;9:294-301.
7. Bae KH. Medicinal Plants of Korea. Seoul: KyoHak Publishing Co., Ltd; 2000.
8. Hotta M, Ogata K, Nitta A, Hosikawa K, Yanagi M, Yamazaki K. Useful Plant of the World. Tokyo: Heibonsha; 1989.
9. Son YK, Lee MH, Han YN. A new antipsychotic effective neolignan from Firmiana simplex. Arch Pharm Res 2005;28:34-8.
10. Berry MN, Friend DS. High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study. J Cell Biol 1969;43:506-20.
11. Liu S, Hou W, Yao P, Zhang B, Sun S, Nüssler AK, et al. Quercetin protects against ethanol-induced oxidative damage in rat primary hepatocytes. Toxicol In Vitro 2010;24:516-22.
12. Aranda A, Sequedo L, Tolosa L, Quintas G, Burello E, Castell JV, et al. Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: A quantitative method for oxidative stress assessment of nanoparticle-Treated cells. Toxicol In Vitro 2013;27:954-63.
13. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal Biochem 1969;27:502-22.
14. Carlberg I, Mannervik B. Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J Biol Chem 1975;250:5475-80.
15. Flohé L, Günzler WA. Assays of glutathione peroxidase. Methods Enzymol 1984;105:114-21.
16. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, et al. Measurement of protein using bicinchoninic acid. Anal Biochem 1985;150:76-85.
17. Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: An overview 2013;2013:162750.
18. Hong CO, Rhee CH, Won NH, Choi HD, Lee KW. Protective effect of 70% ethanolic extract of Lindera obtusiloba Blume on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats. Food Chem Toxicol 2013;53:214-20.
19. Hubert DJ, Dawe A, Florence NT, Gilbert KD, Angele TN, Buonocore D, et al. In vitro hepatoprotective and antioxidant activities of crude extract and isolated compounds from Ficus gnaphalocarpa. Inflammopharmacology 2011;19:35-43.
20. Tian L, Shi X, Yu L, Zhu J, Ma R, Yang X. Chemical composition and hepatoprotective effects of polyphenol-rich extract from Houttuynia cordata tea. J Agric Food Chem 2012;60:4641-8.
21. Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: Chemistry, metabolism and structure-Activity relationships. J Nutr Biochem 2002;13:572-84.
22. Seyoum A, Asres K, El-Fiky FK. Structure-radical scavenging activity relationships of flavonoids. Phytochemistry 2006;67:2058-70.
23. Cho N, Choi JH, Yang H, Jeong EJ, Lee KY, Kim YC, et al. Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines. Food Chem Toxicol 2012;50:1940-5.
24. Bailey SM, Cunningham CC. Contribution of mitochondria to oxidative stress associated with alcoholic liver disease. Free Radic Biol Med 2002;32:11-6.
25. Mendes AP, Borges RS, Neto AM, de Macedo LG, da Silva AB. The basic antioxidant structure for flavonoid derivatives. J Mol Model 2012;18:4073-80.