Systemic and cerebral iron homeostasis in ferritin knock-out Mice

PLoS ONE

Volumn 10, Issue 1, 2015, Pages

  Li, Wei ^a   Garringer, Holly J ^a   Goodwin, Charles B ^a   Richine, Briana ^a   Acton, Anthony ^a   VanDuyn, Natalia ^a   Muhoberac, Barry B ^b   Irimia Dominguez, Jose ^a   Chan, Rebecca J ^a   Peacock, Munro ^a   Nass, Richard ^a   Ghetti, Bernardino ^a   Vidal, Ruben ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; IRON; MESSENGER RNA;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; FTH GENE; FTL GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENE LOSS; GENOTYPE; HEAVY CHAIN; HOMOLOGOUS RECOMBINATION; HOMOZYGOTE; IN VIVO STUDY; IRON BALANCE; IRON METABOLISM; KNOCKOUT MOUSE; LIGHT CHAIN; MALE; MOUSE; NEURODEGENERATION WITH BRAIN IRON ACCUMULATION; NEWBORN; NONHUMAN; SURVIVAL; ANIMAL; BRAIN CORTEX; GENETICS; HOMEOSTASIS; METABOLISM; PHYSIOLOGY;

MUS;

ANIMALS; CEREBRAL CORTEX; FERRITINS; HOMEOSTASIS; IRON; MICE; MICE, KNOCKOUT;

EID: 84961287896     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117435     Document Type: Article

References (23)

1. Vidal R, Delisle MB, Ghetti B (2004). Neurodegeneration caused by proteins with an aberrant carboxylterminus. J Neuropathol Exp Neurol 63:787-800. PMID: 15330334
2. Muhoberac BB, Vidal R (2013) Abnormal iron homeostasis and neurodegeneration. Front Aging Neurosci 5:32. doi: 10.3389/fnagi.2013.00032 PMID: 23908629
3. Zhang DL, Ghosh MC, Rouault TA (2014) The physiological functions of iron regulatory proteins in iron homeostasis - an update. Front Pharmacol 5:124. doi: 10.3389/fphar.2014.00124 PMID: 24982634
4. Kato J, Fujikawa K, Kanda M, Fukuda N, Sasaki K, et al. (2001) A mutation in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload. Am J Hum Genet 69:191-97. PMID: 11389486
5. Bennett TM, Maraini G, Jin C, Sun W, Hejtmancik JF, Shiels A (2013) Noncoding variation of the gene for ferritin light chain in hereditary and age-related cataract. Mol Vis 19:835-44. PMID: 23592921
6. Bowes O, Baxter K, Elsey T, Snead M, Cox T (2014) Hereditary hyperferritinaemia cataract syndrome. Lancet 383(9927):1520. doi: 10.1016/S0140-6736(14)60484-0 PMID: 24766965
7. Baraibar MA, Barbeito AG, Muhoberac BB, Vidal R (2008) Iron-mediated aggregation and a localized structural change characterize ferritin from a mutant light chain polypeptide that causes neurodegeneration. J Biol Chem 283:31679-31689. doi: 10.1074/jbc.M805532200 PMID: 18755684
8. Baraibar MA, Muhoberac BB, Garringer HJ, Hurley TD, Vidal R (2010) Unraveling of the E helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration. J Biol Chem 285:1950-1956. doi: 10.1074/jbc.M109.042986 PMID: 19923220
9. Baraibar MA, Barbeito AG, Muhoberac BB, Vidal R (2012) A mutant light-chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damage. Free Radic Biol Med 52:1692-1697. doi: 10.1016/j.freeradbiomed.2012.02.015 PMID: 22348978
10. Berg D, Youdim MB (2006). Role of iron in neurodegenerative disorders. Top Magn Reson Imaging 17:5-17. PMID: 17179893
11. Rouault TA (2013) Iron metabolism in the CNS: implications for neurodegenerative diseases. Nat Rev Neurosci 14(8):551-64. doi: 10.1038/nrn3453 PMID: 23820773
12. Cozzi A, Santambrogio P, Privitera D, Broccoli V, Rotundo LI, et al. (2013) Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome. J Exp Med 210 (9):1779-1791. doi: 10.1084/jem.20130315 PMID: 23940258
13. Vidal R, Miravalle L, Gao X, Barbeito AG, Baraibar MA, et al. (2008) Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice. J Neurosci 28:60-67. doi: 10.1523/JNEUROSCI.3962-07.2008 PMID: 18171923
14. Barbeito AG, Garringer HJ, Baraibar MA, Gao X, Arredondo M, et al. (2009) Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene. J Neurochem 109:1067-1078. doi: 10.1111/j.1471-4159.2009.06028.x PMID: 19519778
15. Spijker S (2011) Dissection of Rodent Brain Regions. Neuroproteomics, Neuromethods, vol. 57, Springer Protocols, 13-26.
16. VanDuyn N, Settivari R, LeVora J, Zhou S, Unrine J, Nass R (2013) The metal transporter SMF-3/DMT- 1 mediates aluminum-induced dopamine neuron degeneration. J Neurochem 124:147-157. doi: 10. 1111/jnc.12072 PMID: 23106139
17. Ferreira C, Bucchini D, Martin ME, Levi S, Arosio P, et al. (2000) Early embryonic lethality of H ferritin gene deletion in mice. J Biol Chem 275(5):3021-3024. PMID: 10652280
18. Thompson K, Menzies S, Muckenthaler M, Torti FM, Wood T, et al. (2003) Mouse brains deficient in Hferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress. J Neurosci Res 71(1):46-63. PMID: 12478613
19. Gkouvatsos K, Fillebeen C, Daba A, Wagner J, Sebastiani G, Pantopoulos K. (2014) Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels. PLoS One. 9(1):e85530. doi: 10.1371/journal.pone.0085530 PMID: 24409331
20. Finch CA, Bellotti V, Stray S, Lipschitz DA, Cook JD, et al. (1986) Plasma ferritin determination as a diagnostic tool. West J Med 145(5):657-663. PMID: 3541387
21. Madsen E, Gitlin JD (2007) Copper and iron disorders of the brain. Annu Rev Neurosci 30:317-337. PMID: 17367269
22. Ferreira C, Santambrogio P, Martin ME, Andrieu V, Feldmann G, Hénin D, Beaumont C et al. (2001) H ferritin knockout mice: a model of hyperferritinemia in the absence of iron overload. Blood 98(3):525-532. PMID: 11468145
23. Patel BN, Dunn RJ, Jeong SY, Zhu Q, Julien JP, David S (2002) Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci 22(15):6578-6586. PMID: 12151537