Bile salt tolerance of Lactococcus lactis is enhanced by expression of bile salt hydrolase thereby producing less bile acid in the cells

Biotechnology Letters

Volumn 38, Issue 4, 2016, Pages 659-665

  Bi, Jie ^a   Liu, Song ^a   Du, Guocheng ^a   Chen, Jian ^a  

^a JIANGNAN UNIVERSITY   (China)

Author keywords

Bile salt hydrolase; Bile salt tolerance; Conjugated bile salt; Lactic acid bacteria; Lactobacillus; Lactococcus

Indexed keywords

CELL GROWTH; CELLS; CYTOLOGY; GROWTH KINETICS; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; HYDROLASES; LACTIC ACID; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICELLES; ORGANIC POLYMERS; SALTS; TRANSMISSION ELECTRON MICROSCOPY;

BILE SALT HYDROLASE; BILE SALTS; CONJUGATED BILE SALTS; LACTIC ACID BACTERIA; LACTOBACILLUS; LACTOCOCCUS;

BODY FLUIDS;

AMIDASE; BILE ACID; CHOLOYLGLYCINE HYDROLASE; MICELLE;

CHEMISTRY; CYTOPLASM; GENETICS; GROWTH, DEVELOPMENT AND AGING; LACTOCOCCUS LACTIS; METABOLISM; MICELLE; MOLECULAR CLONING; SALT TOLERANCE; TRANSMISSION ELECTRON MICROSCOPY;

AMIDOHYDROLASES; BILE ACIDS AND SALTS; CLONING, MOLECULAR; CYTOPLASM; LACTOCOCCUS LACTIS; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; SALT-TOLERANCE;

EID: 84961208695     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-015-2018-7     Document Type: Article

References (17)

1. Ambalam P, Kondepudi KK, Nilsson I, Wadstrom T, Ljungh A (2012) Bile stimulates cell surface hydrophobicity, Congo red binding and biofilm formation of Lactobacillus strains. FEMS Microbiol Lett 333:10–19
2. Begley M, Sleator RD, Gahan CGM, Hill C (2005) Contribution of three bile-associated loci, bsh, pva, and btlB, to gastrointestinal persistence and bile tolerance of Listeria monocytogenes. Infect Immun 73:894–904
3. Begley M, Hill C, Gahan CG (2006) Bile salt hydrolase activity in probiotics. Appl Environ Microbiol 72:1729–1738
4. Bi J, Fang F, Lu SY, Du GC, Chen J (2013) New insight into the catalytic properties of bile salt hydrolase. J Mol Catal B-Enzym 96:46–51
5. Boggs JM (1987) Lipid intermolecular hydrogen bonding: influence on structural organization and membrane function. Biochim Biophys Acta 906:353–404
6. Dussurget O, Cabanes D, Dehoux P, Lecuit M, Buchrieser C et al (2002) Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis. Mol Microbiol 45:1095–1106
7. Fang F, Li Y, Bumann M, Raftis EJ, Casey PG, Cooney JC et al (2009) Allelic variation of bile salt hydrolase genes in Lactobacillus salivarius does not determine bile resistance levels. J Bacteriol 191:5743–5757
8. Gahan CGM, Hill C (2014) Listeria monocytogenes: survival and adaptation in the gastrointestinal tract. Front Cell Infect Microbiol 4:1–7
9. Hofmann M, Schumann C, Zimmer G, Henzel K, Locher U et al (2001) LUV’s lipid composition modulates diffusion of bile acids. Chem Phys Lipids 110:165–171
10. Hung DT, Zhu J, Sturtevant D, Mekalanos JJ (2006) Bile acids stimulate biofilm formation in Vibrio cholerae. Mol Microbiol 59:193–201
11. Islam K, Fukiya S, Hagio M, Fujii N, Ishizuka S et al (2011) Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology 141:1773–1781
12. Jarocki P, Podlesny M, Glibowski P, Targonski Z (2014) A new insight into the physiological role of bile salt hydrolase among intestinal bacteria from the Genus Bifidobacterium. PLoS ONE 9:e114379
13. Joyce SA, MacSharry J, Casey PG, Kinsella M, Murphy EF et al (2014) Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proc Natl Acad Sci USA 111:7421–7426
14. Kurdi P, Kawanishi K, Mizutani K, Yokota A (2006) Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria. J Bacteriol 188:1979–1986
15. Pumbwe L, Skilbeck CA, Nakano V, Avila-Campos MJ, Piazza RMF et al (2007) Bile salts enhance bacterial co-aggregation, bacterial-intestinal epithelial cell adhesion, biofilm formation and antimicrobial resistance of Bacteroides fragilis. Microb Pathog 43:78–87
16. Wu CD, Zhang J, Wang M, Du GC, Chen J (2012) Lactobacillus casei combats acid stress by maintaining cell membrane functionality. J Ind Microbiol Biotechnol 39:1031–1039
17. Zhu Y, Zhang Y, Li Y (2009) Understanding the industrial application potential of lactic acid bacteria through genomics. Appl Microbiol Biotechnol 83:597–610