Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice

Journal of Experimental Medicine

Volumn 212, Issue 11, 2015, Pages 1771-1781

  Sullivan, Josefa M ^a   Badimon, Ana ^a   Schaefer, Uwe ^b   Ayata, Pinar ^a   Gray, James ^c   Chung, Chun Wa ^c   von Schimmelmann, Melanie ^a   Zhang, Fan ^a   Garton, Neil ^c   Smithers, Nicholas ^c   Lewis, Huw ^c   Tarakhovsky, Alexander ^b   Prinjha, Rab K ^c   Schaefer, Anne ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 6 (4 CHLOROPHENYL) N ETHYL 8 METHOXY 1 METHYL 4H [1,2,4]TRIAZOLO[4,3 A][1,4]BENZODIAZEPINE 4 ACETAMIDE; 7 (3,5 DIMETHYL 4 ISOXAZOLYL) 1,3 DIHYDRO 8 METHOXY 1 [1 (2 PYRIDINYL)ETHYL] 2H IMIDAZO[4,5 C]QUINOLIN 2 ONE; BRAIN DERIVED NEUROTROPHIC FACTOR; BROMODOMAIN AND EXTRATERMINAL PROTEIN; BROMODOMAIN INHIBITOR; CHLOROXYLENOL PLUS HYDROCORTISONE PLUS PRAMOCAINE; DCLK1 PROTEIN; EARLY GROWTH RESPONSE FACTOR; EARLY GROWTH RESPONSE FACTOR 1; EARLY GROWTH RESPONSE FACTOR 2; EARLY GROWTH RESPONSE FACTOR 3; EARLY GROWTH RESPONSE FACTOR 4; I BET 858; IMMEDIATE EARLY RESPONSE PROTEIN 2; IMMEDIATE EARLY RESPONSE PROTEIN 3; IMMEDIATE EARLY RESPONSE PROTEIN 4; IMMEDIATE EARLY RESPONSE PROTEIN 5; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; NUCLEAR RECEPTOR NR4A3; NUCLEAR RECEPTOR RELATED FACTOR 1; PROTEIN; PROTEIN C JUN; PROTEIN FOS; PROTEIN HOMER 1; SEMAPHORIN 3A; SERUM RESPONSE FACTOR; TRANSCRIPTION FACTOR 7 LIKE 1; TRANSCRIPTION FACTOR FOSB; TRANSCRIPTION FACTOR JUNB; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; DNER PROTEIN, MOUSE; NERVE PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; AUTISM; BRAIN CELL; BRAIN FUNCTION; BRAIN TISSUE; CELL MATURATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; EPIGENETICS; EXPLORATORY BEHAVIOR; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE LOCUS; GENE REPRESSION; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPTIC TRANSMISSION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; AUTISM SPECTRUM DISORDER; C57BL MOUSE; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS;

ANIMALS; AUTISM SPECTRUM DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; EPIGENESIS, GENETIC; GENE EXPRESSION; MALE; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; RECEPTORS, CELL SURFACE;

EID: 84961205689     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20151271     Document Type: Article

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