메뉴 건너뛰기




Volumn 38, Issue 3, 2016, Pages 431-444

Ceftazidime-Avibactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination for the Treatment of Resistant Gram-negative Organisms

Author keywords

avibactam; carbapenemase producing organisms; ceftazidime avibactam; cephalosporin lactamase inhibitor; MDR gram negative organisms

Indexed keywords

AVIBACTAM; AVIBACTAM PLUS CEFTAZIDIME; BACTERIAL ENZYME; BETA LACTAMASE AMPC; CARRIER PROTEIN; CEFTAZIDIME; CHLORAMPHENICOL; CYTOCHROME P450; EXTENDED SPECTRUM BETA LACTAMASE; ORAL CONTRACEPTIVE AGENT; PROBENECID; AMPC BETA-LACTAMASES; ANTIINFECTIVE AGENT; AVIBACTAM, CEFTAZIDIME DRUG COMBINATION; AZABICYCLO DERIVATIVE; BACTERIAL PROTEIN; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CARBAPENEMASE; CEPHALOSPORIN DERIVATIVE;

EID: 84961169202     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2016.01.018     Document Type: Review
Times cited : (87)

References (41)
  • 2
    • 79952111025 scopus 로고    scopus 로고
    • Bench-to-bedside review: The role of beta-lactamases in antibiotic-resistant Gram-negative infections
    • K. Bush Bench-to-bedside review: the role of beta-lactamases in antibiotic-resistant Gram-negative infections Crit Care 14 2010 224
    • (2010) Crit Care , vol.14 , pp. 224
    • Bush, K.1
  • 3
    • 77149165713 scopus 로고    scopus 로고
    • Updated functional classification of β-lactamases
    • K. Bush, and G.A. Jacoby Updated functional classification of β-lactamases Antimicrob Agents Chemother 54 2010 969 976
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 969-976
    • Bush, K.1    Jacoby, G.A.2
  • 4
    • 27144490073 scopus 로고    scopus 로고
    • Extended-spectrum β-lactamases: A clinical update
    • D.L. Paterson, and R.A. Bonomo Extended-spectrum β-lactamases: a clinical update Clin Microbiol Rev 18 2005 657 686
    • (2005) Clin Microbiol Rev , vol.18 , pp. 657-686
    • Paterson, D.L.1    Bonomo, R.A.2
  • 5
    • 84961175472 scopus 로고    scopus 로고
    • [package insert] Research Triangle Park GlaxoSmithKline NC
    • Fortaz® (ceftazidime) [package insert] Research Triangle Park 2007 GlaxoSmithKline NC
    • (2007) Fortaz® (Ceftazidime)
  • 6
    • 77957770819 scopus 로고    scopus 로고
    • Alarming beta-lactamase-mediated resistance in multi-drug-resistant Enterobacteriaceae
    • K. Bush Alarming beta-lactamase-mediated resistance in multi-drug-resistant Enterobacteriaceae Curr Opin Microbiol 13 2010 558 564
    • (2010) Curr Opin Microbiol , vol.13 , pp. 558-564
    • Bush, K.1
  • 7
    • 77249104101 scopus 로고    scopus 로고
    • Infections with extended-spectrum beta-lactamase-producing Enterobacteriaceae: Changing epidemiology and drug treatment choices
    • J.D. Pitout Infections with extended-spectrum beta-lactamase-producing Enterobacteriaceae: changing epidemiology and drug treatment choices Drugs 70 2010 313 333
    • (2010) Drugs , vol.70 , pp. 313-333
    • Pitout, J.D.1
  • 8
    • 33747179934 scopus 로고    scopus 로고
    • The beta-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter
    • D.M. Livermore, and N. Woodford The beta-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter Trends Microbiol 14 2006 413 420
    • (2006) Trends Microbiol , vol.14 , pp. 413-420
    • Livermore, D.M.1    Woodford, N.2
  • 10
    • 67749143907 scopus 로고    scopus 로고
    • In vitro activity of NXL104 in combination with beta-lactams against Klebsiella pneumoniae isolates producing KPC carbapenemases
    • A. Endimiani, Y. Choudhary, and R.A. Bonomo In vitro activity of NXL104 in combination with beta-lactams against Klebsiella pneumoniae isolates producing KPC carbapenemases Antimicrob Agents Chemother 53 2009 3599 3601
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 3599-3601
    • Endimiani, A.1    Choudhary, Y.2    Bonomo, R.A.3
  • 12
    • 84894441748 scopus 로고    scopus 로고
    • Ceftazidime-avibactam: An evidence-based review of its pharmacology and potential use in the treatment of Gram-negative bacterial infections
    • P. Lagacé-Wiens, A. Walkty, and J.A. Karlowsky Ceftazidime-avibactam: an evidence-based review of its pharmacology and potential use in the treatment of Gram-negative bacterial infections Core Evid 9 2014 13 25
    • (2014) Core Evid , vol.9 , pp. 13-25
    • Lagacé-Wiens, P.1    Walkty, A.2    Karlowsky, J.A.3
  • 13
    • 84939486487 scopus 로고    scopus 로고
    • The β-lactams strike back: Ceftazidime-avibactam
    • E.J. Zasowski, J.M. Rybak, and M.J. Rybak The β-lactams strike back: ceftazidime-avibactam Pharmacotherapy 35 2015 755 770
    • (2015) Pharmacotherapy , vol.35 , pp. 755-770
    • Zasowski, E.J.1    Rybak, J.M.2    Rybak, M.J.3
  • 14
    • 84882662775 scopus 로고    scopus 로고
    • How to get (a)round: Mechanisms controlling growth and division of coccoid bacteria
    • M.G. Pinho, M. Kjos, and J.W. Veening How to get (a)round: mechanisms controlling growth and division of coccoid bacteria Nat Rev Microbiol 11 2013 601 614
    • (2013) Nat Rev Microbiol , vol.11 , pp. 601-614
    • Pinho, M.G.1    Kjos, M.2    Veening, J.W.3
  • 15
    • 39149088656 scopus 로고    scopus 로고
    • The penicillin-binding proteins: Structure and role in peptidoglycan biosynthesis
    • E. Sauvage, F. Kerff, M. Terrak, and et al. The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis FEMS Microbiol Rev 32 2008 234 258
    • (2008) FEMS Microbiol Rev , vol.32 , pp. 234-258
    • Sauvage, E.1    Kerff, F.2    Terrak, M.3
  • 16
    • 33746891446 scopus 로고    scopus 로고
    • Penicillin binding proteins: Key players in bacterial cell cycle and drug resistance processes
    • P. Macheboeuf, C. Contreras-Martel, V. Job, and et al. Penicillin binding proteins: key players in bacterial cell cycle and drug resistance processes FEMS Microbiol Rev 30 2006 673 691
    • (2006) FEMS Microbiol Rev , vol.30 , pp. 673-691
    • Macheboeuf, P.1    Contreras-Martel, C.2    Job, V.3
  • 17
    • 74249108028 scopus 로고    scopus 로고
    • Three decades of beta-lactamase inhibitors
    • S.M. Drawz, and R.A. Bonomo Three decades of beta-lactamase inhibitors Clin Microbiol Rev 23 2010 160 201
    • (2010) Clin Microbiol Rev , vol.23 , pp. 160-201
    • Drawz, S.M.1    Bonomo, R.A.2
  • 18
    • 84877842576 scopus 로고    scopus 로고
    • Structural insight into portent broad-spectrum inhibition with reversible recyclization mechanism: Avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC beta-lactamases
    • S.D. Lahiri, S. Mangani, T. Durand-Reville, and et al. Structural insight into portent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC beta-lactamases Antimicrob Agents Chemother 57 2013 2496 2505
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 2496-2505
    • Lahiri, S.D.1    Mangani, S.2    Durand-Reville, T.3
  • 19
    • 84929587395 scopus 로고    scopus 로고
    • Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U.S. hospitals (2011 to 2013) and characterization of β-lactamase-producing strains
    • M. Castanheira, J.C. Mills, S.E. Costello, and et al. Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U.S. hospitals (2011 to 2013) and characterization of β-lactamase-producing strains Antimicrob Agents Chemother 59 2015 3509 3517
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 3509-3517
    • Castanheira, M.1    Mills, J.C.2    Costello, S.E.3
  • 20
    • 84927574043 scopus 로고    scopus 로고
    • Ceftazidime-avibactam and comparator agents tested against urinary tract isolates from a global surveillance program (2011)
    • R.K. Flamm, H.S. Sader, D.J. Farrell, and et al. Ceftazidime-avibactam and comparator agents tested against urinary tract isolates from a global surveillance program (2011) Diagn Microbiol Infect Dis 80 2014 233 238
    • (2014) Diagn Microbiol Infect Dis , vol.80 , pp. 233-238
    • Flamm, R.K.1    Sader, H.S.2    Farrell, D.J.3
  • 21
    • 84857173233 scopus 로고    scopus 로고
    • In vitro antibacterial activity of the ceftazidime-avibactam (NXL104) combination against Pseudomonas aeruginosa clinical isolates
    • P. Levasseur, A.M. Girard, M. Claudon, and et al. In vitro antibacterial activity of the ceftazidime-avibactam (NXL104) combination against Pseudomonas aeruginosa clinical isolates Antimicrob Agents Chemother 56 2012 1606 1608
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 1606-1608
    • Levasseur, P.1    Girard, A.M.2    Claudon, M.3
  • 22
    • 84955294377 scopus 로고    scopus 로고
    • Activity of ceftazidime-avibactam against fluoroquinolone-resistant Enterobacteriaceae and Pseudomonas aeruginosa
    • C. Pitart, F. Marco, T.A. Keating, and et al. Activity of ceftazidime-avibactam against fluoroquinolone-resistant Enterobacteriaceae and Pseudomonas aeruginosa Antimicrob Agents Chemother 59 2015 3059 3065
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 3059-3065
    • Pitart, C.1    Marco, F.2    Keating, T.A.3
  • 23
    • 84934963355 scopus 로고    scopus 로고
    • Ceftazidime/avibactam tested against gram-negative bacteria from intensive care unit (ICU) and non-ICU patients, including those with ventilator-associated pneumonia
    • H.S. Sader, M. Castanheira, R.K. Flamm, and et al. Ceftazidime/avibactam tested against gram-negative bacteria from intensive care unit (ICU) and non-ICU patients, including those with ventilator-associated pneumonia Int J Antimicrob Agents 46 2015 53 59
    • (2015) Int J Antimicrob Agents , vol.46 , pp. 53-59
    • Sader, H.S.1    Castanheira, M.2    Flamm, R.K.3
  • 24
    • 84929583498 scopus 로고    scopus 로고
    • Ceftazidime-avibactam activity against multidrug-resistant Pseudomonas aeruginosa isolated in U.S. medical centers in 2012 and 2013
    • H.S. Sader, M. Castanheira, R.E. Mendes, and et al. Ceftazidime-avibactam activity against multidrug-resistant Pseudomonas aeruginosa isolated in U.S. medical centers in 2012 and 2013 Antimicrob Agents Chemother 59 2015 3656 3659
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 3656-3659
    • Sader, H.S.1    Castanheira, M.2    Mendes, R.E.3
  • 25
    • 84940937491 scopus 로고    scopus 로고
    • Effects of Klebsiella pneumoniae carbapenemase subtypes, extended-spectrum β-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae
    • R.K. Shields, C.J. Clancy, B. Hao, and et al. Effects of Klebsiella pneumoniae carbapenemase subtypes, extended-spectrum β-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae Antimicrob Agents Chemother 59 2015 5793 5797
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 5793-5797
    • Shields, R.K.1    Clancy, C.J.2    Hao, B.3
  • 26
    • 84938859514 scopus 로고    scopus 로고
    • In vitro activity of ceftazidime, ceftaroline and aztreonam alone and in combination with avibactam against European gram-negative and gram-positive clinical isolates
    • R. Testa, R. Canton, T. Giani, and et al. In vitro activity of ceftazidime, ceftaroline and aztreonam alone and in combination with avibactam against European gram-negative and gram-positive clinical isolates Int J Antimicrob Agents 45 2015 641 646
    • (2015) Int J Antimicrob Agents , vol.45 , pp. 641-646
    • Testa, R.1    Canton, R.2    Giani, T.3
  • 27
    • 79959230230 scopus 로고    scopus 로고
    • In vitro activity of ceftazidime-NXL104 against 396 strains of beta-lactamase-producing anaerobes
    • D.M. Citron, K.L. Tyrrell, V. Merriam, and et al. In vitro activity of ceftazidime-NXL104 against 396 strains of beta-lactamase-producing anaerobes Antimicrob Agents Chemother 55 2011 3616 3620
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 3616-3620
    • Citron, D.M.1    Tyrrell, K.L.2    Merriam, V.3
  • 28
    • 84961112177 scopus 로고    scopus 로고
    • Ceftazidime-avibactam activity tested against aerobic gram-negative organisms isolated from intraabdominal infections in United States hospitals (2012-2014)
    • Abstract presented at: September 17-21, San Diego, CA. Abstract C-140
    • Sader HS, Castanheira M, Flamm RK, et al. Ceftazidime-avibactam activity tested against aerobic gram-negative organisms isolated from intraabdominal infections in United States hospitals (2012-2014). Abstract presented at: Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC); September 17-21, 2015; San Diego, CA. Abstract C-140.
    • (2015) Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC)
    • Sader, H.S.1    Castanheira, M.2    Flamm, R.K.3
  • 29
    • 84940007604 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of single and multiple ascending doses of avibactam alone and in combination with ceftazidime in healthy male volunteers: Results of two randomized, placebo-controlled studies
    • H. Merdjan, M. Rangaraju, and A. Tarral Safety and pharmacokinetics of single and multiple ascending doses of avibactam alone and in combination with ceftazidime in healthy male volunteers: results of two randomized, placebo-controlled studies Clin Drug Investig 35 2015 307 317
    • (2015) Clin Drug Investig , vol.35 , pp. 307-317
    • Merdjan, H.1    Rangaraju, M.2    Tarral, A.3
  • 30
    • 84937627900 scopus 로고    scopus 로고
    • Phase I study assessing the safety, tolerability, and pharmacokinetics of avibactam and ceftazidime-avibactam in healthy Japanese volunteers
    • N. Tominaga, T. Edeki, J. Li, and et al. Phase I study assessing the safety, tolerability, and pharmacokinetics of avibactam and ceftazidime-avibactam in healthy Japanese volunteers J Infect Chemother 21 2015 551 558
    • (2015) J Infect Chemother , vol.21 , pp. 551-558
    • Tominaga, N.1    Edeki, T.2    Li, J.3
  • 31
    • 84898831378 scopus 로고    scopus 로고
    • Assessment of the mass balance recovery and metabolite profile of avibactam in humans and in vitro drug-drug interaction potential
    • K. Vishwanathan, S. Mair, A. Gupta, and et al. Assessment of the mass balance recovery and metabolite profile of avibactam in humans and in vitro drug-drug interaction potential Drug Metab Dispos 42 2014 932 942
    • (2014) Drug Metab Dispos , vol.42 , pp. 932-942
    • Vishwanathan, K.1    Mair, S.2    Gupta, A.3
  • 32
    • 84911896976 scopus 로고    scopus 로고
    • Microbiological interaction studies between ceftazidime-avibactam and pulmonary surfactant and between ceftazidime-avibactam and antibacterial agents of other classes
    • J. Dallow, L.G. Otterson, M.D. Huband, and et al. Microbiological interaction studies between ceftazidime-avibactam and pulmonary surfactant and between ceftazidime-avibactam and antibacterial agents of other classes Int J Antimicrob Agents 44 2014 552 556
    • (2014) Int J Antimicrob Agents , vol.44 , pp. 552-556
    • Dallow, J.1    Otterson, L.G.2    Huband, M.D.3
  • 33
    • 84877123198 scopus 로고    scopus 로고
    • Comparative study of the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalized adults: Results of a randomized, double-blind, Phase II trial
    • C. Lucasti, I. Popescu, M.K. Ramesh, and et al. Comparative study of the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infections in hospitalized adults: results of a randomized, double-blind, Phase II trial J Antimicrob Chemother 68 2013 1183 1192
    • (2013) J Antimicrob Chemother , vol.68 , pp. 1183-1192
    • Lucasti, C.1    Popescu, I.2    Ramesh, M.K.3
  • 34
    • 84870399321 scopus 로고    scopus 로고
    • Efficacy and safety of ceftazidime-avibactam versus imipenem-cilastatin in the treatment of complicated urinary tract infections, including acute pyelonephritis, in hospitalized adults: Results of a prospective, investigator-blinded, randomized study
    • J.A. Vazquez, L.D. González Patzán, D. Stricklin, and et al. Efficacy and safety of ceftazidime-avibactam versus imipenem-cilastatin in the treatment of complicated urinary tract infections, including acute pyelonephritis, in hospitalized adults: results of a prospective, investigator-blinded, randomized study Curr Med Res Opin 28 2012 1921 1931
    • (2012) Curr Med Res Opin , vol.28 , pp. 1921-1931
    • Vazquez, J.A.1    González Patzán, L.D.2    Stricklin, D.3
  • 35
    • 84949099490 scopus 로고    scopus 로고
    • Efficacy and safety of ceftazidime-avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infection - Results from a Phase III program
    • Abstract presented at: April 25-28, Copenhagen, Denmark. Abstract O191
    • Mazuski JE, Gasnik L, Armstrong J, et al. Efficacy and safety of ceftazidime-avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infection - results from a Phase III program. Abstract presented at: 25th European Congress of Clinical Microbiology and Infectious Diseases; April 25-28, 2015; Copenhagen, Denmark. Abstract O191.
    • (2015) 25th European Congress of Clinical Microbiology and Infectious Diseases
    • Mazuski, J.E.1    Gasnik, L.2    Armstrong, J.3
  • 36
    • 84939841907 scopus 로고    scopus 로고
    • Efficacy and safety of ceftazidime-avibactam and best available therapy in the treatment of ceftazidime-resistant infections - Results from a Phase III study
    • Abstract presented at: April 25-28, Copenhagen, Denmark. Abstract LBEV0061b
    • Carmeli Y, Armstrong J, Laud PJ, et al. Efficacy and safety of ceftazidime-avibactam and best available therapy in the treatment of ceftazidime-resistant infections - results from a Phase III study. Abstract presented at: 25th European Congress of Clinical Microbiology and Infectious Diseases; April 25-28, 2015; Copenhagen, Denmark. Abstract LBEV0061b.
    • (2015) 25th European Congress of Clinical Microbiology and Infectious Diseases
    • Carmeli, Y.1    Armstrong, J.2    Laud, P.J.3
  • 41
    • 84898609105 scopus 로고    scopus 로고
    • Randomized, placebo-controlled study to assess the impact on QT/QTc interval of supratherapeutic doses of ceftazidime-avibactam or ceftaroline fosamil-avibactam
    • S. Das, J. Armstrong, D. Mathews, and et al. Randomized, placebo-controlled study to assess the impact on QT/QTc interval of supratherapeutic doses of ceftazidime-avibactam or ceftaroline fosamil-avibactam J Clin Pharmacol 54 2014 331 340
    • (2014) J Clin Pharmacol , vol.54 , pp. 331-340
    • Das, S.1    Armstrong, J.2    Mathews, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.