Vitamin D Supplementation Reduces Induction of Epithelial-Mesenchymal Transition in Allergen Sensitized and Challenged Mice

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Fischer, Kimberly D ^a   Hall, Sannette C ^a   Agrawal, Devendra K ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; FUNGUS ANTIGEN; HOUSE DUST ALLERGEN; NERVE CELL ADHESION MOLECULE; RAGWEED ANTIGEN; UVOMORULIN; VIMENTIN; VITAMIN D; CADHERIN; CYTOKINE; IMMUNOGLOBULIN E;

AIRWAY REMODELING; ALTERNARIA ALTERNATA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HISTOLOGY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; VITAMIN SUPPLEMENTATION; ANIMAL; BAGG ALBINO MOUSE; COMPLICATION; DIETARY SUPPLEMENT; DRUG EFFECTS; EPITHELIUM; IMMUNOLOGY; INFLAMMATION; LEUKOCYTE; LUNG; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

AIRWAY REMODELING; ALLERGENS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CADHERINS; CYTOKINES; DIETARY SUPPLEMENTS; EPITHELIAL-MESENCHYMAL TRANSITION; EPITHELIUM; FEMALE; IMMUNOGLOBULIN E; INFLAMMATION; LEUKOCYTES; LUNG; MALE; MICE, INBRED BALB C; RESPIRATORY HYPERSENSITIVITY; VIMENTIN; VITAMIN D;

EID: 84960977526     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0149180     Document Type: Article

References (45)

1. Lemanske RF, Busse WW. Asthma. J Allergy Clin Immunol. 2003 Feb; 111(2 Suppl):S502-19. PMID: 12592297
2. Kelly MM, O'Connor TM, Leigh R, Otis J, Gwozd C, Gauvreau GM, et al. Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma. J Allergy Clin Immunol. 2010 Feb; 125(2):349-56.e13. doi: 10.1016/j.jaci.2009.09.011 PMID: 19969339
3. Berair R, Brightling CE. Asthma Therapy and Its Effect on Airway Remodelling. Drugs. 2014 Jul 24
4. Bergeron C, Tulic MK, Hamid Q. Airway remodelling in asthma: From benchside to clinical practice. Can Respir J J Can Thorac Soc. 2010 Aug; 17(4):e85-93.
5. Lambrecht BN, Hammad H. The airway epithelium in asthma. Nat Med. 2012 May; 18(5):684-92. doi: 10.1038/nm.2737 PMID: 22561832
6. Bergeron C, Al-Ramli W, Hamid Q. Remodeling in asthma. Proc Am Thorac Soc. 2009 May 1; 6 (3):301-5. doi: 10.1513/pats.200808-089RM PMID: 19387034
7. Berraies A, Hamzaoui K, Hamzaoui A. Link between vitamin D and airway remodeling. J Asthma Allergy. 2014 Apr 1; 7:23-30. doi: 10.2147/JAA.S46944 PMID: 24729717
8. Yawn J, Lawrence LA, Carroll WW, Mulligan JK. Vitamin D for the treatment of respiratory diseases: Is it the end or just the beginning? J Steroid Biochem Mol Biol. 2015 Apr; 148:326-37. doi: 10.1016/j. jsbmb.2015.01.017 PMID: 25625665
9. Nials AT, Uddin S. Mouse models of allergic asthma: Acute and chronic allergen challenge. Dis Model Mech. 2008; 1(4-5):213-20. doi: 10.1242/dmm.000323 PMID: 19093027
10. Johnson JR, Roos A, Berg T, Nord M, Fuxe J. Chronic Respiratory Aeroallergen Exposure in Mice Induces Epithelial-Mesenchymal Transition in the Large Airways. Samakovlis C, editor. PLoS ONE. 2011 Jan 20; 6(1):e16175. doi: 10.1371/journal.pone.0016175 PMID: 21283768
11. Fan M, Jamal Mustafa S. Role of adenosine in airway inflammation in an allergic mouse model of asthma. Int Immunopharmacol. 2006 Jan; 6(1):36-45. PMID: 16332511
12. Sorkness RL, Herricks KM, Szakaly RJ, Lemanske RF, Rosenthal LA. Altered allergen-induced eosinophil trafficking and physiological dysfunction in airways with preexisting virus-induced injury. Am J Physiol Lung Cell Mol Physiol. 2007 Jan; 292(1):L85-91. PMID: 16905639
13. Shao Z, Bharadwaj AS, McGee HS, Makinde TL, Agrawal DK. Flt-3 Ligand Increases a Lung Dendritic Cell Subset with Regulatory Properties in allergic airway inflammation. J Allergy Clin Immunol. 2009 Apr; 123(4):917-24.e2. doi: 10.1016/j.jaci.2009.01.052 PMID: 19348927
14. Locke NR, Royce SG, Wainewright JS, Samuel CS, Tang ML. Comparison of Airway Remodeling in Acute, Subacute, and Chronic Models of Allergic Airways Disease. Am J Respir Cell Mol Biol. 2007 May 1; 36(5):625-32. PMID: 17237192
15. Ge XN, Bahaie NS, Kang BN, Hosseinkhani MR, Ha SG, Frenzel EM, et al. Allergen-Induced Airway Remodeling Is Impaired in Galectin-3-Deficient Mice. J Immunol. 2010 Jul 15; 185(2):1205-14. doi: 10. 4049/jimmunol.1000039 PMID: 20543100
16. Jensen EC. Quantitative Analysis of Histological Staining and Fluorescence Using ImageJ. Anat Rec. 2013 Mar 1; 296(3):378-81.
17. Kim M-H, Jee J-H, Park S, Lee M-S, Kim K-W, Lee M-K. Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling. J Endocrinol. 2014 Feb; 220(2):117-28. doi: 10. 1530/JOE-13-0381 PMID: 24233023
18. Sun Z, Parrish AR, Hill MA, Meininger GA. N-cadherin, A Vascular Smooth Muscle Cell-Cell Adhesion Molecule: Function and Signaling for Vasomotor Control. Microcirculation. 2014 Apr 1; 21(3):208-18. doi: 10.1111/micc.12123 PMID: 24521477
19. Fischer KD, Agrawal DK. Vitamin D regulating TGF-β induced epithelial-mesenchymal transition. Respir Res. 2014; 15(1):146.
20. Hackett T-L, De Bruin HG, Shaheen F, Van Den Berge M, Van Oosterhout AJ, Postma DS, et al. Caveolin-1 controls airway epithelial barrier function. Implications for asthma. Am J Respir Cell Mol Biol. 2013 Oct; 49(4):662-71. doi: 10.1165/rcmb.2013-0124OC PMID: 23742006
21. Johnson JR, Nishioka M, Chakir J, Risse P-A, Almaghlouth I, Bazarbashi AN, et al. IL-22 contributes to TGF-β1-mediated epithelial-mesenchymal transition in asthmatic bronchial epithelial cells. Respir Res. 2013; 14:118. doi: 10.1186/1465-9921-14-118 PMID: 24283210
22. Micallef L, Vedrenne N, Billet F, Coulomb B, Darby IA, Desmoulière A. The myofibroblast, multiple origins for major roles in normal and pathological tissue repair. Fibrogenesis Tissue Repair. 2012; 5(Suppl 1 Proceedings of Fibroproliferative disorders: From biochemical analysis to targeted therapiesPetro E Petrides and David Brenner):S5. doi: 10.1186/1755-1536-5-S1-S5 PMID: 23259712
23. De Wever O, Westbroek W, Verloes A, Bloemen N, Bracke M, Gespach C, et al. Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-β or wounding. J Cell Sci. 2004 Sep 15; 117(20):4691-703.
24. Zhang M, Zhang Z, Pan H-Y, Wang D-X, Deng Z-T, Ye X-L. TGF-beta1 induces human bronchial epithelial cell-to-mesenchymal transition in vitro. Lung. 2009 Jun; 187(3):187-94. doi: 10.1007/s00408-009-9139-5 PMID: 19252942
25. Doerner AM, Zuraw BL. TGF-β1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1β but not abrogated by corticosteroids. Respir Res. 2009; 10 (1):100.
26. Arshi S, Fallahpour M, Nabavi M, Bemanian MH, Javad-Mousavi SA, Nojomi M, et al. The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma. Ann Allergy Asthma Immunol. 2014 Oct; 113(4):404-9. doi: 10.1016/j.anai.2014.07.005 PMID: 25091714
27. Agrawal T, Gupta GK, Agrawal DK. Calcitriol decreases expression of importin ?3 and attenuates RelA translocation in human bronchial smooth muscle cells. J Clin Immunol. 2012 Oct; 32(5):1093-103. doi: 10.1007/s10875-012-9696-x PMID: 22526597
28. Ramirez AM, Wongtrakool C, Welch T, Steinmeyer A, Zügel U, Roman J. Vitamin D inhibition of profibrotic effects of transforming growth factor ?1 in lung fibroblasts and epithelial cells. J Steroid Biochem Mol Biol. 2010 Feb; 118(3):142-50. doi: 10.1016/j.jsbmb.2009.11.004 PMID: 19931390
29. Hansdottir S, Monick MM, Lovan N, Powers L, Gerke A, Hunninghake GW. Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol Baltim Md 1950. 2010 Jan 15; 184(2):965-74.
30. Agrawal T, Gupta GK, Agrawal DK. Vitamin D supplementation reduces airway hyperresponsiveness and allergic airway inflammation in a murine model. Clin Exp Allergy J Br Soc Allergy Clin Immunol. 2013 Jun; 43(6):672-83.
31. Hatami G, Ghasemi K, Motamed N, Firoozbakht S, Movahed A, Farrokhi S. Relationship between Vitamin D and Childhood Asthma: A Case-Control Study. Iran J Pediatr. 2014 Dec; 24(6):710-4. PMID: 26019776
32. Gorman S, Tan DHW, Lambert MJM, Scott NM, Judge MA, Hart PH. Vitamin D3 deficiency enhances allergen-induced lymphocyte responses in a mouse model of allergic airway disease. Pediatr Allergy Immunol. 2012 Feb 1; 23(1):83-7. doi: 10.1111/j.1399-3038.2011.01146.x PMID: 22283404
33. Gorman S, Weeden CE, Tan DHW, Scott NM, Hart J, Foong RE, et al. Reversible Control by Vitamin D of Granulocytes and Bacteria in the Lungs of Mice: An Ovalbumin-Induced Model of Allergic Airway Disease. PLoS ONE [Internet]. 2013 Jun 24 [cited 2015 Jun 5]; 8(6). Available from: Http://www.ncbi.nlm. nih.gov/pmc/articles/PMC3691156/
34. Taher YA, Esch BCAM van, Hofman GA, Henricks PAJ, Oosterhout AJM van. 1α,25-Dihydroxyvitamin D3 Potentiates the Beneficial Effects of Allergen Immunotherapy in a Mouse Model of Allergic Asthma: Role for IL-10 and TGF-?. J Immunol. 2008 Apr 15; 180(8):5211-21. PMID: 18390702
35. Yin K, Agrawal DK. Vitamin D and inflammatory diseases. J Inflamm Res. 2014; 7:69-87. doi: 10.2147/JIR.S63898 PMID: 24971027
36. Bener A, Ehlayel MS, Tulic MK, Hamid Q. Vitamin D Deficiency as a Strong Predictor of Asthma in Children. Int Arch Allergy Immunol. 2012; 157(2):168-75. doi: 10.1159/000323941 PMID: 21986034
37. Foong RE, Shaw NC, Berry LJ, Hart PH, Gorman S, Zosky GR. Vitamin D deficiency causes airway hyperresponsiveness, increases airway smooth muscle mass, and reduces TGF-? expression in the lungs of female BALB/c mice. Physiol Rep. 2014; 2(3):e00276. doi: 10.1002/phy2.276 PMID: 24760528
38. Freishtat RJ, Iqbal SF, Pillai DK, Klein CJ, Ryan LM, Benton AS, et al. High Prevalence of Vitamin D Deficiency among Inner-City African American Youth with Asthma in Washington, DC. J Pediatr. 2010 Jun; 156(6):948-52. doi: 10.1016/j.jpeds.2009.12.033 PMID: 20236657
39. Majak P, Olszowiec-Chlebna M, Smejda K, Stelmach I. Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol. 2011 May; 127(5):1294-6. doi: 10.1016/j.jaci.2010.12.016 PMID: 21315433
40. Nanzer AM, Chambers ES, Ryanna K, Freeman AT, Colligan G, Richards DF, et al. The effects of calcitriol treatment in glucocorticoid-resistant asthma. J Allergy Clin Immunol. 2014 Jun; 133(6):1755-7.e4. doi: 10.1016/j.jaci.2014.03.015 PMID: 24786237
41. Castro M, King TS, Kunselman SJ, et al. Effect of vitamin d3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin d levels: The vida randomized clinical trial. JAMA. 2014 May 28; 311(20):2083-91. doi: 10.1001/jama.2014.5052 PMID: 24838406
42. Cupisti A, Vigo V, Baronti ME, D'Alessandro C, Ghiadoni L, Egidi MF. Vitamin D status and cholecalciferol supplementation in chronic kidney disease patients: An Italian cohort report. Int J Nephrol Renov Dis. 2015 Nov 19; 8:151-7.
43. Rosen CJ, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, et al. IOM committee members respond to Endocrine Society vitamin D guideline. J Clin Endocrinol Metab. 2012 Apr; 97 (4):1146-52. doi: 10.1210/jc.2011-2218 PMID: 22442278
44. Muehleisen B, Gallo RL. Vitamin D in allergic disease: Shedding light on a complex problem. J Allergy Clin Immunol. 2013 Feb; 131(2):324-9. doi: 10.1016/j.jaci.2012.12.1562 PMID: 23374263
45. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: AN ENDOCRINE SOCIETY CLINical practice guideline. J Clin Endocrinol Metab. 2011 Jul; 96(7):1911-30. doi: 10.1210/jc.2011-0385 PMID: 21646368