Pneumococcal nasopharyngeal carriage in children <5 years of age visiting the pediatric emergency room in relation to PCV7 and PCV13 introduction in southern Israel

Human Vaccines and Immunotherapeutics

Volumn 12, Issue 2, 2016, Pages 268-276

  Ben Shimol, Shalom ^a   Givon Lavi, Noga ^a   Greenberg, David ^a   Dagan, Ron ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

children; impact; nasopharyngeal carriage; pneumococcal conjugate vaccine; vaccine uptake

Indexed keywords

PNEUMOCOCCUS VACCINE; 13-VALENT PNEUMOCOCCAL VACCINE; VACCINE;

AGGLUTINATION TEST; ARTICLE; BACTERIUM IDENTIFICATION; BLOOD GROUP TYPING; CHILD; CONTROLLED STUDY; DISEASE SURVEILLANCE; DRUG UPTAKE; ETHNICITY; HUMAN; IMMUNIZATION; INFANT; ISRAEL; PNEUMOCOCCAL INFECTION; PRESCHOOL CHILD; PROSPECTIVE STUDY; RHINOPHARYNGITIS; SEROTYPE; STREPTOCOCCUS PNEUMONIAE; VACCINATION; HETEROZYGOTE; HOSPITAL EMERGENCY SERVICE; IMMUNOLOGY; MICROBIOLOGY; MICROFLORA; NASOPHARYNX; PNEUMOCOCCAL INFECTIONS;

CARRIER STATE; CHILD, PRESCHOOL; EMERGENCY SERVICE, HOSPITAL; HEPTAVALENT PNEUMOCOCCAL CONJUGATE VACCINE; HUMANS; INFANT; ISRAEL; MICROBIOTA; NASOPHARYNX; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; PROSPECTIVE STUDIES; STREPTOCOCCUS PNEUMONIAE; VACCINATION; VACCINES, CONJUGATE;

EID: 84960950856     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.1080/21645515.2015.1095414     Document Type: Article

References (44)

1. R.Dagan, S.Patterson, C.Juergens, D.Greenberg, N.Givon-Lavi, N.Porat, A.Gurtman, W.C.Gruber, D.A.Scott. Comparative immunogenicity and efficacy of 13-valent and 7-valent pneumococcal conjugate vaccines in reducing nasopharyngeal colonization: a randomized double-blind trial. Clin Infect Dis 2013; 57:952-62; PMID:23804191; http://dx.doi.org/10.1093/cid/cit428
2. M.R.Moore, C.G.Whitney. Use of pneumococcal disease epidemiology to set policy and prevent disease during 20 years of the emerging infections program. Emerg Infect Dis 2015; 21:1551-6; PMID:26291238; http://dx.doi.org/10.3201/eid2109.150395
3. S.Ben-Shimol, N.Givon-Lavi, E.Leibovitz, S.Raiz, D.Greenberg, R.Dagan. Near-elimination of otitis media caused by 13-valent pneumococcal conjugate vaccine (PCV) serotypes in southern Israel shortly after sequential introduction of 7-valent/13-valent PCV. Clin Infect Dis 2014; 59:1724-32; PMID:25159581; http://dx.doi.org/10.1093/cid/ciu683
4. H.Park, A.O.Adeyemi, K.L.Rascati. Direct medical costs and utilization of health care services to treat pneumonia in the United States: An analysis of the 2007-2011 Medical Expenditure Panel Survey. Clin Ther 2015; 37:1466-76 e1; PMID:26001310; http://dx.doi.org/10.1016/j.clinthera.2015.04.013
5. B.Simell, K.Auranen, H.Kayhty, D.Goldblatt, R.Dagan, K.L.O'Brien. The fundamental link between pneumococcal carriage and disease. Expert Rev Vaccines 2012; 11:841-55; PMID:22913260; http://dx.doi.org/10.1586/erv.12.53
6. J.D.Kellner, D.Scheifele, O.G.Vanderkooi, J.Macdonald, D.L.Church, G.J.Tyrrell. Effects of routine infant vaccination with the 7-valent pneumococcal conjugate vaccine on nasopharyngeal colonization with streptococcus pneumoniae in children in Calgary, Canada. Pediatr Infect Dis J 2008; 27:526-32; PMID:18458650; http://dx.doi.org/10.1097/INF.0b013e3181658c5c
7. C.Y.Kuo, K.P.Hwang, Y.C.Hsieh, C.H.Cheng, F.L.Huang, Y.H.Shen, Y.C.Huang, C.H.Chiu, P.Y.Chen, T.Y.Lin. Nasopharyngeal carriage of Streptococcus pneumoniae in Taiwan before and after the introduction of a conjugate vaccine. Vaccine 2011; 29:5171-7; PMID:21621578; http://dx.doi.org/10.1016/j.vaccine.2011.05.034
8. M.R.Moore, T.B.Hyde, T.W.Hennessy, D.J.Parks, A.L.Reasonover, M.Harker-Jones, J.Gove, D.L.Bruden, K.Rudolph, A.Parkinson, et al. Impact of a conjugate vaccine on community-wide carriage of nonsusceptible Streptococcus pneumoniae in Alaska. J Infect Dis 2004; 190:2031-8; PMID:15529269; http://dx.doi.org/10.1086/425422
9. J.D.Loo, L.Conklin, K.E.Fleming-Dutra, M.D.Knoll, D.E.Park, J.Kirk, D.Goldblatt, K.L.O'Brien, C.G.Whitney. Systematic review of the indirect effect of pneumococcal conjugate vaccine dosing schedules on pneumococcal disease and colonization. Pediatr Infect Dis J 2014; 33 Suppl 2:S161-71; PMID:24336058; http://dx.doi.org/10.1097/INF.0000000000000084
10. E.Usuf, H.Badji, A.Bojang, S.Jarju, U.N.Ikumapayi, M.Antonio, G.Mackenzie, C.Bottomley. Pneumococcal carriage in rural Gambia prior to the introduction of pneumococcal conjugate vaccine: a population-based survey. Trop Med Int Health 2015; 20:871-9; http://dx.doi.org/10.1111/tmi.12505
11. G.A.Mackenzie, A.J.Leach, J.R.Carapetis, J.Fisher, P.S.Morris. Epidemiology of nasopharyngeal carriage of respiratory bacterial pathogens in children and adults: cross-sectional surveys in a population with high rates of pneumococcal disease. BMC Infect Dis 2010; 10:304; PMID:20969800; http://dx.doi.org/10.1186/1471-2334-10-304
12. D.Greenberg, N.Givon-Lavi, A.Broides, I.Blancovich, N.Peled, R.Dagan. The contribution of smoking and exposure to tobacco smoke to Streptococcus pneumoniae and Haemophilus influenzae carriage in children and their mothers. Clin Infect Dis 2006; 42:897-903; PMID:16511750; http://dx.doi.org/10.1086/500935
13. A.von Gottberg, L.de Gouveia, S.Tempia, V.Quan, S.Meiring, C.von Mollendorf, S.A.Madhi, E.R.Zell, J.R.Verani, K.L.O'Brien, et al. Effects of vaccination on invasive pneumococcal disease in South Africa. N Engl J Med 2014; 371:1889-99; PMID:25386897; http://dx.doi.org/10.1056/NEJMoa1401914
14. S.Ben-Shimol, D.Greenberg, N.Givon-Lavi, Y.Schlesinger, E.Somekh, S.Aviner, D.Miron, R.Dagan. Early impact of sequential introduction of 7-valent and 13-valent pneumococcal conjugate vaccine on IPD in Israeli children. Vaccine 2014; 32:3452-9; PMID:24690148; http://dx.doi.org/10.1016/j.vaccine.2014.03.065
15. A.Berglund, M.Ekelund, M.A.Fletcher, L.Nyman. All-cause pneumonia hospitalizations in children <2 years old in sweden, 1998 to 2012: impact of pneumococcal conjugate vaccine introduction. PLoS One 2014; 9:e112211; PMID:25379659; http://dx.doi.org/10.1371/journal.pone.0112211
16. A.Lindstrand, R.Bennet, I.Galanis, M.Blennow, L.S.Ask, S.H.Dennison, M.R.Rinder, M.Eriksson, B.Henriques-Normark, A.Ortqvist, et al. Sinusitis and pneumonia hospitalization after introduction of pneumococcal conjugate vaccine. Pediatrics 2014; 134:e1528-36; PMID:25384486; http://dx.doi.org/10.1542/peds.2013-4177
17. M.R.Griffin, E.Mitchel, M.R.Moore, C.G.Whitney, C.G.Grijalva. Declines in pneumonia hospitalizations of children aged <2 years associated with the use of pneumococcal conjugate vaccines - Tennessee, 1998-2012. MMWR Morb Mortal Wkly Rep 2014; 63:995-8; PMID:25375070
18. M.R.Griffin, Y.Zhu, M.R.Moore, C.G.Whitney, C.G.Grijalva. US hospitalizations for pneumonia after a decade of pneumococcal vaccination. N Engl J Med 2013; 369:155-63; PMID:23841730; http://dx.doi.org/10.1056/NEJMoa1209165
19. A.J.van Hoek, C.L.Sheppard, N.J.Andrews, P.A.Waight, M.P.Slack, T.G.Harrison, S.N.Ladhani, E.Miller. Pneumococcal carriage in children and adults two years after introduction of the thirteen valent pneumococcal conjugate vaccine in England. Vaccine 2014; 32:4349-55; PMID:24657717; http://dx.doi.org/10.1016/j.vaccine.2014.03.017
20. S.M.Davis, M.Deloria-Knoll, H.T.Kassa, K.L.O'Brien. Impact of pneumococcal conjugate vaccines on nasopharyngeal carriage and invasive disease among unvaccinated people: review of evidence on indirect effects. Vaccine 2013; 32:133-45; PMID:23684824; http://dx.doi.org/10.1016/j.vaccine.2013.05.005
21. G.Regev-Yochay, Y.Paran, J.Bishara, I.Oren, M.Chowers, Y.Tziba, V.Istomin, M.Weinberger, D.Miron, V.Temper, et al. Early impact of PCV7/PCV13 sequential introduction to the national pediatric immunization plan, on adult invasive pneumococcal disease: A nationwide surveillance study. Vaccine 2015; 33:1135-42; PMID:25613717; http://dx.doi.org/10.1016/j.vaccine.2015.01.030
22. R.Dagan, N.Givon-Lavi, D.Fraser, M.Lipsitch, G.R.Siber, R.Kohberger. Serum serotype-specific pneumococcal anticapsular immunoglobulin G concentrations after immunization with a 9-valent conjugate pneumococcal vaccine correlate with nasopharyngeal acquisition of pneumococcus. J Infect Dis 2005; 192:367-76; PMID:15995949; http://dx.doi.org/10.1086/431679
23. K.Auranen, H.Rinta-Kokko, D.Goldblatt, H.Nohynek, K.L.O'Brien, C.Satzke, B.Simell, A.Tanskanen, H.Käyhty. Colonisation endpoints in Streptococcus pneumoniae vaccine trials. Vaccine 2013; 32:153-8; PMID:24016803; http://dx.doi.org/10.1016/j.vaccine.2013.08.061
24. A.S.Tocheva, J.M.Jefferies, H.Rubery, J.Bennett, G.Afimeke, J.Garland, M.Christodoulides, S.N.Faust, S.C.Clarke. Declining serotype coverage of new pneumococcal conjugate vaccines relating to the carriage of Streptococcus pneumoniae in young children. Vaccine 2011; 29:4400-4; PMID:21504773; http://dx.doi.org/10.1016/j.vaccine.2011.04.004
25. D.M.Weinberger, R.Malley, M.Lipsitch. Serotype replacement in disease after pneumococcal vaccination. Lancet 2011; 378:1962-73; PMID:21492929; http://dx.doi.org/10.1016/S0140-6736(10)62225-8
26. R.Dagan, N.Givon-Lavi, O.Zamir, D.Fraser. Effect of a nonavalent conjugate vaccine on carriage of antibiotic-resistant Streptococcus pneumoniae in day care centers. Pediatr Infect Dis J 2003; 22:532-9; PMID:12799510
27. I.N.Grivea, M.Panagiotou, A.G.Tsantouli, G.A.Syrogiannopoulos. Impact of heptavalent pneumococcal conjugate vaccine on nasopharyngeal carriage of penicillin-resistant Streptococcus pneumoniae among day-care center attendees in central Greece. Pediatr Infect Dis J 2008; 27:519-25; PMID:18469733; http://dx.doi.org/10.1097/INF.0b013e318168d28a
28. R.Cohen, C.Levy, L.deLa F.Rocque, N.Gelbert, A.Wollner, B.Fritzell, E.Bonnet, R.Tetelboum, E.Varon. Impact of pneumococcal conjugate vaccine and of reduction of antibiotic use on nasopharyngeal carriage of nonsusceptible pneumococci in children with acute otitis media. Pediatr Infect Dis J 2006; 25:1001-7; PMID:17072121; http://dx.doi.org/10.1097/01.inf.0000243163.85163.a8
29. C.Azzari, F.Martinon-Torres, H.J.Schmitt, R.Dagan. Evolving role of 13-valent pneumococcal conjugate vaccine in clinical practice. Pediatr Infect Dis J 2014; 33:858-64; PMID:24618937; http://dx.doi.org/10.1097/INF.0000000000000328
30. R.Dagan, N.Givon-Lavi, N.Porat, D.Greenberg. The effect of an alternative reduced-dose infant schedule and a second year catch-up schedule with 7-valent pneumococcal conjugate vaccine on pneumococcal carriage: a randomized controlled trial. Vaccine 2012; 30:5132-40; PMID:22683519; http://dx.doi.org/10.1016/j.vaccine.2012.05.059
31. D.Greenberg, N.N.N.Givon-Lavi, J.bar-Ziv, R.Dagan. Nasopharyngeal carriage of individual Streptococcus pneumoniae serotypes during pediatric pneumonia as a means to estimate serotype disease potential. Pediatr Infect Dis J 2011; 30:227-33; PMID:20861756; http://dx.doi.org/10.1097/INF.0b013e3181f87802
32. D.R.Feikin, E.W.Kagucia, J.D.Loo, R.Link-Gelles, M.A.Puhan, T.Cherian, O.S.Levine, C.G.Whitney, K.L.O'Brien, M.R.Moore. Serotype-specific changes in invasive pneumococcal disease after pneumococcal conjugate vaccine introduction: a pooled analysis of multiple surveillance sites. PLoS Med 2013; 10:e1001517; PMID:24086113; http://dx.doi.org/10.1371/journal.pmed.1001517
33. W.H.Demczuk, I.Martin, A.Griffith, B.Lefebvre, A.McGeer, M.Lovgren, G.J.Tyrrell, S.Desai, L.Sherrard, H.Adam, et al. Serotype distribution of invasive Streptococcus pneumoniae in Canada after the introduction of the 13-valent pneumococcal conjugate vaccine, 2010-2012. Can J Microbiol 2013; 59:778-88; PMID:24313450; http://dx.doi.org/10.1139/cjm-2013-0614
34. A.P.Desai, D.Sharma, E.K.Crispell, W.Baughman, S.Thomas, A.Tunali, L.Sherwood, A.Zmitrovich, R.Jerris, S.Satola, et al. Decline in pneumococcal nasopharyngeal carriage of vaccine serotypes after the introduction of the 13-valent pneumococcal conjugate vaccine in children in Atlanta, Georgia. Pediatr Infect Dis J 2015; 34:1168-74; http://dx.doi.org/10.1097/INF.0000000000000849.
35. S.A.Nzenze, T.Shiri, M.C.Nunes, K.P.Klugman, K.Kahn, R.Twine, L.de Gouveia, A.von Gottberg, S.A.Madhi. Temporal changes in pneumococcal colonization in a rural African community with high HIV prevalence following routine infant pneumococcal immunization. Pediatr Infect Dis J 2013; 32:1270-8; PMID:24061271; http://dx.doi.org/10.1097/01.inf.0000435805.25366.64
36. L.R.Grant, S.E.O'Brien, R.C.Weatherholtz, M.R.Jacobs, S.Bajaksouzian, R.Reid, et al. Reductions in PCV13-type colonization among immunized and unimmunized American Indian community members (Abstract # 478). 9th International Symposium on Pneumococci and Pneumococcal Disease (ISPPD), March 9-13, 2014, Hyderabad, India
37. L.R.Grant, R.C.Weatherholtz, L.L.Hammitt, K.L.O'Brien. Reductions in PCV13-type Colonization among American Indian Community Members. 6th International Meeting on Indigenous Child Health. March 2015, Ottawa, Ontario
38. S.Ben-Shimol, R.Dagan, N.Givon-Lavi, Y.Bar-Ziv, D.Greenberg. Community acquired pneumonia (CAP) in children younger than 5 years of age in southern Israel. Harefuah 2010; 149:137-42, 96
39. Statistical Abstracts of Israel, 2014. No. 65. Central Bureau of Statistics. Jerusalem: State of Israel, 2014
40. S.Ben-Shimol, D.Greenberg, G.Hazan, Y.Shemer-Avni, N.Givon-Lavi, R.Dagan. Seasonality of both bacteremic and nonbacteremic pneumonia coincides with viral lower respiratory tract infections in early childhood, in contrast to nonpneumonia invasive pneumococcal disease, in the pre-pneumococcal conjugate vaccine era. Clin Infect Dis 2015; 60:1384-7; PMID:25595749
41. R.Dagan, N.Givon-Lavi, O.Zamir, M.Sikuler-Cohen, L.Guy, J.Janco, P.Yagupsky, D.Fraser. Reduction of nasopharyngeal carriage of Streptococcus pneumoniae after administration of a 9-valent pneumococcal conjugate vaccine to toddlers attending day care centers. J Infect Dis 2002; 185:927-36; PMID:11920317; http://dx.doi.org/10.1086/339525
42. R.Dagan, C.Juergens, J.Trammel, S.Patterson, D.Greenberg, N.Givon-Lavi, N.Porat, A.Gurtman, W.C.Gruber, D.A.Scott. Efficacy of 13-valent pneumococcal conjugate vaccine (PCV13) versus that of 7-valent PCV (PCV7) against nasopharyngeal colonization of antibiotic-nonsusceptible Streptococcus pneumoniae. J Infect Dis 2015; 211:1144-53; PMID:25355940; http://dx.doi.org/10.1093/infdis/jiu576
43. N.Porat, U.Amit, N.Givon-Lavi, E.Leibovitz, R.Dagan. Increasing importance of multidrug-resistant serotype 6A Streptococcus pneumoniae clones in acute otitis media in southern Israel. Pediatr Infect Dis J 2010; 29:126-30; PMID:19927039; http://dx.doi.org/10.1097/INF.0b013e3181b78e6e
44. S.Ben-Shimol, D.Greenberg, N.Givon-Lavi, N.Elias, D.Glikman, U.Rubinstein, R.Dagan. Rapid reduction in invasive pneumococcal disease after introduction of PCV7 into the National Immunization Plan in Israel. Vaccine 2012; 30:6600-7; PMID:22939907; http://dx.doi.org/10.1016/j.vaccine.2012.08.012