Eriodictyol-induced anti-cancer and apoptotic effects in human hepatocellular carcinoma cells are associated with cell cycle arrest and modulation of apoptosis-related proteins

Bangladesh Journal of Pharmacology

Volumn 11, Issue 2, 2016, Pages 285-291

  Wang, Fang ^a   Wang, Yu Hang ^b   Wang, Jing Jing ^b   Xu, He Lin ^b   Wang, Chang Miao ^b  

^a Department of Healthy Portion ^*  (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Anti cancer; Apoptotic; Cell cycle arrest; Eriodictyol; Hepatocellular carcinoma cell; Tail suspension test

Indexed keywords

ERIODICTYOL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG STRUCTURE; G2 PHASE CELL CYCLE CHECKPOINT; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; UPREGULATION;

EID: 84960925736     PISSN: 1991007X     EISSN: 19910088     Source Type: Journal    
DOI: 10.3329/bjp.v11i2.25549     Document Type: Article

References (13)

1. Amin A, Hamza AA, Bajbouj K, Ashraf SS, Daoud S. Saffron: A potential candidate for a novel anticancer drug against hepatocellular carcinoma. Hepatology. 2011; 54: 857-67.
2. Clavin M, Gorzalczany S, Macho A, Muñoz E, Ferraro G, Acevedo C, Martino V.Anti-inflammatory activity of flavornoids from Eupatorium arnottianum. J Ethnopharmacol. 2007; 112: 585-89.
3. Fabregat I. Dysregulation of apoptosis in hepatocellular carcinoma cells. World J Gastroenterol. 2009; 15: 513-20.
4. Flatt PM, Pietenpol JA. Mechanisms of cell-cycle checkpoints: At the crossroads of carcinogenesis and drug discovery. Drug Metab Rev. 2000; 32: 283-305.
5. George BP, Abrahamse H. A review on novel breast cancer therapies: Photodynamic therapy and plant derived agent induced cell death mechanisms. Anticancer Agents Med Chem. 2015.
6. Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol. 1983; 32; 1141-48.
7. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011; 61: 69-90.
8. Ley JP, Krammer G, Reinders G, Gatfield IL, Bertram HJ. Evaluation of bitter masking flavanones from Herba Santa (Eriodictyon californicum (H. and A.) Torr., Hydrophyllaceae). J Agric Food Chem. 2005; 53: 6061-66.
9. Ngandeu F, Bezabih M, Ngamga D, Tchinda AT, Ngadjui BT, Abegaz BM, Dufat H, Tillequin F. Rotenoid derivatives and other constituents of the twigs of Millettia duchesnei. Phytochemistry 2008; 69: 258-63.
10. Pfeuty B, David-Pfeuty T, Kaneko K. Underlying principles of cell fate determination during G1 phase of the mammalian cell cycle. Cell Cycle. 2008; 7: 3246-57.
11. Pietenpol JA, Stewart ZA. Cell cycle checkpoint signaling: Cell cycle arrest versus apoptosis. Toxicology 2002; 181-182: 475-81.
12. Qazzaz ME, Raja VJ, Lim KH, Kam TS, Lee JB, Gershkovich P, Bradshaw TD. In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine b. Cancer Lett. 2015; 370: 185-97.
13. Tabone M, Pellicano R. Prevention of intrahepatic hepatocarcinoma recurrence in patients with viral cirrhosis: Two potential options. Minerva Gastroenterol Dietol. 2006; 52: 47-52.